The lack of sufficient oral mucosa available for intra-oral reconstruction has been dealt with by the use of skin or oral mucosa grafts harvested from donor sites but grafts requires more than one surgical procedures and could cause donor site morbidity. Many investigators have attempted to increase available soft tissue by tissue engineered skin or oral mucosa replacements for clinical applications. But, reconstructed mucosa by several methods have low physical properties such as rolling and contraction. The aims of this study were to develope an in vitro experimental model that maintains an epithelial-mesenchymal interaction by organotypic raft culture, and to characterize biologic properties of three-dimensionally cultured oral mucosa embedded with Polydioxanone mesh by histological and immunohistochemical analysis. The results were as follows; 1. Oral mucosa reconstructed by three-dimensional organotypic culture revealed similar morphologic characteristics to equvalent normal oral mucosa in the point that they show stratification and differentiation. 2. The expression of cytokeratin 10/13 and involucrin in the cultured tissue showed the same pattern with normal oral mucosa suggesting that organotypic co-culture condition is able to induce cellular differentiation. 3. After insertion of polydioxanone mesh, increased tensile strength were observed. These results suggest that three-dimensional organotypic co-culture of the oral mucosa cell lines with the dermal equvalent consisting type I collagen and fibroblasts reproduce the morphologic and immunohistochemical characteristics similar to those in vivo condition. And increased physical properties by use of polydioxanone mesh will helpful for clinical applications.
Cell Line ; Coculture Techniques ; Collagen Type I ; Fibroblasts ; Humans ; Keratins ; Models, Theoretical ; Mouth Mucosa* ; Mucous Membrane ; Polydioxanone* ; Research Personnel ; Skin ; Tensile Strength ; Tissue Donors ; Transplants

Seventeen cases of paralytic strabismus secondary to abducens nerve palsy were treated with an injection of Botulinum Toxin A(Oculinum(R)) into the medial rectus muscle under the electromyographic control. All 17 cases, including 3 cases of bilateral abducens palsy, were followed up for 6 months to 23 months after the initial injection, there were no systemic side effects. The etiologic factors follow up deviation angle, dosage and complications were analyzed In the Thirteen cases of Oculinum(R) injection in antagonistic medial rectus muscle, the mean correction of preinjection deviation was 48.7%; the four cases who underwent both Jensen's operation and Oculinum(R) injection obtained 64.6%. The most common complication was ptosis which developed in 15 cases(64.7%) with a dosage of 2.75 u or above. From this study. we concluded that Oculinum(R) chemodenervation was effective in the acute case of abducens palsy without the anterior segment ischemia and systemic side effects.
Abducens Nerve Diseases* ; Abducens Nerve* ; Botulinum Toxins* ; Electromyography ; Follow-Up Studies ; Ischemia ; Nerve Block ; Paralysis ; Strabismus

Meningiomas are usually thought of as firm solid tumors and most standard references make no mention of cystic meningiomas. Although several cases of cystic meningioma have been reported in the literature and their neuroradiological features discussed, the rarity of this entity makes its preoperative diagnosis difficult. Recently, the authors encountered a case of cystic meningioma, which was thought as ependymal cyst or infarction, preoperatively. In this report the authors discussed its clinical, neuroradiological and pathological characteristics with brief reviews of the literature.
Cysts ; Meningioma

No abstract available.
Pheochromocytoma* ; Pregnancy*

Waardenburg's syndrome is a very rare hereditary disease with the outstanding clinical characteristics including lateral displacement of the medial canthi of the eyes and of the inferior lacrimal puncta, a broad, prominent root of the nose, hyperplasia of the medial protions of the eye-brows, white or grey forelock, partial or total heterochromia of the irides, and neurosensory deaf-mutism. The authors recently experienced two cases of Waardenburg's syndrome in a 25 year old female and a 20 year old male. So, the literature of the Waardenburg's syndrome was briefly reviewed with clinical history.
Adult ; Deafness ; Female ; Genetic Diseases, Inborn ; Humans ; Hyperplasia ; Male ; Nose ; Waardenburg Syndrome* ; Young Adult

