No abstract available.
Fetal Development* ; Pregnancy*

No abstract available.
Angiotensin II* ; Angiotensins* ; Animals ; Hemorrhage* ; Rats*

PURPOSE: Irritations or painful stimuli to the bladde: may alter voiding behaviorand this may be associated with dysfunction of periurethral muscles. In our study, recording of bladder and sphincter activity in response to intravesical irritants(acetic acid, capsaicin) was done and the effects of Intrathecal administration of transmitters(enkephalin, susbtance P and its antagonist, or calcitonin gene related peptide and its antagonist) was analyzed MATERIALS AND METHODS: Adult male Sprague-Dawley rats(400-500gm) were anesthetized with intraperitoneal urethane mixed with entobar. The left femoral artery and vein were cannulated for blood pressure monitoring and drug administration. A catheter(PE 50) was inserted into the bladder dome through a midline abdominal incision and bipolar electromyographic(EMG) needle electrodes were placed into the urethral sphincter. Peak contractile pressure and EMG activities were measured on a polygraph. Saline, acetic acid, or capsaicin was infused into the bladder at 50mu1/min and saline, enkephalin (ENK), substance P(SP) and its antagonist, or calcitonin gene related peptide (CGRP) and its antagonist was administered intrathecally. RESULTS: Each micturition cycle started with an increase in bladder pressure which triggered the contraction of the external urethral sphincter. Fast Fourier transform(FFT) analysis of the external sphincter EMG revealed a peak activity at 500Hz. The inteNal and duration of EIOG bursts were 38+/-2 msec and 92+/-10 msec respectively. The interval of bladder contraction was 809+/-23 sec. Intravesical acetic acid and capsaicin activated micturition reflex earlier than in control group and intrathecal ENK, SP antagonist, and CGRP antagonist attenuated the parameters in activated micturition reflex. CONCLUSIONS: Urethral sphincte EMG showed constant burst duration and interval in spite of the infusion of acetic acid or capsaicin. Intravesical acetic acid or capsaicin increased the peak amplitude of intravesical pressure, lowered voided volume, and shortened EMG spike duration and voiding interval significantly. Intrathecal injection of ENK, SP, SP antagonist, CGRP, and CGRP antagonist changed the parameters, especially the voiding interval, voiding duration and peak pressure of the bladder.
Acetic Acid ; Adult ; Blood Pressure Monitors ; Calcitonin Gene-Related Peptide ; Capsaicin ; Electrodes ; Enkephalins ; Femoral Artery ; Humans ; Injections, Spinal ; Male ; Muscles ; Needles ; Rats, Sprague-Dawley ; Reflex* ; Urethane ; Urethra ; Urinary Bladder ; Urination* ; Veins

Primary ovarian carcinoid tumors are rare well-differentiated neuroendocrine tumors classified as monodermal teratomas. They usually occur in perimenopausal woman and are accompanied with mature cystic teratoma or mucinous tumors. The diagnosis may be supported by the clinical presentation of carcinoid syndromes such as flushing, diarrhea, or chronic constipation. Here, we report on the case of a 51-year-old female with surgically confirmed primary ovarian carcinoid, describe the MRI features of the tumor, and correlate them with the pathological findings.

Primary ovarian carcinoid tumors are rare well-differentiated neuroendocrine tumors classified as monodermal teratomas. They usually occur in perimenopausal woman and are accompanied with mature cystic teratoma or mucinous tumors. The diagnosis may be supported by the clinical presentation of carcinoid syndromes such as flushing, diarrhea, or chronic constipation. Here, we report on the case of a 51-year-old female with surgically confirmed primary ovarian carcinoid, describe the MRI features of the tumor, and correlate them with the pathological findings.

Primary ovarian carcinoid tumors are rare well-differentiated neuroendocrine tumors classified as monodermal teratomas. They usually occur in perimenopausal woman and are accompanied with mature cystic teratoma or mucinous tumors. The diagnosis may be supported by the clinical presentation of carcinoid syndromes such as flushing, diarrhea, or chronic constipation. Here, we report on the case of a 51-year-old female with surgically confirmed primary ovarian carcinoid, describe the MRI features of the tumor, and correlate them with the pathological findings.

