1.A clinical study of intestinal obstruction.
Won Jae SONG ; Jung Youl HWANG
Journal of the Korean Surgical Society 1993;44(6):1008-1019
No abstract available.
Intestinal Obstruction*
2.T Cell Epitope Analysis of Structural Protein of Adenovirus.
Jae Won HWANG ; Mi Hyung KIM ; Kil Hyoun KIM
Korean Journal of Immunology 1998;20(4):435-442
Thelper (Th) cells play a pivotal role in the regulation of immune responses. Since Th epitopes in adenovirus have not yet been defined, in this study, it was attempted to search for Th epitopes of adenovirus antigens that are restricted by MHC class II (H-2E). Among candidate viral proteins to be screened for Th epitopes, structural protein was selected, since they induced strong IL-2 release from adenovirus immune lyrnph node (LN) cells and the presence of E1 protein, which contains immunodominant cytotoxic T lymphocyte epitopes, did not potentiate the T cell responses. To confirm the presence of Th epitopes in the structural protein, virions were trypsinized and the resulting polypeptides whose molecular weights were lower than 5,000 were fractionated by HPLC. Some of the HPLC fraction turned out to induce LN cell proliferation. Ten synthetic peptides were designed as candidate Th epitopes from the primary amino acid sequences of adenovirus hexon and penton protein which are major constituents of the virion. The selected sequences share the common features of other known H-2E' binding ligands. Among these ten synthetic peptides, peptide of hexon protein amino acid residue 709-721 induced noticeable proliferation of LN cells from preimmune mice, and also able to induce IL-2 secretion from adenovirus-specific T hybridomas, suggesting that the peptide was the most immunodominant Th epitope. Hexon protein 221-233 and hexon protein 676-688 are considered as epitopes also. This study revealed three epitope sequences from adenovirus structural protein that are presented by class II MHC, H-2E.
Adenoviridae*
;
Amino Acid Sequence
;
Animals
;
Cell Proliferation
;
Chromatography, High Pressure Liquid
;
Epitopes
;
Epitopes, T-Lymphocyte*
;
Hybridomas
;
Interleukin-2
;
Ligands
;
Mice
;
Molecular Weight
;
Peptides
;
Trypsin
;
Viral Proteins
;
Virion
3.Response and Toxicity of Chemotherapy in 78Cases of Malignant Ovarian Tumors.
Jae yeon WON ; Il Soo PARK ; Soon Gu HWANG
Korean Journal of Gynecologic Oncology and Colposcopy 1996;7(2):127-134
For evaluation of the response and toxicity of the combination chemotherapy, forty six patients with malignant ovarian tumors who had prior surgery were treated with combination chemotherapy from January 1985 to March 1991 at the Department of Obstetrics and Gynecology, Kyung-pook National University Hospital. The results were as follows : 1. The responses were in complete 20 cases(43.5%), in partial 9 cases(19,6%), in stable 6 cases(13.0%), in progressive 11 cases(23.9%) among 46 patients. 2. By the response rates of various combination chemotherapy regimens, the response rate of CAP was 64%(16/25), CP 57.1%(8/14), VAC 100%(3/3), VBP 50%(1/2), FAM 0%(0/1), and Melphalan 100%(1/1) respectively. 3. As the chemotoxicities of combination chemotherapy, leukopenia 20 cases(46.5%), thrombocytopenia 2 cases(4.7%), anemia 20 cases(46.5%), nephrotoxity 6 cases(14.6%), hepatotoxicity 7 cases(18.4%) were observed.
Anemia
;
Drug Therapy*
;
Drug Therapy, Combination
;
Gynecology
;
Humans
;
Leukopenia
;
Melphalan
;
Obstetrics
;
Thrombocytopenia
4.FRACTURE STRENGTH AND MARGINAL FIT OF IN-CERAM, COPY-MILLED IN-CERAM, AND IPS EMPRESS 2 ALL-CERAMIC BRIDGES.
