1.Gram-negative Septicemia after Infliximab Treatment in an Infant with Refractory Kawasaki Disease.
Jin Hwan LEE ; Jung Min YOON ; Jae Woo LIM ; Kyong Og KO ; Eun Jung CHEON
Korean Journal of Pediatric Infectious Diseases 2014;21(3):225-230
Kawasaki disease (KD) is an immune-mediated disease which is a leading cause of acquired cardiovascular disease in developed country. Recently, tumor necrosis factor-alpha (TNF-alpha) blocker, infliximab has been considered a promising option for patients with refractory KD. Although chronic use of a TNF-alpha blocker could increase risk of opportunistic infections, a few studies have documented that use of infliximab was safe without serious adverse effects in patients with KD. We observed serious bacterial infection after infliximab treatment in an infant with refractory KD. Our patient was a 5-month-old male infant diagnosed with KD who did not respond to repeated doses of intravenous immunoglobulin. We effectively treated him with a single infusion of infliximab (5 mg/kg), but gram-negative (Acinetobacter lwoffii) septicemia developed after infliximab infusion. Therefore, we report a case of serious septicemia after treatment with infliximab, and suggest considering the risk of severe infection when deciding whether to prescribe infliximab to an infant with refractory KD.
Bacterial Infections
;
Cardiovascular Diseases
;
Developed Countries
;
Humans
;
Immunoglobulins
;
Infant*
;
Male
;
Mucocutaneous Lymph Node Syndrome*
;
Opportunistic Infections
;
Sepsis*
;
Tumor Necrosis Factor-alpha
;
Infliximab
2.The Expression of Human Beta Defensins by Thermal Injury.
Hyo Sun JEONG ; Cheon Jae YEON ; Jung Suk LEE
Journal of Korean Burn Society 2012;15(1):39-44
PURPOSE: Defensins are important components of innate immune system. These peptides have antimicrobial activity against a wise variety of pathogens that associated with burn wound infection. In particular, human beta-defensins are expressed in normal epidermal region and showed differential expression of some skin disease. We investigated that expression of human beta-defensin by in vitro and ex-vivo by thermal condition. METHODS: To investigate the expression of human beta-defensins in acute burn condition, we cultured keratinocytes and used to rat's skin at this experiment. After thermal condition, we showed the expression of beta-defensins-2 (hBD-2), -3 (hBD-3), keratins, keratinocyte differentiation and junction protein levels by RT-PCR and immunohistochemistry (IHC). RESULTS: HBD-2 & involucrin were down-regulated from 1 hr to 8 hrs in mRNA level. But others were not changed in mRNA level. In protein level, hBD-3 was decreased but pan-cytokeratin and beta-catenin were not changed. CONCLUSION: HBD-2 was down-regulated in thermal injury. Because thermal injury could induce the influence of keratinocyte differentiation and the decrease of skin protection ability. Our results suggested that human beta-defensins plays an important role in protection by several injury.
beta Catenin
;
beta-Defensins
;
Burns
;
Defensins
;
Humans
;
Immune System
;
Immunohistochemistry
;
Keratinocytes
;
Keratins
;
Peptides
;
Protein Precursors
;
RNA, Messenger
;
Skin
;
Skin Diseases
;
Wound Infection
3.The Therapeutic Effect of Porcine Placenta Extract for Improvement Sequelae of Burn.
Hong Shin KIM ; Jung Hee LEE ; Cheon Jae YEON ; Jung Suk LEE
Journal of Korean Burn Society 2012;15(2):96-101
PURPOSE: Burn injury cause pruritis, pain, psychological and functional sequelae. The one of burn injury sequelae is the hypertrophic scar. It is difficult to control devastating fibrotic condition for hypertrophic scar. The objective of this study was to investigated the therapeutic effect on burn hypertrophic scar and wound healing for sequelae of burn injury by Porcine placenta extract (PPE). METHODS: To investigate the effect of PPE, we performed in vitro cell cytotoxity test (MTT assay), antioxidant activity assay (SOD like activity), melanin content assay, cell migration asssay and RT-PCR. RESULTS: As a result of cell cytotoxity test (MTT assay), PPE showed above 80% cell viability. From Antioxidant activity assay (SOD like activity), this effect was similar to vitamin C. In the melanin content assay, melanin synthesis was inhibited 23% on PPE treatment than control. PPE enhanced cell migration on human fibroblast and decreased the expression of hypertropic scar related gene (a-SMA and P311). CONCLUSION: Our data showed anti-oxidant effect, diminution of melanin and decrease of the expression of hypertropic scar related gene on the treatment of PPE. These results may provide the insight into the potential use of porcine placenta extract as support to control skin fibrosis related to burn hypertrophic scar and alternative medicine for burn sequelae.
Antioxidants
;
Ascorbic Acid
;
Burns
;
Cell Migration Assays
;
Cell Movement
;
Cell Survival
;
Cicatrix
;
Cicatrix, Hypertrophic
;
Complementary Therapies
;
Fibroblasts
;
Fibrosis
;
Humans
;
Melanins
;
Placenta
;
Pruritus
;
Skin
;
Wound Healing
4.CT Findings of Necrotizing Pneumonia.
