Holoprosencephaly is a rare and complex malformation affecting the cleavage of the developing forebrain and is usually associated with defects of the mid Face. We have experienced a case of holoprosencephaly, diagnosed prenatally by ultrasound examination at 31 weeks of pregnancy in a 31-year-old primigravida woman. This case is characterized by holoprosencephaly, cleft palate, cleft lip, left renal aplasia and right renal hypertrophy. The chromosomal study showed a deletion of the long arm of chromosome 7, 46, XX, del(7)(q32), We report with a terminal deletion of chromosome 7q associated with atypical clinical picture and holoprosencephaly.
Adult ; Arm ; Chromosome Aberrations* ; Chromosomes, Human, Pair 7 ; Cleft Lip ; Cleft Palate ; Female ; Holoprosencephaly ; Humans ; Hypertrophy ; Multicystic Dysplastic Kidney* ; Pregnancy ; Prosencephalon ; Ultrasonography

No abstract available.

Takayasu's arteritis is an arteritis of undetermined etiology, which affects the aorta, the proximal portions of its major branches, and the pulmonary arteries, and causes coarctation, occlusion, or aneurysmal dilatation of the affected vessels. Authors has reported 9 cases in 1973, and another 24 cases in 1977. Thereafter, during next 4 years, authors experienced another 42 cases and obtained some additional results. The results are as follows: 1. Among 75 cases, 10 are male and 65 female patients with sex ratio of 1:6.5, and about 2/3 of total patients are under 30 years of age. 2. Headache, dizziness, absent or weak radial pulse and hypertension are the most common symptoms and signs. 3. Conventional chest roentgenography may be helpful but not specific in diagnosis of Takayasu's arteritis. 4. The aortographic findings are characteristic and pathognomonic in diagnosis of Takayasu's arteritis. In our series, the most common findings are stenosis or occlusion of subclavian artery, diffuse narrowing and aneurysmal dilatation of abdominal aorta and its branches, narrowing with irregular contour of descending thoracic aorta, and renal artery involvement. 5. Involvement of the aorta was classified as extensive type in 38 cases, descending thoracic and abdominal type in 22 cases and arch type in 15 cases. 6. As total aortography in cluding abdominal aorta uncovers evidence of unsuspected involvement of aorta and its branches, it is of paramount importance in the diagnosis of Takayasu's arteritis.
Aneurysm ; Aorta ; Aorta, Abdominal ; Aorta, Thoracic ; Aortography ; Arteritis ; Constriction, Pathologic ; Diagnosis ; Dilatation ; Dizziness ; Female ; Headache ; Humans ; Hypertension ; Male ; Pulmonary Artery ; Radiography ; Renal Artery ; Sex Ratio ; Subclavian Artery ; Takayasu Arteritis* ; Thorax

A 42-year old man was admitted for treatment of a fracture of the medial condyle of the left femur. After 10 days of cast immbilization of the above mentioned extremity, erythematous papulo-vesicular eruption was noted under the external splintage. We concluded that this was an unusual allergic contact dermatitis which is caused by CaSO4.1/2H20, and proved it by patch test in our clinic.
Calcium Sulfate ; Dermatitis, Allergic Contact ; Extremities ; Femur ; Patch Tests

Percutaneous transhepatic biliary drainage was successfully made 20 times on 17 patients of obstructivejaundice for recent 1 year since June 1981 at department of radiology in Seoul National University Hospital. Thecauses of obstructive jaundice was CBD Ca in 13 cases, metastasis in 2 cases, pancreatic cancer in 1 case and CBDstone in 1 case. Percutaneous transhepatic biliary drainage is a relatively easy, safe and effective method whichcan be done after PTC by radiologist. It is expected that percutaneous transhepatic biliary drainage should bedone as an essential procedure for transient or permanent palliation of obstructive jaundice.
Drainage ; Humans ; Jaundice, Obstructive ; Methods ; Neoplasm Metastasis ; Pancreatic Neoplasms ; Seoul

