1.A Case of Pulmonary Lymphangiectasis Associated with Chylothorax.
Min Hee KIM ; Jae Kyoung LEE ; Oh Bae CHUN ; Byoung Hoon YOO ; Jae Hyung YOO
Journal of the Korean Pediatric Society 1987;30(4):422-426
No abstract available.
Chylothorax*
;
Lymphangiectasis*
2.Immunohistochemical studies on the rate of positive reaction of estrogen receptors and progesterone receptors in the breast diseases.
Suk Yong SUNG ; Hyun Muck LIM ; Jae Hyung YOO
Journal of the Korean Surgical Society 1991;41(1):29-36
No abstract available.
Breast Diseases*
;
Breast*
;
Estrogens*
;
Progesterone*
;
Receptors, Estrogen*
;
Receptors, Progesterone*
3.Expression of Prostatic Carcinoma Oncogene PTI - 1 in Prostatic Carcinoma , Prostatic Intraepithelial Neoplasia and Benign Prostatic Hyperplasia Using in situ PCR .
Tae Jin LEE ; Eon Sub PARK ; Jae Hyung YOO
Journal of the Korean Cancer Association 2000;32(1):136-147
PURPOSE: Prostatic tumor induced gene-1 (PTI-1) is a mutated human EF-la and putative prostatic carcinoma tumor-inducing oncogene, that is differently expressed in prostatic cancer and benign prostatic hyperplasia. And, it is more sensitive marker than prostate- specific antigen (PSA) for detecting human prostate cancer in the bloodstream. This study invastigated the expression of PTI-1 in paraffin embedded tissue of prostatic carcinoma, prostatic intraepithelial neoplasia, and benign prostatic hyperplasia using in situ PCR. MATERIALS AND METHODS: we evaluated expression of PTI-1 in prostatic carcinoma with prostatic intraepithelial neoplasia (PIN) of 32 cases, benign hyperplasia of 20 cases, high grade transitional cell carcinoma of 10 cases and colon cancer of 10 cases for control group. Also, the immunohistochemical staining for PSA was performed to comparison with clinical value of PSA. RESULTS: The serum level of PSA was closely related to stage and Gleason score (p < 0.05). However, the results of immunohistochemical stains were variable to stage and Gleason score. PTI-1 using in situ PCR expressed in 50% of prostatic carcinoma, 41% of prostatic intraepithelial neoplasia, 10% of benign hyperplasia and colon cancer (p < 0.05). No expression is observed in transitional cell carcinoma. In prostatic carcinoma, PTI-1 expressed in 43.8% (7/16) of stage II, 50.0% (5/10) of stage III, and 66.7% (4/6) of stage IV (p<0.05). In PIN, expression of PTI-1 was similar to prostatic carcinoma (p<0.05). CONCLUSION: PTI-1 represented a relatively sensitive marker for prostatic carcinoma and PIN, indicator of prostatic carcinoma progression.
Carcinoma, Transitional Cell
;
Colonic Neoplasms
;
Coloring Agents
;
Humans
;
Hyperplasia
;
Neoplasm Grading
;
Oncogenes*
;
Paraffin
;
Polymerase Chain Reaction*
;
Prostatic Hyperplasia*
;
Prostatic Intraepithelial Neoplasia*
;
Prostatic Neoplasms
4.A Study on the Heavy Metal Contents of Soil and Rice in the Kum River Basin.
Young Oh KIM ; Hyung Yul YOO ; Jae Hyung LEE ; No Suk KI ; In Dam HWANG
Korean Journal of Preventive Medicine 1988;21(2):320-328
This study was carried out to investigate the heavy metal contents and their correlations between paddy soil and brown rice near the Kum-River area. In this study, eighty soil samples and forty brown rice samples were taken from the paddy soil. The contents of heavy metals were measured by flame atomic absorption spectrophotometry. The results were as follows: 1. The average contents of soluble heavy metals in surface soil were Cd 0.19, Cu 15.31, Zn 18.10 and Pb 9.08 ppm. The average contents of soluble heavy metals in subsurface soil were Cd 0.19, Cu 14.52, Zn 17.75 and Pb8.11 ppm. There wan no statistically significant difference between the two layers. 2. The contents of Cu, Zn and Pb of Taejeon(S6) and Cd of Sinbyung(S5) in surface soil were higher than those of other areas. The contents of Cd and Cu of Taejeon(S6) and Zn and Pb of Kumnam(S3) in brown rice were higher than those of other areas and four heavy metals in soil and brown rice of Simchon(S7) were lower than those of other areas. 3. The ratio of soluble contents(Cd : Cu : Zn : Pb) in surface soil was 1 : 79 : 93 : 47, that of soluble contents in subsurface soil was 1 : 79 : 94 : 43, and that of total contents in brown rice was 1 : 84 : 294 : 12. 4. The correlations of the content between soluble heavy metals in surface(0-15 cm depth) soil total heavy metals in brown rice was found to be order of Cd>Cu>Zn>Pb. The correlations of the content between soluble heavy metals in subsurface(20-30 cm depth) soil and total heavy metals in brown rice was found to be order of Cu>Cd>Zn>Pb.
