1.Application of a New Colostomy Device in Incontinent Dog Model.
Myeung Kook LIM ; Jae Hwang KIM ; Min Chul SHIM
Journal of the Korean Society of Coloproctology 1998;14(3):439-446
BACKGROUND: Recently developed electrically stimulated gracilis neosphicter or artificial sphincter is quite a promising trial in fecal incontinence However, surgical technique is not simple, the devices are expensive and only specialists can perform the procedures successfully. The aim of this study is to evaluate the efficacy of a newly developed simple silicon device in incontinent dog model. METHODS: A New Colostomy Device (NCD; US Patent No. 5,569,216) for fixing in the stoma or rectum of human body, includes an internal balloon, a ring figured extemal balloon surrounding the internal balloon, a connecting tube disposed under the both infernal and external balloons and supply tube containing a pair of air passages and an enema fluid passage. It is designed to be inserted into the rectum and is held in place by an inflatable external balloon and drains irrigated fecal matter through a thin collapsible connecting tube which exist in the anal canal. Six mongrel dog with 22~26 kg of body weight were prepared. Anal incontinence was made by bilateral severing of the internal and external sphincters and puborectalis muscle under the general anesthesia. Marlex mesh ring was applied to the anal canal as Thiersch wire for the prevention of NCD expulsion in straining. After then, NCD with 2.5 cm of luminal diameter was inserted to the rectum proximal to the Malex mesh ring. Daily irrigation and evacuation was done with 800~1000 cc of tepid water in each dogs. Daily food contained 30 gm of Psyllium dextrose. RESULTS: Initially 6 dogs were observed for 7 days. Daily irrigation made evacuation of fecal matter well in each dogs. There was no prolapse of device through the anal orifice. Anoscopic examination after 7 days showed no rectal and anal mucosal injury. Two dogs were kept for 40 days as same manner. Sometimes spontaneous bowel movement without water irrigation was noted when the stool were loose. Weelky anoscopic examination revealed no evidence of mucosal injuries for 40 days also. There was no septic or other complication. CONCLUSION: NCD evacuated fecal matter well enough to empty the rectum in all incontinence dog model. Adequate sized NCD could be used for clinical trials in selected incontinence patients.
Anal Canal
;
Anesthesia, General
;
Animals
;
Body Weight
;
Colostomy*
;
Dogs*
;
Enema
;
Fecal Incontinence
;
Glucose
;
Human Body
;
Humans
;
Phenobarbital
;
Polypropylenes
;
Prolapse
;
Psyllium
;
Rectum
;
Silicones
;
Specialization
;
Water
2.Usefulness of Ultrasound Guided Core Needle Biopsy of Breast Lesions with Automated Gun.
Journal of Korean Breast Cancer Society 1998;1(2):186-191
It is necessary to confirm disease pathologically even though there are several methods of diagnosis for breast abnormality. Ultrasound guided core needle biopsy (UGCNB) of breast lesions with automated gun is widely accepted as a simple and accurate procedure for avoiding open biopsy. From January 1996 to February 1998, 121 breast lesions of 117 women detected with mammogram, ultrasound, physical examination or any combination were selected. UGCNB was performed in all 121 cases with 7.5 MHz transducer and Manan Pro-mag 2.2 automated biopsy gun (2.2 cm excursion). After local anesthesia, 5-6 cores were obtained through 2mm skin incision site. Lesions categorized as probably benign to highly suspicious were included as indications for core biopsy. 67.5% of the 117 patients were in age thirties and forties. The results of the biopsy were benign in 65 lesions and malignant in 56. 15 patients showing benign results which were contrary to clinical findings and pathologic results, underwent open biopsy. Four patients who had previously been diagnosed as being benign, were found to be malignant (false-negative 3.3%). Primary results of four cases of false negative were intraductal papilloma, severe inflammatory change, atypical ductal hyperplasia, and insufficient sampling, respectively. In case of insufficient sampling resulted from small gauge needle (18G), correct diagnosis was possible in all lesions with large needle (14G). Also excisional biopsy was required in women having intraductal papilloma, severe inflammation and atypical ductal hyperplasia which were difficult to differenciate from malignancy. The UGCNB is excellent biopsy method for multiple breast lesions. The method has demonstrated a 96.7% sensitivity specificity 100%, and positive predictive value (PPV) of 46.3%. We also conclude that UGCNB is proved To be an useful alternative to surgical biopsy on simpler procedure with no adverse cosmetic results.
