1.Travel Medicine : Recommendation for Travelers to Tropical Areas.
Journal of the Korean Medical Association 1999;42(7):704-709
No abstract available.
Travel Medicine*
2.The IgG subclass distribution of thyrotropin receptor antibody activities in primary hypothyroidism and the conversion of TSH receptor bound blocking type IgG subclass to the stimulating type by anti-human IgG antibody.
Min Ho SHONG ; Young Kun KIM ; Heung Kyu RO ; Jae Hoon CHUNG
Journal of Korean Society of Endocrinology 1993;8(2):164-170
No abstract available.
Hypothyroidism*
;
Immunoglobulin G*
;
Receptors, Thyrotropin*
;
Thyrotropin*
3.The Diagnosis and Management of Hyperthyroidism Consensus - Report of the Korean Thyroid Association.
Ka Hee YI ; Jae Hoon MOON ; In Ju KIM ; Hee Seung BOM ; Jaetae LEE ; Woong Youn CHUNG ; Jae Hoon CHUNG ; Young Kee SHONG
Journal of Korean Thyroid Association 2013;6(1):1-11
No abstract available.
Consensus
;
Hyperthyroidism
;
Thyroid Gland
4.Negative correlation between the conversion of thyrotropin receptor-bound blocking type thyrotropin receptor antibody to the stimulating type by anti-human IgG antibodies and the biological activity of blocking type thyrotropin receptor antibody.
Bo Youn CHO ; Min Ho SHONG ; Jae Hoon CHUNG ; Hong Kyu LEE ; Chang Soon KOH ; Hun Ki MIN
Journal of Korean Medical Science 1993;8(5):355-360
It has been reported that receptor-bound blocking type TSH receptor antibody (TRAb) can be converted to the stimulating type by anti-human IgG antibodies. To evaluate the relationship between the conversion of receptor-bound blocking type TRAb to the stimulating type and the biological activity of blocking type TRAb, we compared converting activities of blocking type TRAb from 10 patients with primary nongoitrous hypothyroidism with both the doses of blocking type TRAb which show 50% inhibition of 125I-bTSH binding to the TSH receptor and those which show 50% inhibition of TSH-stimulated cAMP production in cultured rat thyroid cells (FRTL-5). The additions of anti-human IgG antibody to FRTL-5 cell-bound blocking IgGs resulted in the increase in cAMP production in a dose-dependent manner and the converting activities (percent increase of cAMP production) also depended on the doses of blocking IgGs. The converting activities were significantly correlated with the doses of blocking IgGs which showed 50% inhibition of 125I-bTSH binding to the TSH receptor (r = 0.71, p = 0.011). And these converting activities were also significantly correlated with the doses of blocking IgGs which showed 50% inhibition of TSH-stimulated cAMP increase (r = 0.81, p = 0.002), and were negatively correlated with thyroid stimulation blocking antibody activities (r = 0.58, p = 0.02). We have demonstrated that all cell-bound blocking type TRAb were converted to the stimulating type by anti-human IgG antibody and the degree of conversion was negatively correlated with the biological activity of blocking type TRAb.(ABSTRACT TRUNCATED AT 250 WORDS)
Adult
;
Aged
;
Antibodies/*immunology
;
Autoantibodies/*immunology
;
Binding, Competitive
;
Female
;
Humans
;
Immunoglobulin G/*immunology
;
Immunoglobulins, Thyroid-Stimulating
;
Middle Aged
;
Receptors, Thyrotropin/*immunology
;
Thyroid Gland/*immunology
5.Follicular and Hurthle cell carcinoma of the thyroid in iodine-sufficient area: retrospective analysis of Korean multicenter data.
