1.Beckwith-Wiedemann sydrome with left adrenal cortical neoplasm .
Jae Hee JUNG ; Jae Kyoung KO ; Young Tack SONG
Journal of the Korean Association of Pediatric Surgeons 2000;6(2):160-165
Beckwith-Wiedemann sydrome is a multisystemic pattern of congenital anomalies with overgrowth. This syndrome is first described independently by Beckwith in 1963 and by Wiedemann in 1964. There is wide spectrum of clinical manifestations, including prenatal or postnatal overgrowth, neonatal hypoglycemia, macroglossia, visceromegaly, omphalocele, hemihypertrophy and a predisposition for embryonal tumors, most frequently Wilms' tumor. We experienced a case of Beckwith-Wiedemann syndrome who developed left adrenal cortical neoplasm of indeterminate malignant potential.
Beckwith-Wiedemann Syndrome
;
Hernia, Umbilical
;
Hypoglycemia
;
Macroglossia
;
Wilms Tumor
2.Atrial Flutter Conversion in Infants and Children Using Transesophageal Atrial Pacing.
Jae Kon KO ; Seoung Ho KIM ; Eun Jung BAE ; I Seok KANG ; Heung Jae LEE
Journal of the Korean Pediatric Society 1994;37(7):969-975
Atrial flutter is and infrequent, but potentially unstable tachyarrythmia that occurs in pediatric ages. Transesophageal atrial pacing was used for treatment of 10 episodes of atrial flutter in 7 patients. At the time of atrial flutter conversion, patients were 6 days to 14 years old. 6 patients had associated with congenital heart disease. The atrial cycle length of atrial flutter ranged from 140 to 280 msec with variable atrioventricular conduction. Transesophageal atrial pacing was performed using a bipolar 4 F transesophageal electrode catheter. Atrial flutter conversion was accomplished with stimulation bursts using about 5 seconds of stimuli, 10 msec in duration at 20 to 27 mA. Pacing cycle length was 45 to 110 msec less than the atrial cycle length of tachycardia in 6 episodes. But in a neonate, underdrive pacing converted atrial flutter to sinus rhythm. Conversion attempts were unsuccessful on 2 occasions. Transesophageal atrial pacing is a safe and effective, minimally invasive technique for treatment of atrial flutter in infants and children.
Adolescent
;
Atrial Flutter*
;
Catheters
;
Child*
;
Electrodes
;
Heart Defects, Congenital
;
Humans
;
Infant*
;
Infant, Newborn
;
Tachycardia
3.Gram-negative Septicemia after Infliximab Treatment in an Infant with Refractory Kawasaki Disease.
Jin Hwan LEE ; Jung Min YOON ; Jae Woo LIM ; Kyong Og KO ; Eun Jung CHEON
Korean Journal of Pediatric Infectious Diseases 2014;21(3):225-230
Kawasaki disease (KD) is an immune-mediated disease which is a leading cause of acquired cardiovascular disease in developed country. Recently, tumor necrosis factor-alpha (TNF-alpha) blocker, infliximab has been considered a promising option for patients with refractory KD. Although chronic use of a TNF-alpha blocker could increase risk of opportunistic infections, a few studies have documented that use of infliximab was safe without serious adverse effects in patients with KD. We observed serious bacterial infection after infliximab treatment in an infant with refractory KD. Our patient was a 5-month-old male infant diagnosed with KD who did not respond to repeated doses of intravenous immunoglobulin. We effectively treated him with a single infusion of infliximab (5 mg/kg), but gram-negative (Acinetobacter lwoffii) septicemia developed after infliximab infusion. Therefore, we report a case of serious septicemia after treatment with infliximab, and suggest considering the risk of severe infection when deciding whether to prescribe infliximab to an infant with refractory KD.
Bacterial Infections
;
Cardiovascular Diseases
;
Developed Countries
;
Humans
;
Immunoglobulins
;
Infant*
;
Male
;
Mucocutaneous Lymph Node Syndrome*
;
Opportunistic Infections
;
Sepsis*
;
Tumor Necrosis Factor-alpha
;
Infliximab
4.CT findings in recurrent pyogenic cholangitis.
