No abstract available.
Transcription Factors*

No abstract available.
Iodine*

PURPOSE: The purpose of this study was to evaluate the plain chest radiological findings of silicosis based on ILO 1980 Classification. METHODS AND MATERIALS: Author studied the plain chest films of 200 patients with silicosis in Taebaek district and silicotic lesions were classified bascd on ILO 1980 Classification. There were 196 males and 4 females among them(mean age;56.2 years). The mean duration of dust cxposurc was 18.8 years. Small and large opacities were classified according to their profusion, size and shape, and size category, respectively. Other associated findings were also analyzed. RESULTS: Amont 200 patients there were 153 cases of small opacities and 47 cases of large opacities. Category 2/2(21.6%) and q/q type(22.9%) were most common for small opacities, according to their profusion, size and shape. Category B is most common for large opacities, according to their size. Incidence and size of large opacities increased with duration of dust exposure. Associated findings of hilar eggshell calcifications(5.5%), calcified silicotic nodules(3.5%), active pulmonary tuberculosis(10.5%) and pleural abnormality(9.0%) were domonstrated, too. CONCLUSION: Plain chest radiological findings of silicosis were fine irrcgular and/or round small opacities in Ifie early phasc, but if advanced, large opacities of progressive massive fibrosis and focal cmphysematous appcared in the upper lung fields. Hilar lymphadenopathy and eggshell calcifications, active pulmonary tuberculosis, pleural thickening and calcifications could be associated.
Classification* ; Dust ; Female ; Fibrosis ; Humans ; Incidence ; Lung ; Lymphatic Diseases ; Male ; Silicosis* ; Thorax* ; Tuberculosis, Pulmonary

No abstract available.
Adult* ; Human Body* ; Humans* ; Male*

In order to evaluate the ability of spin-echo MR imaging to differentiate slow flow from mural thrombus in aortic diseases, we reviewed the spin-echo MR images of 13 patients with intraaortic thrombus documented by CT (N=11) or aortography (N=2). Six patients had aortic aneurysms and seven had aortic dissection. Intraaortic mural thrombi were accompanied by flow-related intraluminal signal of various patterns and extents in all 13 patients. On 10 gated MR studies, slow flow regions showed even-echo rephasing phenomenon (N=8), interslice variation of signal intensities of the intraluminal signal (N=7) and flow-related ghost artifact (N=2). However, these MR flow phenomena were obscured on two of three non-gated studies. Seven of 13 intraaortic thrombi remained hyperintense on T2-weighted second-echo images. In these circumstances, a hypointense boundary layer between slow flow and mural thrombus, which was caused by either 'boundary layer dephasing phenomenon' of slow flow or 'paramagnetic T2 shortening' of fresh clot at the edge of mural thrombus, was useful in discriminating the area of slow flow from that of mural thrombus. Proper interpretation of spin-echo MR images may obviate the need for phase display imaging or gradientecho imaging in differentiating slow flow and mural thrombus.
Aortic Aneurysm ; Aortic Diseases* ; Aortography ; Artifacts ; Humans ; Magnetic Resonance Imaging ; Thrombosis*

In order to evaluate the ability of spin-echo MR imaging to differentiate slow flow from mural thrombus in aortic diseases, we reviewed the spin-echo MR images of 13 patients with intraaortic thrombus documented by CT (N=11) or aortography (N=2). Six patients had aortic aneurysms and seven had aortic dissection. Intraaortic mural thrombi were accompanied by flow-related intraluminal signal of various patterns and extents in all 13 patients. On 10 gated MR studies, slow flow regions showed even-echo rephasing phenomenon (N=8), interslice variation of signal intensities of the intraluminal signal (N=7) and flow-related ghost artifact (N=2). However, these MR flow phenomena were obscured on two of three non-gated studies. Seven of 13 intraaortic thrombi remained hyperintense on T2-weighted second-echo images. In these circumstances, a hypointense boundary layer between slow flow and mural thrombus, which was caused by either 'boundary layer dephasing phenomenon' of slow flow or 'paramagnetic T2 shortening' of fresh clot at the edge of mural thrombus, was useful in discriminating the area of slow flow from that of mural thrombus. Proper interpretation of spin-echo MR images may obviate the need for phase display imaging or gradientecho imaging in differentiating slow flow and mural thrombus.
Aortic Aneurysm ; Aortic Diseases* ; Aortography ; Artifacts ; Humans ; Magnetic Resonance Imaging ; Thrombosis*

