1.An IgE-Mediated Allergic Reaction Caused by Mulberry Fruit.
Jong Hyun CHOI ; Jae Kyoem SIM ; Jee Youn OH ; Gyu Young HUR ; Kyung Hoon MIN ; Sung Yong LEE ; Jae Jeong SHIM ; Kyung Ho KANG
Allergy, Asthma & Immunology Research 2015;7(2):195-198
Mulberry (Morus spp.) is a widespread deciduous tree and its fruit is commonly eaten in Korea and eastern Asia. Some reports demonstrate that mulberry fruit is a food allergen in the Mediterranean area. However, there has been no report of systemic allergic reactions after ingesting mulberry fruit in Korea. An 18-year-old boy with a mulberry fruit allergy visited our allergy clinic. He had experienced generalized urticaria, chest tightness, breathing difficulty, and abdominal cramping after ingesting mulberry fruit. The patient had a positive skin reaction to mulberry fruit extract (mean wheal size, 5 mm). We performed an ELISA to detect specific IgE antibody (Ab) to mulberry fruit extract in the patient's serum compared to those of non-atopic healthy controls and birch-sensitized individuals. Specific IgE Ab to mulberry fruit extract was detected in the patient's serum, as compared to non-atopic healthy controls. Another subject, who was strongly sensitized to birch pollen, also had a positive serum-specific IgE Ab to mulberry fruit. We performed IgE immunoblot analysis using the patient's and the other subject's sera, who had serum-specific IgE to mulberry fruit, to identify the IgE-binding component. An identical IgE-binding component to mulberry extract was detected in the two subjects at around 17 kDa, and which might be PR 10 of Bet v 1. In conclusion, mulberry fruit could induce a systemic allergic reaction through an IgE-mediated mechanism, and cross-reactivity might occur between mulberry fruit and birch pollen.
Adolescent
;
Betula
;
Colic
;
Enzyme-Linked Immunosorbent Assay
;
Far East
;
Food Hypersensitivity
;
Fruit*
;
Humans
;
Hypersensitivity*
;
Immunoglobulin E
;
Korea
;
Male
;
Morus*
;
Pollen
;
Respiration
;
Skin
;
Thorax
;
Trees
;
Urticaria