Jung Won HWANG ; Jae Ho YANG ; Sun Hyung LEE
The Journal of Korean Academy of Prosthodontics 2001;39(6):641-658
All-ceramic restorations have become an attractive alternative to porcelain-fused-to-metal crowns. In-Ceram, and more recently IPS Empress 2 were introduced as a new all-ceramic system for single crowns and 3-unit fixed partial dentures. But their strength and marginal fit are still an important issue. This study evaluated the fracture resistance and marginal fit of three systems of 3 unit all-ceramic bridge fabricated on prepared maxillary anterior resin teeth in vitro. The 3 all-ceramic bridge systems were: (1) a glass-infiltrated, sintered alumina system (In-Ceram) fabricated conventionally, (2) the same system with copy-milled alumina cores (copy-milled In-Ceram), (3) a heat pressed, lithium disilicate reinforced glass-ceramic system (IPS Empress 2). Ten bridges of each system with standardized design of framework were fabricated. All specimens of each system were compressed at 55degree at the palatal surface of pontic until catastrophic fracture occurred. Another seven bridges of each system were fabricated with standard method. All of the bridge-die complexes were embedded in epoxy resin and sectioned buccolingually and mesiodistally. The absolute marginal discrepancy was measured with stereomicroscope at x50 power. The following results were obtained: 1. There was no significant difference in the fracture strength among the 3 systems studied. 2. The Weibull modulus of copy-milled In-Ceram was higher than that of In-Ceram and IPS Empress 2 bridges. 3. Copy-milled In-Ceram (112micrometer) exhibited significantly greater marginal discrepancy than In-Ceram (97micrometer), and IPS Empress 2 (94micrometer at P=0.05. 4. The lingual surfaces of the ceramic crowns showed smaller marginal discrepancies than mesial and distal points. There was no significant difference between teeth (incisor, canine) at P=0.05. 5. All-ceramic bridges of three systems appeared to exhibit sufficient initial strength and acceptable marginal fit values to allow clinical application.
Aluminum Oxide
;
Ceramics
;
Crowns
;
Denture, Partial, Fixed
;
Hot Temperature
;
Lithium
;
Tooth
5.A case of orbital meningioma not connected to optic nerve.
Sung Won CHAE ; Geon CHOI ; Gun CHUNG ; Soon Jae HWANG
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(4):813-817
No abstract available.
Meningioma*
;
Optic Nerve*
;
Orbit*
6.3 cases of tuberculous peritonitis complicating long-term CAPD.
Yi Sook HWANG ; Jae Hyung AHN ; Tae Won LEE ; Chun Gyoo IHM ; Myung Jae KIM
Korean Journal of Nephrology 1991;10(2):245-249
No abstract available.
Peritoneal Dialysis, Continuous Ambulatory*
;
Peritonitis, Tuberculous*
7.A Clinico-Epidemilological Study of 55 Cases of Chidhood Idiopathic Thrombocytopenic Purpura.
Won Ho KANG ; Myung Hee KOOK ; Yong Sang YOO ; Jae Suk MA ; Tai Ju HWANG
Journal of the Korean Pediatric Society 1987;30(11):1207-1212
No abstract available.
Purpura, Thrombocytopenic, Idiopathic*
8.Two cases of virus associated hemophagocytic syndrome.
Jae Hee HAN ; Hyun Chul LEE ; Hwang Min KIM ; Jong Soo KIM ; Kyung Won LEE
Journal of the Korean Pediatric Society 1993;36(10):1458-1465
Virus associated hemophagocytic syndrome, class ll histiocytoses, characterized by high fever, severe constitutional symptoms, abnormal liver function and coagulation, perigheral blood pancytopenia and histiocytic hyperplasis with prominent hemophagocytosis in bone marrow and lymph nodes has been reported and associated with active viral infection. It is non-malignant and reversible. It must be differentiated from histiocytic medullary reticulosis because of the inappopriateness of immunosuppressive of cytotozic therapy which is the therapeutic method for HMR, but is contraindicated in the treatment of VAHS. This paper describes two patients whose clinicopathology was compatible with the diagnosis of virus associated hemophagocytic syndrome.