Anesthesia, Local
;
Biopsy
;
Biopsy, Large-Core Needle*
;
Breast*
;
Diagnosis
;
Female
;
Humans
;
Hyperplasia
;
Inflammation
;
Needles
;
Papilloma, Intraductal
;
Physical Examination
;
Sensitivity and Specificity
;
Skin
;
Transducers
;
Ultrasonography*
3.ANALYSIS OF DONOR SITE OF THE COSTOCHONDRAL GRAFT AFTER TOTAL EAR RECONSTRUCTION.
Seong Jun BAEK ; Jae Ho LIM ; Rong Min BAEK ; Kap Sung OH ; Se Min BAEK
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1997;24(5):1214-1216
No abstract available.
Ear*
;
Humans
;
Tissue Donors*
;
Transplants*
4.Osseous genioplasty: review of 189 patients.
Tae Il LEE ; Jae Ho LIM ; Rong Min BAEK ; Kap Sung OH ; Se Min BAEK
Journal of the Korean Society of Aesthetic Plastic Surgery 1997;3(1):11-22
The chin plays a decisive role in the contour of the lower face. And harmonious jaw will correspond to good facial profile and positive image. Osseous genioplasty is a widely used method to correct the 3-dimensional(sagittal, vertical, tranverse) deformity of the chin with minimal complications. During an 8 year period from 1988, the authors at the In-Je University Seoul Paik Hospital experienced 198 patients of osseous genioplasty. Results of clinical analysis are as follows : 1) Male to female ratio was 1 : 3 with female being predoniment. The average age was 24.9 years. 2) Horizontal advancement genioplasty in 169 cases was the most common procedure with 7.0mm of average advancement. There was 4 cases of horizontal retrusion with average retrusion of 4.3mm. 52 cases had vertical augmentation with average of 7.5mm increase. 9 cases had vertical reduction with average redution of 4.9mm. 3) Although malocclusion is not necessarilly contraindication to genioplasty alone, genioplasty following surgical with or without orthodontical correction of malocclusion is the way to get better result with patient satisfaction. 4) 77% of the patients had adjunctive procedures simultaneously to acheive a better contour and profile 5) Complications such as hematoma, infection, fracture, nerve damage were minimal.
Chin
;
Congenital Abnormalities
;
Female
;
Genioplasty*
;
Hematoma
;
Humans
;
Jaw
;
Male
;
Malocclusion
;
Patient Satisfaction
;
Seoul
5.ERCP Findings in Clonorchiasis.
Jong Il LEE ; Jee Hong YOO ; Gyu Seong LIM ; Chang Hong LEE ; Young Il MIN ; Jae Hoon LIM
Korean Journal of Gastrointestinal Endoscopy 1981;1(1):29-32
We analyzed ERCP findings of 15 patients with clonorchiasis, that were confirmed by stool examination and operation from May, 1976 to September, 1980. The results were as follows. 1) Filling defects due to adult worm of clonorchis sinensis were significant direct findings of clonorchiasis. 2) Irregular stenosis, fuzziness, raggedness, peripheral dilation and disturbance of peripheral filling of intrahepatic bile ducts were significant indirect findings of clonorchiasis. 3) ERCP was excellent method to evaluate biliary tree in patients with clonorchiasis, who showed obstructive jaundice.
Adult
;
Bile Ducts, Intrahepatic
;
Biliary Tract
;
Cholangiopancreatography, Endoscopic Retrograde*
;
Clonorchiasis*
;
Clonorchis sinensis
;
Constriction, Pathologic
;
Humans
;
Jaundice, Obstructive
6.Gram-negative Septicemia after Infliximab Treatment in an Infant with Refractory Kawasaki Disease.
