We have studied the function of lymphokines on human tonsillar B cell prolifertion and differentiation. B cells were stimulated with Staphylococcus aureus Cowanl (SAC) or anti- bead. The followings showed the results of this study. 1) In B cell activation, SAC induced B cell DNA synthesis but anti-mubead did not. SAC could activate and proliferate B cells. Minimal number of B cells were required to proliferate effectively. 2) In B cell proliferation, SAC could proliferate B cell in the abscence of lymphokines. Exogenous IL-2 or IL-4 enhanced B cell proliferation. The roles of IL-2 were very important in B cell proliferation. The effect of IL-4 on the IL-2 induced B cell proliferation was inhibitory in SAC-B cells. IL-4 could enhance the proliferation of anti-mu bead activated B cells. 3) In B cell differentiation, IL-2 was a major factor to differentiate SAC activated B cells, but IL-4 did not. IL-6 had a synergistic effect on the differentiation. The results of this study showed that the different signal transduction mechanisms were involved in B cell proliferation and differentiation. The B cell resposes to lymphokine were different, and it is depend upon antigens or mitogens.
B-Lymphocytes ; Cell Differentiation ; Cell Proliferation* ; DNA ; Humans* ; Interleukin-2 ; Interleukin-4 ; Interleukin-6 ; Lymphokines ; Mitogens ; Signal Transduction ; Staphylococcus aureus

No abstract available.
Tonsillectomy*

No abstract available.
Emergencies* ; Emergency Service, Hospital* ; Hospitals, General* ; Humans

No abstract available.
Hepatitis B Surface Antigens* ; Hospitals, General*

Aortopulmonary fistula is an exceedingly rare vascular malformation. It is commonly derived after chest injuly or from complication of chest operation and aortic dissection and congenital aortopulmonary fistula is only several cases combined with Tetralogy of Fallot or aortic stenosis. But a congenital aortopulmonary fistula without any hemodynamic abnormalities was not reported. A 56-year old man with exertional dyspnea was admitted. In an examination on admission, there were no abnomalities. Aortography showed an aortopulmonary fistula that branches from the ascending aorta adjacent to the right coronary artery, running to the main pulmonary artery. Transcatheter coil embolization was performed and he was discharged 7 day after embolization without complication. Exertional dyspnea disappeared and careful follow up has be performed periodically.
Aorta ; Aortic Valve Stenosis ; Aortography ; Coronary Vessels ; Dyspnea* ; Embolization, Therapeutic ; Fistula* ; Follow-Up Studies ; Hemodynamics ; Humans ; Middle Aged ; Pulmonary Artery ; Running ; Tetralogy of Fallot ; Thorax ; Vascular Malformations

No abstract available.
Aortic Valve Insufficiency*

No abstract available.
Salivary Glands*

Melanoacanthoma is an extremely rare pigmented benign mixed epithelial tumor of both melanocytes and keratinocytes. A 52-year-old female presented an asymptomatic, slightly elevated, 1. 2 cm x 0. 8 cm, dark black-colored plaque on her right buttock of 2 years' duration. Histopathologic finding of the plaque shows hyperkeratosis, focal parakeratosis, follicular plugging, acanthosih, papillomatosis and pseudo-horn cyst in the epidermis. The tumor is composed of basaloid and squarnous cells with many foci of clusters and whorls of melanin pigment-laden cells. Electron microscopic finding reveals many scattered melanocytes in the entire epidermis. Melanin granules are found mostly in the melanocytes but can also be found in a few keratinocytes.
Buttocks ; Epidermis ; Female ; Humans ; Keratinocytes ; Melanins ; Melanocytes ; Middle Aged ; Papilloma ; Parakeratosis

Epiduroscopy is very useful in the treatment of not only low back pain caused by failed back surgery syndrome, epidural scar or herniated disc but also by chronic refractory low back pain which does not respond to interventional conservative treatment including fluoroscopically-directed epidural steroid injections and percutaneous adhesiolysis. Because cauterization using a laser fiber has become recently available, a wider opening is required to enter into the sacral canal in the case of epiduroscopic laser neural decompression (ELND). However, in a few patients, it is difficult to insert a device into the epidural space due to stenosis around the opening, and there is no alternative method. Herein, we report a case where a hiatus rasp specially designed for such patients was used to perform the operation.
Cicatrix ; Constriction, Pathologic ; Decompression ; Epidural Space ; Failed Back Surgery Syndrome ; Humans ; Intervertebral Disc Displacement ; Low Back Pain

BACKGROUND & SIGNIFICANCE: Progressive multifocal leukoencephalopathy(PML), a rare neurologic disease caused by papovavirus, has been sporadically reported with defective cell-mediated immunity. We report one case of pathologically proven PML complicating chronic myelocytic leukemia(CML). CASE: The patient was a 42-year-old women, who had been diagnosed as CML at age 32 and received autologous bone marrow transplantation 16 months before. She admitted because of progressive memory disturbance and anomic aphasia over several months. Neuropsychological test suggested a left temporal lobe lesion. On T2-weighted brain MR image, there was a diffuse high signal intensity lesion in the left temporal lobe with some mottled enhancement and also in the left corona radiata and deep frontal area. Brain biopsy was done and the JC strain of papovairus was detected by in-situ hybridization technique. Cytarabine, alphainterferon, and acyclovir were tried. About 2 weeks after the medications, significant clinical improvement was noticed. A follow-up MRI 2 month and 6 months later revealed a significant reduction in the extent of the lesion. CONCLUSION: This is the firsts reported case of pathologically-proven PML in Korea. Unlike the usual PML described in the literature, our patient have showed clinical and radiological improvement in the course of illness.
Acyclovir ; Adult ; Anomia ; Biopsy ; Bone Marrow Transplantation ; Brain ; Cytarabine ; Female ; Follow-Up Studies ; Humans ; Immunity, Cellular ; Korea ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive* ; Leukoencephalopathy, Progressive Multifocal* ; Magnetic Resonance Imaging ; Memory ; Neuropsychological Tests ; Temporal Lobe