1.Malignant fibrous histiocytoma of the maxillary sinus and nasal cavity.
Jai Goo CHUN ; Hyun Sook KIM ; Jae Duck YO ; Young Min KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(6):1345-1348
No abstract available.
Histiocytoma, Malignant Fibrous*
;
Maxillary Sinus*
;
Nasal Cavity*
2.A case report of emphysematous pyelonephritis associated with renal adenoma in diabetic patient.
Kyung Sik KO ; Jae Hyung AHN ; Tae Won LEE ; Chun Gyoo IHM ; Myung Jae KIM ; Sung Goo CHANG
Korean Journal of Nephrology 1993;12(4):686-689
No abstract available.
Adenoma*
;
Humans
;
Pyelonephritis*
3.Analysis of lymphocytes subsets in nasal polyps.
Hak Jun KANG ; Jae Goo CHUN ; Hyun Sook KIM ; Jae Duck YOO ; Sun Chul LEE ; Sang Won YOON ; Chang Duk JUN ; Hun Taek CHUNG
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(6):1206-1213
No abstract available.
Lymphocytes*
;
Nasal Polyps*
4.Behenoyl cytarabine-associated reversible encephalopathy in a patient with acute myelogenous leukemia.
Seok Goo CHO ; Hanlim MOON ; Jae Hee LEE ; Sung Yong LEE ; Chun Choo KIM ; Kyung Shick LEE
Journal of Korean Medical Science 1999;14(1):89-92
We report a case of reversible encephalopathy syndrome in a 16-year-old girl with acute myelogenous leukemia (AML), who is undergoing during consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin. On the 6th day of chemotherapy, she was in a drowsy state following generalized tonic clonic seizure lasting 20 minutes. MR images revealed extensive cortical and subcortical white matter brain edema. Alertness returned over the 24 hr following by the discontinuation of BH-AC and intravenous administration of diphenylhydantoin, although she complained of intermittent headaches and visual disturbance. She gradually recovered from these symptoms during subsequent 7 days. Previously noted abnormal signal intensities have nearly disappreared on follow-up MRI obtained on the 22nd day after the first seizure. She was discharged without any neurologic sequela. This case suggests that BH-AC, a derivative of cytosine arabinoside (1-beta-D-arabinofuranosylcytosine) could be a cause of reversible encephalopathy syndrome.
Adolescence
;
Antineoplastic Agents/therapeutic use
;
Antineoplastic Agents/adverse effects*
;
Brain/radiography
;
Case Report
;
Cytarabine/therapeutic use
;
Cytarabine/analogs & derivatives*
;
Cytarabine/adverse effects
;
Female
;
Human
;
Leukemia, Myelocytic, Acute/drug therapy
;
Leukemia, Myelocytic, Acute/complications*
;
Magnetic Resonance Imaging
;
Seizures/radiography*
;
Seizures/chemically induced
5.Cytogenetic Analysis in 785 Cases of Midtrimester Amniocentesis Using In Situ Coverslip Culture.
Ji Hyun KIM ; Jae Chun BYUN ; Ji Hyun SHIN ; Geun A SONG ; Goo Hwa JE ; Jin Yeong HAN
Korean Journal of Obstetrics and Gynecology 2004;47(5):863-869
OBJECTIVE: Amniocentesis is the most commonly used invasive method for prenatal diagnosis of genetic disorders. We performed this study to analyze the indications, distributions of maternal age and cytogenetic results of midtrimester amniocentesis. METHODS: We retrospectively analyzed 785 cases of midtrimester prenatal genetic amniocentesis which were performed in the cytogenetics laboratory using in situ coverslip culture at Dong-A University Hospital from January 1995 to March 2003. RESULTS: Amniocentesis was practiced mostly from 15 weeks to 20 weeks of gestational ages. Requested indications of amniocentesis were abnormal maternal serum screening (421, 53.7%), advanced maternal age (233, 29.7%) and abnormal ultrasonographic finding (61, 7.8%) in the order of decrease. The overall incidence of chromosome abnormalities was 5.1% (40 cases), and it contains 27 cases (3.4%) of numerical abnormalities and 13 cases (1.7%) of structural abnormalities. Among autosomal abnormalities Down syndrome was most common (13 cases) and followed by Edward syndrome (2 cases). Of the sex chromosomal abnormalities, three cases of Turner syndrome and three cases of Kleinefelter syndrome were found. Chromosomal abnormalities were most frequently noted in the maternal age of 30 to 34 years old (14 cases, 35.0%), 25 to 29 years old (12 cases, 30.0%), followed by 35 to 39 years old (7 cases, 17.5%). The frequency of pseudomosaicism were 5 cases (0.6%). CONCLUSION: Maternal serum screening, advanced maternal age and antenatal ultrasonographic finding must be important screening methods for amniocentesis which is considered to the most effective diagnostic procecdure for prenatal cytogenetic studies. I conclude that the karyotyping analysis of midtrimester amniocentesis is efficacious method for detection of chromosomal aberration and genetic counselling for parents.
