1.Clinical Efficacy and Safety of Gepefrin in the Treatment of Hypotension.
Kun Joo RHEE ; Suck Koo CHOI ; Byong Ok KIM ; Kyung Jae NAM ; Won Sang YOO
Korean Circulation Journal 1994;24(2):307-312
BACKGROUND: The proper management of the patients with hypotention remains a difficult clinical problem. This study was designed to evaluate the efficacy and safety of gepefrin in the treament of symptomatic hypotensive patients in outpatient clinic of university hospital. METHODS: Thirty milligrams of Gepefrin was given twice daily for 4 weeks in 30 patients with hypotension(6 males, 24 females ; 23-60 years of age). Blood pressure, heart rate, subjective symptoms and side effects were checked before medication and at the end of 1st, 2nd, 3rd, 4th week of medication. RESULTS: 1) Grpefrin increased sitting systolic blood pressure significantly(p<0.05) by the end of 1st week and thereafter. 2) Hypotensive symptoms were improved in 76% of hypotensive patients and overall rate of usefulness was 70%. 3) Heart rate did not change significantly. 4) One patient complained of loose bowel movement and another one, of anorexia among 30 study patients and all laboratory parameters were within normal limits before and after drug treatment, thus the rate of safety was 93%. CONCLUSION: Results from this study suggests that gepefrin 60mg daily increases the blood pressure mildly and improves the symptoms moderately in symptomatic hypotensive patients.
Ambulatory Care Facilities
;
Anorexia
;
Blood Pressure
;
Female
;
Heart Rate
;
Humans
;
Hypotension*
;
Male
;
Quality of Life
2.A case of carcinomatous polyarthritis.
Suk In LEE ; Woo Kyung KIM ; Jae Suk JUN ; Kyung Ran BAIK ; Sung Hyun YANG ; Young Joo BANG ; Young Ok SONG
Journal of the Korean Cancer Association 1993;25(2):307-314
No abstract available.
Arthritis*
3.A clinicopathologic study of lupus nephritis in children.
Hye Ok ROH ; Ki Soo PAI ; Kee Hyuck KIM ; Jae Seung LEE ; Pyung Kil KIM ; Hyeon Joo JEONG ; In Joon CHOI
Korean Journal of Nephrology 1993;12(3):334-342
No abstract available.
Child*
;
Humans
;
Lupus Nephritis*
4.A Survery on the Present Status of Infant Feeding.
Seung Joo LEE ; Jae Ok PARK ; Chang Sung SOHN ; Hae Ran LEE ; Jae Hoon SHIN ; Hae Il CHUNG ; Seung Il KIM
Journal of the Korean Pediatric Society 1994;37(12):1657-1668
5.A Survery on the Present Status of Weaning.
Seung Joo LEE ; Jae Ok PARK ; Chang Sung SOHN ; Hae Ran LEE ; Jae Hoon SHIN ; Hae Il CHUNG ; Seung Il KIM
Journal of the Korean Pediatric Society 1994;37(12):1643-1656
No abstract available.
Weaning*
6.Evaluation of Left Ventricular Systolic Function by-M-Mode Echo/Phonocardiography and Automated Border Detection(ABD) Echocardiography.
