No abstract available.
Lymphoma, T-Cell* ; Nasal Cavity* ; T-Lymphocytes*

No abstract available.
Anoxia* ; Neurons*

In central neurons, an excessive or sustained rise in the concentration of free cytoplasmic Ca2+ ions([Ca2+]i) after hypoxia may promote rapid neurodegeneration both in vitro and in vivo. Treating cells with Ca2+ chelating agents may prevent or delay a loss of cellular Ca2+ homeostasis after hypoxic injury and thus constitute an effective strategy for minimizing neuronal damage. Cell-permeant Ca2+ chelators such as 1,2-bis-(2-aminophenoxy) ethrane -N,N,N',N' -tetraacetic acid acetoxymethyl ester(BAPTA-AM) have shown evidence of neuroprotective effect against hypoxic neuronal injury. This study was designed to examine dose response and to estimate therapeutic window of BAPTA-AM for the recovery from hypoxia in vitro. Electrophysiological studies were made in CA1 neurons in rat hippocampal slices which were superfused with artificial cerebrospinal fluid(ASCF) in tissue chamber. Hypoxia was induced by replacement of 95% N2+5% CO2 from 95% O2+5% CO2 for 20min. Recovery from hypoxic injury was evaluated by using a percentage recovery of population spike. BAPTA-AM in concentration of 1, 10 and 50micrometer were administered to the artificial cerebrospinal fluid(ASCF) for 2 hours prior to hypoxia, simultaneous with hypoxia and after hypoxia. The experimental specimens were divided to seven groups and each group was compared to control ASCF group. Recovery of population spike after hypoxia was about 70% in control ASCF group, which was mild type hypoxic injury. BAPTA-AM in 10 micrometer concentration, when given just prior to hypoxia, enhanced recovery of poppulation spikes at 15 and 30min following reoxygenation(p<0.05), in comparison with control ASCF. BAPTA-AM had no neuroprotective acitvity when given after the onset of hypoxia. Also, BAPTA-AM in 1 and 50 micrometer concentration did not accentuate recovery of population spike after hypoxia. Dose response curve was inverted U-shape and the response was maximun in 10 micrometer concentration of BAPTA-AM.
Animals ; Anoxia ; Chelating Agents ; Cytoplasm ; Enflurane ; Homeostasis ; Neurons ; Neuroprotective Agents* ; Rats

Paragangliomas are neoplasms that arise from autonomic nervous system-associated paraganglia ; most often, they are benign, but have infrequently been reported to metastasize. Involvement of the spine is rare and is usually intradural at the level of the cauda equina. The authors report one case of metastatic malignant paraganglioma to the spine, which resulted in radiculopathy caused by extradural spinal root compression ; a review of the literature is also provided. Management of the reported patient involved spinal root decompression and spinal stabilization ; long-term symptom-free ambulatory status was maintained. After surgical removal of these tumors, radiation therapy may be an important adjunctive procedure.
Cauda Equina ; Decompression ; Humans ; Neoplasm Metastasis ; Paraganglioma* ; Radiculopathy ; Spinal Nerve Roots* ; Spine

A nerve ganglion cyst is characterized by the accumulation of a mucoid substance in or around the nerve, which leads to the formation of a pseudocyst. This 53-year-old man presented with left foot drop of three-year duration, using magnetic resonance imaging, 3-cm ganglion cyst of the peroneal nerve was preoperatively diagnosized. Surgical exploration disclosed a lobulated cystic mass filled with gelatinous material, and the lesion was completely resected. No connection with the knee joint was found, and postoperative recovery of motor function was good. The authors describe a case of intraneural ganglion cyst of the peroneal nerve which illustrates the value of MR in diagnostic imaging.
Diagnosis* ; Diagnostic Imaging ; Foot ; Ganglion Cysts* ; Gelatin ; Humans ; Knee Joint ; Magnetic Resonance Imaging* ; Middle Aged ; Peroneal Nerve*

A nerve ganglion cyst is characterized by the accumulation of a mucoid substance in or around the nerve, which leads to the formation of a pseudocyst. This 53-year-old man presented with left foot drop of three-year duration, using magnetic resonance imaging, 3-cm ganglion cyst of the peroneal nerve was preoperatively diagnosized. Surgical exploration disclosed a lobulated cystic mass filled with gelatinous material, and the lesion was completely resected. No connection with the knee joint was found, and postoperative recovery of motor function was good. The authors describe a case of intraneural ganglion cyst of the peroneal nerve which illustrates the value of MR in diagnostic imaging.
Diagnosis* ; Diagnostic Imaging ; Foot ; Ganglion Cysts* ; Gelatin ; Humans ; Knee Joint ; Magnetic Resonance Imaging* ; Middle Aged ; Peroneal Nerve*

PURPOSE: The prognosis for patients with stage IV gastric cancer is very poor. However, recently, some studies have reported benefits from a gastric resection for metastatic gastric cancer. This clinical study was performed to evaluate the effectiveness of a noncurative gastrectomy in treating stage IV gastric cancer with hepatic metastasis. MATERIALS AND METHODS: A retrospective analysis was performed on 98 gastric cancer patients who had undergone gastric resection, in spite of hepatic metastasis, between January 1990 and December 1996 at the Department of Surgery in 11 General Hospitals in Korea. RESULTS: The average age was 58 years old, and the male-to-female ratio was 69: 29. The laboratory tests were unable to predict hepatic metastasis. In 54 cases, hepatic metastasis was not identified before the surgery. The most common location of gastric cancer was antrum (72 cases). The most common gross type was Bonmann type III (78 cases). The serosa-exposed cases were 80. The peritoneal seeding was combined in 17 cases. A total gastrectomy was performed in 18 cases and a distal gastrectomy in 80. Lymph-node dissection was performed in 23 Dl, and 51 D2 cases. Hepatic resection was performed in 36 cases, The frequent histologic types were moderately differentiated and poorly differentiated tubular adenocarcinoma. Postoperative adjuvant chemotherapy was done in 70 cases. The complication rate (7%) was low. The median survival time was 15 months, with mean survival time of 18 months. The 2-year and 3-year survival rates were 23%, and 7%, respectively. In the univariate analysis, good survival was closely related to limitation of hepatic metastasis to one lobe, a few metastases to both lobes, negativity of peritoneal seeding and lymph node dissection more than D2 (p<0.05), CONCLUSIONS: An aggressive gastric resection for stage IV gastric cancer with hepatic metastasis might be beneficial in lengthening the survival period. A prospective study is needed, especiaUy one with an exact evaluation and analysis of the quality of life between the gastrectomy and nonresection groups.
Adenocarcinoma ; Chemotherapy, Adjuvant ; Gastrectomy* ; Hospitals, General ; Humans ; Korea ; Lymph Node Excision ; Middle Aged ; Neoplasm Metastasis* ; Prognosis ; Quality of Life ; Retrospective Studies ; Stomach Neoplasms* ; Survival Rate