We have studied the function of lymphokines on human tonsillar B cell prolifertion and differentiation. B cells were stimulated with Staphylococcus aureus Cowanl (SAC) or anti- bead. The followings showed the results of this study. 1) In B cell activation, SAC induced B cell DNA synthesis but anti-mubead did not. SAC could activate and proliferate B cells. Minimal number of B cells were required to proliferate effectively. 2) In B cell proliferation, SAC could proliferate B cell in the abscence of lymphokines. Exogenous IL-2 or IL-4 enhanced B cell proliferation. The roles of IL-2 were very important in B cell proliferation. The effect of IL-4 on the IL-2 induced B cell proliferation was inhibitory in SAC-B cells. IL-4 could enhance the proliferation of anti-mu bead activated B cells. 3) In B cell differentiation, IL-2 was a major factor to differentiate SAC activated B cells, but IL-4 did not. IL-6 had a synergistic effect on the differentiation. The results of this study showed that the different signal transduction mechanisms were involved in B cell proliferation and differentiation. The B cell resposes to lymphokine were different, and it is depend upon antigens or mitogens.
B-Lymphocytes ; Cell Differentiation ; Cell Proliferation* ; DNA ; Humans* ; Interleukin-2 ; Interleukin-4 ; Interleukin-6 ; Lymphokines ; Mitogens ; Signal Transduction ; Staphylococcus aureus

BACKGROUND: Although there are varied etiological factors in the pathogenesis of psoriasis, recent data where viral hepatitis is more frequently found in psoriasis patients than in the normal population, suggests the possibility that some kinds of viral antigens may participate as causative factors of psoriasis. Hepatitis C virus(HCV) in particular, which has been proven to be associated with many dermatoses such as porphyria cutanea tarda, lichen planus and vasculitis, is currently suspected as a possible pathogen in psoriasis. OBJECTIVE: This study was conducted to estimate the prevalence of viral hepatitis infection among psoriasis patients in Korea where it is known to be endemic. Additionally, we analysed the relationship between the clinical severity of psoriasis and viral hepatitis according to the serotypes. METHODS: In this study, we looked for the presence of HCV, HBV, HAV, HDV and HEV infection in 65 enrolled psoriasis patients and 98 non-psoriatic patients by enzyme immunoasay, recombinant immunoblotting, radioimmunoassay and reverse transcription polymerase chain reactions. RESULTS: 1. We found a higher prevalence of viral hepatitis in the psoriasis group(70.8%) than the control group(45.9%). 2. 10.7% of patients were shown to be infected with HCV in the psoriasis group, in comparison with 2% in the control group. Also 52.7% of psoriatic patients were positive to HBV markers as HBcAb and HBsAg in comparison with 38.8% in the control group. 3. There was a statistically significant correlative relationship between the clinical severity of psoriasis and the presence of viral hepatitis. 4. We could establish a significant association among higher titers of ALT, positivity of HBcAb and HBsAg, and HCV hepatitis in psoriatic patients. CONCLUSION: Psoriatic patients had a higher prevalence of viral hepatitis than normal controls. Also psoriatic patients with viral hepatitis showed relatively different clinical features and labaratory results in comparison with those without it.
Antigens, Viral ; Hepatitis B Surface Antigens ; Hepatitis C ; Hepatitis* ; Humans ; Immunoblotting ; Korea ; Lichen Planus ; Polymerase Chain Reaction ; Porphyria Cutanea Tarda ; Prevalence ; Psoriasis* ; Radioimmunoassay ; Reverse Transcription ; Skin Diseases ; Vasculitis

Accurate reproduction of intraoral tissue is essential in the fabrication of fixed prosthesis. This selection of impression material and method is very important. In this study, vinyl polysiloxane type impression material Panasil was used. Three impression methods ; one-step technique, individual tray technique, and individual tooth tray technique using the vinyl polysiloxane type bite registration material Futar Occlusion, were used to take horizontal and vertical impression. Improved stone models were fabricated. The amount of occlusal surface discrepaneies, interabutment distance discrepancies, amount of marginal defect were evaluated with the X-PLAN360d and photoscanning. The results were as follows. 1. There was no significant difference in occlusal surface according to the directions and techniques of impression taking. 2. There was no significant difference in interabutment distance discrepancies according to the directions and techniques of impression taking 3. There was no significant difference in marginal discrepancies according to the direction of impression taking but there was significant difference between one-step technique and individual tray technique, individual tooth tray technique (P<0.05). Taken together, these results suggest that individual tray technique and individual tooth tray technique are more accurate for impression taking than one-step technique.
Jaw Relation Record ; Prostheses and Implants ; Reproduction ; Siloxanes ; Tooth