Metals, Heavy
;
Rivers*
;
Soil*
;
Spectrophotometry, Atomic
5.Expression of Glutathione S-Transferase, E-Cadherin, and Catenins during N,N-Diethylnitrosamine-Induced Hepatocarcinogenesis in Rat Liver.
Hyoung Joong KIM ; Yon Sik YOO ; Tae Jin LEE ; Mi Kyung KIM ; Eon Sub PARK ; Jae Hyung YOO
Korean Journal of Pathology 2000;34(12):982-993
N,N-Diethylnitrosamine (DEN) has been proved to have carcinogenic potential in the initiation or promotion stage and the transformed cells proliferate to form preneoplastic nodules which are positive for placental form of glutathione S-transferase (GST-P). E-Cadherin, a member of the cadherin family, is expressed in epithelial cells. To evaluate the role of adhesion molecules (E-Cadherin, alpha-catenin, and beta-catenin), which have not been well understood in carcinogenesis, we investigated the changes of E-cadherin, alpha-Catenin and beta-Catenins by immunohistochemistry and immunoblotting in DEN-induced hepatocarcinogenesis of rat liver. In addition, the sequential analysis of histopathology and the expression of GST-P were also examined. Immunoreactive areas for GST-P were gradually increased from early period of carcinogenesis and strong GST-P positive foci were noted in various lesions, especially in the clear cell and eosinophilic cell nodules. Immunohistochemically, the E-Cadherin expression was increased in DEN-treated preneoplastic nodules in 4 and 10 weeks and hepatocellular carcinomas displayed relatively reduced expression compared with the hyperplastic nodules. But alpha- and beta-catenin expression was increased in hyperplastic nodules and hepatocellular carcinomas. Immunoblotting studies revealed that the level of alpha-catenin (cytosol and membranous fraction) was overexpressed in hyperplastic nodules as well as hepatocellular carcinomas, which showed markedly increased expression. The membranous fraction of beta-catenin was markedly increased in 10 weeks of DEN treatment and slightly reduced in hepatocellular carcinomas. These findings suggest that during DEN-induced hepatocarcinogenesis, the clear cell and eosinophilic cell nodules expressing GST-P in their cytoplasm are early transformed cell nodules. The altered expression of E-Cadherin and catenins is closely related with tumor propagation. Loss or reduced expression of E-cadherin may play a role in the progression of late hyperplastic nodule to hepatocellular carcinoma in DEN-induced rat hepato carcinogenesis.
alpha Catenin
;
Animals
;
beta Catenin
;
Cadherins*
;
Carcinogenesis
;
Carcinoma, Hepatocellular
;
Catenins*
;
Cytoplasm
;
Eosinophils
;
Epithelial Cells
;
Glutathione Transferase*
;
Glutathione*
;
Humans
;
Immunoblotting
;
Immunohistochemistry
;
Liver*
;
Rats*
6.Esophagus, Stomach & Intestine; One Case of Early Gastric Stump Cancer Following Partial Gastrectomy for Gastroptosis.
Joong Won PARK ; Byung Chul YOO ; Sil Moo PARK ; Jae Gyu KIM ; Jae Hyuk DO ; Cheol Heang HEO ; Chul MUN ; Kyung Kum YOO ; Hyung Joon KIM ; Sae Kyoung CHANG ; Jae Hyung YOO
Korean Journal of Gastrointestinal Endoscopy 1997;17(2):173-180
Gastric stump cancer is defined as cancers that develop in the gastric remnant after the gastric resection of nonmalignant lesions or malignant lesions. The interval between gastrectomy and the detection of gastric stump cancer must be over 5 years in nonmaligant lesions and 10 years in malignant lesions. Symptoms of gastric stump cancer are not specific, so, diagnosis is often delayed. Early detection and curative operation is very important in gasric stump cancer and follow-up endoscopic examination is the most importaint diagnostic tool to detect gastric stump cancer. Recently we experienced a case of early gastric stump cancer. We report review of the literature to remind the important of gastric stump cancer and the important of follow-up endoscopic examination.
Diagnosis
;
Esophagus*
;
Follow-Up Studies
;
Gastrectomy*
;
Gastric Stump*
;
Intestines*
;
Stomach*
7.Correlation of Expression of E-Cadherin, alpha-Catenin, beta-Catenin, and Clinicopathologic Parameters in Colorectal Adenocarcinomas.
