These days, the computer network has become the most popular and widely used source of information. There are two kinds of computer networks, the first one is multimedia internet world wide web site and the second one is text based commercial network (etc. Hitel, Chollian. Nownuri, Unitel). With the rapid development of internet, various kinds of medical-related sites are newly appearing on the internet. Even in Korea, several medical-related information sites are on service, however, there are very few compared with foreign sites. World wide web is popular, and creating the homepage for each hospital is becoming more important. In Korea, the number of homepage of about medicine and medical institutes, is increasing. For the construction of Soonchunhyang University Hospital's Computer Information Network, the authors first investigate Korean medical-related information sites available in internet and commercial network. After researching the authors then construct the Computer Information Network of Soonchunhyang University Hospital. This article is written with the intent of assisting those interested in creating and managing their own computer information network system by means of providing relevant data obtained during this process.
Academies and Institutes ; Information Services* ; Internet ; Korea ; Multimedia

This study was conducted to collect data on the educational needs for hospital administrations and related departments to redesign the existing hospital information management and administration programs for Bachelor and Master degree students of medical informatics in one university. We surveyed the web sites and admission brochures of all the educational facilities of hospital administration related workers in Korea. We also surveyed hospital workers in hospital administration departments at three university affiliated hospitals using a questionnaire developed by the author. The survey results showed that most hospital employees indicated a need to take very fundamental classes in their fields. In order to satisfy the needs of the students up to date, the department of medicine in one university developed a new medical informatics course specially designed for Bachelor and Master degree students in hospital administration. In addition, the Graduate School of Industrial Information Engineering of one university decided to offer basic as well as a specialized training courses for the graduate students who are hospital administrators.
Curriculum* ; Education ; Hospital Administration* ; Hospital Administrators ; Hospitals, University* ; Humans ; Information Management ; Korea ; Medical Informatics ; Pamphlets ; Surveys and Questionnaires

It is generally agreed that CT is a good staging method of renal cell carcinoma. However, CT has its ownpitfalls. Herein we reviewed 31 patients with renal cell carcinoma whose CT and pathologic stages were available.CT accurately staged 12 of 14 patients with Robson's stage I (86%), 6 of 8 with stage II (75%), 4 of 4 with stageIIIa (100%), 2 of 3 with stage IIIb (67%), and 1 of 2 with stage IV (50%). Overall staging accuracy of CT was 81%(25 of 31). CT failed to differentiate stage I and stage II in 4 cases. CT also failed to diagnose the microscopiclymph node metastasis in 1 case, and invasion of Gerota's fascia in another case. However CT was satisfactory indifferentiating surgically curable stage I to III from surgically incurable stage IV, and high reliable in thediagnosis of inferior vena caval thrombosis. Therefore it is suggested that CT is highly useful in determining thetreatment plan of renal cell carcinoma.
Carcinoma, Renal Cell ; Fascia ; Humans ; Methods ; Neoplasm Metastasis ; Thrombosis

OBJECTIVE: This study aims to investigate the needs, uses and evaluation of Internet health information among students in a provincial university. METHODS: Nine hundred and sixty one student from seven different classes of S University located in Chungnam province participated in this study from 2nd to 9th May, 2005. A self-reported questionnaire was used to collect data. Collected data were analyzed on SPSS 11.0. RESULTS: 58.2% of them have needed some health information before and 84.6% of them needed the health information offered by a University. 67.2% of them use the Internet more than any other resource to acquire Health Information. 90.9% of them used a search engines to get health information on the Internet. 57.6% of them have searched for Internet health information to get information about specific disease or medical problem. The most frequently searched topics were LASIK(laser in-situ Keratomileusis), diabetes, and contraception. 39.6% of them evaluated the Internet health information was reliable and 55.8% of them satisfied with the Internet health information. CONCLUSION: Universities and their in-campus health centers are needed to offer the trustworthy Internet health informtaion on their official homepages so that the student can refer to the reliable and qualified Internet health information.
Chungcheongnam-do ; Community Health Centers ; Consumer Health Information ; Contraception ; Humans ; Internet* ; Search Engine ; Student Health Services

