2.Adenovirus-mediated mGM-CSF in vivo Gene Transfer Inhibits Tumor Growth.
Sang Hyeon KIM ; Kwang Sun SUH ; See Young CHOI ; Jae Rang RHO ; Jin Sang YOO
Journal of the Korean Society of Virology 2000;30(2):141-150
No Abstract Available.
4.Perimpullary Carcinoma: A Study on Prognostic Factors Influencing long Term Survival After Pancreaticoduodenectomy.
Jae Beom SONG ; Kyoung Hyeon CHOI ; Sung Do LEE
Journal of the Korean Surgical Society 1997;52(1):100-106
From November 1987 to December 1995, 76 patients with periampullary cancer underwent resectional surgery in the department of surgery, Kosin medical college. The object of this study was to assess the prognostic factors of the periampullary cancer after pancreaticoduodenectomy. The postoperative mortality rate was 11.8%. Significant morbidity occurred in 39.5% of the patients, early reoperation was required in 9.2% of these patients, and the mean hospital stay was 21.7 days. Univariate analysis on all patients revealed that the survival rate was significantly related to the size of the tumor (> or =3.0 cm 13%, <3.0 cm 41.4%; p<0.05), lymph node status (invasion 8.7%, no invasion 31.8%; p<0.05) and the age of the patient (>50 20.5%, < or =50 34.5%; p<0.05). The site was less significant(distal CBD 27%, ampulla of Vater 16.7%, pancreas 9%, duodenum 2%; p>0.05). These results indicated that patients with a tumor size lesser than 3cm, without lymph node involvement, and under the age of 50 had a long term survival rate.
Ampulla of Vater
;
Duodenum
;
Humans
;
Length of Stay
;
Lymph Nodes
;
Mortality
;
Pancreas
;
Pancreaticoduodenectomy*
;
Reoperation
;
Survival Rate
5.Rediscovery of Seven Long-Forgotten Species of Peronospora and Plasmopara (Oomycota)
Jae Sung LEE ; Hyeon-Dong SHIN ; Young-Joon CHOI
Mycobiology 2020;48(5):331-340
The family Peronosporaceae, an obligate biotrophic group of Oomycota, causes downy mildew disease on many cultivated and ornamental plants such as beet, cucumber, grape, onion, rose, spinach, and sunflower. To investigate the diversity of Peronosporaceae species in Korea, we performed morphological analysis for dried plant herbariums with downy mildew infections by two largest genera, Peronospora and Plasmopara. As a result, it was confirmed that there are five species of Peronospora and two species of Plasmopara, which have been so far unrecorded in Korea, as well as rarely known in the world; Pl. angustiterminalis (ex Xanthium strumarium), Pl. siegesbeckiae (ex Siegesbeckia glabrescens), P. chenopodii-ambrosioidis (ex Chenopodium ambrosioides), P. chenopodii-ficifolii (ex Chenopodium ficifolium), P. clinopodii (ex Clinopodium cf. vulgare), P. elsholtziae (ex Elsholtzia ciliata), and P. lathyrina (ex Lathyrus japonicus). In addition, their phylogenetic relationship was inferred by molecular sequence analysis of ITS, LSU rDNA, and cox2 mtDNA. By rediscovering the seven missing species and barcoding their DNA sequences, this study provides valuable insights into the diversity and evolutionary studies of downy mildew pathogens.
6.Clinical Manifestations of Invasive Infections due to Streptococcus pyogenes in Children.
Nuri YANG ; Hyeon Seung LEE ; Jae Hong CHOI ; Eun Young CHO ; Eun Hwa CHOI ; Hoan Jong LEE ; Hyunju LEE
Korean Journal of Pediatric Infectious Diseases 2014;21(2):129-138
PURPOSE: Streptococcus pyogenes is an important cause of invasive diseases in children. We aimed to describe the clinical characteristics of invasive infections due to S. pyogenes in children in Korea. METHODS: A retrospective study of children under 18 years of age with invasive infections due to S. pyogenes at Seoul National University Children's Hospital between March 1992 and December 2012, and Seoul National University Bundang Hospital between March 2003 and December 2012 was conducted. Demographic factors, clinical characteristics, laboratory findings, treatment, mortality and morbidity of all patients were reviewed. RESULTS: A total of 30 among 36 cases identified as invasive disease due to S. pyogenes were available for review. There was a predominance for male subjects (male:female=2.75:1). The median age was 50 months (range 12 days to 15 years) and 53.3% were under 5 years of age. Skin and soft tissue infections (9/30, 30.0%), bacteremia without identified focus (4/30, 13.3%) and bone and joint infections (6/30, 20.0%) were the most frequent clinical presentations. Streptococcal toxic shock syndrome (3/30, 10.0%) pulmonary, abdomen and central nervous system infections (2/30, 6.7%) were also seen. There was a peak in number of patients in year 2012 (9/30, 30.0%). There were no cases of mortality. Erythromycin and clindamycin resistance rates were low by 3.8% and 7.5%, respectively. CONCLUSION: We studied the clinical presentations of invasive infections due to S. pyogenes during the past 20 years in Korean children. The findings of this study help us understand the characteristics of the disease, enhancing early recognition and prompting adequate antibiotic therapy which is important in reducing morbidity and mortality.
