No abstract available.
Down Syndrome* ; Myeloproliferative Disorders*

Although intraocular involvement in Hodgkin's disease is infrequent, there were reported iridocyclitis, exudative retinal detatchment, retinal hemorrhage, necrotizing retinitis, anterior and posterior uveitis, perivascular chorioretinitis. We report a 61 years old male patient with Hodgkin's disease who developed retinal lesion with decreased visual acuity in his right eye during a period of quiscence in his disease, 10 months since diagnosed. On first ophthalmic examination, best corrected vision of right eye was 0.6 and 1.0 on left eye. Fundus examination of the left eye was normal; however, the right eye revealed cotton wool patches, retinal edema, and intraretinal hemorrhage along the superior temporal venules. Fluorescein angiography showed blockage of choroidal flush in early phase and focal area of hyper fluorescence with perivascular leakage of dye in late phase. The results of TORCH test were negative, and the patient didn't have hypertension, diabetes mellitus, and bleeding tendency. Therefore we this case presumed perivascular retinitis associated with Hodgkin's disease.
Chorioretinitis ; Choroid ; Diabetes Mellitus ; Fluorescein Angiography ; Fluorescence ; Hemorrhage ; Hodgkin Disease* ; Humans ; Hypertension ; Iridocyclitis ; Male ; Middle Aged ; Papilledema ; Retinal Hemorrhage ; Retinaldehyde ; Retinitis* ; Uveitis, Posterior ; Venules ; Visual Acuity ; Wool

Glassy cell carcinoma (GCC) of the uterine cervix is a rare and highly malignant tumor, accounting for only 1%~2% of all cervical carcinomas. It is typically composed of malignant cells having a moderate amount of cytoplasm with "ground glass" appearance, distinct cell membranes that stain with eosin or periodic acid-Schiff, and large nuclei with prominent nucleoli. Since its original description in 1956 by Glucletmann and Cherry, 200 - 250 cases of GCC of the uterine cervix have been listed in the literature. We report here the clinicopathological study of one case of glassy cell carcinoma with brief review of the literature.
Cell Membrane ; Cervix Uteri* ; Cytoplasm ; Eosine Yellowish-(YS) ; Female ; Prunus

No abstract available.
Breast Neoplasms* ; Breast* ; Humans ; Soil*

Anophthalmos or microphthalmos is a rare congenital anomaly in which there is an absence of ocular tissue or small eyeball. This anomaly results in a small bony orbit and deformity of the asssociated skeletal, and soft tissues. Conventional management of the anophthalmic or microphthalmic orbit is started with the intraorbital placement of progressively increasing conformers as early as possible without enucleation. If an early treatment was not started, there could be retardation of growth of bony orbit and ipsilateral facial hypoplasia which is a necessity of more complex, disappointing application of three dimensional expansion osteotomy and socket reconstruction. The goal of treatment is the insertion of a comfortable prosthesis with good cosmesis. We treated 3 microphthalmic patients, who could not insert prosthesis on the first visit. We inserted an acrylic conformer into the orbit and then exchanged at interval of 6-8 weeks in order to expand the orbit. We obtained good cosmetic results. and the parents of patients were pleased with the appearance of their children fitting prosthesis.
Anophthalmos ; Child ; Congenital Abnormalities ; Humans ; Microphthalmos* ; Orbit ; Osteotomy ; Parents ; Prostheses and Implants

PURPOSE: To evaluate the impact of postoperative radiotherapy (PORT) on patterns of failure and survivals in uterine carcinosarcoma patients treated with radical surgery. MATERIALS AND METHODS: Between October 1998 and August 2010, 19 patients with stage I-III uterine carcinosarcoma received curative hysterectomy and bilateral salpingo-oophorectomy with or without PORT at Seoul National University Hospital. Their hospital medical records were retrospectively reviewed. PORT and non-PORT groups included 11 and 8 patients, respectively. They were followed for a mean of 22.7 months (range, 7.8 to 126.6 months). RESULTS: At 5 years, the overall survival rates were 51.9% for entire, 61.4% for PORT, and 41.7% for non-PORT groups, respectively. There was no statistical difference between PORT and non-PORT groups with regard to overall survival (p = 0.682). Seven out of 19 (36.8%) patients showed treatment failures, which all happened within 12 months. Although the predominant failures were distant metastasis in PORT group and loco-regional recurrence in non-PORT group, there was no statistically significant difference in loco-regional recurrence-free survival (LRRFS) (p = 0.362) or distant metastasis-free survival (DMFS) (p = 0.548). Lymph node metastasis was found to be a significant prognostic factor in predicting poor LRRFS (p = 0.013) and DMFS (p = 0.021), while the International Federation Gynecology and Obstetrics (FIGO) stage (p = 0.043) was associated with LRRFS. CONCLUSION: Considering that adjuvant radiotherapy after surgical resection was effective to decrease loco-regional recurrence and most treatment failures were distant metastasis, multimodal therapy including surgery, radiotherapy, and chemotherapy might be an optimal treatment for uterine carcinosarcoma patients.
Carcinosarcoma ; Gynecology ; Humans ; Hysterectomy ; Lymph Nodes ; Medical Records ; Neoplasm Metastasis ; Obstetrics ; Radiotherapy, Adjuvant ; Recurrence ; Retrospective Studies ; Survival Rate ; Treatment Failure ; Uterus

