Fractures of the capitellum humeri are rare and the recommendations for treatment vary. It can involve a significant portion of the articular surface, rendering the elbow joint unstable. In this situation, it is desirable to reduce and internally fix the capitellar fragment, because this restores the articular surface and augments joint stability. We experienced two cases of capitellar fractures which one case was spontaneously anatomical reduced and the other case was treated by open reduction. In one case the capitellar fragment was spontaneous reduced to a stable position although it was noticed radiographically as an unstable displaced fracture preoperatively. The other case was treated by open reduction and internal fixation with 3.5mm, small, AO, cannulated screw and K-wire. Both cases are reported here with references.
Elbow Joint ; Joints

We retrospectively reviewed clinical and radiologic findings of 19 patients who had been diagnosed as epithelial tumors of the lacrimal gland histopathologically after biopsy and surgery at Shinchon Severance Hospital from April, 1991 to July, 1998 and evaluated their correlation to the pathologic diagnosis, treatment and prognosis. There were 7 men and 12 women with the mean age of 41.0+/-13.3 years. Histopathologically, there were 7 cases of adenoid cystic carcinoma, 1 case of adenocarcinoma, 1 case of malignant mixed tumor, 9 cases of pleomorphic adenoma, and 1 case of benign oncocytoma. In comparison with benign epithelial tumor of the lacrimal gland, the characteristic clinical findings of malignant epithelial tumor of the lacrimal gland were pain, limitation of motion, and diplopia[44.4%]. The mean duration of the symptoms of malignant epithelial tumor was shorter[10.3+/-6.6 months] than that of benign epithelial tumor[19.5+/-14.4 months]. In radiologic CT and MRI findings, there were characteristic bony destructions in malignant epithelial tumors of the lacrimal gland[55.6%] compared with benign tumors and poorly marginated outline of the tumor was noted in malignant tumors[44.4%] but not in benign tumors. Therefore, clinical and radiologic findings of epithelial tumors of the lacrimal gland were well correlated with the pathologic diagnosis and would attribute to early diagnosis of malignant tumors.
Adenocarcinoma ; Adenoma, Oxyphilic ; Adenoma, Pleomorphic ; Biopsy ; Carcinoma ; Carcinoma, Adenoid Cystic ; Diagnosis ; Early Diagnosis ; Female ; Humans ; Lacrimal Apparatus* ; Magnetic Resonance Imaging ; Male ; Mixed Tumor, Malignant ; Prognosis ; Retrospective Studies

There are many difficult problems of reduction and its maintaining in the treatment of unstable intertrochanteric fractures. Especially, in cases of elderly patients with marked osteoporosis, prolonged immobilization brings more serious complication. In order to solve these problems, in cases of unstable intertrochanteric fractures with large lesser trochanteric fragment, we have carried out anatomical reduction and rigid internal fixation with compression hip screw and additional transfixation screw on posteromedial fragment. The unstable fractures have been convrted into the stable fractures by transfixation screw. We analyzed the 1 1cases with additional transfixation screw and they showed good results in one year follow up.
Aged ; Femoral Fractures ; Femur ; Follow-Up Studies ; Hip Fractures ; Hip ; Humans ; Immobilization ; Osteoporosis

BACKGROUND AND OBJECTIVES : Resveratrol (RVT) is a polyphenolic phytoalexin, and it has been demonstrated to be capable of protecting against cardiovascular disease. The aim of this study was to identify whether RVT might protect against monocrotaline (MCT)-induced pulmonary hypertension and whether vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), and inducible nitric oxide synthase (iNOS) are involved in the beneficial effects. MATERIALS AND METHODS : Thirty Sprague Dawley rats were divided into three groups: the control (n=6), the MCT (n=12) and the MCT with RVT (5 mg/kg/day, n=12) groups. After 28 days, the tissue samples were obtained for morphometric analysis and Western blotting. RESULTS : In the MCT group, the right ventricle/(left ventricle+septum) weight ratio was significantly increased compared with that of the control group (0.51+/-0.07 vs. 0.20+/-0.03, p<0.01), which was markedly suppressed in the RVT treated group (0.35+/-0.08, p<0.01). Histological analysis also showed that MCT treatment increased the medial wall thickness of the pulmonary arterioles compared with that of the control group (36+/-8% vs. 17+/-5%, p<0.01), which also was significantly suppressed in the RVT treated group (27+/-5%, p<0.01). In addition, Western blot demonstrated the decreased expression of VEGF in the MCT group (p<0.01), which was upregulated after long term RVT treatment (p<0.01). The expression of eNOS was increased after MCT treatment (p<0.01), but upregulation of eNOS could not be reversed by the RVT treatment. The expression of iNOS was not significantly modulated. CONCLUSION : These results suggest that RVT attenuates MCT-induced pulmonary hypertension and it may represent a new strategy for the treatment of pulmonary hypertension.
Animals ; Arterioles ; Blotting, Western ; Cardiovascular Diseases ; Hypertension, Pulmonary* ; Monocrotaline ; Nitric Oxide Synthase Type II ; Nitric Oxide Synthase Type III ; Rats* ; Rats, Sprague-Dawley ; Up-Regulation ; Vascular Endothelial Growth Factor A