OBJECTIVE AND METHODS: To determine correlations among ambulatory renin activity, ambulatory blood pressure and microalbumin excretion rate, 66 Korean essential hypertensives were studied after 4 week wash-out period. The ambulatory blood pressure was monitored every 30 minutes and mean BP were calculated automatically. Urinary microalbumin excretion rate(UAER) and ambulatory plasma renin activity(aPRA) collected at mid-day were measured by radioimmunoassays. Subjectives were divided into 2 groups by aPRA value(2ng/ml/hr). RESULT: 14 cases were high renin group and 52 cases low renin group. The mean BP were 148.83/94.69mmHg in low renin group, and 146.57/98.07mmHg in high-renin group without difference. UAER were not different also between both groups. 23.07%(4/14) of non-dippers were included in high renin group and 25.58%(12/52) in low renin group without statistical difference. The aPRA was significantly related to UAER and systolic and diastolic mean blood pressure. Also UAER was related significantly to day mean blood pressures. CONCLUSION: Thus aPRA is thought to be a meaningful indicator to predict hypertensive renal target organ damage as well as blood pressure measured with 24-hr ABPM.
Blood Pressure* ; Hypertension* ; Plasma* ; Radioimmunoassay ; Renin*

No abstract available.
Fibroblasts* ; Skin*

About 40% of patients with diabetes mellitus develops to diabetic nephropathy, and these patients show increment of glomerular filtration rate and renal volume at early phase. 99mTc-DMSA SPECT (single photon emission computed tomography) can measure a functional renal volume because 99mTc- DMSA it is taken up by the viable proximal tubular cells located in the renal cortex. To evaluate the renal volume in early diabetic nephropathy, we compared functional renal volume between diabetic patients and control, renal transplantation donor. 99mTc-DMSA was injected intravenously and SPECT was done after 2 hours in 15 diabetic patients, 18 renal transplantation donors, and 2 patients with end stage renal disease due to chronic glomerulonephritis. In diabetic patients with creatinine clearance more than 30ml/min and proteinuria, right and left renal volume were 247+/-22ml/BSA(m2), 256+/-37ml/BSA (m2), which were greater than those of diabetic patients with normal renal function and without proteinuria, or renal transplantation donors(P<0.05). In conclusion, we measured the functional renal volume by 99mTc-DMSA SPECT. Renal volume of diabetic patients with proteinuria were larger than the volume of control group or diabetic patients with normal renal function and without proteinuria. 99mTc-DMSA SPECT was thought to be useful test a for the measurement of functioning renal volume.
Creatinine ; Diabetes Mellitus* ; Diabetic Nephropathies ; Glomerular Filtration Rate ; Glomerulonephritis ; Humans ; Kidney Failure, Chronic ; Kidney Transplantation ; Proteinuria ; Succimer ; Technetium Tc 99m Dimercaptosuccinic Acid* ; Tissue Donors ; Tomography, Emission-Computed, Single-Photon*

This study aimed to evaluate the appropriateness of cataract surgery and identify the characteristics of patients and surgeons, clinical and functional outcomes, and surgical methods associated with appropriate cataract surgery. For this purpose, Korean cases of cataract surgery were rated as either 'necessity', 'appropriate', 'uncertain' or 'inappropriate', based on RAND/UCLA Ratings. For this assessment, the cases of 222 patients who underwent cataract surgery, on either one or both eyes, were studied. The surgeries were performed by 20 ophthalmologists practicing at one of fourteen medical institutions (university hospitals and general hospitals). Patients were interviewed and clinical data collected. The Doctors were questioned with self-entered questionnaire forms. The medical records were also examined to gain an understanding of the surgical process. The ratings were as follows: 30.6% (68 patients) of surgeries belonged to the bracket "necessity", 46.4% (103 patients) to "appropriate", 15.3% (34 patients) to "uncertain" and 7.7% (17 patients) to "inappropriate". In this study, "necessity" and "appropriate" were defined as "appropriate" (77.0%, 171 patients), and "uncertain" and "inappropriate" as "inappropriate" (23.0%, 51 patients). The low preoperative Snellen visual acuity and visual function, advanced age and male patients were associated with appropriate surgery. It is concluded that appropriate surgery was related to the clinical and functional outcomes (visual acuity and visual function) and patient characteristics (age and male).
Aged ; Cataract Extraction/*standards/*utilization ; Female ; Human ; Male ; Middle Aged ; *Outcome Assessment (Health Care) ; Patient Satisfaction ; Questionnaires ; Unnecessary Procedures ; Visual Acuity

No abstract available.
Arthritis, Rheumatoid* ; Humans ; Neuroma*