We herein report a case of Spitz nevus which occurred in a 6-year-old girl with acute lymphocytic leukemia. The lesion was a well delimited, symmetric, 1.0 * 1.0cm sized, dome-shaped light pinkish nodule with a shiny surface on her forehead. The histopathological findings of the excisional biopsy specimen revealed mild epidermal hyperplasia ; numerous uniform nests of spindle cells and epitheloid cells with sparce pigmentation along the dermoepidermal junction; colloid body-like eosinophilic globules ; multinucleated giant nevus cells in the epidermis and edema in the upper dermis. Since the complete excision of her lesion was accomplished, there have been no new lesions over the past year.
Biopsy ; Child ; Colloids ; Dermis ; Edema ; Eosinophils ; Epidermis ; Female ; Forehead ; Humans ; Hyperplasia ; Nevus ; Nevus, Epithelioid and Spindle Cell* ; Pigmentation ; Precursor Cell Lymphoblastic Leukemia-Lymphoma*

No abstract available.
Titanium*

BACKGROUND: The current recommendation of rescue breathing techniques in the infant is to blow both the nose and mouth of infants by caregiver's mouth but recent studies suggest some caregivers may have trouble sealing a infant's mouth and nose. The purpose of this study is to estimate the ability of mothers to create a seal to their infants for the provision of rescue breathing according to current recommendation. METHODS: Infants up to 1 year of age(n=98) and their mothers were enrolled from emergency department of Chonbuk National University Hospital. We measured the facial lengths of the infants and the width of mouth in their mothers and compared mouth widths of mothers with their infant's nose-to-mouth lengths. RESULTS: In infants between 0 to 6 months, Mother transverse lengths were significantly larger than mouth, nose and nose-to-mouth lengths of the infants. In infants between 7 to 12 months, Mother transverse lengths were significantly larger than mouth and nose lengths of the infants but there was no statistically significant difference between mother transverse lengths and nose-to-mouth lengths of infants. CONCLUSION: The finding indicate that the present recommendation to cover mouth and nose is partly not possible. We recommend that the mouth-to-nose ventilation of rescue breathing techniques for the infants who have respiratory arrest be taught to mothers.
Caregivers ; Emergency Service, Hospital ; Humans ; Infant* ; Jeollabuk-do ; Mothers ; Mouth ; Nose ; Respiration* ; Ventilation

No abstract available.
Coronary Vessels*

Among previously proposed etiological factors of chondromalacia patellae, abnormality in the extensor mechanism of the knee joint has been attributed as a cause of chondromalacia patellae by many authors Malalignment in the extensor mechanism of the knee joint is supposed to cause the positional change of patella. This positional change of patella can be measured by Q angle and P/PT ratio. Hereby we intened to classify the relationahip between the above measurement lenoting the positional change of patella and chondromalacia patellae. These values were obtained from 60 patients found to have chondromalacia patellae in Han Gang Sacred Heart Hospital, from Jan. 1977 to Sep. 1978. Values were also obtained from 60 normal persons as a control group. Thus a statistical analysis was made for the possible relationship between extensor mechanism of the knee joint and chondromalacia patellae. The following conclusion were made, 1. The sex ratio was 1:1.3 with female preponderance. There was 26 male and 34 female patients, common age group of chondromalacia patellae was age 20-40 years. 2. The average value of Q angle was 11 in control group, while 18 in chondromalacia patellae, having the difference of 7. 3. The average values of Q angle among different sexes were reviewed. The male control group had 9 of average value of Q angle, while male chondromalacia patellae had 16. The female control group had 12 of average value of Q angle, while female chondromalacia patellae had 20. 4. The average value of P/PT ratio was 1.03 in control group, while 0.9 in chondromalacia patellae, having the difference 0.13. For P/PT ratio in different sexes, the average value was 1.01 in male control group. while 0.9 in male chondromalacia patellae. The average value of P/PT ratio was 1.04 in female control group, while 0.89 in female chondromalacia patellae, 5. For statistical survey for these differences, P value was examined by t-test methods. The statistical diffrences of Q angle in male control group and chondromalacia patellae was 3.4 and it was 2.06 in he female. The difference between control group and the chondromalacia patellae in the overall seves was 2.61, thus having statistical significance.
Cartilage Diseases ; Chondromalacia Patellae ; Female ; Heart ; Humans ; Knee Joint ; Knee ; Male ; Patella ; Sex Ratio

No abstract available in English.
Pseudarthrosis ; Tibia

No abstract available.
Bronchoscopy* ; Hemoptysis* ; Hemorrhage*