1.A clinical study of intestinal obstruction.
Won Jae SONG ; Jung Youl HWANG
Journal of the Korean Surgical Society 1993;44(6):1008-1019
No abstract available.
Intestinal Obstruction*
2.Response and Toxicity of Chemotherapy in 78Cases of Malignant Ovarian Tumors.
Jae yeon WON ; Il Soo PARK ; Soon Gu HWANG
Korean Journal of Gynecologic Oncology and Colposcopy 1996;7(2):127-134
For evaluation of the response and toxicity of the combination chemotherapy, forty six patients with malignant ovarian tumors who had prior surgery were treated with combination chemotherapy from January 1985 to March 1991 at the Department of Obstetrics and Gynecology, Kyung-pook National University Hospital. The results were as follows : 1. The responses were in complete 20 cases(43.5%), in partial 9 cases(19,6%), in stable 6 cases(13.0%), in progressive 11 cases(23.9%) among 46 patients. 2. By the response rates of various combination chemotherapy regimens, the response rate of CAP was 64%(16/25), CP 57.1%(8/14), VAC 100%(3/3), VBP 50%(1/2), FAM 0%(0/1), and Melphalan 100%(1/1) respectively. 3. As the chemotoxicities of combination chemotherapy, leukopenia 20 cases(46.5%), thrombocytopenia 2 cases(4.7%), anemia 20 cases(46.5%), nephrotoxity 6 cases(14.6%), hepatotoxicity 7 cases(18.4%) were observed.
Anemia
;
Drug Therapy*
;
Drug Therapy, Combination
;
Gynecology
;
Humans
;
Leukopenia
;
Melphalan
;
Obstetrics
;
Thrombocytopenia
3.T Cell Epitope Analysis of Structural Protein of Adenovirus.
Jae Won HWANG ; Mi Hyung KIM ; Kil Hyoun KIM
Korean Journal of Immunology 1998;20(4):435-442
Thelper (Th) cells play a pivotal role in the regulation of immune responses. Since Th epitopes in adenovirus have not yet been defined, in this study, it was attempted to search for Th epitopes of adenovirus antigens that are restricted by MHC class II (H-2E). Among candidate viral proteins to be screened for Th epitopes, structural protein was selected, since they induced strong IL-2 release from adenovirus immune lyrnph node (LN) cells and the presence of E1 protein, which contains immunodominant cytotoxic T lymphocyte epitopes, did not potentiate the T cell responses. To confirm the presence of Th epitopes in the structural protein, virions were trypsinized and the resulting polypeptides whose molecular weights were lower than 5,000 were fractionated by HPLC. Some of the HPLC fraction turned out to induce LN cell proliferation. Ten synthetic peptides were designed as candidate Th epitopes from the primary amino acid sequences of adenovirus hexon and penton protein which are major constituents of the virion. The selected sequences share the common features of other known H-2E' binding ligands. Among these ten synthetic peptides, peptide of hexon protein amino acid residue 709-721 induced noticeable proliferation of LN cells from preimmune mice, and also able to induce IL-2 secretion from adenovirus-specific T hybridomas, suggesting that the peptide was the most immunodominant Th epitope. Hexon protein 221-233 and hexon protein 676-688 are considered as epitopes also. This study revealed three epitope sequences from adenovirus structural protein that are presented by class II MHC, H-2E.
Adenoviridae*
;
Amino Acid Sequence
;
Animals
;
Cell Proliferation
;
Chromatography, High Pressure Liquid
;
Epitopes
;
Epitopes, T-Lymphocyte*
;
Hybridomas
;
Interleukin-2
;
Ligands
;
Mice
;
Molecular Weight
;
Peptides
;
Trypsin
;
Viral Proteins
;
Virion
4.FRACTURE STRENGTH AND MARGINAL FIT OF IN-CERAM, COPY-MILLED IN-CERAM, AND IPS EMPRESS 2 ALL-CERAMIC BRIDGES.
Jung Won HWANG ; Jae Ho YANG ; Sun Hyung LEE
The Journal of Korean Academy of Prosthodontics 2001;39(6):641-658
All-ceramic restorations have become an attractive alternative to porcelain-fused-to-metal crowns. In-Ceram, and more recently IPS Empress 2 were introduced as a new all-ceramic system for single crowns and 3-unit fixed partial dentures. But their strength and marginal fit are still an important issue. This study evaluated the fracture resistance and marginal fit of three systems of 3 unit all-ceramic bridge fabricated on prepared maxillary anterior resin teeth in vitro. The 3 all-ceramic bridge systems were: (1) a glass-infiltrated, sintered alumina system (In-Ceram) fabricated conventionally, (2) the same system with copy-milled alumina cores (copy-milled In-Ceram), (3) a heat pressed, lithium disilicate reinforced glass-ceramic system (IPS Empress 2). Ten bridges of each system with standardized design of framework were fabricated. All specimens of each system were compressed at 55degree at the palatal surface of pontic until catastrophic fracture occurred. Another seven bridges of each system were fabricated with standard method. All of the bridge-die complexes were embedded in epoxy resin and sectioned buccolingually and mesiodistally. The absolute marginal discrepancy was measured with stereomicroscope at x50 power. The following results were obtained: 1. There was no significant difference in the fracture strength among the 3 systems studied. 2. The Weibull modulus of copy-milled In-Ceram was higher than that of In-Ceram and IPS Empress 2 bridges. 3. Copy-milled In-Ceram (112micrometer) exhibited significantly greater marginal discrepancy than In-Ceram (97micrometer), and IPS Empress 2 (94micrometer at P=0.05. 4. The lingual surfaces of the ceramic crowns showed smaller marginal discrepancies than mesial and distal points. There was no significant difference between teeth (incisor, canine) at P=0.05. 5. All-ceramic bridges of three systems appeared to exhibit sufficient initial strength and acceptable marginal fit values to allow clinical application.
