1.Clinical Evaluation of 781 Cases of Cesarean Section .
Choon Nam PARK ; Young Hwa MOON ; Chang Jae KWON
Korean Journal of Anesthesiology 1976;9(2):177-182
Maternal and fetal effects of anesthesis for 781 cases ceasarean sections, performed during the past 10 years (1965~1974) in Hanil Hospital have been evaluated clinically. It is emphasized that the selection of anesthetic agents and methods, should depend upon the physical status of the patients and the ability of both obstetricians and anesthesiologists. Optimal results require effective teamwork amongst obstetricians, anesthesiologists and nursing personnel. The anesthesiologist should be fully infermed of obstetric aspects. A variety of anesthetic techniques can be used for elective and emergency Caesarean sections. Each technique has its own advantages, disadvantages and limitations which must be thoroughly understood for proper application. The choice of anesthesia should be determined primarily by the experience of the operator, the degree of ugency, condition of the monther and the fetus, the physiopathology, the skill of the obstetrician and the desires and the emotional state of the monther.
Anesthesia
;
Anesthetics
;
Cesarean Section*
;
Emergencies
;
Female
;
Fetus
;
Humans
;
Nursing
;
Pregnancy
2.Huge hematoma in the pelvic cavityafter mechanical valve replacement: A report of case.
Hwa Kyun SHIN ; Nam Hyeuk KIM ; Yong Jae LEE ; Chang Hee KANG ; Oh Choon KWON ; Kihi Roh LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(2):158-159
No abstract available.
Hematoma*
3.The Clinical Investigation of Pre- and Post-Operative Liver Function after Halothane Anesthesia in the Electric Burn Patients.
Yeo Song CHO ; Soon Ok SUNG ; Choon Nam PARK ; Chang Jae KWON
Korean Journal of Anesthesiology 1983;16(4):320-323
After the clinical introduction of halothane, the problem of hepatotoxicity and mechanism has major implications for the practice of anesthesiology. This study was undertaken to investigate the liver function change after halothane anesthesia in 22 cases of electric burn patient. In this study, all cases had a great elevation of SGOT and SGPT levels, and previous experience of inhalation anesthesia, jaundice and who had not been transfused during this study. The following results were obtained: 1) Elevation of the SGOT and SGPT in electric burn patients may be influenced by damage of skeletal muscle and transaminase released into systemic circulation. 2) In the electric burn patients, elevation of the SGOT and SGPT does not enhance the susceptibility of the liver to injury by halothane.
Alanine Transaminase
;
Anesthesia*
;
Anesthesia, Inhalation
;
Anesthesiology
;
Aspartate Aminotransferases
;
Burns, Electric*
;
Halothane*
;
Humans
;
Jaundice
;
Liver*
;
Muscle, Skeletal
4.Corrigendum: Moderate and Deep Hypothermia Produces Hyporesposiveness to Phenylephrine in Isolated Rat Aorta.
Jun Woo CHO ; Chul Ho LEE ; Jae Seok JANG ; Oh Choon KWON ; Woon Seok ROH ; Jung Eun KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 2014;47(1):75-75
There was an error in article.
5.Expression of Dopamine D2 Receptor in Response to Apomorphine Treatment in the Striatum of the Rat with Experimentally Induced Parkinsonism.
Seung Jin CHOI ; Jae Hoon SUNG ; Byung Chul SON ; Choon Keun PARK ; Sung Oh KWON ; Moon Chan KIM ; Sang Won LEE
Journal of Korean Neurosurgical Society 2000;29(7):868-876
No abstract available.
Animals
;
Apomorphine*
;
Dopamine*
;
Parkinsonian Disorders*
;
Rats*
;
Receptors, Dopamine D2*
6.Herpes Simplex virus thymidine kinase gene therapy delivered by retroviral or adenoviral vector in mouse model of lewis lung carcinoma.
