No abstract available.
Animals ; Mouth Mucosa ; Rats

No abstract available.
Carcinoma, Squamous Cell ; Drug Therapy ; Head

Animals ; Calcium Sulfate ; Osteogenesis ; Periosteum ; Rats ; Skull

No abstract available.
Hyperplasia

The pleomorphic adenoma is the most common neoplasm involving both the major and minor salivary glands. It is a benign, slowgrowing tumor, but local recurrences can occur. The pleomorphic adenoma gene 1 (PLAG1), which is a novel zinc finger gene, is frequently activated by reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. This experimental study was preformed to observe the translocation patterns between PLAG1 gene and the three translocation partner genes. We also have analyzed the presence of PLAG1 transcripts by RT-PCR. CTNNB1/PLAG1 gene fusion was observed in three of nine pleomorphic adnomas. However, LIFR/PLAG1 and SII/PLAG1 gene fusions were not detectable. All of three gene fusions was not detectable in one Warthin's tumor and three inflammatory salivary gland tissues. PLAG1 transcripts were expressed in all inflammatory salivary gland tissues and tumors except for three pleomorphic adenomas. Of particular one pleomorphic adenoma showing CTNNB1/P AG1 gene fusion did not express PLAG1 transcipt. Our data indicate that gene fusion involving PLAG1 is a frequent event in pleomorphic adenoma, but correlation between gene fusion involving PLAG1 and PLAG1 transcription is not definite.
Adenoma, Pleomorphic* ; Gene Fusion ; Recurrence ; Salivary Glands* ; Salivary Glands, Minor ; Translocation, Genetic ; Zinc Fingers

Anesthesia ; Anesthesia, Local ; Animals ; Constriction ; Epinephrine ; Hemostasis ; Lidocaine ; Mandibular Nerve ; Rats ; Tongue

We had experienced a case of traumatic myositis ossificans arising in right masseter muscle, inferior to zygomatic arch occurred on 25 year old male. He had some trauma on the site one year ago and visited with complaint of mouth opening limitation and swelling. Palpable mass with facial disfigurement was noted. and several ovoid radiopaque masses were revealed on C.T. examination. On histopathologic examination, multiple bone trabeculae with osteoblasts in its periphery was noted in connective tissues and invaded to neighbouring muscles, but any chondroid components were not revealed.
Adult ; Connective Tissue ; Humans ; Male ; Masseter Muscle* ; Mouth ; Muscles ; Myositis Ossificans* ; Myositis* ; Osteoblasts ; Zygoma

OBJECTIVES: This study was conducted to compare a self-administered hand symptom diagram with other diagnostic tests and to assess its value in the diagnosis of carpal tunnel syndrome. METHODS: A self-administered hand symptom diagram has been developed for the evaluation of upper extremity paresthesias. A rating system was devised to classify the diagrams into four categories: classic, probable, possible, or unlikely carpal tunnel syndrome. Before nerve conduction testing, a medical history and demographic data were collected, a physical examination was conducted, and a hand symptom diagram was obtained from each patient. The diagram ratings of 85 patients(130 hands) were evaluated by an occupational and environmental medicine physician and a nerve conduction study was administered and interpreted by a rehabilitation medicine physician. RESULTS: Of 85 patients, 48(56.5 %) had carpal tunnel syndrome confirmed by nerve conduction study. A hand symptom diagram rating of classic or probable CTS had a sensitivity of 75.6 %, a specificity of 59.6 %, a positive predictive value of 73.8 % and a negative predictive value of 62.0 %. Of the combinations of clinical findings in carpal tunnel syndrome, a classic or probable hand symptom diagram or a positive Tinel's sign showed the highest sensitivity. CONCLUSIONS: A self-administered hand symptom diagram is valuable in the diagnosis of carpal tunnel syndrome among patients with upper extremity paresthesias. It is a useful diagnostic tool and may be valuable for occupational or population screening.
Carpal Tunnel Syndrome* ; Diagnosis* ; Diagnostic Tests, Routine ; Environmental Medicine ; Hand* ; Humans ; Mass Screening ; Neural Conduction ; Paresthesia ; Physical Examination ; Rehabilitation ; Sensitivity and Specificity ; Upper Extremity

The purpose of this study was to identifu the preventive and the preventive and the progressive inhibitory effects of enamel demineralization with fluoride releasing light-and self-cured orthodontic sealants(FluoroBond), in vitro, under the polarizing light microscope and the scanning electon microscope. The polarizing light microscopic group was subdivided into seven groups(Group A-Group G). The scanning electron microscopic group was also subdivided into seven groups(Group A'-Group G'). For polarzing light microscopic evaluation, longitudinal sections were made longitudinally by Maruto cutter(Maruto Co., Japan) and Maruto grinding machine(Maruto Co., Japan). Sections were examined and photographed by the polarizing light microscope(Olympus Optical Co., Japan) using crossed polars and with the enamel rod longitudinal axis oriented at 45degrees to the extinction position. For scanning electron microscopic evaluation, the specimens were coated with a highly conducting layer of gold palladium in a model Hus-4 high0vacuum evaporator* and examined in an ISI-100B scanning electron microcpe** operated at 20kV. The results of this study were as follows : 1. The mean deoths of artificial carious lesions under a polarized light microscope were Group A(5.08microgram), Group B(47.82microgram), Group C(8.42microgram), Group D(7.20microgram), Group E(85.41microgram), Group F(60.38microgram), Group G(60.13microgram). 2. There were statistically significant differences in Group B compared with Group A, C, and D(p<0.05), and also, in Group E compared with Group F and Group G(p<0.05). 3. Light-and self-cured orthodontic sealants had the preventive effects of enamel demineralization. 4. Light-and self-cured orthodontic sealants had the progressive inhibitory effects enamel demineralization. 5. The time progress of demineralizing agent no ingluecse on the samples of light-and self-cured orthodontic sealants under the scanning electron microscope. 6. There was no difference between the specimens of light-and self-cured orthodontic edalants both in the polarized light microscopic group and in the scanning electron microscopic group. *Hitachi Ltd, Tokyo, Japan **International Scientific Instruments, Santa Clara, Calif.
Axis, Cervical Vertebra ; Dental Enamel* ; Fluorides* ; Japan ; Palladium

No abstract available.
Animals ; Dogs ; Mandible