1.Clinical experience in transpedicular modular segmental spinal instrumentation.
Jae Yoon CHUNG ; Chang Moon SEO
The Journal of the Korean Orthopaedic Association 1992;27(4):1037-1044
No abstract available.
2.Comparison of Oxygenation and Lung Damage of High Frequency Flow Interruption to Conventional Ventilation in Surfactant Deficient Rabbits.
Chang Keun KIM ; Churl Young CHUNG ; Hye Jae CHO
Journal of the Korean Pediatric Society 1995;38(5):591-601
No abstract available.
Lung*
;
Oxygen*
;
Rabbits*
;
Ventilation*
3.Restoration of Hormone Dependency in Estrogen Receptor - Lipofected MDA-MB-231 Human Breast Cancer Cells.
Young Jin SUH ; Jae Hee CHANG ; Chung Soo CHUN
Journal of the Korean Cancer Association 1999;31(3):473-482
PURPOSE: The loss of estrogen and progesterone receptors appeats to be associated with a progression to less differentiated and hormone-independent tumors. The gain of hormone independency over time even in estrogen receptor-positive tumors has become another obstacle to endocrine therapy for breast cancer. We tried to regain the hormone dependency in estrogen receptor-negative breast cancer cells by lipofecting estmgen receptor cDNA. MATERIALS AND METHODS: The mutant human estrogen receptor cDNA (pSGS-HEO) was lipofected into estrogen receptor-negative human breast cancer cell line MDA-MB-231, in an attempt to restore their sensitivity to antiestrogen. Then the effects of 17p-estradiol and tamoxifen were studied by counting viable cell numbers after treating the lipofected cell line with either one or together. RESULTS: Culture medium cantaining phenol red, a weak estrogen, has growth advantages compared with culture medium without it. In both culture conditions, cell growth was most profoundly inhibited in 4 days after lipofection with mutant human estrogen receptor cDNA, which was overcome after that day. Tamoxifen, as an antiestrogen, showed a growth inhibitory effect slightly stronger tban combined conditions of tamoxifen and 17- estradiol compared to estrogen-treated group and to control, and the inhibitory effect was lasted 4 days. CONCLUSION: The temporary induction of estrogen receptor by lipofection with pSGS-HEO on estrogen receptor-negative human breast cancer cell line MDA-MB-231 showed negative growth control on these cells by tamoxifen, indicating that liposome-mediated estrogen receptor transfection may be used as a novel therapeutic strategy for hormane independent human breast cancers in the near future.
Breast Neoplasms*
;
Breast*
;
Cell Count
;
Cell Line
;
DNA, Complementary
;
Estradiol
;
Estrogen Receptor Modulators
;
Estrogens*
;
Genetic Therapy
;
Humans*
;
Phenolsulfonphthalein
;
Receptors, Progesterone
;
Tamoxifen
;
Transfection
4.Mannitol induced acute oliguric renal failure.
Young Mi CHUNG ; Jae Seung LEE ; Chang Jun COE
Journal of the Korean Pediatric Society 1991;34(6):857-862
No abstract available.
Acute Kidney Injury
;
Mannitol*
;
Renal Insufficiency*
5.A case of Behcet's syndrome.
Ju Hwa JIN ; Gong Chang HAN ; Jae Hoon CHUNG
Korean Journal of Obstetrics and Gynecology 1991;34(4):603-606
No abstract available.
Behcet Syndrome*
6.Clinical application of absolute ethanol as an embolizing material
Jae Hyung PARK ; Kee Hyun CHANG ; Man Chung HAN
Journal of the Korean Radiological Society 1982;18(3):416-420
Transcatheter infusion of absolute ethanol was applied clinically in 3 cases of artificial embolization; 25yrsold female with bilateral renal angiomyolipoma, 19yrs old female with right paralumbar liposarcoma and 25 yrs oldmale with hypernephroma of right kidney. Selective or subselective manual infusion was made and 9 to 22cc of pureethanol was delivered in a speed of 1 to 2cc per second. The sclerosing effect of absolute ethanol was potent.However, all 3 cases revealed mild post-emboliaztion syndrome.
Angiomyolipoma
;
Carcinoma, Renal Cell
;
Ethanol
;
Female
;
Humans
;
Kidney
;
Liposarcoma
7.Changes of the Renal Arteries Accordding to Various Embolic Materials.