No abstract available.
Tonsillectomy*

Refractory deformity in ankylosing spondylitis is caused by loss of normal lordotic curvature in lumbar spine. For the correction of deformity, monosegmental osteotomy, intracorporal decancellation and multisegmental osteotomy are used. Among them, multisegmental osteotomy is reported to be safe because of its small correction amount at each level. Since 1989, authors treated 5 cases of ankylosing spondylitis with severe kyphotic deformity by multisegmental osteotomy and transpedicular instrumentation. All were young males between 22 and 35 years of age. Preoperative kyphotic deformity was 80°, 105°, 72°, 35°, 55° (Av. 70°) and amount of correction was 55°, 105°, 72°, 20°, 40° (Av. 58°) respectively. Levels for osteotony were 4 to 8 segments and correction at a level was 5° to 13° (Av. 8.3°). Normal standing upright posture and vision for straight forward were obtained in all. Instrumentation was Zielke in three Cotrel-Dubousset in two. One case of Zielke instrumentation showed rod failure. However, all showed solid bony union without any loss of correction or pseudoarthrosis. From the above experience, multisegmental osteotomy for the treatment of kyphotic deformity in ankylosing spondylitis was believed to be a safe and effective method of treatment.
Congenital Abnormalities ; Humans ; Male ; Methods ; Osteotomy ; Posture ; Pseudarthrosis ; Spine ; Spondylitis, Ankylosing

We have made a statistical survey on 2441 amputated limbs of 2150 patients who were treated at the Depart- ment of Orthopedic Surgery and who were prescribed the prosthetics at the Prosthetic Center of Veterans Hospital from Mar. 1972 to Feb. 1982. 1. The peak incidence was in the age group from 21 to 30 years with 1546 cases (63.3%). Of 2150 patients only 9 patients were female. 2. The main causes of amputation were trauma with 1901 cases (77.9%), vascular insufficiency with 326 cases (13.4%) and chronic osteomyelitis with 157 cases (6.4%). And the most fre#quent cause of traumatic amputation was explosive injury with 1080 cases (56.8%). 3. Of the 2441 amputated limbs, 1756 cases (71.91°) were at the lower extremity and the most frequent site was below the knee with 1000 cases (57%). 4. Minor limb amputation was performed on 326 cases (13.4%). 5. Multiple limb amputation was performed on 255 patients (11.9%) and of these 12 patients were amputated on 4 extremities. 6. Reoperation was performed on 420 cases (17.2%). It was most prevalent in the lower extremity with 365 cases (86.9%) and their main cause was neuroma with 171 cases (40.7%). The most frequent site was below the knee with 240 cases (57.2%).
Amputation ; Amputation, Traumatic ; Amputees ; Extremities ; Female ; Hospitals, Veterans ; Humans ; Incidence ; Knee ; Lower Extremity ; Neuroma ; Orthopedics ; Osteomyelitis ; Reoperation

To investigate the properties and mechanism of PAF and TNF on the synthesis of prostaglandin E2 in human amnion, primary monolayer culture method was used for human amnion cell incubation. Amnion cells were incubated with various concentrations of PAF or TNF in Ca++ containing medium for various duration. Then PG E2 concentrations were measured by RIA and analyzed for the effect of PAF and TNF on PG E2 production according to their doses and incubation time. To test the role of Ca++ in E2 production, Ca++ free medium, Ca++ -channel antagonist and cyclo-oxygenase inhibitor were substituted or added in incubation medium. Following results were obtained. The synthesis of PG E2 was significantly enhanced by PAF of 10(-6) mol/L. The TNF also stimulated PG E2 synthesis at concentration of 10(-6)g/ml. The maximal level in PAF(10-6mol/L)-stimulated release of PG E2 was observed after 16 hours in incubation. The TNF(10(-6)g/ml)-induced PG E2 release was maximal after 24 hours of incubation. Combined application of PAF and TNF produced positive effect in PG E2 production. PAF or TNF stimulated-PG E2 production in Ca++ -free media was much lower than that of Ca++ -containing media. The PAF-stimulated PG E2 release was significantly inhibited by Ca++ -channel antagonist but TNF-stimulated PG E2 release was not effected by Ca++ -channel antagonist or cyclo-oxygenase inhibitor. It is strongly suggested us that both PAF and TNF enhance PG E2 release by amnion cell, although Ca++ -channel opening is essential only for PAF stimulation.
Amnion* ; Blood Platelets* ; Dinoprostone* ; Humans* ; Platelet Activating Factor* ; Prostaglandin-Endoperoxide Synthases ; Tumor Necrosis Factor-alpha*