1.Beckwith-Wiedemann sydrome with left adrenal cortical neoplasm .
Jae Hee JUNG ; Jae Kyoung KO ; Young Tack SONG
Journal of the Korean Association of Pediatric Surgeons 2000;6(2):160-165
Beckwith-Wiedemann sydrome is a multisystemic pattern of congenital anomalies with overgrowth. This syndrome is first described independently by Beckwith in 1963 and by Wiedemann in 1964. There is wide spectrum of clinical manifestations, including prenatal or postnatal overgrowth, neonatal hypoglycemia, macroglossia, visceromegaly, omphalocele, hemihypertrophy and a predisposition for embryonal tumors, most frequently Wilms' tumor. We experienced a case of Beckwith-Wiedemann syndrome who developed left adrenal cortical neoplasm of indeterminate malignant potential.
Beckwith-Wiedemann Syndrome
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Hernia, Umbilical
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Hypoglycemia
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Macroglossia
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Wilms Tumor
2.Effect of Gl Cyclins Expression on Clinical Prognostic Parameters in Cervical Carcinoma.
Young Tae KIM ; Byung Hoon CHOE ; Jae Wook KIM ; Jae Hoong KO ; Eun Kyoung CHOI
Korean Journal of Gynecologic Oncology and Colposcopy 1999;10(3):233-241
Alterations in the expression of genes that control the cell cycle may be of critical importance in tumorigenesis and malignant transformation. The major regulatory events leading to cell proliferation occur in Gl phase of cell cycle, and the deregulated expression of Gl cyclins is related to oncogenesis. Cyclins Dl and E play important roles in the progression of cell through Gl phase of the cell cycle. Amplification and/or overexpression of the cyclin Dl gene and aberrant expression of cyclin E has been described in various forms of human cancer. However, the role of cyclins Dl and E in cervical cancer has been poorly defined. In this study, we examined the expression of cyclins Dl and E by Northern blot technique and the status of human papil- lomavirus(HPV) type 16 and 18 by polymerase chain reaction in 25 cases of cervical carcinoma to explore the relationship between cyclins Dl and E and cervical cancer. We found cyclin Dl expression showed down-regulated expression in cervical cancer but cyclin E expression was increased in cancer group. Other clinicopathological prognostic factors were not correlated with cyclins D1 and E expression. Further study based on larger numbers of cases with correlation of cyclins D1 and E status and survival data will be needed to elucidate the use of cyclin expressions as prognostic factor.
Blotting, Northern
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Carcinogenesis
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Cell Cycle
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Cell Proliferation
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Cyclin E
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Cyclins*
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Humans
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Polymerase Chain Reaction
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Uterine Cervical Neoplasms
3.Clinical and Angiographic Outcomes: Subcutaneous Nadroparin versus Ticlopidine after Coronary Stenting.
Kyoung Deok SHIN ; Jei Keon CHAE ; Sung Ki MOON ; Won Ho KIM ; Jae Ki KO
Korean Circulation Journal 1999;29(3):259-265
BACKGROUNG AND OBJECTIVES: It was reported that low molecular weight heparin (LMWH) was more effective than unfractionated heparin in patients with acute coronary syndrome. Recent studies have shown that the pathophysiology of restenosis in stented lesions was different from those of nonstented lesions. Treatment strategies designed to limit cellular proliferation that were ineffective in nonstented lesions may be efficacious in reducing in-stent restenosis. This study was aimed to compare the clinical and angiographic results of LMWH (nadroparin) after coronary stenting with those of conventional ticlopidine regimen. MATERIALS AND METHODS: Patients were eligible for inclusion if they had angina and/or objective evidence of myocardial ischemia, and a significant (>50%) stenosis that was documented on a recent coronary angiogram. After stenting, prospective randomized comparison study was performed. Patients were randomly assigned to either nadroparin (200 IU/kg, sc, bid) or ticlopidine (250 mg bid) plus aspirin (200 mg qd) treatment groups. Repeat coronary angiography (KERN=*)was performed at 236+/-90days after stenting, and quantitative coronary angiographic analysis (QCA) was done. RESULTS: Intracoronary stent implantation was performed in eighty five lesions in eighty one patients (ticlopidine:40, nadroparin:41). There was no significant difference in any baseline clinical/angiographic variables between the two treatment groups. There were no subacute stent thrombosis, infarction and death in both groups. Six-month event-free survival was 36 (90%) in the ticlopidine group and 35 (85.4%) in the nadroparin group. Follow-up quantitative angiographic data such as late loss (1.35+/-0.70 vs 1.32+/-0.69), loss index (0.53+/-0.70 vs 0.56+/-0.23) and restenosis rate (36% vs 25.8%) were not different between ticlopidine and nadroparin groups. CONCLUSION: Effects of nadroparin were not different from those with ticlopidine therapy in the prevention of restenosis and subacute stent thorombosis after coronary stenting. Clinical outcomes between two strategies were similar. Low molecular weight heparin may be an alternative to ticlopidine in patients that ticlopidine cannot be administered because of severe adverse effects.