In order to reduce a depth and slope of edge of ablation, the technique using 2 or 3 ablaiton zones has been applied to excimer laser photorefracitve keratectomy (PRK) for high myopic patients. In this study, excimer PRK using 2 zones (5.0mm; 100%, 6.0mm; 70%) or 3 zone (5.0mm; 100%, 5.5mm; 70%, 6.0mm; 50%) were used to each 10 patients having a range of refractive power between -8D and -9.5D randomly and divided into group 1 and group 2, respectively. corneal epithelial healing was delayed in group 2 comparaed to group 1 and the diference of that between group 1 and group 2 were statistical significant (P<0.05). However, the difference of spherical equivalent between group 1 and group 2 was not statistically significant at each follow-up (p>0.05). Uncorrected visual acuities of 20/40 or better were achieved in all patients of both groups at the last postoperrative visit (mean+/-SD, 22+/-3.4 weeks). Spherical equivalent less than 1.0 diopter was achieved in 60% of group 1 and 80% of group 2. As a complication 3 eyes (30%) in group 1 and 1 eye (10%) in group 2 lost 2 lines of best corrected visual acuity and thee was no statistically significant difference in both corneal haziness and patients' complaints between group 1 and group 2. With these results we could find a similar clinical results between excimer PRK using 2 zones and 3 zones by 6 months.
Follow-Up Studies ; Humans ; Lasers, Excimer ; Myopia* ; Photorefractive Keratectomy* ; Visual Acuity

Small cell carcinoma does originate from APUD cells of any parts of the body. Usually the cases discovered in the lung and have poor prognosis. In esophagus only about 100 cases are reported world widely after McKneown reports in 1952 and only 2 cases were reported in Korea. There was a cese of small cell carcinoma developed multiple lesions in esophagus but no reports said that small cell carcinoma developed syncronously in esophagus and other organs. We are to report a case that showed a multiple lesions in esophagus and cardia. The patient 60 yeata old man, has suffered from the substernal discomfort and significant weight loss for one month.
APUD Cells ; Carcinoma, Small Cell* ; Cardia* ; Esophagus* ; Humans ; Korea ; Lung ; Prognosis ; Stomach ; Weight Loss

PURPOSE: A prolonged administration of etoposide increases its effectiveness on the suggestion that pralonged maintenance of low levels is an important factor in determining its activity. Many studies have been tried to define the efficacy of combination of oral etoposide with other chemotherapeutic drugs such as cisplatin, 5-FU, and ifosfamide in patients with advanced non-small cell lung cancer (NSCLC). In this study, we evaluated the effectiveness and toxicities of combination chemotherapy of oral etoposide with intravenous cisplatin and ifosfamide in advanced NSCLC patients. MATERIALS AND METHODS: Thirty-three patients with inoperable NSCLC who had measurable diseases and had not been treated with chemotherapeutic drug, were enrolled in this study (from May 1995 to April 1998). Treatment consisted of intravenous cisplatin (20 mg/m(2)/day, Day 1-3) and ifosfamide (1,800 mg/m(2)/day, Days 1-3) with Mesna (1,100 mg/m(2)/day, Days 1-3), and oral etoposide (50 mg/m(2)/day, Days 4-17). This treatment was repeated every 4 weeks. Patients showing stable disease or a better response were continued on treatment with the range of one to nine cycles (medium: 3 cycles). All patients were evaluated for the response, survival, and toxicity of this combination chemotherapy. RESULTS: Eleven patients showed either complete responses [CR, 3 (9%)] or partial responses [PR, 8 (24%)]. The median number of treatment cycles were 5 (range, 3-9) for responders and 2 (range, 1-7) for non-responders. The responders had median response duration of 10 months and the overall survival of 12 months. The overall survival of responders were longer than that of non-responders (median 19 vs 5 months, p 0.0232). The toxicities of this treatment were tolerable without treatment related death. Limiting toxicities were myelosuppression and oral mucbsities, Grade 3 or 4 leukopenia and oral mucosities were observed in 34% and 9%, respectively. CONCLUSION: The combination of cisplatin, ifosfamide, and oral etoposide produced encouraging response rates and median survival duration in patients with response. Further study of this combination is warranted in comparison with standard cisplatin+etoposide regimen or intravenous etoposide, cisplatin and ifosfamide regimen.
Carcinoma, Non-Small-Cell Lung ; Cisplatin* ; Drug Therapy, Combination* ; Etoposide* ; Fluorouracil ; Humans ; Ifosfamide* ; Leukopenia ; Mesna ; Small Cell Lung Carcinoma*

