1.Serum Interleukin-10 Levels in Rheumatoid Arthritis Patients.
Bin YOO ; Jae Kyoung PARK ; Won Il OH ; Sun Whan OH ; Hee Bom MOON
The Journal of the Korean Rheumatism Association 1997;4(1):33-38
OBJECTIVE: To investigate whether the serum levels of IL-10 in patients with rheumatoid arthritis are different from those of normal controls and SLE patients and to find out any correlation with disease activity parameters of rheumatoid arthritis. METHODS: Sera from 20 healthy normal persons, 16 rheumatoid arthritis patients and 16 patients with systemic lupus erythematosus were collected and measured for IL-10 and IL-6. Various disease activity parameters were measured in RA patients. RESULTS: The serum level of IL-10 in RA patients was significantly elevated compared to normal controls but lower than those of SLE patients. In RA patients there was no definite correlation between the disease activity parameters and serum IL-10 levels. Despite significant improvements in terms of various disease activity parameters, there was no significant change of serum IL-10 levels after treatment in RA patients. In seropositive RA patients, positive correlation was found between serun IL-10 and rheumatoid factor levels. CONCLUSION: Our findings show that the serum IL-10 levels in patietns with RA are elevated compared to normal controls but lower than those of SLE patients. There was no correlation between serum IL-10 levels and disease acivity parameters of RA.
Arthritis, Rheumatoid*
;
Humans
;
Interleukin-10*
;
Interleukin-6
;
Lupus Erythematosus, Systemic
;
Rheumatoid Factor
2.Defecography.
Min Joo MOON ; Jae Whan OH ; Hyun Shig KIM ; Jong Kyun LEE
Journal of the Korean Radiological Society 1993;29(1):126-134
To evaluate the results and clinical impact of defecography in patients with anorectal diseases, 304 defecographic examinations from 304 patients were reviewed. The defecographic results were screened for the anorectal angle and perineal descent at rest, squeezing and during straining. Changes of rectal configuration and canal width during straining were reviewed. 304 patients had defecation problems such as terminal constipation, defecation defficulty, blood or mucus discharge, tenesmus, obstruction sensation etc. They were performed anorectal physical examination and anal manometry etc., and were later treated by operation and conservative management. Normal anorectal angle were measured to be 101°, 91°, 131°at rest, during squeezing and straining respectively. In the spastic pelvic floor syndrome, increase of anorectal angle less than 10 ° from rest to straining was observed. Incontinent patients had a larger anorectal angle (mean: 128°) at rest. 7.8cm of perineal descent was found in descending perineal syndrome in comparison to 4.0cm in normal. Normal anal canal width was measured 1.4cm only during straining but identified in incontinent patients at rest (mean:1.2cm). Abnormal rectal configuration was found in 254 defecographic examinations: rectoceles were observed in 235 cases and were associated with rectal prolapse in 115 cases, and rectal prolapses were found in 134 cases. In conclusion, the anorectal angle was valuable in evaluation of spastic pelvic floor syndrome and fecal incontinence. Degree of perineal descent was abnormally increased in descending perineal syndrome. In the cases of the rectoceles and rectal prolapses, defecography is helpful in preoperative evaluation of rectal wall change and postoperative follow up.
Anal Canal
;
Constipation
;
Defecation
;
Defecography*
;
Fecal Incontinence
;
Follow-Up Studies
;
Humans
;
Manometry
;
Mucus
;
Muscle Spasticity
;
Pelvic Floor
;
Physical Examination
;
Rectal Prolapse
;
Rectocele
;
Sensation
3.Transoral Fusion of the Odontoid Process Fracture.
Kang IL LEE ; Jae Oh KIM ; Ki Won SUNG ; Jong Oh LEE ; Dae Whan KIM ; Sung Gyun PARK
Journal of Korean Neurosurgical Society 1988;17(2):375-380
The Odontoid process fracture has been treated by prolonged external immobilization of by internal fixation and fusion. We reported congential and traumatic odontoid process fracture which were successfully treated by transoral fusion. Operative preparation, technique and postoperative management are described by in detail.