Abdomen
;
Bacteremia
;
Bacterial Infections
;
Central Nervous System Infections
;
Child*
;
Clindamycin
;
Demography
;
Erythromycin
;
Humans
;
Joints
;
Korea
;
Male
;
Mortality
;
Retrospective Studies
;
Seoul
;
Shock, Septic
;
Skin
;
Soft Tissue Infections
;
Streptococcus pyogenes*
7.Clinical studies of 12 cases on alport's syndrome.
Joon Soo LEE ; Im Jae PARK ; Ki Soo PAI ; Jae Seung LEE ; Pyung Kil KIM ; Yoon Jung CHOI ; Hyeon Joo JEONG ; In Joon CHOI
Korean Journal of Nephrology 1993;12(3):440-451
No abstract available.
Nephritis, Hereditary*
8.A Case of Lipoid Pneumonia Associated with Silicon Oil Injection into Breast.
Jae Hyeon CHOI ; Mi Kyoung KIM ; Jae Geun PARK ; Yong Kun PARK ; Kang Hyeon CHOI ; Ki Man LEE ; Jin Young AN
Tuberculosis and Respiratory Diseases 2010;69(4):288-292
Exogenous lipoid pneumonia occurs rarely in healthy people. In most cases, exogenous lipoid pneumonia is usually caused by aspiration of mineral, vegetable, or animal oil. We report the case of 42-year-old woman, who have experienced lipoid pneumonia after silicon injection into her breast for cosmetic purposes. The patient experienced fever, dyspnea, sputum, and hemoptysis after silicon injection into her breast. Chest computed tomography demonstrated non-segmental distribution of bilateral consolidation in both lung fields. A transbronchial lung biopsy specimen shows foamy microphages in alveolar spaces. Papanicolaous staining of bronchoalveolar lavage fluid showed abundant foamy marcrophages and many neutrophils. With these results, we confirmed lipoid pneumonia was associated with silicon oil injection into breast.
Adult
;
Animals
;
Biopsy
;
Breast
;
Bronchoalveolar Lavage Fluid
;
Cosmetics
;
Dyspnea
;
Female
;
Fever
;
Hemoptysis
;
Humans
;
Lung
;
Mammaplasty
;
Neutrophils
;
Pneumonia
;
Pneumonia, Lipid
;
Silicone Oils
;
Sputum
;
Thorax
;
Vegetables
9.Prognostic Factors in Childhood IgA Nephropathy.
Byoung Soo CHO ; Deog Yoon KIM ; Jae Hyun PARK ; Pyung Kil KIM ; Hyeon Joo JEONG ; In Joon CHOI
Journal of the Korean Society of Pediatric Nephrology 1997;1(1):17-23
The authors report series of 360 cases of transthoracic fine-needle aspiration cytology (TFNA) from Oct. 1982, through Aug. 1986 at the Seoul National University Hospital. A diagnosis of neoplastic lesion was established in 50.3% of the cases. A non-neop- lastic diagnosis was made in 38.5%, nondiagnostic one in 6.5% and inadequate one in 4.7% of the total. Statistical findings on cytological diagnoses were as follows. Specificity was 100%: sensitivity, 92%; predictive value for positive, 1.0: predictive value for negative, 0.9; concordance rate, 84.2%: diagnostic accuracy in non-neoplastic lesion, 65.4%, and typing accuracy in malignant tumor, 0.77.
Biopsy, Fine-Needle
;
Diagnosis
;
Glomerulonephritis, IGA*
;
Immunoglobulin A*
;
Sensitivity and Specificity
;
Seoul
10.Percutaneous Removal of Bladder Stones in Children.
Hwang CHOI ; Hyeon Hoe KIM ; Wun Jae KIM
Korean Journal of Urology 1986;27(3):429-432
Transurethral removal of bladder or urethral stones in children is not easy and open removal of the stone is required in many cases because the urethra in a child is narrow and adequate equipment is not available. In a 6-year old boy with multiple urinary stones who had underwent vesicolithotomy twice before, we tried percutaneous removal of the bladder stones using suprapubic trocar and adult cystourethroscope set. Nelaton catheter was used as a guide wire in Seldinger technique while switching the instruments through the suprapubic cystostomy tract. With the same technique we removed a urethral stone in a 5-year boy successfully."
Adult
;
Catheters
;
Child*
;
Cystostomy
;
Humans
;
Male
;
Surgical Instruments
;
Urethra
;
Urinary Bladder Calculi*
;
Urinary Bladder*
;
Urinary Calculi