OBJECTIVES: This study is designed to discuss the pros and cons related to the 'separation of drug prescription and dispensation' system when 5 years have passed by since the introduction of this system. METHODS: The 592 psychiatrists from 1,107 working places took part in nationwide survey by mail or E-mail from June to September, 2005. The response rate was 23.8%, most of respondents came from private clinics. RESULTS: The average age of psychiatrist was 44.6 years old, ranging from 25 to 75, most of them was predominantly male. The main results were as followings: 1) The ratio of psychiatric prescription out of hospital based on out-patients departments was the lowest in clinics, following by hospitals, general hospitals and university hospitals by order. 2) The main reasons of customer's preference for out of hospital prescription were economic advantage and self-awareness of prescription. As for the disliking for it, the most complaints were the anxiety about disclosure of psychiatric treatment, in convenience for delay and concern about drug change. CONCLUSION: Five years didn't seem to give a change on how the psychiatrists perceive the 'separation of drug prescription and dispensation' system at all. The confidentiality and human right issues on the part of psychiatric patients should never be ignored in order to manage this system successfully.
Anxiety ; Confidentiality ; Surveys and Questionnaires ; Disclosure ; Drug Prescriptions* ; Electronic Mail ; Follow-Up Studies* ; Hospitals, General ; Hospitals, University ; Human Rights ; Humans ; Male ; Outpatients ; Postal Service ; Prescriptions ; Psychiatry

PURPOSE: This study was to determine the incidence and severity of venous irriation in patients receiving vinorelbine tartrate (Navelbine ) in combination chemotherapy. MATERIAL AND METHODS: Twenty four patients histologically confirmed non-small cell lung cancer were enrolled in this study who receiving vinorelbine in combination chemotherapy through a peripheral vein from Oct. 1997 to Mar. 1999 with retrospective study design method. One group was 6~10 minutes infusion rate, the other was 10~20 minutes infusion rate with the same free-flow intravenous infusion. RESULTS: A total of 126 infusions were observed in this study. Sixty-two infusions were admi nistered at the 6~10 minutes, and 64 infusions were administered at the 10~20 minutes. The incidence of any venous irritation was 3.2% (2/62) in the group that received the infusion in 6~10 minutes and 10.9% (7/64) in 10~20 minutes (p=0.164), so we could not acquire any statistical significance. However the incidence of severe venous irritation (grade 3, 4) was 0% (0/62) in 6~10 minutes infusion group and 9.4% (6/64) in 10~20 minutes infusion group. There was a significant difference between two groups (p=0.028) CONCLUSION: Our results suggest that venous irritation associated with vinorelbine tartrate infusion can be reduced by shorter duration of administration and vinorelbine tartrate might be recom mended to administer at 6~10 minutes infusion in clinical practice.
Carcinoma, Non-Small-Cell Lung ; Drug Therapy, Combination ; Humans ; Incidence* ; Infusions, Intravenous ; Retrospective Studies ; Veins

BACKGROUND: Hyperbaric oxygen (HBO) therapy is applied for the treatments of various diseases inducing hypoxic states. However, reoxygenation of previously hypoxic tissue results in significant tissue damages through the mechanisms of oxygen toxicity. The authors investigated the characteristics of the EEG changes by hyperbaric oxygenation after the exposure to carbon monoxide, and the protective effects of allopurinol, an inhibitor of xanthine oxidase (XO), to the brain. METHODS: Sixty eight male rabbits of New Zealand white weighing 1,350-2,000 gm, were used. The rabbits were divided in 4 groups and measured EEG for 21 hours of experiments. RESULT: The delta waves were significantly increased and alpha waves significantly decreased, during CO exposure, HBO exposure only, and HBO exposure after CO exposure (P< 0.05 in all groups). The wave changes were most remarkable in CO-HBO group, and in this case the changes continued to the last period of the ambient air exposure stage. The brain injury did not decrease as appeared in EEG changes in rabbits treated with allopurinol. This result suggests that many other mechanisms might be involved in CO-HBO condition. The paroxysmal electrical discharges were mostly appeared during or after HBO exposure stages. CONCLUSION: The changes of EEG characteristic in hyperbaric oxygenation are the increase of delta wave and electrical paroxysmal discharges. There is no protective effect of allopurinol to the brain, which suggests that many other mechanisms other than XO might be involved.
Allopurinol ; Brain ; Brain Injuries ; Carbon Monoxide* ; Carbon* ; Electroencephalography* ; Humans ; Hyperbaric Oxygenation ; Male ; New Zealand ; Oxygen ; Rabbits ; Xanthine Oxidase