Seung Hye JUNG ; Jae Hoon LIM ; Young Tae KO ; Dong Ho LEE
Journal of the Korean Radiological Society 1991;27(4):555-558
No abstract available.
Cholangitis*
5.Bone Health Knowledge, Self-Efficacy, and Behaviors in Middle-Aged Korean Women.
Eui Geum OH ; Jae Yong YOO ; Jung Eun LEE ; Il Sun KO ; Sang Hui CHU
Korean Journal of Health Promotion 2012;12(2):90-99
BACKGROUND: With the rapid growth of the elderly population, osteoporosis has become a major health problem worldwide. Although health knowledge and self-efficacy are important assets to facilitate healthy behaviors and disease prevention, such information as it relates to individuals and their bone health is limited. The purpose of this study was to assess the levels of knowledge, self-efficacy, and health behaviors on promoting bone health in middle-aged Korean women. METHODS: This is a cross-sectional survey study. A convenience sampling of middle-aged women (> or =40 years) was done at a community health center in Korea. Bone mineral density was measured by dual energy X-ray absorptiometry with the DEXXUM T. The level of knowledge was measured with the Knowledge of Osteoporosis Scale, and self-efficacy with the Osteoporosis Self-efficacy Scale. A questionnaire for bone health behaviors was developed for this study. Collected data were analyzed through descriptive methods, independent t-test, analysis of variance, and Pearson's correlation analysis. RESULTS: A total of 150 middle-aged women whose mean age was 59.8+/-11.5 years participated in the study. Most (74%) were menopausal. Less than one-quarter of participants (22.7%) had osteoporosis and less than half (42%) had osteopenia based on the T-score at the left femur neck site. Level of knowledge (mean score, 10.35) and self-efficacy (mean score, 47.67) ranged from low to moderate. Intake of calcium and vitamin D-rich foods was insufficient in our subjects. Bone health behaviors had significant positive relationships with knowledge (r=0.22, P=0.008) and self-efficacy (r=0.29, P<0.001) on promoting bone health. CONCLUSIONS: These results indicate that educational interventions are needed to enhance knowledge and confidence and to encourage middle-aged women to engage in bone health behaviors.
Absorptiometry, Photon
;
Aged
;
Bone Density
;
Bone Diseases, Metabolic
;
Calcium
;
Community Health Centers
;
Cross-Sectional Studies
;
Female
;
Femur Neck
;
Health Behavior
;
Humans
;
Korea
;
Middle Aged
;
Osteoporosis
;
Self Efficacy
;
Vitamins
6.Analysis of the Gene Expression by Laser Captured Microdissection (I): Minimum Conditions Required for the RNA Extraction from Oocytes and Amplification for RT-PCR.
Chang Eun PARK ; Jung Jae KO ; Kwang Yul CHA ; Kyung Ah LEE
Korean Journal of Fertility and Sterility 2001;28(3):183-190
OBJECTIVE: Recently, microdissection of tissue sections has been used increasingly for the isolation of morphologically identified homogeneous cell populations, thus overcoming the obstacle of tissue complexity for the analysis cell-specific expression of macromolecules. The aim of the present study was to establish the minimal conditions required for the RNA extraction and amplification from the cells captured by the laser captured microdissection. METHODS: Mouse ovaries were fixed and cut into serial sections (7 micrometer thickness). Oocytes were captured by laser captured microdissection (LCM) method by using PixCell IITM system. The frozen sections were fixed in 70% ethanol and stained with hematoxylin and eosin, while the paraffin sections were stained with Multiple stain. Sections were dehydrated in graded alcohols followed by xylene and air-dried for 20 min prior to LCM. All reactions were performed in ribonuclease free solutions to prevent RNA degradation. After LCM, total RNA extraction from the captured oocytes was performed using the guanidinium isothiocyanate (GITC) solution, and subsequently evaluated by reverse transcriptase -polymerase chain reaction (RT-PCR) for glyceraldehyde-3-phosphate-dehydrogenase (GAPDH). RESULTS: With the frozen sections, detection of the GAPDH mRNA expression in the number of captured 25 oocytes were not repeatable, but the expression was always detectable from 50 oocytes. With 25 oocytes, at least 27 PCR cycles were required, whereas with 50 oocytes, 21 cycles were enough to detect GAPDH expression. Amount of the primary cDNA required for RT-PCR was reduced down to at least 0.25 microl with 50 oocytes, thus the resting 19.75 microl cDNA can be used for the testing other interested gene expression. Tissue-to-slide, tissue-to-tissue forces were very high in the paraffin sections, thus the greater number of cell procurement was required than the frozen sections. CONCLUSION: We have described a method for analyzing gene expression at the RNA level with the homogeneously microdissected cells from the small amount of tissues with complexity. We found that LCM coupled with RT-PCR could detect housekeeping gene expression in 50 oocytes captured. This technique can be easily applied for the study of gene expression with the small amount of tissues.