Jin Hwan LEE ; Jung Min YOON ; Jae Woo LIM ; Kyong Og KO ; Eun Jung CHEON
Korean Journal of Pediatric Infectious Diseases 2014;21(3):225-230
Kawasaki disease (KD) is an immune-mediated disease which is a leading cause of acquired cardiovascular disease in developed country. Recently, tumor necrosis factor-alpha (TNF-alpha) blocker, infliximab has been considered a promising option for patients with refractory KD. Although chronic use of a TNF-alpha blocker could increase risk of opportunistic infections, a few studies have documented that use of infliximab was safe without serious adverse effects in patients with KD. We observed serious bacterial infection after infliximab treatment in an infant with refractory KD. Our patient was a 5-month-old male infant diagnosed with KD who did not respond to repeated doses of intravenous immunoglobulin. We effectively treated him with a single infusion of infliximab (5 mg/kg), but gram-negative (Acinetobacter lwoffii) septicemia developed after infliximab infusion. Therefore, we report a case of serious septicemia after treatment with infliximab, and suggest considering the risk of severe infection when deciding whether to prescribe infliximab to an infant with refractory KD.
Bacterial Infections
;
Cardiovascular Diseases
;
Developed Countries
;
Humans
;
Immunoglobulins
;
Infant*
;
Male
;
Mucocutaneous Lymph Node Syndrome*
;
Opportunistic Infections
;
Sepsis*
;
Tumor Necrosis Factor-alpha
;
Infliximab
7.A case of relapsed minimal-change nephrotic syndrome with multiple brain infarction.
Jun YOON ; Chi Youl KIM ; Min Joon CHOI ; Hyeong Eun LIM ; Moon Jae KIM
Korean Journal of Nephrology 1991;10(2):228-233
No abstract available.
Brain Infarction*
;
Brain*
;
Nephrotic Syndrome*
8.Three cases of purpura fulminans.
Sun Hee SUH ; Hwang Min KIM ; Jae Seung YANG ; Baek Keun LIM
Journal of the Korean Pediatric Society 1993;36(5):725-732
Purpura fulminans is one of rare consumptive coagulopathy in children. The most common predisposing conditions of purpura fulminans are infectious disease like streptococcal infection and chickenpox. This disease is characterized by ecchymotic lesions that are usually distributed symmetrically on the lower extremities and buttocks. These ecchymotic lesions undergo necrosis, unless there is effective treatment. We experienced 3 cases of purpura fulminans which improved almost completely after early heparin administration. In the case 1, a 12 month old girl, purpura fulminans developed during sepsis and gastroenteritis. In the case 2, a 4 month old boy, purpura fulminans developed during acute sepsis. We reported 3 cases with a brief review of related literature.
Buttocks
;
Chickenpox
;
Child
;
Communicable Diseases
;
Dacarbazine
;
Female
;
Gastroenteritis
;
Heparin
;
Humans
;
Infant
;
Lower Extremity
;
Male
;
Necrosis
;
Purpura Fulminans*
;
Purpura*
;
Sepsis
;
Streptococcal Infections
9.Three Cases of Transverse Myelopathy.
Hae Joung JOUNG ; Hwang Min KIM ; Jae Seung YANG ; Baek Keun LIM ; Jong Soo KIM
Journal of the Korean Pediatric Society 1990;33(10):1418-1422
No abstract available.
Spinal Cord Diseases*
10.Bone mineral density deficits in childhood cancer survivors: Pathophysiology, prevalence, screening, and management.
Korean Journal of Pediatrics 2013;56(2):60-67
As chemotherapy and other sophisticated treatment strategies evolve and the number of survivors of long-term childhood cancer grows, the long-term complications of treatment and the cancer itself are becoming ever more important. One of the most important but often neglected complications is osteoporosis and increased risk of fracture during and after cancer treatment. Acquisition of optimal peak bone mass and strength during childhood and adolescence is critical to preventing osteoporosis later in life. However, most childhood cancer patients have multiple risk factors for bone mineral loss. Cancer itself, malnutrition, decreased physical activity during treatment, chemotherapeutic agents such as steroids, and radiotherapy cause bone mineral deficit. Furthermore, complications such as growth hormone deficiency and musculoskeletal deformity have negative effects on bone metabolism. Low bone mineral density is associated with fractures, skeletal deformity, pain, and substantial financial burden not only for childhood cancer survivors but also for public health care systems. Thus, it is important to monitor bone health in these patients and minimize their risk of developing osteoporosis and fragility fractures later in life.
Adolescent
;
Bone Density
;
Congenital Abnormalities
;
Growth Hormone
;
Humans
;
Malnutrition
;
Mass Screening
;
Motor Activity
;
Organothiophosphorus Compounds
;
Osteoporosis
;
Prevalence
;
Public Health
;
Risk Factors
;
Steroids
;
Survivors