Jun Cheol LEE ; Byoung Gun LEE ; Dong Ok KIM ; Yong Soo KIM ; Tae Jun CHA ; Seung Jae JOO ; Jae Woo LEE
Korean Circulation Journal 1996;26(5):992-998
BACKGROUND: The rate of rise of left ventricular(LV) systolic pressure, dp/kt, and the peak ejection rate(PER) of LV may be more accurate indices for assessing LV systolic function than ejection fraction(EF). Both can be easily obtained by noninvasive methods, M-mode echo/phonocardiography and automated border detection(ABD) echocardiography, respectively. Mean dp/dt by M-mode echo/phonocardiography and PER by ABD echocardiography were compared with mean dp/dt by Doppler echocardiography. METHODS: Twenty-one adult patients who had normal sinus rhythm, mitral regurgitant signals by continuous wave Doppler echocardiography and an apical 4 chamber view of LV in which at least 75% of the endocardium was clearly visualized were selected for our study. The off-line estimation of LV end-diastolic volume (1) were performed by the method of disc, after manually tracing the endocardial border on the apical 4 chamber view and EF was calculated. M-mode echocardiography of the aortive valve and phonocardiography were simultaneously recorded on the strip chart to measure the isovolumic contraction time(dtM). A blood pressure (2) and LV end-diasolic pressure(LVEDP) was assigned 20mmHg in patients with Q wave myocardial infarction or EF< or =40% and 10mmHg in others. The mean dp/dtM during isovolumic contraction time was calculated as (aortic diastolic pressure-LVEDP)/dtM and was compared with the Doppler-derived mean rate of LV pressure rise(dp/dtDoppler) over the time period between velocities of 1 and 3m/sec on the ascending slope of the Doppler velocity spectrum. ABD system was used to measure the changes in LV volume and PER on the apical four chamber view. PER was compared with mean dp/dtDoppler. RESULTS: Mean dp/dtM positively correlated with mean dp/dtDoppler(r=0.73, p<0.001), but the limits of agreement between two methods were somewhat wide(-659-937mmHg/sec). PER also positively correlated with dp/dtDoppler and EF(r=0.73, p<0.001 ; r=0.80, p<0.001). CONCLUSIONS: Mean dp/dtM by M-mode echo/phomocardiography and PER by ABD echocardiography may be useful indices for assessing LV systolic function.
Adult
;
Blood Pressure
;
Echocardiography*
;
Echocardiography, Doppler
;
Endocardium
;
Humans
;
Myocardial Infarction
;
Phonocardiography
7.The Infection after Augmentation Rhinoplasty Using Silicone Implant.
Jae Ok JOO ; Seung Jae LEE ; Seong Hee HONG ; Jong Hoon LEE
Journal of the Korean Society of Aesthetic Plastic Surgery 2007;13(2):133-138
Augmentation rhinoplasty using silicone implant is one of the most common cosmetic procedures in Korea, but is not without several complications such as exposure of the implant, its deviation and deformity. Above all, infection and extrusion through the skin is most serious complication. The purpose of this study was to determine the type of microbial colonization on silicone implant removed from symptomatic patients and to prevent from the infection. Over the past 11 years, from February of 1996 to February of 2007, we have done 134 aesthetic rhinoplasties using silicone implant in our clinic, patient ages ranged from 15 to 62 years with an average of 29.2 years. 78 percent of patients (105) were female, and 22 percent (29) were male. Among them, four cases had the local infection. The infection rate was 2.9 percent. Total six cases of implant including the other two case augmented elsewhere having the infection were removed and submitted for Gram stain, standard aerobic and anaerobic bacterial culture, and fungal cultures. Staphylococcus aureus was isolated most frequently (four cases), followed by Pseudomonas aeruginosa (one case) and Proteus mirabilis (one case). No fungal infections were identified. In order to reduce the infection rates after augmentation rhinoplasty using silicone implant, rhinorrhea as a source of bacterial nutrients should thoroughly be managed perioperatively. The hairs of the nostril should appropriately be shaved, and the patient's entire face and internal nares meticulously prepared. The implant should be shaped to be shorter, smaller and thinner, appropriately to the patient's nasal phenotype. Also, subperiosteal implantation rather than subcutaneous or subfascial is better choice.
Colon
;
Congenital Abnormalities
;
Dental Implantation, Subperiosteal
;
Female
;
Hair
;
Humans
;
Korea
;
Male
;
Phenotype
;
Proteus mirabilis
;
Pseudomonas aeruginosa
;
Rhinoplasty*
;
Silicones*
;
Skin
;
Staphylococcus aureus
8.A Case of Bronchial Glomus Tumor.
Eun Woo LEE ; Soo Ok KIM ; In Jae OH ; Jin Young JU ; Gye Jung CHO ; Kyu Sik KIM ; Young Chul KIM ; Kyung Ok PARK ; Kook Joo NA ; Jae Il MYUNG
Tuberculosis and Respiratory Diseases 2002;53(4):445-449
An 18-year-old female was admitted because of dyspnea at rest. A chest computed tomography (CT) scan and fiberoptic bronchoscopy demonstrated a polypoid tumor in the left main bronchus, 0.5cm distal from the carina. Surgical resection of the tumor was performed, along with. A pathological evaluation and the immunohistochemical findings led to the diagnosis of a glomus tumor, which originated from the bronchus, an area where this type of tumor has rarely been reported.
