No abstract available.
Animals ; In Situ Hybridization* ; Linoleic Acid* ; Mice*

For the purpose of ascertaining the status of physical growth and health status of the University students, an intensive survey was conducted by the authors towards a total of 1,250 (Male 792, Female 458) who passed the written entrance examination at the Kyung Hee University in 1972. The items included the measurements on physical growth, various physical and nutritional indices, status of visual distourbance, dental status and tuberculosis. The findings and results can be summarized as follows ; 1. Physical Growth and Development. i) The average of body height by anthropometric was 169.39+/-5.05cm in male and 157.45+/-4.43cm in female. ii) The averages of body weight by sex were 59.42+/-6.47Kg and 51.81+/-5.21Kg, respectively. iii) The averages of chest-girth were 87.18+/-5.30cm and 80.51+/-4.53cm. iv) The averages of sitting-height were 92.21+/-2.79cm and 86.28+/-2.57cm. In all cases the male measurements were higher than female. 2. Various ludices about Physical Growth and Development; i) Relative body weight by sex were 35.08and 32.91, relative chestgirth 51.47 and 51.13, and relative sitting-height 54.43, 54.79, respectively. ii) Rohrer index was 1.222 in males and 1.327 in females, Kaup index 2.071 and 2.089, Verveck index 86.54 and 84.04, and Pelidisi index 91.15 and 93.08, respectively. 3. Status of visual distourbance. The vision of the students under 0.8 with Landolt's testing chart was 45.4% in left eye and 46.6% in right eye (male : 44.4% and 45.7%, female : 47.2% and 48.0%), while under 0.6in both visions was 41.0% and 40.5% (male 40.8% and 40.7%, female : 41.5% and 40.2%),respectively. 4. Dental Status. Out of total 19.4% (male 19.2%, female 19.6%) had gingivitis, the female incidence rate of gingivitis was higher than male. Average number of teeth in each subjects was 29.6 teeth; male had 29.9 teeth and female had 29.1 teeth. The caries rate was 78.9%(male 75.6%, female 84.5%), the female caries rate was higher than male. The average number of i) Caries per tooth rate was 8.5% in male and 9.2% in female, ii) Missing per tooth rate was 0.3% and 0.2%, iii) Filling per tooth rate was 3.9% and 4.2%, in all cases, the female incidences were higher than the male. The average number of D.M.F. was 3.8 teeth in male and 4.0 teeth in female, female was higher than male. The average rate of D.M.F. was 12.7% in male and 13.7 in female, female was higher than male. 5. Pulmonary infiltration. Among the total, 53 students were diagnosed as pulmonary infiltration (tuberculosis), of whom 51 were minimal cases, one were moderately advanced case and one were far advanced case.
Body Height ; Body Weight ; Female ; Gingivitis ; Growth and Development ; Humans ; Incidence ; Male ; Nutrition Assessment ; Tooth ; Tuberculosis

For the purpose of ascertaining the status of physical growth and health status of the University students, an intensive survey was conducted by the authors towards a total of 1,250 (Male 792, Female 458) who passed the written entrance examination at the Kyung Hee University in 1972. The items included the measurements on physical growth, various physical and nutritional indices, status of visual distourbance, dental status and tuberculosis. The findings and results can be summarized as follows ; 1. Physical Growth and Development. i) The average of body height by anthropometric was 169.39+/-5.05cm in male and 157.45+/-4.43cm in female. ii) The averages of body weight by sex were 59.42+/-6.47Kg and 51.81+/-5.21Kg, respectively. iii) The averages of chest-girth were 87.18+/-5.30cm and 80.51+/-4.53cm. iv) The averages of sitting-height were 92.21+/-2.79cm and 86.28+/-2.57cm. In all cases the male measurements were higher than female. 2. Various ludices about Physical Growth and Development; i) Relative body weight by sex were 35.08and 32.91, relative chestgirth 51.47 and 51.13, and relative sitting-height 54.43, 54.79, respectively. ii) Rohrer index was 1.222 in males and 1.327 in females, Kaup index 2.071 and 2.089, Verveck index 86.54 and 84.04, and Pelidisi index 91.15 and 93.08, respectively. 3. Status of visual distourbance. The vision of the students under 0.8 with Landolt's testing chart was 45.4% in left eye and 46.6% in right eye (male : 44.4% and 45.7%, female : 47.2% and 48.0%), while under 0.6in both visions was 41.0% and 40.5% (male 40.8% and 40.7%, female : 41.5% and 40.2%),respectively. 4. Dental Status. Out of total 19.4% (male 19.2%, female 19.6%) had gingivitis, the female incidence rate of gingivitis was higher than male. Average number of teeth in each subjects was 29.6 teeth; male had 29.9 teeth and female had 29.1 teeth. The caries rate was 78.9%(male 75.6%, female 84.5%), the female caries rate was higher than male. The average number of i) Caries per tooth rate was 8.5% in male and 9.2% in female, ii) Missing per tooth rate was 0.3% and 0.2%, iii) Filling per tooth rate was 3.9% and 4.2%, in all cases, the female incidences were higher than the male. The average number of D.M.F. was 3.8 teeth in male and 4.0 teeth in female, female was higher than male. The average rate of D.M.F. was 12.7% in male and 13.7 in female, female was higher than male. 5. Pulmonary infiltration. Among the total, 53 students were diagnosed as pulmonary infiltration (tuberculosis), of whom 51 were minimal cases, one were moderately advanced case and one were far advanced case.
Body Height ; Body Weight ; Female ; Gingivitis ; Growth and Development ; Humans ; Incidence ; Male ; Nutrition Assessment ; Tooth ; Tuberculosis

