To know the effect of subconjunctival injection of liposome encapsulated cytarabine on proliferation of conjunctival fibroblasts, the conjunctiva was isolated at 180 degrees from the injection site 3 days after subconjunctival injection of the normal saline (control), cytarabine, liposome encapsulated cytarabine, and 1 day after injection of cytarabine, and then those were inoculated in the culture media of fibroblasts. In the case of 3 days after injection of cytarabine, there was 49% and 42% inhibition of proliferation of conjunctival fibroblasts compared with the control respectively. Therefore, the authors concluded that the liposome encapsulated cytarabine is effective on inhibition of proliferation of conjunctival fibroblasts and reduces the frequencies of subconjunctival injection compared with the cytarabine itself.
Conjunctiva ; Culture Media ; Cytarabine* ; Fibroblasts* ; Liposomes*

We conducted this cohort analytic study to determine whether women with unexplained elevations of maternal serum hCG at 15-18 weeks' gestation are at increased risk for pregnancy complications and adverse perinatal outcomes. The inclusion criteria were a singleton gestation, a confirmed gestational age, and an hCG level greater than 2.0 multiples of the median (MoM). The exclusion criteria were fetal anomalies, an abnormal karyotype, molar pregnancy, and an MSAFP level greater than 2.5 multiples of the median (MoM). A group of randomly selected women with hCG levels under 2.0 MoM served as controls. Patients with elevated levels of hCG had a significantly higher risk for PIH (17.9% versus 4.5%; P <.05) and preterm delivery (17.9% versus 3.5%; P<, 05) than control. But no significant differences were observed in the incidence of intrauterine growth restriction and low birth weight and in the newborn weight. We suggested that pregnancies with unexplained elevated hCG levels should be regarded as high-risk pregnancies. And these patients require careful monitoring with adequate obstetric management.
Abnormal Karyotype ; Chorionic Gonadotropin* ; Cohort Studies ; Female ; Gestational Age ; Humans* ; Hydatidiform Mole ; Incidence ; Infant, Low Birth Weight ; Infant, Newborn ; Pregnancy ; Pregnancy Complications ; Pregnancy Outcome* ; Pregnancy* ; Pregnancy, High-Risk

We report a case of atypical eruption due to chemotherapeutic agent in a 60-year-old man who presented with asymptomatic, erythematous, 0.5cm in diameter, confluent, and elevated papules and plaques confined to the face. The patient was previously diagnosed with small cell carcinoma of the lung with liver metastasis. Two months after the diagnosis, a first course of chemotherapy including etoposide was started. Five days after starting the chemotherapy, the patient developed a facial eruption. Histopathologic examination demonstrated increased epidermal mitotic figures, cells in metaphase arrest, basal cell layer hyperpigmentation, prominent dyskeratosis, and squamous atypia. The most distinctive histologic feature was the presence of starburst cells, which are markedly enlarged pale staining keratinocytes containing small basophilic fragments of nuclear debris haphazardly scattered throughout the cytoplasm in a starburst pattern.
Basophils ; Carcinoma, Small Cell ; Cytoplasm ; Diagnosis ; Drug Therapy ; Etoposide ; Humans ; Hyperpigmentation ; Keratinocytes ; Liver ; Lung ; Metaphase ; Middle Aged ; Neoplasm Metastasis

Renal angiomyolipomas are uncommon benign neoplasms composed of mature adipose tissue, thick-walled blood vessels and smooth muscle in varying proportions, which are found in more than half of the patients with tuberous sclerosis. When associated with tuberous sclerosis, they are usually small, bilateral and multifocal. We present a case of bilateral renal angiomyolipoma with tuberous sclerosis in a 33-year-old female.
Adipose Tissue ; Adult ; Angiomyolipoma* ; Blood Vessels ; Female ; Humans ; Muscle, Smooth ; Tuberous Sclerosis*

Hypereosinophilic syndrome represents a heterogenous group filisorders with the common features of idiopathic prolonged eosinophilia of undetectable cause and orgar, system dysfunction. We experienced a case af hypereosinophilic syndrome in a 58 year old man who has been suffered from fever, chilling, generelized exfoliative dermatitis, periorbital sngioedema and oral ulcer for 3 weeks duration. The blood eosinophil count was 7436/mm and skin, liver, bone marrow biopsy revealed marked infiltration of eosinophils. We treated him with co ticosteroid, but 5 months later, he died due to hepatoencephalopathy, hepatorenal syndrome, dissernimted intravascular coagulopathy and acute respiratory distress syndrome.
Biopsy ; Bone Marrow ; Dermatitis, Exfoliative ; Eosinophilia ; Eosinophils ; Fever ; Hepatorenal Syndrome ; Humans ; Hypereosinophilic Syndrome* ; Liver ; Middle Aged ; Oral Ulcer ; Respiratory Distress Syndrome, Adult ; Skin