PURPOSE: Although considered uncommon, periprosthetic fracture of the femur after hip arthroplasty is a serious complication that can be difficult to treat. Authors analyzed the types of fracture and modality of treatment. MATERIALS AND METHODS: Between Jan. 1983 and Dec. 1997, 17 cases of postoperative periprosthetic fractures had been treated at our hospital. These cases were followed up for an average of 58 (13-123) months. The fractures were classified according to Duncan and Masri classification. Three cases of type A, and 6 cases of type B1, 3 cases of type B2, 3 cases of type B3 and 2 cases of type C. The 3 cases of type A and 2 cases oftype B1 were conservative treatments. The 4 cases of type B1 were treated with open reduction and internal fixation with bone graft. The 3 cases of type B2 and 3 cases in type B3 were treated with long stem revision. The 2 cases of type C were treated with open reduction and internal fixation with bone graft. RESULTS: Bony union happened in all cases. The results according to Beals and Tower criteria were excellent in 12 cases, good in 3 cases and poor in 2 cases. CONCLUSIONS: The most frequent cause of periprostic fracture was trauma and other causes were loosening and osteolysis. Proper treatment method of periprosthetic fracture were important for stability of femoral stem
Arthroplasty ; Arthroplasty, Replacement, Hip* ; Classification ; Femur* ; Hip ; Osteolysis ; Periprosthetic Fractures ; Transplants

No abstract available.

We analyzed the records of 124 eyes of 124 perforating ocular injury patients retrospectively from June 1 1994 to examine the relationship between final visual acuity and preoperative factors such as age, sex, initial visual acuity, location of injury, length of injury, mechanism of injury, intraocular foreign body, traumatic catarcact, secondary operation, hyphema, vitreous hemorrhage. The preoperative factors that influence final visual were age, initial visual acuity, length of infury, vitreous hemorrahage, secondary operation. However, other factors such as gender, mechanism, location of injury, intraocular foreign body, traubatic cataract, and hyphema did not influence final visual acuity. Final visual acuity was better in the case of young patients, good initial visual acuity were age, initial visual acuity, length of injury, vitreous hemorrhage, secondary operation, However, other factors such as gender, mechanism, location of injury, intraocular foreign body, traumatic cataract, and hyphema did not influence final visual acuity. Final visual acuity was better in the case of young patients, good initial visual acuity, short wound length, absence of vitreous hemorrhage and secondary operation.
Cataract ; Foreign Bodies ; Humans ; Hyphema ; Retrospective Studies ; Visual Acuity ; Vitreous Hemorrhage ; Wounds and Injuries

Dengue fever is an important health problem for international travelers to all endemic areas. The steadily increasing numbers of tourists visiting endemic areas raise the risk of exposure, and imported dengue cases are increasingly observed in nonendemic area. Dengue has a wide spectrum of clinical presentations, often with unpredictable clinical evolution and outcome. While most patients recover following a self-limiting, non-severe clinical course, a small proportion progress to severe disease such as dengue hemorrhagic fever or dengue shock syndrome. Therefore, it is important to suspect dengue fever in every febrile patient returning from the tropics. Whenever it is suspected, a quick diagnosis and adequate managements are essential to avoid complications. We report two cases of imported dengue fever in Korean children presenting with fever, headache, nausea, and rash.
Child ; Dengue ; Dengue Hemorrhagic Fever ; Exanthema ; Fever ; Headache ; Humans ; Korea ; Nausea ; Philippines

PURPOSE: We studied the clinical outcome of nasolacrimal probing according to the age and silicone tube intubation for congenital nasolacrimal duct obstruction. METHODS: We analyzed a total of 76 patients (99 eyes) who had undergone nasolacrimal duct probing performed in the office under topical anesthesia and 18 patients (20 eyes) who had undergone silicone tube intubation under general anesthesia between February 1997 and March 2001. Patients who had undergone probing were grouped according to their age at the time of probing: 6 months or less (group 1), 7 to 12 months (group 2) and 13 months or older (group 3). RESULTS: The overall success rate by probing was 84%. The success rate of probing in those under 6 months of age was 88%; in those from age 7 to 12 months, 86%; and in those 13 months or older, the rate decreased to 76%. The decrease in success rate after 13 months was statistically significant (P<0.05). The success rate of silicone tube intubation was 95%. CONCLUSION: We concluded that early office probing under 12 months of age for congenital nasolacrimal duct obstruction is an effective method for treatment of symptomatic nasolacrimal duct obstruction. In case over 13 months of age, probing is also considered as the first choice of treatment although its success rate is lower than the former. Silicone tube intubation is an effective method in case of failure of repeated probing and over 20 months of age.
Anesthesia ; Anesthesia, General ; Humans ; Intubation* ; Nasolacrimal Duct* ; Silicones*