No abstract available.
Alopecia* ; Minoxidil*

No abstract availble.
DNA Mutational Analysis ; Humans ; *Microsatellite Instability ; Neoplasm Staging ; Prognosis ; Stomach Neoplasms/*diagnosis/genetics/surgery

No abstract available.
Gastroesophageal Reflux* ; Helicobacter pylori* ; Helicobacter*

No abstract available.
Gastroesophageal Reflux* ; Helicobacter pylori* ; Helicobacter*

Endoscopic mucosal resection (EMR) has become a standard treatment for selected cases of early gastric cancer (EGC) because of its minimal invasiveness and comparable survival outcomes to surgical resection. The currently recognized indications of EMR for EGC are differentiated mucosal tumor < 2 cm for elevated and < 1 cm for flat and depressed type lesions. Recently, expanded criteria have been proposed in Japan. However, its wide acceptance is being limited in Korea by the lack of long-term outcome data and difficulty in pathological interpretation. In Korean multicenter study including 514 EGC cases resected by EMR, en bloc and complete resection rates were 71.8% and 77.6%, respectively. Local recurrence was detected in 24 cases (6.0%) after complete resection during the median 23.5 months of follow-up. Bleeding and perforation rates were 13.8% and 0.6%. Recently, endoscopic submucosal dissection (ESD) method was introduced to overcome the size limitation of EMR and consequently to improve en bloc resection rate. This technique has been widely accepted in Korea these days. In Korean multicenter study including 534 EGC cases treated by ESD, en bloc and complete en bloc resection rates were 95.3% and 87.7%, respectively. Bleeding and perforation rates were 15.6% and 1.2%. To make EMR and ESD more reliable and safer methods of treating EGC, more long-term follow-up data and standardization of techniques and pathological interpretation were required.
Follow-Up Studies ; Hemorrhage ; Japan ; Korea ; Recurrence ; Stomach Neoplasms

No abstract available.
Anti-Infective Agents/*therapeutic use ; Drug Resistance, Bacterial ; Helicobacter Infections/*drug therapy/microbiology ; Helicobacter pylori/*drug effects ; Humans ; Metronidazole/*therapeutic use

Noncardiac chest pain (NCCP) is defined as recurring angina-like retrosternal chest pain of noncardiac origin. Although gastroesophageal reflux disease (GERD) is recognized as the most frequent cause of this disorder, the pathophysiology remains to be elucidated fully. In Western countries, upper endoscopy has limited value in the differential diagnosis of NCCP because most of the mucosal findings detected are consistent with GERD. By contrast, in Korea the prevalence of gastric or duodenal ulcers in NCCP patients ranges from 17.9 to 20.7%. Considering this high prevalence and the different treatment strategies for GERD and peptic ulcer disease, upper endoscopy should be included in the initial work-up for NCCP in Korean patients.
Chest Pain ; Diagnosis, Differential ; Duodenal Ulcer ; Endoscopy ; Gastroesophageal Reflux ; Humans ; Korea ; Peptic Ulcer ; Prevalence ; Thorax ; Upper Gastrointestinal Tract

PURPOSE: This study examined the results of a single or double V-Y advancement flap, which was found to be technically simple for the management of chronic plantar ulcer in patients with neuropathic diabetic foot. MATERIALS AND METHODS: From January 2004 to December 2005, 29 patients who were hospitalized for the management of a neuropathic diabetic foot plantar ulcer were examined. All patients underwent single- or double-V-Y advancement flap for the management of the ulceration. Hematological, hemodynamic, diabetic, bacteriologic, and radiological tests wereperformed prior to surgery. The condition of the wound was checked during surgery, and the healing rate, healing time and recurrence during the follow-up examinations were evaluated after surgery. RESULTS: The mean age of the patients was 53.4 years (36-69). The plantar ulcers were the most commonly found in the forefoot area (12 cases). Nine cases showed ulcers in the hindfoot area, 6 cases were found are in the lateral foot area, and 2 cases were identified in the medial foot area. The area covered with the V-Y advancement flap averaged 2.05 cm(2) (0.8-3.9). The mean healing time of the wound was 4.7 weeks (3-8). One day after surgery, there were 7 cases of partial circulation disturbance that were managed with a partial stitch out and secondary intension wound healing. There were 5 cases of recurrence of the wound. CONCLUSION: A V-Y advancement flap to manage chronic diabetic plantar ulcers can produce excellent or good results. However, a high incidence of delay in healing of the surgical wound can be expected, and a longer period is needed to protect the wound comparing with normal patients.
Diabetic Foot ; Follow-Up Studies ; Foot ; Foot Ulcer ; Hemodynamics ; Humans ; Incidence ; Recurrence ; Ulcer ; Wound Healing