The second phase of this study was performed with the same procedures as the first phase, and the study population was limited to young recruits in the Army. After examination of 1028 normal eyegrounds, it became apparent that there are several definite and easily recognizable variations in the distribution of the vessels as they emerge from the optic nerve head. The classification is made by dividing the surface of the nerve head into four quadrants, Le., tbe upper and lower nasal and the upper and lower temporal. Since there are four main branches of the retinal artery, namely, the superior and inferior temporal and tbe superior and inferior nasal, there are nine possible variation in the distribution of these vessels over the surface of the optic nerve head.
Classification* ; Head ; Optic Disk* ; Retinal Artery*

Most common annoyant for angular blepharitis has long been known as a diplobacillus of Morax-Axenfeld since 1897. Bacteriological study has been done on 56 patients (102 eyes) being suffered from angular blepharitis clinically diagnosed in the Dept. of Ophthalmology, Yonsei University College of Medicine. Most angular blepharitis involved bilaterally (82%), 34 cases of angular blepharitis were seen in the nasal canthus (61%). Staphylococcus epidermidis was isolated from 50 eyes (49%) with angular blepharitis and staphylococcus au reus from 41 eyes (40%). No diplobacillus of Morax-Axenfeld was demonstrated in the culture from angular blepharitis.
Blepharitis* ; Humans ; Ophthalmology ; Staphylococcus ; Staphylococcus epidermidis

Normal gingival fibroblasts functioning is fundamental for the maintenance of periodontal connective tissue as well as wound healing. Nicotine have been found to affect DNA synthesis and cell proliferation, which appear to depend on the type of cells. This in vitro study was done to determine the effects of nicotine, a major component of tobacco, on cell proliferation, viability, activity, cell cycle distribution, and expression of cell cycle regulatory proteins in human gingival fibroblasts. Nicotine has been tested for 2 days or 4 days in 5 different concentrations; 0.1 microgram/ml; 1 microgram/ml; 10 microgram/ml; 100 microgram/ml; 1000 microgram/ml. To assess cell proliferation and viability, viable and non-viable cells were counted by hemocytometer; to evaluate cellular activity, MTT assay was employed; to analyze cell cycle distribution, fluorescent propidium iodide-DNA complex were measured using fluorocytometer; to determine the expression of cell cycle regulatory proteins, western blot analysis was performed. After 2 days and 4 days incubation respectively, at concentrations of 1 microgram/ml - 1000 microgram/ml, nicotine significantly inhibited proliferation comparing to non-supplemented controls. The cell viability was significantly decreased after 2 days and 4 days at concentrations of 1 microgram/ml - 1000 microgram/ml and at 10 microgram/ml - 1000 microgram/ml respectively. After 2 days and 4 days, the cellular activity was significantly decreased at concentrations of 10 microgram/ml - 1000 microgram/ml. Treatment with 100 microgram/ml nicotine for 48 hours caused an increase in the proportion of G1-phase cells (from 46.41% to 53.46%) and a decrease in the proportion of S-phase cells (from 17.80% to 14.27%). The levels of cyclin D1 and CDK 4 proteins in nicotine-treated fibroblasts were lower than that of controls, whereas the levels of p16 and pRB were higher than that of controls. These results suggest that the decrease of cell proliferation and lengthened Gap phases (G1) by nicotine may due to the increased expression of p16 and pRB as well as decreased expression of cyclin D1 and CDK 4 in human gingival fibroblasts.
Blotting, Western ; Cell Cycle Proteins* ; Cell Cycle* ; Cell Proliferation ; Cell Survival ; Connective Tissue ; Cyclin D ; Cyclin D1 ; DNA ; Fibroblasts* ; Humans* ; Nicotine* ; Propidium ; Tobacco ; Wound Healing