Jae Ho CHO ; Kil Ho CHO ; Jae Chung CHANG ; Bok Hwan PARK ; Dong Sug KIM
Yeungnam University Journal of Medicine 1995;12(1):96-104
The transarterial embolization has been widely used to control bleeding. It has a variety of clinical utility; to reduce bleeding on the surgical field, to reduce the size of malignant tumor as a preopearative treatment, to treat arteriovenous malformation or arterial aneurysm as a curative method and to promote life qua' ity of patient with diffuse or multiple hepatocellular carcinoma as a palliative treatment, etc. With the advance of modem technology, various embolic materials have been also developed. IIowever, it has not- been -fully investigated of histopathologic changes of the embolized organs according to the embolic materials used. This study was undertaken to investigate the histopathologic changes of embolized renal artery in rabbit by various embolic materials, according to each embolic material and to time passed by after embolization. Of the 5 arteries embolized by ethylene vinyl alcohol copolymer(EVAL), one showed abscess formation in embolized kidney. The other 4 allowed to perform further pathologic study: within a week after embolization there was no any specific change in vessels, however, r,unimal endothelial hypertrophy was observed following 2 weeks of embolization. Of the 8 renal arteries embolized by N-buthyl-2-cyanoacrylate(Histoacryl), 4 showed total occlusion of the main renal arteries as well as renal infarction, which reflects the strong adhesiveness of Histoacryl to vascular wall. The other 4 showed fibrinoid degeneration in vascular wall within a week. However, further change was not observed thereafter. In all the 5 renal arteries embolized by polyvinyl
Abscess
;
Adhesiveness
;
Aneurysm
;
Arteries
;
Arteriovenous Malformations
;
Carcinoma, Hepatocellular
;
Enbucrilate
;
Hemorrhage
;
Humans
;
Hypertrophy
;
Infarction
;
Kidney
;
Modems
;
Palliative Care
;
Polyvinyls
;
Renal Artery*
8.Angiearchitecture of Brain Arteriovenous Malformation and its Clinial Correlation.
Dong Ik KIM ; Young Hoon RYU ; Kyu Chang LEE ; Jae Joon CHUNG ; Tae Sub CHUNG ; Jung He SUH
Journal of the Korean Radiological Society 1994;31(4):583-591
PURPOSE: To analyze angiearchitecture of arteriovenous malformations(AV malformation) in order to clarify the angiegraphic risk factors for intracerebral hemorrhage and other nonhemorrhagic symptoms. MATERIALS AND METHODS: Eighty-five patients with angiegraphically-proved brain arteriovenous malformation were included in this study. Retrospective review of clinical history and angiography was done. Topographic analysis and evaluation of 17 angiearchitectural characteristics were conducted. RESULTS: Deep-seated and cortico-callosal type, small nidus size, intranidal pouch, one draining vein, deep venous drainage only venous stenosis and venous aneurysm were the most discriminating or predictive characteristics of hemorrhage in brain arteriovenous malformation. And those with large nidus size, dural supply and venous hypertension were correlated with nonhemorrhagic symptoms such as seizure, headache and neurologic deficit. CONCLUSION: Detailed analysis of the angiearchitecture of brain arteriovenous malformations is needed to identify the features that are correlated with prognostic implications for the treatment of patients with ^V malformations.
Aneurysm
;
Angiography
;
Arteriovenous Malformations*
;
Brain*
;
Cerebral Hemorrhage
;
Constriction, Pathologic
;
Drainage
;
Headache
;
Hemorrhage
;
Humans
;
Hypertension
;
Neurologic Manifestations
;
Retrospective Studies
;
Risk Factors
;
Seizures
;
Veins
9.99mTc-labeling of monoclonal antibody to carcinoembryonic antigenand biodistribution.
Dae Hyuk MOON ; June Key CHUNG ; Myung Chul LEE ; Chang Soon KOH ; Hong Keun CHUNG ; Jae Gahb PARK
Korean Journal of Nuclear Medicine 1992;26(2):380-391
No abstract available.
10.A case of bilateral granulosa cell tumors of both ovaries.
Bo Ok LEE ; Chang Qyun CHUNG ; Hyun Young BAE ; Jae Ho YOON ; Yong Hae PARK ; Ho Soon CHUNG
Korean Journal of Obstetrics and Gynecology 1992;35(8):1259-1263
No abstract available.
Female
;
Granulosa Cell Tumor*
;
Granulosa Cells*
;
Ovary*