Adult
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Amniocentesis*
;
Chromosome Aberrations
;
Cytogenetic Analysis*
;
Cytogenetics*
;
Down Syndrome
;
Female
;
Gestational Age
;
Humans
;
Incidence
;
Karyotyping
;
Mass Screening
;
Maternal Age
;
Parents
;
Pregnancy
;
Pregnancy Trimester, Second*
;
Prenatal Diagnosis
;
Retrospective Studies
;
Turner Syndrome
6.Change of Somatosensory Evoked Field Potential according to the Severity of Hydrocephalus in Kaolin-induced Hydrocephalus of Rats.
Dong Seok KIM ; Kwang Soo LEE ; Yong Goo PARK ; Se Hyuk KIM ; Joong Uhn CHOI ; Bae Hwan LEE ; Jae Wook RYOU ; Chun Zhi ZHAO
Journal of Korean Neurosurgical Society 2000;29(1):5-14
No abstract available.
Animals
;
Hydrocephalus*
;
Rats*
7.Differential Effects of Olanzapine and Haloperidol on MK-801-induced Memory Impairment in Mice.
Jae Chun SONG ; Mi Kyoung SEO ; Sung Woo PARK ; Jung Goo LEE ; Young Hoon KIM
Clinical Psychopharmacology and Neuroscience 2016;14(3):279-285
OBJECTIVE: We investigated the differential effects of the antipsychotic drugs olanzapine and haloperidol on MK-801-induced memory impairment and neurogenesis in mice. METHODS: MK-801 (0.1 mg/kg) was administered 20 minutes prior to behavioral testing over 9 days. Beginning on the sixth day of MK-801 treatment, either olanzapine (0.05 mg/kg) or haloperidol (0.05 mg/kg) was administered 40 minutes prior to MK-801 for the final 4 days. Spatial memory performance was measured using a Morris water maze (MWM) test for 9 days (four trials/day). Immunohistochemistry with bromodeoxyuridine (BrdU) was used to identify newborn cells labeled in tissue sections from the dentate gyrus of the hippocampus. RESULTS: MK-801 administration over 9 days significantly impaired memory performance in the MWM test compared to untreated controls (p<0.05) and these deficits were blocked by treatment with olanzapine (p<0.05) but not haloperidol. The administration of MK-801 also resulted in a decrease in the number of BrdU-labeled cells in the dentate gyrus (28.6%; p<0.01), which was prevented by treatment with olanzapine (p<0.05) but not haloperidol. CONCLUSION: These results suggest that olanzapine has a protective effect against cognitive impairments induced by MK-801 in mice via the stimulating effects of neurogenesis.
Animals
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Antipsychotic Agents
;
Behavior Rating Scale
;
Bromodeoxyuridine
;
Cognition Disorders
;
Dentate Gyrus
;
Dizocilpine Maleate
;
Haloperidol*
;
Hippocampus
;
Humans
;
Immunohistochemistry
;
Infant, Newborn
;
Memory*
;
Mice*
;
Neurogenesis
;
Spatial Memory
;
Water
8.Usefulness of the Rendezvous Technique for Biliary Stricture after Adult Right-Lobe Living-Donor Liver Transplantation with Duct-To-Duct Anastomosis.
Jae Hyuck CHANG ; In Seok LEE ; Ho Jong CHUN ; Jong Young CHOI ; Seung Kyoo YOON ; Dong Goo KIM ; Young Kyoung YOU ; Myung Gyu CHOI ; Kyu Yong CHOI ; In Sik CHUNG
Gut and Liver 2010;4(1):68-75
BACKGROUND/AIMS: Replacement of a percutaneous transhepatic biliary drainage (PTBD) catheter with inside stents using endoscopic retrograde cholangiography is difficult in patients with angulated or twisted biliary anastomotic stricture after living donor liver transplantation (LDLT). We evaluated the usefulness and safety of the rendezvous technique for the management of biliary stricture after LDLT. METHODS: Twenty patients with PTBD because of biliary stricture after LDLT with duct-to-duct anastomosis underwent the placement of inside stents using the rendezvous technique. RESULTS: Inside stents were successfully placed in the 20 patients using the rendezvous technique. The median procedure time was 29.6 (range, 7.5-71.8) minutes. The number of inside stents placed was one in 12 patients and two in eight patients. One mild acute pancreatitis and one acute cholangitis occurred, which improved within a few days. Inside stent related sludge or stone was identified in 12 patients during follow-up. Thirteen patients achieved stent-free status for a median of 281 (range, 70-1,351) days after removal of the inside stents. CONCLUSIONS: The rendezvous technique is a useful and safe method for the replacement of PTBD catheter with inside stent in patients with biliary stricture after LDLT with duct-to-duct anastomosis. The rendezvous technique could be recommended to patients with angulated or twisted strictures.