Aluminum Oxide
;
Ceramics
;
Crowns
;
Denture, Partial, Fixed
;
Hot Temperature
;
Lithium
;
Tooth
5.A case of orbital meningioma not connected to optic nerve.
Sung Won CHAE ; Geon CHOI ; Gun CHUNG ; Soon Jae HWANG
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(4):813-817
No abstract available.
Meningioma*
;
Optic Nerve*
;
Orbit*
6.3 cases of tuberculous peritonitis complicating long-term CAPD.
Yi Sook HWANG ; Jae Hyung AHN ; Tae Won LEE ; Chun Gyoo IHM ; Myung Jae KIM
Korean Journal of Nephrology 1991;10(2):245-249
No abstract available.
Peritoneal Dialysis, Continuous Ambulatory*
;
Peritonitis, Tuberculous*
7.A Clinico-Epidemilological Study of 55 Cases of Chidhood Idiopathic Thrombocytopenic Purpura.
Won Ho KANG ; Myung Hee KOOK ; Yong Sang YOO ; Jae Suk MA ; Tai Ju HWANG
Journal of the Korean Pediatric Society 1987;30(11):1207-1212
No abstract available.
Purpura, Thrombocytopenic, Idiopathic*
8.Simultaneous Bilateral Cementless Total Hip Arthroplasty: a Minimum 17-year Follow-up Study - Comparison Study with Unilateral Cementless Total Hip Arthroplasty -.
Sung Kwan HWANG ; Jang Hee PARK ; Won Sik YOON ; Jae Hack CHA
Hip & Pelvis 2013;25(1):21-29
PURPOSE: Long-term follow-up results of concurrent bilateral or unilateral cementless hip arthroplasty were compared. MATERIALS AND METHODS: Forty eight and 49 patients with concurrent bilateral and unilateral hip artrhoplasties who had more than a 17-year follow-up time were selected. At final follow-up, mean ages were 69.1 and 66.7 years old in the bilateral and unilateral groups, respectively. Mean follow-up times were 21.5 and 22.4 years in the bilateral and unilateral groups, respectively. Clinical results were attained using Harris hip score and standardized anteroposterior and lateral view X-rays. RESULTS: The bilateral group had mean Harris scores of 44.3(standard deviation 3.78) preoperatively, and 81.2 (10.75) at final follow-up. For the unilateral group, the mean scores were 46.5(3.27) preoperatively, and 80.1 (12.05) at final follow-up. At final follow-up, an acetabular cup was securely located in 78.9% and 82.8% of the bilateral and unilateral groups, respectively, and all cases showed firm fixation of the femoral stem in both groups. Osteolysis around the cup and stem were found in 26.3% and 31.4% of the bilateral group and 16.6% and 17.1% of the unilateral group, respectively. Polyethylene wear rate was 0.17 mm/yr and 0.16 mm/yr in the unilateral and bilateral groups, respectively. Using the Kaplan-Meier method, 17-year survival rates for cup and stem were 78% and 89% in the bilateral group, respectively, and 78% and 86% in the unilateral group, respectively. CONCLUSION: In 17-year long-term follow-up, concurrent bilateral hip arthroplasty was insignificantly different clinically and radiologically from the result of unilateral hip arthroplasty.
Arthroplasty
;
Follow-Up Studies
;
Hip
;
Humans
;
Osteolysis
;
Polyethylene
;
Survival Rate
9.Clinical and Laboratory Findings of the 2012 Winter Seasonal Influenza A and B Outbreak at a Single Institution.
Jae Won CHOI ; Hyun Jun CHO ; Hwang Min KIM ; Seok HAHN
Korean Journal of Pediatric Infectious Diseases 2014;21(1):1-8
PURPOSE: The aim for this study was to investigate clinical manifestation of seasonal influenza A and B during the 2012 winter season in Wonju, South Korea. Their clinical and laboratorial characteristics and effect of oseltamivir were compared and analyzed. METHODS: Children under the age of 18 years who visited the Wonju Severance Christian Hospital with fever or acute respiratory symptoms and who were diagnosed with influenza A or B by rapid antigen test from nasopharyngeal swab were selected for the study. The medical records of patients were retrospectively reviewed. RESULTS: Influenza A was detected in 374 patients (83.7%), and influenza B in 72 (16.6%). The incidence of influenza A was highest in February (n=186), while that of influenza B was highest in March (n=36). The most common symptoms were fever (n=434, 97.1%) and cough (n=362, 81.0%). No significant differences were observed between influenza A and B in symptoms and laboratory data. Patients who had used oseltamivir within 2 days showed statistically lower admission rate, shorter admission duration, and lower incidence of pneumonia. CONCLUSION: This study found no statistical difference between influenza A and B, in symptoms, progression, and laboratory test, but those who were treated with oseltamivir given within 2 days of the onset of fever experienced more positive outcomes.
Child
;
Cough
;
Fever
;
Gangwon-do
;
Humans
;
Incidence
;
Influenza, Human*
;
Korea
;
Medical Records
;
Oseltamivir
;
Pneumonia
;
Retrospective Studies
;
Seasons*
10.The effect of vaginal bleeding in the first half of pregnancy on outcome.
Jae Whan KWAK ; Jin Wan PARK ; Tai Young HWANG ; Hyun Ho KIM ; Won Ki LEE
Korean Journal of Obstetrics and Gynecology 1992;35(11):1577-1582
No abstract available.
Pregnancy*
;
Uterine Hemorrhage*