1.Antinociceptive Effects of the Essential Oil of Ocimum Basilicum in Mice.
Sun Seek MIN ; Seung Ho HAN ; Jaeyong YEE ; Chan KIM ; Geun Hee SEOL ; Jae Hyeung IM ; Hyung Tae KIM ; Kyu Chang LEE ; Hye Young KIM ; Myeong Jong LEE
The Korean Journal of Pain 2009;22(3):206-209
BACKGROUND: The essential oil of Ocimum basilicum (EOOB) has a pleasant aroma and is known to have antimicrobial and insecticidal activities. In addition, it is used as a pain reliever in folk medicine. However, there are few reports on the antinociceptive activities of EOOB. METHODS: This study examined the antinociceptive effects of EOOB using formalin and a plantar test in mice. In the formalin test, EOOB (50 mg/kg, 100 mg/kg, 150 mg/kg) was administered intraperitoneally and the licking time of the mice was measured. In the plantar test, intraperitoneal EOOB (50 mg/kg, 100 mg/kg) was administered and the withdrawal latency was measured using the Hargreaves method. RESULTS: In the formalin test, EOOB (50 mg/kg, IP) showed significant decreases in licking time in the second phase. On the other hand, in the plantar test, there were no significant effects in any of the groups examined. CONCLUSIONS: These results support the traditional use of EOOB for the treatment of painful conditions. However, there is a need for more research to determine the active chemical constituents and the precise mechanism.
Animals
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Formaldehyde
;
Hand
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Medicine, Traditional
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Mice
;
Ocimum
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Ocimum basilicum
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Pain Measurement