No abstract available.
Animals ; Carcinoma, Hepatocellular* ; Mice*

No abstract available.
Animals ; Mice* ; Plants, Medicinal* ; Sarcoma 180* ; Sarcoma*

To evaluate the role of postoperative pelvic radiation therapy in rectal cancer, a retrospective analysis was done on 189 patients with modified Astler-Coller stages B2+3, C1, and C2+3 who were treated from February 1979 to June 1986. Forty-seven patients were staged as B2+3, 17 as C1, and 125 as C2+3. As a curative resection, 41 received low anterior resection, 143 received abdomino-perineal resection, and five received pelvic exenteration. The survival and disease-free survival rates of the total patients at five year were 45.3% and 44.1%, respectively. The stage was an important prognostic factor for survival and disease-free survival: the survival rates at five year were 55.7% in B2+3, 65.7% in C1, and 36.4% in C2+3, respectively (p<0.01). The liver was the most frequently involved organ of recurrence followed by the lung and the perineum. The patients who received low anterior resection achieved better disease-free survival but were more prone to late radiation bowel morbidities than those who received abdominoperineal resection. Postoperative pelvic radiation therapy proved to be effective in locoregional disease control but did not prevent the appearance of distant metastasis, which was of major concern in advanced stages. Patterns of treatment failure, and factors relating to radiation morbidity are discussed, and therapeutic options for better results are proposed.
Disease-Free Survival ; Humans ; Liver ; Lung ; Neoplasm Metastasis ; Pelvic Exenteration ; Perineum ; Rectal Neoplasms* ; Recurrence ; Retrospective Studies ; Survival Rate ; Treatment Failure

5-fluorouracil(5-FU) and its derivatives have been prescribed preoperatively in Korea for oral administration to patients with gastric cancer as an adjuvant therapy. Since the conditions of the patients after gastrectomy may be different and thereby influence the absorption of 5-fluorouracil, we were interested in the pharmacokinetic changes of 5-fluorouracil absorption after gastric resection. Fourteen of 40 gastric cancer patients, who underwent radical subtotal gastrectomy with D2 lymphnode dissection for gastric cancer, were selected at Ewha Womans University Mok-Dong Hospital from May 1996 to December 1996. The plasma concentrations of 5-fluorouracil were determined before oral administration of 5-FU(500 mg/M2) at 15-min intervals for two hours, and then at 30-min intervals for two hours after oral administration during the pre- and the post-operative periods. High pressure liquid chromatography was used to determine the plasma concentrations of 5-FU. The pharmacokinetic indices included the area under the curve (AUC), the peak concentration (Cmax), and the time to peak concentration (Tmax). The mean postoperative AUC for 5-FU was 25.8+/-14.8% of the mean preoperative AUC, which was a significant decrease in the amount of 5-FU absorption postoperatively. The mean postoperative Cmax was 33.4+/-30.2% of the mean preoperative Cmax, which also meant a significant decrease of the peak concentration postoperatively. The Tmax of most patients were delayed postoperatively, but there was no significant change statistically. In conclusion, we found that the amount of absorbed 5-FU, as calculated by the AUC and the Cmax, significantly decreased after a subtotal gastrectomy by as much as 75 percent compared to the preoperation. Hence, it may be necessary to increase the dose of 5-FU after a subtotal gastrectomy by more than 75% of the preoperative dose. The subtotal gastrectomy did not have a significant effect on the absorptive velocity of 5-FU.
Absorption* ; Administration, Oral ; Area Under Curve ; Chromatography, Liquid ; Female ; Fluorouracil* ; Gastrectomy* ; Humans ; Korea ; Pharmacokinetics ; Plasma ; Stomach Neoplasms