Bone Marrow
;
Diagnosis
;
Fever
;
Histiocytosis
;
Humans
;
Liver
;
Lymph Nodes
;
Lymphohistiocytosis, Hemophagocytic*
;
Pancytopenia
9.Clinical and Laboratory Findings of the 2012 Winter Seasonal Influenza A and B Outbreak at a Single Institution.
Jae Won CHOI ; Hyun Jun CHO ; Hwang Min KIM ; Seok HAHN
Korean Journal of Pediatric Infectious Diseases 2014;21(1):1-8
PURPOSE: The aim for this study was to investigate clinical manifestation of seasonal influenza A and B during the 2012 winter season in Wonju, South Korea. Their clinical and laboratorial characteristics and effect of oseltamivir were compared and analyzed. METHODS: Children under the age of 18 years who visited the Wonju Severance Christian Hospital with fever or acute respiratory symptoms and who were diagnosed with influenza A or B by rapid antigen test from nasopharyngeal swab were selected for the study. The medical records of patients were retrospectively reviewed. RESULTS: Influenza A was detected in 374 patients (83.7%), and influenza B in 72 (16.6%). The incidence of influenza A was highest in February (n=186), while that of influenza B was highest in March (n=36). The most common symptoms were fever (n=434, 97.1%) and cough (n=362, 81.0%). No significant differences were observed between influenza A and B in symptoms and laboratory data. Patients who had used oseltamivir within 2 days showed statistically lower admission rate, shorter admission duration, and lower incidence of pneumonia. CONCLUSION: This study found no statistical difference between influenza A and B, in symptoms, progression, and laboratory test, but those who were treated with oseltamivir given within 2 days of the onset of fever experienced more positive outcomes.
Child
;
Cough
;
Fever
;
Gangwon-do
;
Humans
;
Incidence
;
Influenza, Human*
;
Korea
;
Medical Records
;
Oseltamivir
;
Pneumonia
;
Retrospective Studies
;
Seasons*
10.A Case of Type I Glycogen Storage Disease with Decreased Growth Hormone Secretion.
Chi Kwan HWANG ; Sun Hee LEE ; Jeong Won SHIN ; Jae Hong YU ; Dae Young KANG
Journal of Korean Society of Pediatric Endocrinology 2001;6(1):85-91
Glycogen storage diseases(GSD) are inherited disorders affecting glycogen metabolism and type I GSD is due to the absence or deficiency of glucose-6-phosphatase(G6Pase) enzyme in the liver, kidney, and intestinal mucosa. The defect leads to inadequate hepatic conversion of G6P to glucose and thus make affected individuals susceptible to fasting hypoglycemia, and the accumulation of glycogen occurs in the liver and other organs. Type Ia is the most common form of GSD and clinically growth retardation may manifest of GSD itself rather than growth hormone deficiency(GHD), but we experienced a case of type I GSD with GHD in a 14-year-o1d male. The height was 125 cm, compatible with 50 th percentile of height of 8 years of age. He has doll-like face with fat cheek, relatively thin extremities, and metabolic acidosis, hyperuricemia, hypoglycemia, hyperlipidemia. GH stimulation test with clonidine and L-dopa revealed that the patient had decreased GH secretion. After laboratory work up including liver biopsy, he was diagnosed as type I GSD. Hypoglycemia was managed with frequent feeding with high starch diet(uncooked cornstarch). Metabolic acidosis and hyperuricemia were treated with sodium bicarbonate, allopurinol and probenecid. The patient is being followed at out-patient clinic with clinical improvement after of diet therapy and GH administration.
Acidosis
;
Allopurinol
;
Biopsy
;
Cheek
;
Clonidine
;
Diet Therapy
;
Extremities
;
Glucose
;
Glycogen Storage Disease*
;
Glycogen*
;
Growth Hormone*
;
Humans
;
Hyperlipidemias
;
Hyperuricemia
;
Hypoglycemia
;
Intestinal Mucosa
;
Kidney
;
Levodopa
;
Liver
;
Male
;
Metabolism
;
Outpatients
;
Probenecid
;
Sodium Bicarbonate
;
Starch