Glomus tumors are maturely organized proliferations of glomus cells and vascular channels. Such tumors are rare in the stomach, and only two cases have been reported in Korea. Because specific clinical or radiologic features are not associated with the glomus tumor, it can be recognized only by histologic characteristics. Although available data are inadequate for determining the histogenesis of this tumor, it may represent a hamartoma rather than a neoplastic disease. The treatment of choice is local resection. In frozen sections, it may be misidentified as a carcinoid tumor, leading to more extensive surgery than required for cure. We report a case of a glomus tumor of the stomach in a 30-year-old female patient who was operated on, and we present a review of the literature on this subject.
Adult ; Carcinoid Tumor ; Female ; Frozen Sections ; Glomus Tumor* ; Hamartoma ; Humans ; Korea ; Stomach*

Glomus tumors are maturely organized proliferations of glomus cells and vascular channels. Such tumors are rare in the stomach, and only two cases have been reported in Korea. Because specific clinical or radiologic features are not associated with the glomus tumor, it can be recognized only by histologic characteristics. Although available data are inadequate for determining the histogenesis of this tumor, it may represent a hamartoma rather than a neoplastic disease. The treatment of choice is local resection. In frozen sections, it may be misidentified as a carcinoid tumor, leading to more extensive surgery than required for cure. We report a case of a glomus tumor of the stomach in a 30-year-old female patient who was operated on, and we present a review of the literature on this subject.
Adult ; Carcinoid Tumor ; Female ; Frozen Sections ; Glomus Tumor* ; Hamartoma ; Humans ; Korea ; Stomach*

PURPOSE: To analyse the parameters of in vivo pharmacokinetics such as absorption, distributionin , and excretion of adriamycin patients with hepatocellular carcinoma, and investigate the stagnation of adriamycin, in the liver. MATERIALS AND METHODS: Five patients in whom hepatocellular carcinoma was diagnosed and who were admitted for transhepatic chemoembolization were involved in this study. Fifty mg of adriamycin was mixed with 2.5 mL of water-soluble contrast material and 12 -15 mL of lipiodol, and the emulsion was injected into a selected tumor-supplying artery using a 3-F catheter. Between 1 minute and 72 hours after chemoembolization, peripheral blood samples were then obtained, and from these the blood concentration curve of adriamycin was calculated and applied to a two-compartment model. Using the model, several pharmacokinetic parameters were estimated. RESULTS: The volume of the central and the peripheral compartment was 45 L and 4090.6 L, respectively. 75.14% of adriamycin was delivered to the liver directly, and the absorption rate constant was 2.448/hr. Distribution clearance was 969.3 L/hr, and excretion and metabolic clearance was 136.4 L/hr. CONCLUSION: Using a two-compartment model, the in vivo pharmacokinetics of adriamycin after hepatic arterial chemoembolization were successfully analyzed. On the basis of the parameters determined, it may be concluded that in these five patients, adriamycin remained in the liver in much greater quantities and for longer. Index words : Liver neoplasms Liver neoplasms, chemotherapeutic embolization Chemotherapy, regional
Absorption ; Arteries ; Carcinoma, Hepatocellular ; Catheters ; Doxorubicin* ; Drug Therapy ; Ethiodized Oil ; Humans ; Liver ; Liver Neoplasms ; Pharmacokinetics*

No abstract available.
Fever*

A clinical and radiological study was done on 96 cases of spontaneous pneumothorax, encoutered in the Dept. ofRadiology, Busan National University Hospital during last 3 years from March. 1979 to March 1982. The results weresummarized as follows; 1. In the age distribution, the ages between 20 and 39 years were most highest, as 54 cases(56.3%). In the sex distribution, the ratio of male to female was 5:1 in male predominance. 2. The underlyingpathology of the total 96 cases of spontaneous pneumothorax were of tuberculous origin in 33.3% andnon-tuberculous origin in 66.7%. And below 20 years, most were of non-tuberculous origin. 3. In the cases of lungcollapse over 2/3, non-tuberculous origin was more than tuberculous origin and had characteristics of significantmediastinal shifting, in contrast to lower percentage of fluid level by chest radiography. 4. The rupture of blebsor bullae was the main immediate causes of spontaneous pneumothorax, independent of the underlying pathology. 5.In only 27 cases (28.1%) among total 96 cases, bullae or blebs could be detected on the chest radiography. 6. Intreatment of spontaneous pneumothorax, the closed thoracotomy with under water seal drainage is accepted to be thegeneral method of treatment. But open thoracotomy is considered as the best useful therapeutic procedure toprevent the recurrence, whenever bullae of blebs are found on the chest radiography. 7. In the cases of closedthoracotomy, the recurrent rate was 25.0% and most cases were found at the ipsilateral side of the first attack.8. Within a week, the collpased lung were well expanded in most cases of total 96 cases, after closed thoracotomy.
Age Distribution ; Blister ; Busan ; Drainage ; Female ; Humans ; Lung ; Male ; Methods ; Pathology ; Pneumothorax ; Radiography ; Recurrence ; Rupture ; Sex Distribution ; Thoracotomy ; Thorax ; Water

