A retinal pigment epithelium tumor is extremely rare, and the distinction from malignant melanoma or reactive hyperplasia of pigment epithelium is mandatory, clinically or pathologically. We report a case of adenoma of retinal pigment epithelium. A 21 year-old female presented with a sudden decrease of visual acuity. She had no previous inflammatory ocular disease. Fundic examination revealed an elevated mass at the temporal side of the right eye. With the suspicion of choroidal malignant melanoma, a right eye enucleation was done. Grossly there was a 0.7x0.5 cm dark soft broad-based elevated lesion in the temporal side. The anterior border was the ora serrata, and the posterior border reached the equatorial area. The tumor was confined to the intraocular portion. Histologically, the tumor mass was composed of the cuboidal or columnar cells arranged in papillary, trabecular, or solid pattern with fine fibrovascular stroma. The tumor cells were heavily pigmented. The cytoplasmic border of the tumor cell was indistinct and there was a finely granular brown pigment diffusely scattered in the cytoplasm. Mild anisokaryosis noted, but hyperchromatism or pleomorphism were negligible. The nucleoli were small. A transition between normal retinal pigment epithelium and tumor mass was noted. Reactive gliosis was noted at the periphery of the tumor.
Female ; Humans ; Adenoma

No abstract available.
Constriction, Pathologic*

Parosteal lipoma is a rare and generally asymptomatic benign tumor of mature adipose tissue that is located in direct apposition to the external surface of the bone. These tumors are occasionally associated with reactive changes in the underlying bone. The reactive bone formation is generally restricted to the base of the tumor, that is, near the periosteum. We recently experienced a case of parosteal lipoma in the proximal femur, which displayed exuberant bone and cartilage formation, and this led us to a misdiagnosis of chondroblastic osteosarcoma on the initial biopsy. We report here on this case with a special emphasis on making the differential diagnosis from osteosarcoma.
Adipose Tissue ; Biopsy ; Cartilage ; Chondrocytes ; Diagnosis, Differential ; Diagnostic Errors ; Femur* ; Lipoma* ; Osteogenesis ; Osteosarcoma ; Osteosarcoma, Juxtacortical ; Periosteum

The cystic hypersecretory duct carcinoma of the breast was first described in 1984 by Rosen and Scott and warrants separate discussion because of its unusual pathological features. It is morphologically distinguishable from juvenile (secretory) carcinoma and from mucinous (colloid) carcinoma or mucocele-like tumor. We present a case report of intraductal cystic hypersecretory carcinoma of the breast with hormone receptor and oncogene study. The histologic differential diagnosis, with an emphasis on benign lesions that may have a predominant cystic component, is also discussed.
Breast Neoplasms ; Breast* ; Diagnosis, Differential ; Mucins ; Oncogenes

We report a case of malignant tumor of the stomach showing both carcinoma and sarcoma components in a 47 year-old woman. The resected stomach revealed two tumors which were in different location. The one mass was a 2 x I cm, poorly demarcated tumor at the body, along the lesser curvature and the other was a 6 x 7 cm, well demarcated polypoid tumor with a central depression at cardia of the posterior stomach wall. The tumor at the body was a poorly differentiated adenocarcinoma which showed strong reactivity for CEA. The tumor at the cardia was composed of epithelioid or spindle shaped cells with abundant eosinophilic cytoplasm and revealed 5-6 mitoses per ten high power field. The tumor at the cardia was diagnosed as epithelioid leiomyosarcoma and showed reactivity for vimentin but none for actin, desmin,keratin, and CEA. This is different from the usual carcinosarcoma.
Female ; Humans ; Adenocarcinoma

OBJECTIVE: The purpose of this article is to report mixed germ cell tumor, which revealed changes compatible with early transformation of dysgerminoma to endodermal sinus tumor(EST) through histogenetic considerations and immunohistochemical stains. METHODS: Ovarian germ cell tumors were reviewed from files of Dept. Ob/Gyn. Seoul Paik Hospital fiom 1992.1 to 1996.12. Total of 5 cases include 4 pure dysgerminoma and 1 mixed germ cell tumars. All tissues were fixed in 10% neutral buffered formalin and embedded in paraffin and reviewed by two pathologists with immunohistochemical staining for cytokeratin, vimentin, AFP, PCNA, p53 & bc1-2. RESULTS: Grossly, the areas of transformation were located at the middle of the mixed tumor. The outer layer of the tumor mass was filled with typical pure dysgerminoma. They were characterised as the presence of microcysts and small glandular structures in hematoxylin-eosin(H-E) stains with positive stain for vimentin, except the tissue of the EST. The cells in the intermediate layer were characterised as the mixed form of dysgerminomatous and EST structures in H-E stains. AFP in the dysgerminomatous cells in intermediate layer and EST were stained, but not in outer layer. CONCLUSION: Dysgerminoma may possess the ability to transform to EST. There might be intermediate stage between dysgerminoma and EST, and Immunohistochemical staining for AFP, cytokeratin, vimentin, PCNA also can be used for prognosis of germ cell tumor.
Coloring Agents ; Dysgerminoma* ; Endoderm ; Endodermal Sinus Tumor* ; Formaldehyde ; Germ Cells ; Keratins ; Neoplasms, Germ Cell and Embryonal ; Paraffin ; Prognosis ; Proliferating Cell Nuclear Antigen ; Seoul ; Vimentin ; Yolk Sac*

No abstract available.
Rhabdomyosarcoma*

No abstract available.
Pilomatrixoma*

No abstract available.
Biopsy, Fine-Needle* ; Liver*

No abstract available.
Bile*