Acute Coronary Syndrome
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Aspirin
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Cell Proliferation
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Constriction, Pathologic
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Coronary Angiography
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Disease-Free Survival
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Follow-Up Studies
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Heparin
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Heparin, Low-Molecular-Weight
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Humans
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Infarction
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Myocardial Ischemia
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Nadroparin*
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Prospective Studies
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Stents*
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Thrombosis
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Ticlopidine*
4.Activation of the Cardiac ATP-Sensitive K+Channel by KR-30816,Newly Synthesized Potassium Channel Opener.
Kyoung Suk RHEE ; Jae Ki KO ; Yong Geun KWAK ; Soo Wan CHAE
Korean Circulation Journal 1994;24(6):889-898
BACKGROUND: The effects of a newly synthesized potassium channel opener, KR-30816((-)(nitro-2-hydroxymethyl-2-methy-2H-1-benzopyran-4-y1)pyridine oxide) on the action potential of papillary muscles of guinea pigs and the ATP-sensitive potassium channel current(IKATP) of single ventricular muscle cells of rats were examined to make clear its action mechanism of the KATPchannel. METHODS: We used the conventional microelectrode and the excised inside-out patch configuration. RESULTS: KR-30816 caused a shortening of the action potential duration in dose-dependent manner, which was inhibited by glibenclamide(3microM). Before run-down of the K+channel, KR-30816 activated the cardiac ATP-sensitive K+ channel only in the presence of ATP and shifted the dose-response relation curve between [ATP]i and the channel activity to the right in parallel. After run-down of the KATP channel, KR-30816 did not after the channel opening either in the absence or in the presence of UDP. CONCLUSION: These results suggest that KR-30816 antagonizes the inhibitory effect of ATP on the KATPchannel in a competitive manner, thereby enhancing the channel openings.
Action Potentials
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Adenosine Triphosphate
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Animals
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Guinea Pigs
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Heart
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Microelectrodes
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Muscle Cells
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Papillary Muscles
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Potassium Channels*
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Potassium*
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Rats
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Uridine Diphosphate
5.The distribution of inositol 1,4,5-trisphosphate 3-kinase in rat cerebellum.
Hae Kyoung LEE ; Jae Pil KO ; Seung Jun HWANG ; Young Suk SUH
Korean Journal of Anatomy 1993;26(1):94-102
No abstract available.
Animals
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Cerebellum*
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Inositol 1,4,5-Trisphosphate*
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Inositol*
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Rats*
6.Coracoclavicular Ligament Suture Augmentation with Anatomical Locking Plate Fixation for Distal Clavicle Fracture.
Tae Kang LIM ; Min Soo SHON ; Hyung Gon RYU ; Jae Sung SEO ; Jae Hyun PARK ; Young KO ; Kyoung Hwan KOH
Clinics in Shoulder and Elbow 2014;17(4):175-180
BACKGROUND: For Neer type IIB fracture of distal clavicle with coracoclavicular ligament injury, various surgical treatments have been used in literatures. However, there was no consensus on the optimal treatment. The aim of this study is to report the clinical and radiological results of open reduction and internal fixation of unstable distal clavicle fracture and suture augmentation of disrupted coracoclavicular ligament. METHODS: A prospective study was performed in 23 patients with Neer type IIB distal clavicle fracture in Seoul Medical Center, Eulji Hospital, and National Medical Center. Firstly, suture anchors are inserted in the base of coracoid process and preliminary reduction was achieved by tie-off of three suture limbs around the clavicle. Then, the final fixation was completed with anatomical locking plate. Bony union and the distance between coracoclavicular ligaments were evaluated. Clinical results and complications including stiffness and secondary procedures were evaluated. RESULTS: Bony union was achieved in all cases except one (22 of 23). At mean 14.9 months, no significant difference in the mean coracoclavicular distance was observed compared to uninjured shoulder (8.2 +/- 7.9 mm versus 7.3 +/- 3.4 mm, p=0.14). Pain visual analogue scale, American Shoulder and Elbow Surgeons score, Constant score, and Disabilities of the Arm, Shoulder and Hand score were 0.5, 83.4, 78.5, and 6.2, respectively. Revision surgery was performed in one case of nonunion. Four patients who complained of skin irritation underwent implant removal. CONCLUSIONS: In cases of an unstable distal clavicle fracture with coracoclavicular ligament disruption, satisfactory clinical results were obtained by locking plate fixation and coracoclavicular ligament suture augmentation concurrently.