Hepatocyte growth factor (HGF) is a glycoprotein secreted from stromal fibroblasts which bind to the transmembrane Met receptor. This receptor is expressed from a variety of tumors, including gastric carcinomas. To look for a possible paracrine loop between gastric cancer cells and their surrounding fibroblasts in a gastric carcinoma, the effect of HGF on the morphology and expression of the cell- adhesion molecule E-cadherin was examined using fifty resected gastric carcinomas. The expression of Met and E-cadherin in primary gastric carcinoma was examined using immunohistochemical staining. The level of HGF in the tumor extracts was determined by using an Immunis HGF EIA kit (Institute of Immunology). The levels of HGF in the tumor extracts correlated significantly with the progression of the tumor stage (p<0.05). The mean level of HGF was significantly higher in the tumors of an undifferentiated type than in those of a differentiated type (p<0.05). Eighty-two percent (82%) of the tumors showed increased Met expression, but no significant correlation was found between Met expression and tumor progression or differentiation. Twenty-six (52%) tumors revealed a preserved E-cadherin expression similar to that of a normal gastric mucosa. Abnormal E-cadherin expression was found in twenty-four tumors (48%). There was a significant correlation between the degree of E-cadherin expression and the progression and differentiation of the tumor. The level of HGF in a tumor with cytoplasmic E-cadherin expression was significantly higher than that with membranous E-cadherin expression. In conclusion : we can conclude that HGF has the ability to modulate E-cadherin expression and induce intracellular translocation of E-cadherin in gastric carcinomas.
Cadherins* ; Cytoplasm ; Fibroblasts ; Gastric Mucosa ; Glycoproteins ; Hepatocyte Growth Factor ; Stomach Neoplasms

PURPOSE: This investigation was to evaluate the efficacy of catheter-directed thrombolysis with urokinase in treating symptomatic deep vein thrombosis (DVT). METHODS: Eight patients with DVT underwent treatment for 8 affected limbs. The average urokinase dose was 487.5 million IU (range, 1.5 million to 6.5 million IU) infused over an average of 48 hour (range 24~72 hours). RESULTS: Lysis was complete in 5 (63%), and partial in 2 (25%), not achieved in 1 (12%). One chronically occluded proximal iliac vein through popliteal vein antegradely and tibial vein through internal jugular vein retrogradely could not be crossed with a guide wire. Angioplasty (n=3) and stent placement (n=1) were applied in three limbs with underlying venous stenosis. One limb among three limb of initial complete lysis was detected thrombus at femoral vein but this patient was asymptomatic at 6 month later. There were no major complications or clinically detectable pulmonary emboli. CONCLUSION: This initial experience suggests that catheter-directed thrombolysis with urokinase for treatment of symptomatic DVT is safe and effective.
Angioplasty ; Constriction, Pathologic ; Extremities ; Femoral Vein ; Humans ; Iliac Vein ; Jugular Veins ; Popliteal Vein ; Stents ; Thrombolytic Therapy* ; Thrombosis ; Urokinase-Type Plasminogen Activator ; Veins ; Venous Thrombosis*