Adolescent
;
Bronchi
;
Bronchoscopy
;
Diagnosis
;
Dyspnea
;
Female
;
Glomus Tumor*
;
Humans
;
Thorax
9.Interferon Treatment on HBeAg Positive Chronic Hepatitis B with HBV Precore Mutant in Liver Tissue.
Youn Jae LEE ; Sung Cheul OK ; Sang Hyuk LEE ; Sang Young SEOL ; Jung Myung CHUNG ; Yeong Hong PARK ; Nam Young JOO
Korean Journal of Medicine 1998;55(1):43-51
BACKGROUND: This study investigates the prevalance of HBV precore mutant in chronic B hepatitis patients and whether HBV precore mutants affect hepatic inflammation and response to interferon alfa. METHODS: HBV DNA in liver tissue from 48 chronic hepatitis patients was amplified by polymerase chain reaction. The HBV precore mutants were detected by direct sequencing of amplified PCR products. Thirty-three HBeAg-positive patients (Group 1: wild- type, Group 2: mixed) were received 3-6 MU INF three times a week for 4-6 months. We did follow-ups for at least six months(mean : Group 1-11.3, Group 2- 13.7 months). A complete responder was defined as persistent(>6 months) normalization of transaminase and loss of HBeAg and/or seroconversion. RESULTS: The HBV precore mutants were found in 15 cases(31.2%) among 48 patients: 7 cases(21.2%) in 33 HBeAg-positive patients and 8 cases(53.3%) in 15 HBeAg-negative patients. The HBV precore mutants were more frequently found in HBeAg-negative patients(p= 0.043). Differences in severity of hepatic pathology were not observed in the wild-type versus mutant-type chronic hepatitis B patients(p =1.00). Initial response rate was not significantly different between two Groups(p= 0.228), but complete response rate had a lower tendency in Group 2 (p=0.073). CONCLUSION: There is a tendency for HBV precore mutants to be less responsive to INF therapy than wild type. Therefore the patients with chronic hepatitis B should be treated as early as possible in natural history of their liver disease before the emergence of HBV precore mutants.
DNA
;
Follow-Up Studies
;
Hepatitis
;
Hepatitis B e Antigens*
;
Hepatitis B, Chronic*
;
Hepatitis, Chronic*
;
Humans
;
Inflammation
;
Interferon-alpha
;
Interferons*
;
Liver Diseases
;
Liver*
;
Natural History
;
Pathology
;
Polymerase Chain Reaction
10.Adenomyoma of the common bile duct.
Ung Gill JEONG ; Jong Gill JEONG ; Nam Hyun YOON ; Jae Hong JANG ; Mi Ok PARK ; Im Gwan JOO
Korean Journal of Hepato-Biliary-Pancreatic Surgery 2001;5(1):175-178
A fifty year old Korean female was admitted with a few months history of general malaise. On admission, positive HBs Ag, negative HBs Ab and HBe Ag was negative. The liver function tests showed AST 274 U/L, ALT 126 U/L, CEA 1.87 ng/ml. With the clinical impression of chronic hepatitis B, abdominal CT and ERCP were performed and demonstrated a narrowing of the distal common bile duct suggesting a malignant etiology. The Whipple's procedure was done. The intraoperative finding revealed neoplastic involvement of the distal 1 cm of the common bile duct with severe narrowing and proximal dilatation. Microscopic findings demonstrated cystically dilated ductular structures and intervening irregular hypertrophic smooth muscle bundles.
Adenomyoma*
;
Cholangiopancreatography, Endoscopic Retrograde
;
Common Bile Duct*
;
Dilatation
;
Female
;
Hepatitis B, Chronic
;
Humans
;
Liver Function Tests
;
Muscle, Smooth
;
Tomography, X-Ray Computed