Background: The advance in microsurgical technique has facilitated a proper approach for reconstruction of extensive head and neck defects. For the success of free tissue reconstruction, selection of the recipient vessel is one of the most important factors. However, the vascular anatomy of this region is very complex, and a clear guideline about this subject is still lacking. In this study, we present our 30 years of experiences of free tissue reconstruction for head and neck defects. Methods: In this retrospective study, we analyzed a total of 138 flaps in 127 patients who underwent head and neck reconstruction using free tissue transfer following tumor resection between October 1986 to August 2019. Patients who underwent facial palsy reconstruction were excluded. Medical records including patient’s demographics, detailed operation notes, follow-up records, and photographs were collected and analyzed. Results: Among a total of 127 patients, 10 patients underwent a secondary operation due to cancer recurrence. The most commonly used type of flap was radial forearm flap (n= 107), followed by the anterolateral thigh flap (n= 18) and fibula flap (n= 10). With regard to recipient vessels, superior thyroid artery was most commonly used in arterial anastomosis (58.7%), and internal jugular vein (51.3%) was the first choice for venous anastomosis. The flap survival rate was 100%. Four cases of venous thrombosis were resolved with thrombectomy and re-anastomosis. Conclusion Superior thyroid artery and internal jugular vein were reliable choices as recipient vessels. Proper recipient vessel selection could improve the result of head and neck reconstruction.

Menetrier's disease is a rare, characterized by the presence of large rugal folds involving part or all of the stomach. Patients with hypertrophic gastropathy often have distressing abdominal symptoms, weight loss, and edema due to gastric protem loss. A 64 year old male patient was admitted with the chief complaint of epigastric discomfort. Endoscopic, radiologic and histologic examination, revealed characteristic findings of Menetrier's disease. A case of Menetrier's disease is reported with a brief review of literature.
Edema ; Gastritis, Hypertrophic* ; Humans ; Male ; Middle Aged ; Stomach ; Weight Loss

Drug-induced acute interstitial nephritis is characterized by renal interstitial inflammatory cell infiltration and commonly presents as acute renal failure. This is caused mainly by methicillin, non-steroidal antiinflammatory drugs, sulfonamide diuretics such as thiazide, but cases induced by furosemide are rare. We report a patient with acute interstitial nephritis causing reversible acute renal failure and dermatitis while she was taking furosemide. A 37-year old woman was referred to our hospital because of generalized skin rash and non-oliguric acute renal failure. She had peripheral eosinophilia (1,577/mm3) and serum creatinine level of 6.8mg/dL. Skin biopsy showed leukoclastic vasculitis and percutaneous renal biopsy showed severe interstitial infiltration of lymph ocyte and mild interstitial fibrosis with focal tubular atrophy. After withdrawal of furosemide, renal function and skin lesions were completely recovered.
Acute Kidney Injury ; Adult ; Atrophy ; Biopsy ; Creatinine ; Dermatitis ; Diuretics ; Eosinophilia ; Exanthema ; Female ; Fibrosis ; Furosemide* ; Humans ; Methicillin ; Nephritis, Interstitial* ; Skin ; Vasculitis

Central hyperthermia is a very rare disease; however, once it happens, it is associated with a poor prognosis and high mortality for patients with severe brainstem strokes. Following a pontine hemorrhage, a 46-years-old female developed prolonged hyperthermia. Work-ups to the fever gave no significant clues for the origin of fever, and hyperthermia did not respond to any empirical antibiotics or antipyretic agents. The patient's body temperature still fluctuated in a range of 37.5degrees C to 39.2degrees C. Considering the lesion of hemorrhage, we suspected central hyperthermia rather than infectious diseases. We started with baclofen administration at a dose of 30 mg/day. The body temperature changed to a range of 36.6degrees C to 38.2degrees C. We raised the dose of baclofen to 60 mg/day. The patient's body temperature finally dropped to a normal range. Central hyperthermia, caused by failures of thermoregulatory pathways in brainstem, following the pontine hemorrhage rarely occurs. Baclofen can be used to treat suspected central hyperthermia in a patient with pontine hemorrhage.
Anti-Bacterial Agents ; Antipyretics ; Baclofen* ; Body Temperature ; Brain Stem ; Communicable Diseases ; Female ; Fever* ; Hemorrhage* ; Humans ; Mortality ; Pons ; Prognosis ; Rare Diseases ; Reference Values ; Stroke