Gingival fibroblasts are major cellular component of gingiva. However, the molecular mechanisms of senescence of human gingival fibroblasts are unknown. Human fibroblasts undergo replicative senescence in vitro after a limited number of population doublings. A reduced rate of proliferation is a prominent phenomenon observed in senescent fibroblasts. This phenomenon is happened with cell cycle arrest that was controled by cell cycle regulatory proteins. The purpose of present study was to investigate the effect of replicative senescence on cell cycle progression and to find out its molecular mechanisms in human gingival fibroblasts. Replicative senescence of gingival fibroblasts were induced by subsequent cultures that were repeated up to 18 passage. In the present study, I examined change of cell proliferation, cell activity, cell viability and cell cycle progression during the replicative process. Also, I examined expression of cell cycle regulatory proteins which was estimated by western blot analysis. Cell proliferation, cell activity and cell viability of gingival fibroblasts were notably decreased with increase of population doubling level(PDL). S phase was decreased and G1 phase was increased with increase of PDL. Western blot analysis showed that levels of p16, p21 and p53 of senescent gingival fibroblasts(PDL41, PDL58) were higher than young fibroblasts(PDL27) and cdk4 were lower than young fibroblasts(PDL27). In conclusion, these results suggest that proliferative function of human gingival fibroblasts may be decreased by replicative senescence and its molecular mechanisms may be activatied with p16, p21, p53 and pRB, and repressed wtih cdk4.
Aging ; Blotting, Western ; Cell Aging* ; Cell Cycle Checkpoints ; Cell Cycle Proteins ; Cell Cycle* ; Cell Proliferation ; Cell Survival ; Fibroblasts* ; G1 Phase ; Gingiva ; Humans* ; S Phase

PURPOSE: We investigated the characteristics of the distribution of the serum prostate- specific antigen (PSA) and evaluated the factors influencing the serum PSA levels in healthy men under 50 years old. MATERIALS AND METHODS: A total of 5,701 healthy Korean men under 50 years old who visited the Health Promotion Center at our hospital for a routine health checkup were enrolled into a prospective study. All the men underwent a PSA determination using a Hybritech Tandem-R assay, anthropometric measurements, liver function tests, renal function tests, and other constituents. The risk factors associated with an increase in the serum PSA among these clinical parameters were investigated using univariate and multivariate logistic regression analyses. RESULTS: Almost no change was observed in the median and 95th percentiles serum PSA value in men under 50 years old. Univariate logistic regression analysis indicated that the hematocrit, sodium, potassium, osmolarity, albumin, and globulin levels were the risk factors associated with an increase in the serum PSA. In the multivariate model used, the hematocrit, potassium and albumin levels were found to be independent predictors of an increase in the serum PSA, whereas the sodium, and globulin levels, and the osmolarity had no statistical significance. CONCLUSIONS: Age does not appear to influence the serum PSA levels of healthy Korean men under 50 years old. The results also suggest that the chemical constituents in young adults may exert an influence on the serum PSA levels.
Health Promotion ; Hematocrit ; Humans ; Kidney ; Liver ; Liver Function Tests ; Logistic Models ; Male ; Middle Aged* ; Osmolar Concentration ; Potassium ; Prospective Studies ; Prostate-Specific Antigen* ; Risk Factors ; Sodium ; Young Adult

PURPOSE: We investigated the influence of age, rate of obesity, hepatic function and renal function on serum prostate-specific antigen in healthy men older than 50 years. MATERIALS AND METHODS: From January 1999 to December 2000, 2,296 healthy Korean men older than 50 years who visited Health Promotion Center at our hospital for a routine health checkup were entered into a prospective study. All men underwent detailed clinical examinations, including serum prostate-specific antigen (PSA) determination using Hybritech Tandem-R assay, anthropometric measurements, tests for liver disease, tests for renal function, and other constitutes. We determined the risk factors of the increase of serum PSA among these clinical parameters using univariate and multivariate logistic regression analyses. RESULTS: The univariate logistic regression analysis indicated that age, alanine aminotransferase (ALT), hemoglobin, potassium, albumin, high-density lipoprotein (HDL) were the risk factors of the increase of serum PSA. In the multivariate model used, age, ALT, alkaline phosphatase, albumin, HDL and cholesterol were an independent predictors of the increase of serum PSA, whereas hemoglobin and potassium lost their statistical significance. CONCLUSIONS: Our findings suggest that the health status as well as may influence on serum PSA level of healthy men older than 50 years. Additional work is needed to determine and validate the clinical significance of these findings.
Alanine Transaminase ; Alkaline Phosphatase ; Cholesterol ; Health Promotion ; Humans ; Lipoproteins ; Liver Diseases ; Logistic Models ; Male ; Obesity* ; Potassium ; Prospective Studies ; Prostate-Specific Antigen* ; Risk Factors