Won Gu KIM ; Tae Yong KIM ; Tae Hyuk KIM ; Hye Won JANG ; Young Suk JO ; Young Joo PARK ; Sun Wook KIM ; Won Bae KIM ; Minho SHONG ; Do Joon PARK ; Jae Hoon CHUNG ; Young Kee SHONG ; Bo Youn CHO
The Korean Journal of Internal Medicine 2014;29(3):325-333
BACKGROUND/AIMS: Follicular thyroid carcinoma (FTC) and Hurthle cell carcinoma (HCC) of the thyroid are relatively uncommon thyroid malignancies in iodine-sufficient areas. In this study we evaluated the clinical behavior, prognostic factors and treatment outcomes of FTC and HCC in Korea. METHODS: This multicenter study included 483 patients with FTC and 80 patients with HCC who underwent an initial surgery between 1995 and 2006 in one of the four tertiary referral hospitals in Korea. We evaluated clinicopathological factors associated with distant metastases and recurrence during a median of 6 years of follow-up. RESULTS: HCC patients were significantly older (49 years vs. 43 years; p < 0.001) and had more lymphovascular invasions (22% vs. 14%; p = 0.03) compared with FTC patients. Distant metastases were confirmed in 40 patients (8%) in the FTC group and in two patients (3%) in the HCC group (p = 0.07). Distant metastases were significantly associated with older age, widely invasive cancer and extrathyroidal invasion. Only 14 patients (3%) had recurrent disease and there was no significant difference between FTC and HCC groups (p = 0.38). Recurrence was associated with larger tumor size and cervical lymph node metastasis. CONCLUSIONS: HCC patients were older and had more lymphovascular invasions than FTC patients. However, FTC and HCC patients had similar initial clinicopathological features. Older age, wide invasiveness and extrathyroidal invasion were independent risk factors for predicting distant metastases in FTC and HCC patients.
Adenocarcinoma, Follicular/*epidemiology/secondary/surgery
;
Adult
;
Age Factors
;
*Diet
;
Female
;
Humans
;
*Iodine
;
Lymphatic Metastasis
;
Male
;
Middle Aged
;
Neoplasm Recurrence, Local
;
*Nutritional Status
;
Republic of Korea/epidemiology
;
Retrospective Studies
;
Risk Factors
;
Tertiary Care Centers
;
Thyroid Neoplasms/*epidemiology/pathology/surgery
;
Thyroidectomy
;
Time Factors
;
Treatment Outcome
6.Clinical Characteristics of Poorly Differentiated Carcinoma of the Thyroid and Comparison of Its Survival to the Tall Cell and Columnar Cell Variants of Papillary Carcinoma.
Tae Sik JUNG ; Jae Hoon CHUNG ; Young Lyun OH ; Tae Yong KIM ; Young Kee SHONG ; Won Bae KIM ; Kyung Won KIM ; Young Joo PARK ; Bo Youn CHO
Journal of Korean Society of Endocrinology 2006;21(2):132-141
BACKGROUND: Poorly differentiated carcinoma (PDC) of the thyroid includes tall and columnar cell variants (TCV) of the papillary carcinoma as well as the thyroid carcinoma with trabecular, insular and solid (TIS) growth patterns. There have been a few clinical studies on the PDC of the thyroid. We evaluated the clinical characteristics and the outcome of the PDC. METHODS: We investigated the clinicopathologic features of the thyroid carcinoma with TIS growth patterns (n = 46) and TCV of the papillary carcinoma (n = 14). We investigated the clinical features of ten patients diagnosed as PDC of the thyroid who had been undergone thyroidectomy for well differentiated carcinoma previously and compared these outcome with those of patients primarily diagnosed as PDC of the thyroid (n = 60). RESULTS: The clinical course of the thyroid carcinoma with TIS growth patterns was slightly more aggressive than that of TCV of the papillary carcinoma. However, disease-specific survivals of both cancers were not significantly different. Disease-specific survival was independently correlated with the presence of distant metastasis at diagnosis and high dose radioiodine therapy. The clinical features and outcome of the patients with PDC detected at recurred sites after operation for well-differentiated carcinoma were more aggressive than those diagnosed as PDC of the thyroid. CONCLUSION: The prognosis of the thyroid carcinoma with TIS growth patterns and TCV of the papillary carcinoma were similar. The PDC which was detected after thyroidectomy for well-differentiated carcinoma had worse prognosis than primarily diagnosed as PDC of the thyroid.
Carcinoma, Papillary*
;
Diagnosis
;
Humans
;
Neoplasm Metastasis
;
Prognosis
;
Thyroid Gland*
;
Thyroid Neoplasms
;
Thyroidectomy
7.Korean Adult Growth Hormone Deficiency Treatment Registry.