Hee Chung KWON ; Jae Min JEONG ; Jung Hyeon KIM ; Yong Ho HAM ; Ji Sook SEO ; Ki Ho CHANG ; Min KIM ; Han Soo LEE ; Choon Taek LEE
Tuberculosis and Respiratory Diseases 2000;49(3):298-309
BACKGROUND: The antitumor effects of herpes simplex virus thymidine kinase(HSV-tk) and ganciclovir(GCV) strategies for cancer gene therapy have a the following advantages:1) a direct cytotoxicity to HSV-tk modified cancer cells by GCV 2) a cell death by the local transfer of toxic metabolites from the HSV-tk modified cells to nearby unmodified tumor cells(bystander effect), and 3) in vivo bystander effect such as antitumor-immunity. Retroviral and adenoviral sequences can silence transgene expression in cells and mice. In this study, we investigated the above described advantages of HXV-tk/GCV strategy in Lewis lung cell and mouse lung cancer model using retroviral vector and adenoviral vector. Also, we observed whether the expression of a silenced gene can be reactivated by treating cell with butyrate. METHODS: Retrovirus-HSV-tk and adenovirus-HSV-tk vectors were used for the transduction of Lewis lung carcinoma(LLC) cells. The change of HSV-tk expression by butyrate was measured by Western blot.The antitumor activities containing bystander effect were observed in vivo(by MTT assay) and in vivo tumor models of various combinations of LLC and LLC-tk. RESULTS: 1. Butyrate induced the enhancement of HSV-tk expression from adenovirally transduced cells but not from retrovirally transduced cells. 2. Both retrovirus-HSV-tk and adenovirus-HSV-tk vectors with GCV treatment were effective for killing of tumor cell in vitro and suppression of LLC tumorigenicity. Bystander effect was responsible for killing of mixture of LLC-tk and LLC in vitro and in vivo-tumorigenicity model. CONCLUSION: Butyrate could augment adenoviral vector seems to be an effective approach for lung cancer therapy.
Adenoviridae
;
Animals
;
Butyrates
;
Bystander Effect
;
Carcinoma, Lewis Lung*
;
Cell Death
;
Genes, Neoplasm
;
Genetic Therapy*
;
Herpes Simplex*
;
Homicide
;
Lung
;
Lung Neoplasms
;
Mice*
;
Phosphotransferases*
;
Retroviridae
;
Simplexvirus*
;
Thymidine
;
Transgenes
;
Zidovudine*
7.Role of C-Reactive Protein and Procalcitonin in Differentiation of Tuberculosis from Bacterial Community Acquired Pneumonia.
Young Ae KANG ; Sung Youn KWON ; Ho IL YOON ; Jae Ho LEE ; Choon Taek LEE
The Korean Journal of Internal Medicine 2009;24(4):337-342
BACKGROUND/AIMS: We investigated the utility of serum C-reactive protein (CRP) and procalcitonin (PCT) for differentiating pulmonary tuberculosis (TB) from bacterial community-acquired pneumonia (CAP) in South Korea, a country with an intermediate TB burden. METHODS: We conducted a prospective study, enrolling 87 participants with suspected CAP in a community-based referral hospital. A clinical assessment was performed before treatment, and serum CRP and PCT were measured. The test results were compared to the final diagnoses. RESULTS: Of the 87 patients, 57 had bacterial CAP and 30 had pulmonary TB. The median CRP concentration was 14.58 mg/dL (range, 0.30 to 36.61) in patients with bacterial CAP and 5.27 mg/dL (range, 0.24 to 13.22) in those with pulmonary TB (p<0.001). The median PCT level was 0.514 ng/mL (range, 0.01 to 27.75) with bacterial CAP and 0.029 ng/mL (range, 0.01 to 0.87) with pulmonary TB (p<0.001). No difference was detected in the discriminative values of CRP and PCT (p=0.733). CONCLUSIONS: The concentrations of CRP and PCT differed significantly in patients with pulmonary TB and bacterial CAP. The high sensitivity and negative predictive value for differentiating pulmonary TB from bacterial CAP suggest a supplementary role of CRP and PCT in the diagnostic exclusion of pulmonary TB from bacterial CAP in areas with an intermediate prevalence of pulmonary TB.
Adolescent
;
Adult
;
Aged
;
Aged, 80 and over
;
C-Reactive Protein/*analysis
;
Calcitonin/*blood
;
Community-Acquired Infections/blood/*diagnosis
;
Diagnosis, Differential
;
Female
;
Humans
;
Male
;
Middle Aged
;
Pneumonia, Bacterial/blood/*diagnosis
;
Prospective Studies
;
Protein Precursors/*blood
;
Severity of Illness Index
;
Tuberculosis, Pulmonary/blood/*diagnosis
8.Inferior Vena Cava Thrombectomy in a Patient with Antiphospholipid Syndrome : A case report.