Immobilization
;
Odontoid Process*
4.A clinical analysis of laryngotracheal stenosis.
Jae Wook EOM ; Seong Kook PARK ; Eun Pyo PARK ; Bong Whan OH ; Jae Wan LEE ; Sang Cheol LEE ; Chun Keun PARK
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(4):785-794
No abstract available.
Constriction, Pathologic*
5.Effects of Monocyte Chemoattractant Protein-1 on Growth and Migration of Cultured Human Vascular Smooth Muscle Cells.
Ho Chul PARK ; Jung Whan CHOI ; Soo Myung OH ; Jae Kyung PARK
Journal of the Korean Society for Vascular Surgery 1999;15(1):12-21
No abstract available.
Chemokine CCL2*
;
Humans*
;
Monocytes*
;
Muscle, Smooth, Vascular*
6.Treatment of Diffuse In-stent Restenosis with Rotational Atherectomy Followed by Radiation Therapy with a 188Re-MAG3-Filled Balloon.
Seong Wook PARK ; June Hong KIM ; Siwan CHOI ; Myeong Ki HONG ; Dae Hyuk MOON ; Seung Jun OH ; Cheol Whan LEE ; Jae Joong KIM ; Seung Jung PARK
Korean Circulation Journal 2001;31(5):466-475
BACKGROUND: Rotational atherectomy has been shown to be safe and efficient for the treatment of ISR, but the recurrence rate is still high. Intracoronary-irradiation after rotational atherectomy may be a reasonable approach to prevent recurrent ISR. SUBJECTS & METHODS: Fifty consecutive patients with diffuse ISR (length > 10 mm) in native coronary arteries underwent rotational atherectomy and adjunctive balloon angioplasty followed by beta irradiation using a 188Re-MAG3-filled balloon catheter. The radiation dose was 15 Gy at 1.0 mm deep into vessel wall. RESULTS: Mean length of the lesion and irradiated segment was 25.6 +/- 12.7 mm and 37.6 +/- 11.2 mm, respectively. The radiation was delivered successfully to all patients, with a mean irradiation time of 201.8 61.7 seconds. No adverse event including myocardial infarction, death, or stent thrombosis occurred during the follow-up period (mean 10.3 +/- 3.7 months) and non-target vessel revascularization was needed in one patient. Six-month binary angiographic restenosis rate was 10.4 % and loss index was 0.17 +/- 0.31. CONCLUSIONS: beta irradiation using 188Re-MAG3-filled balloon following rotational atherectomy is safe and feasible for patients with diffuse ISR, and it may improve the clinical and angiographic outcomes. Further prospective randomized trials are warranted to evaluate the synergistic effect of debulking and irradiation in patients with diffuse ISR.
Angioplasty, Balloon
;
Atherectomy, Coronary*
;
Catheters
;
Coronary Vessels
;
Follow-Up Studies
;
Humans
;
Myocardial Infarction
;
Recurrence
;
Stents
;
Thrombosis
7.Huge Fresh Mobile Thrombus Attached to the Descending Thoracic Aorta.
Jin Kyung OH ; Jae Hyeong PARK ; In Whan SEONG
Korean Circulation Journal 2017;47(6):978-980
No abstract available.
Aorta, Thoracic*
;
Thrombosis*
8.A Case of Chronic Active Hepatitis Developed in Patient with Psoriasis after Long-term Methotrexate Treatment.
Dae Hyun KIM ; Jae Hyun JO ; Min Su KEUM ; Seong Gon CHOI ; Chang Hyeong LEE ; Young Oh KWEON ; Sung Kook KIM ; Yong Whan CHOI ; Joon Mo CHUNG
The Korean Journal of Hepatology 1997;3(1):78-84
Methotrexate (MTX) has been widely used in the treatment of psoriasis and rheumatoid arthritis. But prolonged use of MTX can induce hepatic fibrosis and even cirrhosis. To date, in Korea, there have been very few reports on hepatotoxicity due to MTX, and no report on biopsy-proven chronic active hapatitis. We report one patient who developed chronic acitve hepatitis while taking long-term daily dose of MTX(10mg per day) for psoriasis for a prolonged period.