Sung Woon KIM ; Seong Yeon KIM ; Su Youn NAM ; Yoon Sok CHUNG ; Jae Hoon CHUNG ; In Kyung JUNG ; Jong Ryeal HAHM ; Minho SHONG ; Dong Sun KIM ; Seong Keun LEE ; Sung Dae MOON ; Hyun Koo YOON ; Doo Man KIM ; Sang Woo KIM ; Hye Kyung PARK
Journal of Korean Society of Endocrinology 2002;17(1):43-47
BACKGROUND: Adult growth hormone (GH) deficiency is related with decreased lean body mass, increased body fat, and poor quality of life. In western countries, adult GH deficiency treatment registriesy provide a database of the effects and safety of GH deficiency treatment. The Korean Adult Growth Hormone Study Group of the Korean Society of Endocrinology register adult GH deficiency since 1996. METHEODS: Subjects were aged over 15 years, had organic hypothalamo-pituitary disease, and GH deficiency as documented by GH stimulation test or serum insulin-like growth factor-I (IGF-I) level. The underlying etiology for GH deficiency, serum IGF-I level, starting and maintenance dose, and adult GH deficiency assessment (AGHDA) score were investigated. RESULTS: From January 1996 to May 2001. 115 patients were enrolled. Mean age was 43.7 13.8 years and 60% were female. Thirteen medical institutions were involved in the registry. The most common underlying diseases were Sheehan's syndrome and pituitary adenomas. GH starting dose was from 0.4 to 1.0 units. Maintenance dose was between 0.5 and 1.2 units. Serum IGF-I levels were increased after GH treatment (0-week, 93.7 69.7 ng/mL; 2-weeks, 184.9 89.0 ng/mL; 6-weeks, 188.4 94.8 ng/mL; 10-weeks, 207.6 111.1 ng/mL; 6 months, 281.9 95.5 ng/mL). AGHDA scores slightly improved from 10.25 6.70 to 8.58 5.47 after 6 months of GH deficiency treatment. CONCLUSION: The GH Treatment Registry will be beneficial in monitoring the effects of GH deficiency treatment on Korean adult GH deficient subjects
Adipose Tissue
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Adult*
;
Endocrinology
;
Female
;
Growth Hormone*
;
Humans
;
Hypopituitarism
;
Insulin-Like Growth Factor I
;
Pituitary Neoplasms
;
Quality of Life
8.Peroxiredoxin I and II are Involved in Hydrogen Peroxide Regulation in FRTL-5 Thyroid Cells.
Ho KIM ; Tae Hoon LEE ; Eun Shin PARK ; Jae Mi SUH ; Soo Jung PARK ; Hyo Kyun CHUNG ; Hyun Jin KIM ; Soo Hong CHAE ; Do Hee KIM ; O Yu KWON ; Young Kun KIM ; Min Ho SHONG ; Heung Kyu RO
Journal of Korean Society of Endocrinology 2000;15(1):55-69
BACKGROUND: Peroxiredoxins (Prx) play an important role in regulating cellular differentiation and proliferation in several types of mammalian cells. One mechanism for this action involves modulation of hydrogen peroxide (H2O2)-mediated cellular responses. This report examines the expression of Prx I and Prx II in thyroid cells and their roles in eliminating H2O2 produced in response to TSH. METHODS: The expression of Prx-I and Prx-II were quantiated in FRTL-5 after stimulation with Thyroid stimulating hormone (TSH), Forskolin (FSK), Methimazole (MMI) and hydrogen peroxide (H2O2). Transient transfections were carried out with FRTL-5 cells at 80% confluency and 20microgram of pCRprx I and pCRprx II or equivalent molar amounts of the pCR3.1TM basic vector. Transient transfection used an electroporation technique. Intracellular H2O2 was assayed in FRTL-5 cells with a fluorescent dye, 2', 7'-dichlorofluoresceindiacetate (DCFH-DA). Apoptosis of cells were evaluated by using an detection kit (Promega, Inc., Madison, WI). RESULTS: Prx I and Prx II are constitutively expressed in FRTL-5 thyroid cells. Prx I expression, but not Prx II expression, is stimulated by exposure to TSH and H2O2. In addition, methimazole (MMI) induces a high level of Prx I mRNA and protein in these cells. Overexpression of Prx I and Prx II enhance the elimination of H2O2 produced by TSH in FRTL-5 cells. Treatment with 500microM H2O2 causes apoptosis in FRTL-5 cells as evidenced by standard assays of apoptosis (i.e., terminal deoxynucleotidyl transferase deoxyuridine triphosphate-biotin nick end-labeling (TUNEL), BAX expression and PARP cleavage. Overexpression of Prx I and Prx II reduces the amount of H2O2-induced apoptosis measured by these assays. CONCLUSION: These results suggest that Prx I and Prx II are involved in the removal of H2O2 in thyroid cells, and can protect these cells from undergoing apoptosis. These proteins are likely to be involved in the normal physiological response to TSH-induced production of H2O2 in thyroid cells.