BACKGROUND: Xanthoma is an interesting disease entity that often indicates underlying lipid abnormalities. but, clinical studies about hyperlipopropeinemia in xanthoma were rarely present. OBJECTIVE: The purpose of this study is to observe the clinical and histopathologic features in xanthoma and to evaluate relationship between hyperlipoproteinemia and underlying xanthoma. METHOD: 57 cases of xanthoma were analyzed. In 35 cases, blood lipids including triglyceride, cholesterol and high density lipoprotein were analyzed. And clinical characterics of xanthoma and hyperlipoproteinemia were evaluated in 10 cases of our hyperlipoproteinemic patients confirmed by electrophoresis. RESULTS: The ratio between male and female was 1: 1.45 in xanthoma excluding xanthelasma and was 1: 1.86 in xanthelasma only. The mean age of each group was 28 years and 52 years. The incidence of each type, in descending order, was xanthelasma(35%), tuberous xanthoma(20%), eruptive xanthoma(14%), plane xanthoma(7%), tendinous xanthoma(2%), and unclassified(17.5%). The associated diseases, in descending order, were diabetes mellitus(9/15), fatty liver(2/15) etc. Among these, diabetes mellitus was the most common associated disease in hyperlipoproteinemia group(6/10). Histopathological features in 26 cases revealed lipid-laden foamy cells in all cases, and foreign body giant cells, fibrosis, cholesterol clefts in some cases. Among 35 cases, the rate of abnormal lipid profiles, in descending order, was xanthelasma(63.3%), eruptive xanthoma(62.5%), and tuberous xanthoma(38%). The frequent types of hyperlipoproteinemia in our cases, in descending order, are V(5/10), type IIa(3/10), IV(2/10). In previously reported hyperlipoproteinemia with xanthoma patients, the frequent types of xanthoma, are tuberous xanthoma(12/30), plane xanthoma(8/30), eruptive xanthoma(6/30), mixed type (2/30), and xanthelasma(1/30), and the frequent types of hyperlipoproteinemia in descending order are IIa (9/30), IV(8/30), V(4/30), IIb(3/30), III(3/30), unclassified(2/30), and I(1/30). CONCLUSION: The most common type of hyperlipoproteinemia in our cases and literatures is type IIa. but, recently type IV and type V are increasing and are associated with increased incidence of diabetes. The incidence of abnormal lipid profiles in xanthelasma is 63.3% and routine lipid profile study will be needed in the evaluation of xanthoma including xanthelasma.
Cholesterol ; Diabetes Mellitus ; Electrophoresis ; Female ; Fibrosis ; Giant Cells, Foreign-Body ; Humans ; Hyperlipoproteinemias* ; Incidence ; Lipoproteins ; Male ; Triglycerides ; Xanthomatosis*

BACKGROUNDS/AIMS: MRI performed preoperatively for Hepatocellular Carcinoma(HCC) not only detects and provides information on the tumor characteristics but can also be used as a noninvasive method via MR-angiogram. MR-angiogram can reconstruct the tumor and its relation to vessels in three dimension. Therefore, it has the advantage of presenting the exact relations of the tumor and the intrahepatic vessels. Recently, preoperative imaging in HCC has become more complex. The invasive angiography is at the center of these various, complex tests and there is a tendency for unnecessary, repeated testing. The cost of these complex tests is hard to ignore. The purpose of this study was to compare single preoperative MRI with other tests and weigh the advantages. METHODS: The subjects were thirty-nine patients who underwent surgery for HCC from November, 1997 through October, 1998. Ten of these patients who had HCC with the diameter of less than 5cm, were evaluated with MRI and when necessary MR angiogram only. The control group were eleven patients with tumor of the same size as above but whom were evaluated with abdominal CT + Hepatic angiogram + Transcatheter arterial chemoembolization(TACE) + lipodol CT, abdominal CT + Hepatic angiogram + CT - AP + TACE + lipodol CT or abdominal CT + Hepatic angiogram + CT - AP + TACE during the identical period. RESULTS: The average cost of preoperative testing was lowest with MRI only. There were no deaths in either group and complication occured in one case of each group. Comparison of the duration of admission between these groups showed a statistically significant difference(p=0.003). The MRI only group with an average of 22.5 days and the control group of 30.8 days. This was due to shortening of the preoperative testing time. Another point worth noting is that patients who underwent MRI alone complained less of discomfort. CONCLUSION: MRI alone group was comparable to control group in providing of preoperative anatomical information. Not performing angiography did not increase risks technically during operation. The authors suggest that MRI as the single preoperative imaging test can be in alternative to the various preoperative imaging test.
Angiography ; Carcinoma, Hepatocellular* ; Humans ; Magnetic Resonance Imaging* ; Tomography, X-Ray Computed

Ovarian tumors of an epithelial origin in pediatric age are uncommon and mucinous cystadenoma, borderline malignancy is extremely rare. We experienced a case of ovarian mucinous cystadenoma, borderline malignancy in a 14-year-old girl. She was admitted due to huge abdominal distension for 2 months. Her past history and family history were normal. The physical examination was normal except tense and distended abdomen. All laboratory findings were normal. On abdominal ultrasonography and CT scan, a huge cystic tumor filled with fluid and inner multiseptation was noted. Unilateral salphingo- oophorectomy was done and pathologic findings were compatible with ovarian borderline malignancy of mucionous cystadenoma. The postoperative course was uneventful.
Abdomen ; Adolescent ; Cystadenoma ; Cystadenoma, Mucinous* ; Female ; Humans ; Mucins* ; Ovariectomy ; Physical Examination ; Tomography, X-Ray Computed ; Transcutaneous Electric Nerve Stimulation ; Ultrasonography