We report a case of mycosis fungoides in a 28 year-old female patient who had multiple, bizzare, kidney or annular shaped, erythematous to brownishaly patches and plaques on the trunk, buttock, upper and lower extremities. Histopathologic finclingm showed epidermotropism and Pautrir microabscess in the epidermis and sssatypical lymphocytes infiltration in the dermis. T cell marker in leukocyte common antigen were positively stained in an immunohistochemical study. The skin lesions were reproved markedly after treatment it a total dose of 45 x 10 IU recombinant interferonaiv combination with a total dose of 385 iules/art PUVA.
Adult ; Antigens, CD45 ; Buttocks ; Dermis ; Epidermis ; Female ; Humans ; Interferons* ; Kidney ; Lower Extremity ; Lymphocytes ; Mycosis Fungoides* ; Skin

No abstract available.

Dentocutaneous fistula of the face neck is an infrequent manifestation of chronic dental infection. A periapical dental abscess may be initiated by disease, trauma, or thermal or chemical injury and develops into an extensive necrosis of surrounding tissue. Diagnostic errors can result in multiple excision, biopsies, and ineffective long-term antibiotic therapy. Awarness that periapical dental abscess is the most common etilolgic factor of cutaneous sinus tracts involves the face & neck will facilitate their early diagnosis and prevent needless treatment or anxiety for the patient. From 1994 to 1998, we have performed 6 cases of dentocutaneous fistula. Among of them, three were men and the others were women, age ranged from 18 to 66-year-old, and morbidity period was from 3 weeks to 3 years, the follow-up period ranged from 5 to 18 months (mean period 11 months). In conclusion, an understanding of the pathogenesis of cutaneous fistulae arising from dental infections will lead to proper early diagnosis and treatment without unnecessary surgery.
Abscess ; Aged ; Anxiety ; Biopsy ; Cutaneous Fistula ; Diagnostic Errors ; Early Diagnosis ; Female ; Fistula* ; Follow-Up Studies ; Humans ; Male ; Neck ; Necrosis ; Unnecessary Procedures

The double-blind, placebo-controlled study was performed to evaluate the efficacy and safety of once-a-day terazosin in 35 patients with benign prostatic hyperplasia. The dose of terazosin was titrated to 5 mg during 4 week period and then maintained throughout 24 week follow up. In terazosin group(n= 18), the maximum flow rates improved 32% from 10.4ml/sec at baseline to 13.7ml/sec, and the mean flow rate improved 38% from 5.5ml/sec to. 7.6ml/sec after 24 weeks of treatment(p <0.01). The obstructive symptom score decreased 59% from 9.8 to 4.l, and the irritative symptom score decreased 34% from 5.4 to 3.5 after.24 weeks of terazosin therapy (p<0.01). In placebo group(n= 17), the obstructive symptom score only significantly decreased 39% from 9.1 at baseline to 5.5 after 24 weeks of terazosin therapy(p>0.06). Adverse event occurred in one case of the terazosin group. In summary, terazosin administered once-a-day improved the obstructive and irritative symptoms of BPH and urine flow rates. Terazosin was well tolerated.
Follow-Up Studies ; Humans ; Prostatic Hyperplasia*

PURPOSE: This study was done to identify effects of carbonated water intake on constipation in elders who have experienced a cerebrovascular accident (CVA) and are bed-ridden. METHODS: Forty elderly patients with CVA were randomly assigned to one of two groups in a double-blind study. Patients in the experimental group drank carbonated water and those in the control group drank tap water for two weeks. Six patients dropped out during the study period. Data were analyzed by repeated measured ANCOVA and the covariance was the dose of laxatives used for the two weeks. RESULTS: Frequency of defecation increased significantly and symptoms of constipation decreased significantly for patients in the experimental group. CONCLUSION: The study results suggest that the intake of carbonated water is an effective method for the intervention of constipation in elderly patients with CVA.
Aged ; Analysis of Variance ; Carbonates/*therapeutic use ; Constipation/complications/*drug therapy ; Double-Blind Method ; Female ; Humans ; Laxatives/therapeutic use ; Male ; Middle Aged ; Stroke/*complications