BACKGROUND/AIMS: Probiotics are expected to modify the composition of gut microbiota. We aimed to investigate the changes in the composition and diversity of gut microbiota by the administration of probiotics in healthy individuals. METHODS: Twelve healthy volunteers with age range of 30–42 years provided baseline fecal samples. Subsequently, they took commercially available probiotic capsules (a mixture for Bifidobacterium, Lactobacillus, and Enterococcus) for 4 weeks. Fecal samples were collected at 4 weeks of administration and 2 weeks after the stop of administration. Fecal microbiota was analyzed via 16S ribosomal RNA gene sequencing. RESULTS: The mean Shannon index was not significantly altered by the 4-week administration of probiotics (4.365 vs 4.556, P > 0.05). The proportion of Bacteroidetes, Actinobacteria, Firmicutes, and Proteobacteria was not significantly changed by the 4-week administration of probiotics. At the genus level, the proportions of Lactobacillus (2.138% vs 2.773%, P = 0.028) and Enterococcus (0.022% vs 2.758%, P = 0.004) significantly increased 4 weeks after the administration of probiotics, but reduced 2 weeks after the stop of administration (2.773% vs 3.292%, P = 0.064 and 2.758% vs 0.001%, P = 0.001). CONCLUSIONS: The diversity of fecal microbiota is not significantly affected by 4 weeks of probiotics administration. The proportion of fecal microbiota at the genus level is significantly altered by the administration of probiotics. However, this effect does not seem to last long, probably because of homeostasis or dietary influence.
Actinobacteria ; Bacteroidetes ; Bifidobacterium ; Capsules ; Enterococcus ; Firmicutes ; Gastrointestinal Microbiome ; Healthy Volunteers ; Homeostasis ; Lactobacillus ; Microbiota ; Probiotics ; Proteobacteria ; RNA, Ribosomal, 16S

The surgical treatment of diseases of thoracic aorta has had much better success rate in recent years compaired to the past. Aortic aneurysms or dissections that extend along the entire thoracic aorta are usually approached in two or three stages. Recently we successfully performed one-stage aortic replacement from the aortic root to the abdominal aorta in chronic DeBakey type I dissection. A 25 year-old man who had dyspnea on exertion (NYHA Fc II) and a Marfanoid feature was operated under the diagnosis of chronic type I dissection with severe aortic regurgitation. At operation, a huge ascending aorta with two intimal tearings was seen and the blood supply of intercostal arteries and right renal artery was done from the false lumen. Modified Bentall operation with total aortic replacement was done successfully, and the patient is being followed-up without major complications.
Adult ; Aorta* ; Aorta, Abdominal ; Aorta, Thoracic ; Aortic Aneurysm ; Aortic Valve Insufficiency ; Arteries ; Diagnosis ; Dyspnea ; Humans ; Renal Artery

No abstract available.
Carcinoma, Transitional Cell* ; Tuberculosis, Renal* ; Ureter*

Blunt chest trauma can cause various types of cardiac injuries such as myocardial contusion,cardiac ruptrue, valvular or papillary muscle injuries, and pericardial or coronary artery injuries. Complete rupture of both papillary muscles accompanied by left ventricular(LV) rupture following blunt chest trauma to our knowledge has not been previously reported. A 40-year-old female was referred because of severe dyspnea and anterior chest pain which occured immedicately after blunt chest trauma. Echocardiography demonstrated a moderate pericardial effusion as well as rupture of both papillary muscle with severe mitral regurgitation. Hemopericardium and a complets tear of the anterolateral papillary muscle at the mid portion were observed. The posteromedial papillary muscle was totally transected at the attachment site of LV wall and accompanied by external rupture of left ventricle at that site. Mitral valve replacement and primary repair of LV ruptrue was performed successfully. In the case we report, complete rupture of both papillary muscles developed after blunt chest trauma and LV rupture occurred as the papillary muscle was torn from the LV wall.
Adult ; Chest Pain ; Coronary Vessels ; Dyspnea ; Echocardiography ; Female ; Heart Ventricles ; Humans ; Mitral Valve ; Mitral Valve Insufficiency ; Papillary Muscles* ; Pericardial Effusion ; Rupture* ; Thorax*