Neospora caninum is an important cause of abortion in cattle, and dogs are its only known definitive host. Its seroprevalence among domestic urban and rural dogs and feral raccoon dogs (Nyctereutes procyonoides koreensis) in Korea was studied by indirect fluorescent antibody test (IFAT) and by the neospora agglutination test (NAT), respectively. Antibodies to N. caninum were found in 8.3% of urban dogs and in 21.6% of dogs at dairy farms. Antibody titers ranged from 1: 50 to 1: 400. Antibodies to N. caninum were found in six (23%) of 26 raccoon dogs. However, the potential role of raccoon dogs as a source of horizontal transmission of bovine neosporosis needs further investigation. The results of this study suggest that there is a close relationship between N. caninum infection among dairy farm dogs and cattle in Korea. This study reports for the first time upon the seroprevalence of N. caninum infection in raccoon dogs in Korea.
Animals ; Animals, Domestic ; Animals, Wild ; Antibodies, Protozoan/*blood ; Carnivora/*parasitology ; Coccidiosis/epidemiology/*veterinary ; Dog Diseases/*epidemiology/parasitology ; Dogs ; Korea/epidemiology ; Neospora/*immunology ; Seroepidemiologic Studies

PURPOSE: To document the radiologic characteristics of Korean Gaucher disease. MATERIALS AND METHODS: Fifteen bone marrow biopsy and laboratory data confirmed Gaucher disease patients (age 1 -21, mean 10.9 yr) wereundertaken plain X ray and MRI. Number of type I were 10, type II, 2, type III, 3. Seven were splenectomized oninitial evaluation or during follow up. Five enzyme treated patient were undertaken follow-up MR examinationduring 6 -40 month with 6 month interval. Conventional T1 and T2WI of spine and femur was performed and FMPSPGR inand out of phase image was also done. Volume of liver and spleen were measured, and bone marrow infiltration andpresence of infarction were scored according to 6 scale scoring system. Clinical data were also reviewed andcorrelated with the MR findings. RESULTS: Marrow infiltration was noted in 71.4% of all patients in MRI, while itwas in 45.7% with plain radiography. Type I group showed marrow infiltration in all but one cases, which wasparallel with ages, SGPT, and presence of osteopenia, reversely correlated with spleen size. Severe bonecomplications (infarction or fracture) were noted in 7 of 10 type I group, and 6 patients showed severe growthretardation (below 3rd percentile). Follow up MR examination of 5 patient showed decrease in liver and spleen sizefirst without bone change until 6 months. There showed bone regeneration in 2 patient 1 year after, and increasedfat signal in one patient 3.5 years after. In and out of phase images couldn't help in quantifying fatcomposition in bone marrow. CONCLUSION: Korean Gaucher patients revealed as more severe skeletal complicationsthan others reported from Western groups. MR examination is a effective modality to evaluate and monitor ofGaucher patients.
Alanine Transaminase ; Biopsy ; Bone Diseases, Metabolic ; Bone Marrow ; Bone Regeneration ; Femur ; Follow-Up Studies ; Gaucher Disease* ; Humans ; Infarction ; Liver ; Magnetic Resonance Imaging ; Metabolism ; Radiography ; Spine ; Spleen