Apoptosis
;
Colforsin
;
Deoxyuridine
;
DNA Nucleotidylexotransferase
;
Electroporation
;
Hydrogen Peroxide*
;
Hydrogen*
;
In Situ Nick-End Labeling
;
Methimazole
;
Molar
;
Peroxiredoxins*
;
RNA, Messenger
;
Thyroid Gland*
;
Thyrotropin
;
Transfection
9.Revised Korean Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Thyroid Cancer.
Ka Hee YI ; Young Joo PARK ; Sung Soo KOONG ; Jung Han KIM ; Dong Gyu NA ; Jin Sook RYU ; So Yeon PARK ; In Ae PARK ; Chung Hwan BAEK ; Young Kee SHONG ; Young Don LEE ; Jaetae LEE ; Jeong Hyun LEE ; Jae Hoon CHUNG ; Chan Kwon JUNG ; Seung Ho CHOI ; Bo Youn CHO
Endocrinology and Metabolism 2010;25(4):270-297
No abstract available.
Humans
;
Thyroid Gland
;
Thyroid Neoplasms
;
Thyroid Nodule
10.Disease-Specific Mortality of Differentiated Thyroid Cancer Patients in Korea: A Multicenter Cohort Study.
Min Ji JEON ; Won Gu KIM ; Tae Hyuk KIM ; Hee Kyung KIM ; Bo Hyun KIM ; Hyon Seung YI ; Eun Sook KIM ; Hosu KIM ; Young Nam KIM ; Eun Heui KIM ; Tae Yong KIM ; Sun Wook KIM ; Ho Cheol KANG ; Jae Hoon CHUNG ; Young Kee SHONG ; Won Bae KIM
Endocrinology and Metabolism 2017;32(4):434-441
BACKGROUND: Little is known regarding disease-specific mortality of differentiated thyroid cancer (DTC) patients and its risk factors in Korea. METHODS: We retrospectively reviewed a large multi-center cohort of thyroid cancer from six Korean hospitals and included 8,058 DTC patients who underwent initial surgery between 1996 and 2005. RESULTS: Mean age of patients at diagnosis was 46.2±12.3 years; 87% were females. Most patients had papillary thyroid cancer (PTC; 97%) and underwent total thyroidectomy (85%). Mean size of the primary tumor was 1.6±1.0 cm. Approximately 40% of patients had cervical lymph node (LN) metastases and 1.3% had synchronous distant metastases. During 11.3 years of follow-up, 150 disease-specific mortalities (1.9%) occurred; the 10-year disease-specific survival (DSS) rate was 98%. According to the year of diagnosis, the number of disease-specific mortality was not different. However, the rate of disease-specific mortality decreased during the study period (from 7.7% to 0.7%). Older age (≥45 years) at diagnosis, male, follicular thyroid cancer (FTC) versus PTC, larger tumor size (>2 cm), presence of extrathyroidal extension (ETE), lateral cervical LN metastasis, distant metastasis and tumor node metastasis (TNM) stage were independent risk factors of disease-specific mortality of DTC patients. CONCLUSION: The rate of disease-specific mortality of Korean DTC patients was 1.9%; the 10-year DSS rate was 98% during 1996 to 2005. Older age at diagnosis, male, FTC, larger tumor size, presence of ETE, lateral cervical LN metastasis, distant metastasis, and TNM stages were significant risk factors of disease-specific mortality of Korean DTC patients.
Cohort Studies*
;
Diagnosis
;
Female
;
Follow-Up Studies
;
Humans
;
Korea*
;
Lymph Nodes
;
Male
;
Mortality*
;
Neoplasm Metastasis
;
Retrospective Studies
;
Risk Factors
;
Thyroid Gland*
;
Thyroid Neoplasms*
;
Thyroidectomy