Hyoung Joong KIM ; Tae Jin LEE ; Eon Sub PARK ; Jae Hyung YOO
Korean Journal of Pathology 2000;34(4):264-272
The E-cadherin, alpha-catenin, and beta-catenin expressions were immunohistochemically investigated in paraffin-embedded materials of 80 cases of colorectal adenocarcinomas. The staining similar to normal colorectal mucosa with preserved strong membranous staining pattern was considered normal or preserved expression. The X2 test was used to analyse the statistical correlation of cadherin/catenin expression with clinicopathologic parameters and the Breslow test for the correlation with survival length. Normal colorectal mucosa showed strong membranous expression of cadherin/catenin complex. The reduced E-cadherin, alpha-catenin, and beta-catenin expression were found in 53/80 (66.3%), 46/80 (57.5%), and 44/80 (55.5%) cases of colorectal cancers examined, respectively. There were significant correlations between E- cadherin and alpha -catenin (p=0.035), and between alpha-catenin and beta-catenin (p=0.013). The reduced E-cadherin expression was associated with histologic dedifferentiation, tumor depth, lymph node metastasis, clinical stage (p<0.05), poor clinical outcome in stage II (p=0.016) and the reduced alpha-catenin expression with lymph node metastasis and clinical stage (p<0.05). Reduced expression of two or more proteins was correlated with lymph node matastasis, histologic dedifferentiation, clinical stage, and survival (p<0.05). The present study demonstrates a significant down-regulation of E-cadherin and alpha-catenin expression in colorectal cancer is associated with tumor invasiveness, histologic dedifferentiation, lymph node metastasis, and clinical stage. These results suggest that E-cadherin and alpha-catenin may be useful markers of invasiveness, lymph node metastatic potential, and clinical stage and of value as prognostic markers in the earlier stage. Further studies are needed to confirm the prognostic value of these cadherin/catenin complex.
Adenocarcinoma*
;
alpha Catenin*
;
beta Catenin*
;
Cadherins*
;
Colorectal Neoplasms
;
Down-Regulation
;
Lymph Nodes
;
Mucous Membrane
;
Neoplasm Metastasis
8.Intraocular Pressure Changes After Gas Tamponade.
Ha Kyoung KIM ; Jae In YOO ; Hyung Chan KIM
Journal of the Korean Ophthalmological Society 1989;30(5):741-744
100% sulfur hexafluoride(SF6) was injected into the vitreous cavity of nonvitrectomized retinal detachment patients. A total of 0.5ml of gas was injected with a single shot in 3 eyes or two 0.25ml in 3 eyes without lowering of intraocular pressure. And in 3 eyes, single shot of 0.5ml of gas was used after lowering of intraocular pressure. The changes of intraocular pressure were monitored at 5 minute intervals for 60 minutes and at one hour intervals for 8 hours after injection. Marked elevation of intraocular pressure was noted in both single shot group, but the elevation of intraocular pressure of double shot group was much smaller. But in all groups, the intraocular pressures were returned to under 30mmHg within 20 minutes and no re-elevation of intraocular pressure was noted in all cases after initial return to normal. In a case with two 0.3ml shots, the highest pressure was 49mmHg and with 0.35ml shots, the highest pressure was 78mmHg. So the effect of SF6 on intraocular pressure seemed to be negligible so long as the injection volume was limited to 0.5ml or less in single shot; and 0.6ml in double shots.
Humans
;
Intraocular Pressure*
;
Retinal Detachment
;
Sulfur
9.Trismus casued by inverse activity of masticatory muscles.
Byung Ho CHOI ; Jae Ha YOO ; Hyung Jun KIM ; Jeong Mee PARK ; Ueon Woo RAH
Journal of the Korean Association of Oral and Maxillofacial Surgeons 1993;19(3):385-388
No abstract available.
Masticatory Muscles*
;
Trismus*
10.Renomedullary Interstitial Cell Tumor.
Eon Sub PARK ; Mi Kyung KIM ; Jae Hyung YOO ; Kye Yong SONG
Korean Journal of Pathology 1989;23(3):371-373
We present an ultrastructure of an incidentally found renomedullary interstitial tumor also called as medullary fibroma in a 77 year-old female who had a metastatic adenocarcinoma of colon to the ureter. This tumor was a small and grayish white nodule in renal medulla, measuring 0.4 x 0.4 cm. Microscopically the tumor composed of spindle cells, with some vacuolation and intercellular collagen fibers. The electron microscopic observation of the spindle cells reveal that nuclei are spindle to oval shape and cytoplasm contain abundant rough endoplasmic reticulum, polyribosome without microfilaments and cisterna like structures supporting that the renomedullary interstitial cell tumor is renal interstitial cell origin than fibroblasts.
Female
;
Humans
;
Adenocarcinoma
;
Neoplasm Metastasis