Alcohols
;
Animals
;
DNA, Complementary
;
Eosine Yellowish-(YS)
;
Ethanol
;
Female
;
Frozen Sections
;
Gene Expression*
;
Genes, Essential
;
Guanidine
;
Hematoxylin
;
Mice
;
Microdissection*
;
Oocytes*
;
Ovary
;
Paraffin
;
Polymerase Chain Reaction
;
Ribonucleases
;
RNA Stability
;
RNA*
;
RNA, Messenger
;
RNA-Directed DNA Polymerase
;
Xylenes
7.Prevalence of dementia in the elderly in a Myun area of Yungil county, Kyungpook province.
Jonghan PARK ; Hyo Jin KO ; Jae Chang HA ; Young Nam PARK ; Chul Ho JUNG
Journal of Korean Neuropsychiatric Association 1991;30(6):1121-1129
No abstract available.
Aged*
;
Dementia*
;
Gyeongsangbuk-do*
;
Humans
;
Prevalence*
8.Prevalence of dementia in the elderly in a Myun area of Yungil county, Kyungpook province.
Jonghan PARK ; Hyo Jin KO ; Jae Chang HA ; Young Nam PARK ; Chul Ho JUNG
Journal of Korean Neuropsychiatric Association 1991;30(6):1121-1129
No abstract available.
Aged*
;
Dementia*
;
Gyeongsangbuk-do*
;
Humans
;
Prevalence*
9.Clinical Studies on Ventricular Septal Defect with Septal Aneurysm.
Jae Kon KO ; Jung Yun CHOI ; Yong Soo YUN ; Chang Yee HONG ; Kyung Mo YEON
Journal of the Korean Pediatric Society 1986;29(5):40-45
No abstract available.
Aneurysm*
;
Heart Septal Defects, Ventricular*
10.Subpulmonic Ventricular Septal Defect with Aortic Insufficiency.
Jae Kon KO ; Won Soon PARK ; Jung Yun CHOI ; Yong Soo YUN ; Chang Yee HONG
Korean Circulation Journal 1986;16(1):151-154
From January to December 1984, 191 patients with associated ventricular septal defect(VSD) were studied in the cardiac cathetherization laboratory. Among theses 191 cases, 58 cases(30.4%) of subpulmonic VSD were identified by angiocardiography. Among the 59 cases of subpulmonic VSD, 12 cases(20.6%) were complicated with aortic infficiency(AI). The relative frequency of subpulmonic VSD increased with the increase of age and the frequency of complication of AI with the subpulmonic VSD also increased with the increase of age. The amount of left to right shunt in the patients with subpulmonic VSD and AI was small and Qp/Qs ratio was less than 2.0 in all of the 12 cases. Among the 12 patients 4 cases had a pressure gradient greater than 20 mmHg across the infundibular region of the right ventricle.
Angiocardiography
;
Heart Septal Defects, Ventricular*
;
Heart Ventricles
;
Humans