Arthritis, Rheumatoid
;
Fibrosis
;
Hepatitis
;
Hepatitis, Chronic*
;
Humans
;
Korea
;
Methotrexate*
;
Psoriasis*
9.Analysis of Infections in Renal Transplant Recipients Receiving Mycopheolate Versus Azathioprine-based Immunosuppression.
Jae Chang LEE ; Suk Whan KO ; Soo Myung OH ; Ho Chul PARK
The Journal of the Korean Society for Transplantation 2005;19(1):36-41
PURPOSE: Immunosuppression is important for early success of renal transplantation. Mycofenolate mofetil (MMF) has been substituted for Azathioprine (AZA) and has been shown to have greater effect on T cell and also on B cell function than AZA. Although many side effects like infections have been investigated in patients who received AZA based therapy, they have not extensively been studied in MMF based protocol. The aim of this study is to evaluate the differences in incidence and frequency of infections during the first 6 months in the patients who received AZA or MMF based therapy. METHODS: Renal transplant recipients who received either AZA or MMF based therapy were reviewed. From January 1994 to December 2003, 112 patients were enrolled and analyzed the types and frequency of infection. RESULTS: 78 patients received AZA based therapy, and 34 patients received MMF based therapy. Infection developed in 37 (47.4%) and 12 (35.3%) patients respectively. AZA group showed higher incidence of infection than MMF group (P<0.05). In AZA group, UTI developed in 15 patients (19.2%), URI in 7 patients(9%), CMV infection in 7 patients (9%), tuberculosis in 2 patients (2.6%), and wound infection in 6 patients (7.7%). In MMF group, UTI developed in 6 patients (17.6%), URI in 2 patients (5.9%), CMV infection in 2 patients (5.9%), tuberculosis in 1 patient (2.9%), wound infection in 1 patient (2.9%). There were no significant differences in the type of various infectious episodes between two groups. CONCLUSION: AZA group showed higher incidence in total infection, but there were no differences in the type of various infectious episodes between two groups. MMF has more powerful immunosuppressive effect (18) but has similar infectious adverse effects compared with AZA.
Azathioprine
;
Humans
;
Immunosuppression*
;
Incidence
;
Kidney Transplantation
;
Transplantation*
;
Tuberculosis
;
Wound Infection
10.Diagnostic Trial of Epiluminescence Microscopy in Two Cases of Pigmented Basal Cell Carcinomas (PBCCs).
Jae Hong PARK ; Jeung Tae JEONG ; Hae Jun SONG ; Chil Whan OH ; Il Hwan KIM
Korean Journal of Dermatology 2001;39(10):1127-1132
Basal cell carcinomas(BCCs) are the most common skin cancers in Korea and a proportion of BCCs contain pigment. Pigmented basal cell carcinomas(PBCCs) are included in the differential diagnosis of invasive melanoma and other benign pigmented skin lesions(PSLs) because of their growth patterns and asymmetry of pigmentation. Epiluminescence microscopy(ELM) describes the non-invasive in vivo examination of skin lesions with a microscope using incident light delivered from an acute angle and oil immersion. Many studies have shown that epiluminescence microscopy can improve the diagnostic accuracy of PSLs. Menzies et al analyzed the morphologic features of a large set of 142 pigmented BCCs and produced a simple ELM method for diagnosis that would allow differentiation from melanomas and benign pigmented lesions. We observed morphologic features of two PSLs with a handheld 10 epiluminescence microscopy (Episcope, Welch Allyn Inc, Skaneateles Falls, NY). After the ELM examination, two PSLs were excised and processed for histopathology. The ELM findings and histopathologic diagnosis were compared for each lesion. ELM permits the recognition of two PBCCs and the fact that it is a non-invasive in vivo method makes it even more attractive as a diagnostic tool in clinical practice.
Carcinoma, Basal Cell*
;
Dermoscopy*
;
Diagnosis
;
Diagnosis, Differential
;
Immersion
;
Korea
;
Melanoma
;
Pigmentation
;
Skin
;
Skin Neoplasms