Arm
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Clavicle*
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Consensus
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Elbow
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Extremities
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Hand
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Humans
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Ligaments*
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Prospective Studies
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Seoul
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Shoulder
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Shoulder Fractures
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Skin
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Suture Anchors
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Sutures*
7.The Priming Effect of the Old Age People with Mild Cognitive Impairment.
Jae Woo PARK ; Do Kwan KIM ; Sun Kyu KO ; Hyo Jung KO ; Sung Hwan KIM ; Jae Kyoung KIM ; Min Young SEO ; In Soo LEE ; Ji Hae KIM
Journal of Korean Neuropsychiatric Association 2002;41(3):498-507
OBJECTIVES: In this study, the cognitive characteristics, especially priming effect, of above 50 years old age group who had less than 25 points in K-MMSE were investigated. METHODS: In this study, an implicit memory test measuring priming effect was made and adminis-tered to old age people who had less than 25 points in K-MMSE in screening session. To control the effect of age, educational level and intelligence, demographic variables were measured, and the subtests of KWIS, vocabulary and block design were administered. Descriptive statistical analysis of the two priming measures and correlational analysis between variables were done. To test the effect of cognitive functioning on priming effect multiple regression analysis was done. RESULTS: Correlational analysis revealed priming score obtained from correct identification response was positively correlated with K-MMSE and ADAS-Cog. And priming score obtained from mean reaction time was positively correlated with age and negatively correlated with vocabulary substest of KWIS. The regression analysis results indicated general cognitive functioning measured by ADAS-Cog has significant effect on priming score obtained from correct identification response, whereas age has significant effect on priming score obtained from mean reaction time. CONCLUSIONS: The results revealed that as cognitive deterioration progresses priming effect which identify primed stimulus correctly diminish, and as one grow older within age 50 to 70, priming effect which identifies primed stimulus quickly increase.
Humans
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Intelligence
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Mass Screening
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Memory
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Middle Aged
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Mild Cognitive Impairment*
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Reaction Time
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Vocabulary
8.The Case of Pseudocyst Formation after Spontaneous Neonatal Gastric Perforation.
Jung Min YOON ; Jae Woo LIM ; Eun Jung CHEON ; Kyoung Og KO ; Woo Kyun MOK
Journal of the Korean Society of Neonatology 2006;13(2):273-277
Spontaneous gastric perforation of the newborn is a rare, serious and life-threatening problem. This is surgical emergency because of high mortality. Most historical reports have described gastric perforation in the neonate as spontaneous cause. But, recent reviews report the contributing factor including prematurity and mechanical ventilation. Usually clinician identifies the pneumoperitoneum in simple abdomen X-ray. The final diagnostic method is surgical finding and the treatment of gastric perforation is immediate surgical correction. Early diagnosis, hemodynamic monitoring and fluid therapy for hypovolemia improve outcome. Pseudocyst formation after gastric perforation is very rare in newborn. We report a rare case of pseudocyst formation after spontaneous gastric perforation in full term newborn.
Abdomen
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Early Diagnosis
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Emergencies
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Fluid Therapy
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Hemodynamics
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Humans
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Hypovolemia
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Infant, Newborn
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Mortality
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Pneumoperitoneum
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Respiration, Artificial
9.Change of early atherosclerotic markers in obese children.
