1.A clinical study of the atlantoaxial instability.
Nam Hyun KIM ; Hwan Mo LEE ; Jae In AHN ; Yong Jae LIM
The Journal of the Korean Orthopaedic Association 1991;26(4):1188-1195
No abstract available.
2.Primary Malignant Fibrous Histiocytoma of the Liver: 2 Cases Report.
Hee Chul YU ; Sung Hoo JUNG ; Baik Hwan CHO ; Jae Chun KIM ; Nam Poo KANG
The Korean Journal of Hepatology 1999;5(3):240-245
The malignant fibrous histiocytoma (MFH) was first introduced in 1963 to refer to a group of soft-issue tumors characterized by a storiform or cartwheel-ike growth pattern and predominantly fibroblastic appearance. It was postulated that they were derived from histiocytes that could assume the appearance and function of fibroblasts. MFH has been recognized to be the most common sarcoma in the soft tissue of late adult life which involves the deep fascia or skeletal muscles of the extremities or retroperitoneum. It has been noted in other organs, however, it rarely arises in the liver. We report two cases of primary malignant fibrous histiocytoma of the liver histopathologically confirmed after surgical resection-storiform pleomorphic and myxoid subtypes in the 55 year old male and 49 year old female patients, respectively, and describes the clinical courses, characteristics and pathologic aspects with review of the related literatures.
Adult
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Extremities
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Fascia
;
Female
;
Fibroblasts
;
Histiocytes
;
Histiocytoma, Malignant Fibrous*
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Humans
;
Liver*
;
Male
;
Middle Aged
;
Muscle, Skeletal
;
Sarcoma
3.Regulation of Obesity and Non-alcoholic Fatty Liver Diseases by Modulation of the Gut Microbiota Through Inflammasome; its Mechanism and Potential for Clinical Use.
Journal of Bacteriology and Virology 2012;42(4):359-362
The revelation that gut microbes are associated with the pathogenesis of human diseases such as obesity, colon cancer, inflammatory bowel disease and liver-related diseases has resulted in the role of gut microbes becoming a novel research topic in basic and clinical science. Recently, emphasis has been placed on the role of gut microbes in non-alcoholic fatty liver disease (NAFLD) and its progressive form, non-alcoholic steatohepatitis (NASH). Researchers have suggested that inflammasome deficiency-changed dysbiosis is associated with exacerbating NAFLD/NASH progression. This particular study also showed a direct 'gut-liver axis' regulated by modulation of gut microbiota. This paper (Nature 2012;482: 179-185) was summarized herein and the potential clinical applications were discussed.
Colonic Neoplasms
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Fatty Liver
;
Humans
;
Inflammatory Bowel Diseases
;
Metagenome
;
Obesity
4.Infectobesity: a New Area for Microbiological and Virological Research.
Journal of Bacteriology and Virology 2011;41(2):65-76
Obesity is connected with numerous diseases, such as type 2 diabetes, atherosclerosis, cancer, and nervous system dysfunctions. Obesity is affected by genetic, environmental, and cultural factors. However, numerous studies indicate that several pathogens might cause obesity. This review discusses recent data and the characteristics of pathogens that are implicated in obesity. In particular, human adenovirus 36 (Ad36) is the most clearly implicated virus in human obesity. It was recently shown that obese groups from the USA, Korea, and Italy have a higher prevalence of serum antibodies against Ad36. The mechanisms of Ad36-induced obesity remain unclear. However, glucose uptake and inflammation are possible mechanisms of Ad36-induced obesity. Overall, this new understanding of causes of obesity has developed into the concept of 'infectobesity' and the possibility of developing a 'vaccine' or 'therapeutic agents' for obesity.
Adenoviruses, Human
;
Antibodies
;
Atherosclerosis
;
Glucose
;
Humans
;
Inflammation
;
Italy
;
Korea
;
Nervous System
;
Obesity
;
Prevalence
;
Viruses
5.Novel Role of Invariant Natural Killer T-cell in Glycemic Control: Regulation by human Adenovirus 36.
Journal of Bacteriology and Virology 2013;43(3):229-232
Obesity is associated with a state of chronic low-grade inflammation. This abnormal inflammation state may cause metabolic dysfunction. Many studies have supported the claim that immune cells such as adipose tissue macrophage and invariant natural killer T-cells (iNKT) are related to the development of metabolic diseases like diabetes. It has recently been reported that while human adenovirus 36 (Ad36) infection is associated with human obesity, it also helps to improve the serum level of lipid factors (glycemic control). However, the detailed cellular mechanism remains unclear. This study (The Journal of Clinical Investigation, 2012;122:3343-54) showed that iNKT cell-deficient mice on a low-fat diet used as a control for high-fat diet boasted insulin resistance phenotype without adipose tissue inflammation. The results of this study offer insight into the possibility of a novel role for iNKT related to the improvement of metabolic diseases, especially insulin resistance, and hint that Ad36-induced inflammation may be associated with iNKT in adipose tissue, while also playing a role in the improvement of glycemic control.
Adenoviruses, Human
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Adipose Tissue
;
Animals
;
Diet, Fat-Restricted
;
Diet, High-Fat
;
Humans
;
Inflammation
;
Insulin Resistance
;
Macrophages
;
Metabolic Diseases
;
Mice
;
Natural Killer T-Cells
;
Obesity
;
Phenotype
6.Is Obesity One of Physiological Factors which Exert Influenza Virus-induced Pathology and Vaccine Efficacy?.