Adult
;
Catheters
;
Cholangiography
;
Cholangitis
;
Constriction, Pathologic
;
Dioxolanes
;
Drainage
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Fluorocarbons
;
Follow-Up Studies
;
Humans
;
Liver
;
Liver Transplantation
;
Living Donors
;
Pancreatitis
;
Sewage
;
Stents
9.Post-mortem re-cloning of a transgenic red fluorescent protein dog.
So Gun HONG ; Ok Jae KOO ; Hyun Ju OH ; Jung Eun PARK ; Minjung KIM ; Geon A KIM ; Eun Jung PARK ; Goo JANG ; Byeong Chun LEE
Journal of Veterinary Science 2011;12(4):405-407
Recently, the world's first transgenic dogs were produced by somatic cell nuclear transfer. However, cellular senescence is a major limiting factor for producing more advanced transgenic dogs. To overcome this obstacle, we rejuvenated transgenic cells using a re-cloning technique. Fibroblasts from post-mortem red fluorescent protein (RFP) dog were reconstructed with in vivo matured oocytes and transferred into 10 surrogate dogs. One puppy was produced and confirmed as a re-cloned dog. Although the puppy was lost during birth, we successfully established a rejuvenated fibroblast cell line from this animal. The cell line was found to stably express RFP and is ready for additional genetic modification.
Animals
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Animals, Genetically Modified
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Cloning, Organism/methods/*veterinary
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Dogs/*genetics
;
Female
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Gastrointestinal Tract/metabolism
;
Gene Expression Regulation
;
Kidney/metabolism
;
Liver/metabolism
;
Luminescent Proteins/*genetics/metabolism
;
Lung/metabolism
;
Male
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Myocardium/metabolism
;
Nuclear Transfer Techniques/veterinary
;
Spleen/metabolism
;
Trachea/metabolism
10.Incidence of Dimethylacetamide Induced Toxic Liver Injury among Workers in a Synthetic Fiber Manufacturing Company.
Yong Seok JANG ; Seong Yong YOON ; Seong Yong JO ; Tae Sung CHOI ; Jay Young YOO ; Kuck Hyun WOO ; Bong Goo HA ; Sang Jae JUNG ; Byung Yeol CHUN ; Jin Seok KIM
Korean Journal of Occupational and Environmental Medicine 2006;18(3):246-254
OBJECTIVES: The main goal of this study was to find the incidence of the dimethylacetamide (DMAc) induced toxic liver injury among workers who were exposed to DMAc for about 5 years in a synthetic fiber factory. METHODS: In our investigation, total 1,021 workers had been exposed to DMAc from 1st February, 2000 to 30th June, 2004. Among them, 24 workers who had initial abnormal hepatic enzyme level or was viral hepatitis B carrier were excluded. Finally, 997 DMAc exposed workers were followed up for their incidence of toxic liver injury. To find out DMAc induced toxic liver injury case, we carried out regular examinations including liver enzyme tests such as AST and ALT. RESULTS: We followed up 997 workers and among them 72 cases coincided with our case definition. Incidence density method was 6.05 per 100 person-year. and, a cumulative incidence by life table method was 0.0965 within a year. The incidence of the DMAc-induced toxic liver injury peaked at 4 to 5 in weeks after employment. There was no toxic liver injury case within second week after exposure to DMAc. Five new cases developed in 2th to 3th week, 25 cases in 4th to 5th week, 14 cases in 6th to 7th week, 12 cases in 8th to 9th week, 5 cases in 10th to 11th week, 4 cases in 12th to 13th week, 4 cases in 14th to 15th week, 1 case in 16th to 17th week, 1 case in 30th to 31th week, and there was one case in 48th to 49th week. CONCLUSIONS: The incidence rate of toxic liver injury was considerably high during the 1st year after a worker is placed. So it is needed to take careful monitoring of hepatic enzyme level for newly exposed worker.
Employment
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Hepatitis B
;
Incidence*
;
Life Tables
;
Liver*