Hyae Young KIM ; Jung Gi IM ; Sung Il WHANG ; Jung Eun CHEON ; Jae Kyo LEE ; Jae Woo SONG
Journal of the Korean Radiological Society 1998;39(1):101-107
Necrotizing pneumonia causes necrosis of pulmonary parenchyma and may lead to pulmonary gangrene. Prior to theantibiotic era, extensive pulmonary involvement was potentially fatal, but the incidence of necrotizing pneumoniais now less common. On contrast-enhanced CT scans, consolidation with contrast enhancement containing necroticfoci with low attenuation and cavities is characteristic. Radiologic findings do not differ according to thecausative organism and in most of cases, specific diagnosis may be impossible. Clinical findings and certaincharacteristic radiologic findings may be helpful for narrowing the differential diagnosis. We illustrate theclinical and radiologic characteristics of necrotizing pneumonia according to causative bacterial organisms.
Diagnosis
;
Diagnosis, Differential
;
Gangrene
;
Incidence
;
Necrosis
;
Pneumonia*
;
Tomography, X-Ray Computed
5.Clinical Analysis of 149 Cases of Twin Pregnancies.
Yeoung Chan PARK ; Sun Hee KO ; Tae In LEE ; Jae Nam MA ; Kang Woo JUNG ; Jong Cheon WEON ; Yong Pil KIM
Korean Journal of Obstetrics and Gynecology 2000;43(9):1539-1543
No abstract available.
Humans
;
Pregnancy, Twin*
7.A Case of Term Cesarean Delivery in Patient with Ascending Aortic Aneurysm : Complicated by Rupture of Aortic Dissection.
Jae Nam MA ; Tae In LEE ; Sun Hee KO ; Kang Woo JUNG ; Jong Cheon WEON ; Yong Pil KIM
Korean Journal of Perinatology 2001;12(1):54-57
No abstract available.
Aortic Aneurysm*
;
Humans
;
Rupture*
8.FDG-PET/CT Complements Bone Scan with Respect to the Detection of Skip Metastasis of Osteosarcoma: A Case Report.
Gi Jeong CHEON ; Jae Gol CHOE ; In Jung CHAE ; Dae Hee LEE ; Sang Heon SONG ; Myo Jong KIM ; Jong Hoon PARK
The Journal of the Korean Bone and Joint Tumor Society 2012;18(1):45-49
Skip lesion is not uncommon feature in osteosarcoma and considered to be importantly associated with poor prognosis factor, and thus, should be excised with the main mass. The accurate pre-operative evaluation of the intramedullary extent of osteosarcoma is essential, because it determines the level of bone resection. Among the reliable detection methods, bone scan has a drawback of high rate of false negative results and regional MRI has a difficulty to cover the whole involved lesions without clinical suspicion. The authors report a case of osteosarcoma of the distal femur with a proximal skip lesion that was not detected by either regional MR imaging or by bone scan, but which was visualized by FDG-PET/CT.
Complement System Proteins
;
Femur
;
Neoplasm Metastasis
;
Osteosarcoma
;
Prognosis
9.Effects of Skin Rehabilitation Massage Therapy on Pruritus, Skin Status, and Depression in Burn Survivors.
Young Sook ROH ; Hee CHO ; Jung Ok OH ; Cheon Jae YOON
Journal of Korean Academy of Nursing 2007;37(2):221-226
PURPOSE: Hypertrophic scarring and depression are the principal problems of burn rehabilitation. This study was done to verify the effects of skin rehabilitation massage therapy (SRMT) on pruritus, skin status, and depression for Korean burn survivors. METHODS: A pretest-posttest design using a nonequivalent control group was applied to examine the effects of SRMT for 3 months in a group of 18 burn survivors. The major dependent variables-including pruritus, objective and subjective scar status, and depression-were measured at the beginning and at the end of the therapy to examine the effects of SRMT. RESULTS: Burn survivors receiving SRMT showed reduced pruritus, improved skin status, and depression. The remaining scar also showed improvement in skin pigmentation, pliability, vascularity, and height (compared to the surrounding skin) as measured on the Vancouver Scar Scale (VSS). CONCLUSIONS: The findings demonstrate that SRMT for burn survivors may improve their scars both objectively and subjectively, and also reduce pruritus and depression.
Adult
;
Burns/complications/*rehabilitation
;
Cicatrix, Hypertrophic/etiology/*prevention & control
;
Depressive Disorder/etiology/*prevention & control
;
Female
;
Humans
;
Male
;
*Massage
;
Pruritus/etiology/*prevention & control
10.Effects of intracerebroventricular angiotensin II on the response to hemorrhage in conscious normotensive and hypertensive rats.
Dong Kuk AHN ; Dong Wook CHEON ; Yoon Yub PARK ; Hyeong Jin KIM ; Jae Sik PARK ; Won Jung LEE
Journal of Korean Society of Endocrinology 1993;8(2):141-148
No abstract available.
Angiotensin II*
;
Angiotensins*
;
Animals
;
Hemorrhage*
;
Rats*