Eui Jung ROH ; Jung Min YOON ; Jae Woo LIM ; Eun Jung CHEON ; Kyoung Og KO
Korean Journal of Pediatrics 2006;49(4):368-374
PURPOSE: The prevalence of obesity in children is increasing rapidly. Epidemiologic studies suggest that obesity induced atherosclerosis may start in childhood. We investigated whether obese children show early abnormalities of the arterial wall and endothelial dysfunction. METHODS: Thirty-eight obese children(14-16 years old of age, male, body mass index 29.40+/-3.18 kg/m2) and forty-five age and sex-matched healthy control children(body mass index 18.43+/-1.01 kg/ m2) were enrolled. Their carotid artery intima-media thickness(IMT) and brachial artery flow-mediated dilation(FMD) response were measured by high-quality ultrasound system, and compliance, distensibility, stiffness index, incremental elastic modulus and wall stress were calculated by equation. In addition, we looked at the relations between these arterial features and metabolic cardiovascular risk factors. RESULTS: The obese children had significantly increased IMT(0.52+/-0.09 mm vs 0.40+/-0.07 mm, P< 0.001) and markedly impaired FMD(7.35+/-7.78 percent vs 20.34+/-16.81 percent, P<0.001) than the healthy controls. But the compliance and distensibility were lower, and the stiffness index, incremental elastic modules and wall stress were higher in the obese group than the control group, but not statistically significantly. Body mass index was highly associated with increased IMT(r=0.612, P< 0.001) and reduced FMD(r=-0.414, P<0.001). CONCLUSION: We showed the deleterious effect of child obesity on both early functional and structural atherosclerotic markers. The ultrasonic findings will be used for screening and follow up markers to identify high-risk patients among obese children.
Atherosclerosis
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Body Mass Index
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Brachial Artery
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Carotid Arteries
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Child*
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Compliance
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Elastic Modulus
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Epidemiologic Studies
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Humans
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Male
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Mass Screening
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Obesity
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Pediatric Obesity
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Prevalence
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Risk Factors
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Ultrasonics
;
Ultrasonography
10.Association of apolipoprotein E polymorphisms with serum lipid profiles in obese adolescent.
Jung Min YOON ; Jae Woo LIM ; Eun Jung CHEON ; Kyoung Og KO
Korean Journal of Pediatrics 2008;51(1):42-46
PURPOSE: Apolipoprotein E (Apo E) plays a major role in lipoprotein metabolism and lipid transport. Many investigators have described that Apo E polymorphisms is one of the most important genetic determinants for cardiovascular disease. The purpose of this study was to evaluate the association between Apo E polymorphisms and serum lipid profiles in obese adolescent. METHODS: We measured the serum concentrations of glucose, apolipoprotein (Apo) A1, Apo B, total cholesterol (TC), triglyceride (TG), HDL and LDL-cholesterol after overnight fasting in obese adolescent. Apo E polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: 86 obese adolescents participated in this study. The body mass index (BMI) of participants were excess of 95 percentile by age and sex. Male to female ratio was 1.7 and mean age of study group was 16.2+/-1.8 years. Mean BMI was 27.4+/-2.5 kg/m2. The frequency of epsilon2, epsilon3 and epsilon4 allele were 8.1%, 87.2% and 4.7% respectively. Study populations were classified into the following three genotypes 1) Apo E2 group (n=13, 15.1%) carrying either the epsilon2/epsilon2 or epsilon2/epsilon3 2) Apo E3 group (n=65, 75.6%) carrying the most frequent epsilon3/epsilon3 3) Apo E4 group (n=8, 9.3%) carrying either the epsilon3/epsilon4 or epsilon4/epsilon4. No differences were found among Apo E genotypes concerning age, sex, weight, height and BMI. Apo B and LDL-cholesterol concentrations were significantly higher in the Apo E4 group (P<0.05). No association were found between Apo E genotypes and glucose, Apo A1, TC, TG and HDL. CONCLUSIONS: We confirmed that serum concentrations Apo B and LDL-cholesterol were influenced by Apo E genotypes. Apo E polymorphisms seems to influence some alteration of lipid metabolism associated with obesity in adolescent.
Adolescent
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Alleles
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Apolipoprotein A-I
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Apolipoprotein E2
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Apolipoprotein E3
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Apolipoprotein E4
;
Apolipoproteins
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Apolipoproteins B
;
Apolipoproteins E
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Body Mass Index
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Cardiovascular Diseases
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Cholesterol
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Fasting
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Female
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Genotype
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Glucose
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Humans
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Lifting
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Lipid Metabolism
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Lipoproteins
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Male
;
Obesity
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Research Personnel