Journal of Bacteriology and Virology 2014;44(3):226-235
Obesity has been considered a risk factor for infectious diseases including the influenza virus. Most epidemiological investigations indicated that obesity is connected to the severity of influenza, although there are some exceptions. Many studies using obese humans and animal models showed that immune response was impaired in the obese group, increasing susceptibility and severity of influenza virus. However, the exact mechanism by which obesity inhibits anti-viral immune response remains unknown. This review discusses current studies about the properties of immune cells in obesity. In obesity, the balance of adipokines is disrupted and the level of proinflammatory cytokine is increased compared with non-obese control. Moreover, macrophages induced systemic inflammation by secreting cytokines such as TNF-alpha and IL-6, antigen presenting capacity of dendritic cells was diminished which affect T cell responses, and influenza-specific antibody production seems reduced and decreased even faster after vaccination in obese mouse. The number of circulating T cells and proliferation of mitogen-stimulated T cells dropped and T cell memory was significantly low in influenza infected obese mouse. Therefore, obesity may be one of factors for disease progression in influenza virus infection and vaccine efficacy.
Adipokines
;
Animals
;
Antibody Formation
;
Communicable Diseases
;
Cytokines
;
Dendritic Cells
;
Disease Progression
;
Humans
;
Inflammation
;
Influenza Vaccines
;
Influenza, Human*
;
Interleukin-6
;
Leptin
;
Macrophages
;
Memory
;
Mice
;
Mice, Obese
;
Models, Animal
;
Obesity*
;
Orthomyxoviridae
;
Pathology*
;
Risk Factors
;
T-Lymphocytes
;
Tumor Necrosis Factor-alpha
;
Vaccination
7.Atypical Variant of Bullous Pemphigoid: Prolonged Eruptions of Papulourticarial Lesions.
Chang Woo LEE ; Tchae Sik NAM ; Jae Hong KIM ; Joong Hwan KIM
Annals of Dermatology 1989;1(1):33-36
No abstract available.
Pemphigoid, Bullous*
8.A Case of Lupus Vulgaris Followed by Miliary Tuberculosis.
Soon Nam SOH ; Yoo Jung HWANG ; Jae Hong KIM ; Joong Hwan KIM
Annals of Dermatology 1990;2(2):125-127
No abstract available.
Lupus Vulgaris*
;
Tuberculosis, Miliary*
9.Influence of the Host Factors on Human Papillomavirus Infection and Vaccine Efficacy.
Journal of Bacteriology and Virology 2015;45(3):179-188
Human papillomavirus (HPV) is associated with cervical cell changes, genital warts, recurrent respiratory papillomatosis, laryngeal papillomatosis, head and neck cancer, and cervical cancer. Two commercial HPV vaccines have successfully been made available in the clinical field. This review covers the progress of cervical disease by understanding the nature of HPV infection, as well as the relationship between the host factors and HPV vaccine effectiveness. Among these host factors, microbiota has been revealed to influence the development and function of both the innate and adaptive immune systems. Therefore, the composition of the microbiome may ultimately affect vaccine efficacy. Understating the relationship between host factors and HPV infection/vaccine efficacy may prove to be useful in earlier diagnosis, as well as disease prophylaxis.
Condylomata Acuminata
;
Diagnosis
;
Head and Neck Neoplasms
;
Humans*
;
Immune System
;
Microbiota
;
Papilloma
;
Papillomavirus Infections*
;
Papillomavirus Vaccines
;
Probiotics
;
Uterine Cervical Neoplasms
10.Epidemiological Treatment for Postgonococcal Urethritis in Uncomplicated Male Gonococcal Urethritis.
Soon Nam SOH ; Joong Hwan KIM ; Young Tae KIM ; Jae Hong KIM
Korean Journal of Dermatology 1990;28(1):34-38
An important concern in treatment for gonorrhea is the high frequency of coexisting chlarnydial and gonococcal infections. But there is difficulty in the diagnosing chlamydial infection. And so, CDC recommends epidemiological treatment, of both gonorrhea and non-gonococcal urethritis in the gonorrheal treatment in order to prevent post-gonococcal urethritis(PGU), A total of 140 male patients with uncomplicated gonococcal urethritis at the VD clinic, Choong-ku Publir. Health Center, in Seoul during December, 1987 February, 1988 were subjected to this study. The patients treated with kanamycin(KM), 2g and aqueous penicillin G(ACPG) 8 million units imaccompanied by probenecid(BEN) 1g by mouth. This combination regimen showed good effect in the treatment of gonococcal urethritis (failure rate 4.2% ). After gonorrheal treatment, the patients were divided randomly into group A and group B. In the group A, adminstrated with doxycycline monohydrate, 100mg, by mouth two times daily for 7 days, 44 and 29 patients were followed at 7th and 14th day after gonorrheal treatment. In the group B, administrated with placebo, 1 tablet, by mouth two times daily for 7 days, 49 and 39 patients were followed at 7th and 14th day after gonorrheal treatment. The PGU incidences were 27.3%(12/44), 20.7%(6,'29) in the group A and 55. 1%(27,'49), 53.8(21/39) in the group B at 7th and 14th day after gonorrheal treatment. Conclusively, eoncornitant administration of doxycycline monohydrate, 100mg, by mouth two times daily for 7 days with gonorrheal treatment lowered PGU significantly.
Centers for Disease Control and Prevention (U.S.)
;
Doxycycline
;
Gonorrhea
;
Humans
;
Incidence
;
Male*
;
Mouth
;
Penicillins
;
Seoul
;
Urethritis*