5-fluorouracil(5-FU) and its derivatives have been prescribed preoperatively in Korea for oral administration to patients with gastric cancer as an adjuvant therapy. Since the conditions of the patients after gastrectomy may be different and thereby influence the absorption of 5-fluorouracil, we were interested in the pharmacokinetic changes of 5-fluorouracil absorption after gastric resection. Fourteen of 40 gastric cancer patients, who underwent radical subtotal gastrectomy with D2 lymphnode dissection for gastric cancer, were selected at Ewha Womans University Mok-Dong Hospital from May 1996 to December 1996. The plasma concentrations of 5-fluorouracil were determined before oral administration of 5-FU(500 mg/M2) at 15-min intervals for two hours, and then at 30-min intervals for two hours after oral administration during the pre- and the post-operative periods. High pressure liquid chromatography was used to determine the plasma concentrations of 5-FU. The pharmacokinetic indices included the area under the curve (AUC), the peak concentration (Cmax), and the time to peak concentration (Tmax). The mean postoperative AUC for 5-FU was 25.8+/-14.8% of the mean preoperative AUC, which was a significant decrease in the amount of 5-FU absorption postoperatively. The mean postoperative Cmax was 33.4+/-30.2% of the mean preoperative Cmax, which also meant a significant decrease of the peak concentration postoperatively. The Tmax of most patients were delayed postoperatively, but there was no significant change statistically. In conclusion, we found that the amount of absorbed 5-FU, as calculated by the AUC and the Cmax, significantly decreased after a subtotal gastrectomy by as much as 75 percent compared to the preoperation. Hence, it may be necessary to increase the dose of 5-FU after a subtotal gastrectomy by more than 75% of the preoperative dose. The subtotal gastrectomy did not have a significant effect on the absorptive velocity of 5-FU.
Absorption* ; Administration, Oral ; Area Under Curve ; Chromatography, Liquid ; Female ; Fluorouracil* ; Gastrectomy* ; Humans ; Korea ; Pharmacokinetics ; Plasma ; Stomach Neoplasms

Total of 53 patients of unresectable and recurrent rectal cancer treated with neutron beam during the period from Oct. 1987 to Apr. 1992 were analyzed. Dose fractionation for the neutron only group was 1.5 Gy per fraction, 3 fraction per week, 21 Gy/41/2 wks for 42 patients out of 53(76%). Neutron only but modified fractionation schedule (10% more or less of total dose) was applied for 9 patients, and mixed team (neutron boost) was for 4 patients. Complete tumor response was obtained in 40 patients(76% response rate). Local control rate was 28 out of 53(53%). Statistically significant better prognostic factors for local control were age below 49 years old (15/22, 68%) than above 50 years old (13/31, 42%), male (20/32, 63%) than female(8/21, 38%), tumor size less than 5 cm and non-metastatic(16/24, 67%) than size more than 5 cm or metastatic(12/29, 4l%). Major complication had developed in 7 patients (13%). Two year overall survival rate by Kaplan-Meier method was 30%, but it was rised to, 47% when the tumor was less than 5cm non-metastatic.
Appointments and Schedules ; Dose Fractionation ; Humans ; Male ; Middle Aged ; Neutrons* ; Rectal Neoplasms* ; Survival Rate

Contrast-induced encephalopathy after cerebral angiography is a rare complication and until now, only few cases have been reported. This paper reports on contras-induced encephalopathy mimicking meningoencephalitis after cerebral angiography by using iodixanol, an iso-osmolar non-ionic contrast agent. A 58-year-old woman underwent cerebral angiography for the evaluation of multiple intracranial aneurysms. A few hours later, she had persistent headache, vomiting, fever, and seizures. Brain computed tomography (CT) showed sulcal obliteration of right cerebral hemisphere and cerebrospinal fluid profile was unremarkable. The next day, she developed left side hemiparesis, sensory loss, and left-sided neglect with drowsy mentality. Brain magnetic resonance imaging (MRI) showed cerebral swelling with leptomeningeal enhancement in the right parieto-occipital lobe without sign of ischemia or hemorrhage. The patient was managed with intravenous dexamethasone, mannitol and anticonvulsant. There was a progressive neurological improvement with complete resolution of the symptoms at day 6. This observation highlights that contrast-induced encephalopathy can be caused by an iso-osmolar non-ionic contrast agent. This rare entity should be suspected if neurologic deterioration after cerebral angiography is not explained by other frequent causes such as acute infarction or hemorrhage.
Angiography ; Brain ; Brain Diseases* ; Cerebral Angiography* ; Cerebrospinal Fluid ; Cerebrum ; Dexamethasone ; Female ; Fever ; Headache ; Hemorrhage ; Humans ; Infarction ; Intracranial Aneurysm ; Ischemia ; Magnetic Resonance Imaging ; Mannitol ; Meningoencephalitis ; Middle Aged ; Paresis ; Seizures ; Vomiting