Jae Seok JANG ; Oh Choon KWON ; Sub LEE ; Seok KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 2009;42(3):371-374
A 36-year-old woman with a history of spontaneous abortion and photosensitivity was admitted to our hospital with periumbilical pain and lower extremity edema. The preoperative CT scan revealed massive inferior vena cava thrombus, which extended from the suprarenal portion of the vena cava to the hepatic vein. The laboratory data showed an elevated level of anticardiolipin antibody, which suggested the diagnosis of antiphospholipid syndrome. After medical management, she underwent an operation for removal of an vena cava thrombus by performing cavectomy and thrombectomy. After the operation, she has been taking oral anticoagulation and she is doing quite well at 9 months after her operation
Abortion, Spontaneous
;
Adult
;
Antibodies, Anticardiolipin
;
Anticoagulants
;
Antiphospholipid Syndrome
;
Edema
;
Female
;
Hepatic Veins
;
Humans
;
Lower Extremity
;
Pregnancy
;
Thrombectomy
;
Thromboembolism
;
Thrombosis
;
Vena Cava, Inferior
9.Alteration of Molecules and Cytokines Related to the Activation of T Lymphocyte in Immune Tolerance Induced Mice Model.
Sung Mo HUR ; Choon Hyuck KWON ; Jae Won JOH ; Sung Joo KIM
The Journal of the Korean Society for Transplantation 2005;19(2):119-123
PURPOSE: Monoclonal antibodies (mAb) specific for CD45RB as a potent tolerogenic target can prolong allograft survival in several animal models. The mechanisms of CD45RB mAb-mediated tolerance are largely unknown. Therefore, the present studies were performed to determine the immunomodulatory effects of CD45RB mAb on T cells in early or late time after allogenic skin transplantation. METHODS: Skin grafts and bone marrows from BALB/c donor mice were transplanted on C57BL/6 recipient mice and Busulfan was administerd. Group 1 was composed of anti-CD154 mAb administerd mice, group 2 was composed of anti-CD154 and anti-CD45RBB mAb administerd mice, and group 3 consisted of anti-CD154 mAb and CTLA4-Ig administerd mice. The proportion of splenic CD4+ and CD8+ T cell and range of CD45RB was observed by flow cytometry. Cytokines secreted by CD4+ T cell were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: CD45RB mAb in combination with CD154 mAb enhanced graft survival in allogenic skin transplantation model where CD45RB mAb specific for CD45RB, which was proven mainly expressed by CD8+ T cells, had inhibitory effects on the proportion of splenocyte-derived CD8+ and CD4+CD45RB(high) T cells in early or late time posttransplant. CONCLUSION: The combined therapy showed decreases in the proliferation of CD8+ T cells in vivo and allospecific responses of IFN-gamma-producing cells. Such immunomodulatory effects may be associated with the tolerogenic ability of CD45RB mAb in allogenic skin transplantation.
Abatacept
;
Allografts
;
Animals
;
Antibodies, Monoclonal
;
Bone Marrow
;
Busulfan
;
Cytokines*
;
Enzyme-Linked Immunosorbent Assay
;
Flow Cytometry
;
Graft Survival
;
Humans
;
Immune Tolerance*
;
Lymphocytes*
;
Mice*
;
Models, Animal
;
Skin
;
Skin Transplantation
;
T-Lymphocytes
;
Tissue Donors
;
Transplants
10.Clinical Diversity of Struma Ovarii.
Ki Hong CHANG ; Young Tae KIM ; Hee Sug RYU ; Hyuck Chan KWON ; Eun Joo LEE ; Hee Choon LEE ; Jae Wook KIM ; Kie Suk OH
Korean Journal of Obstetrics and Gynecology 1997;40(8):1683-1689
Struma ovarii is a rare tumor of the ovary pathologically resembling teratomas with thyroid components. The presenting clinical, radiological, and pathological features of patie-nts with consequent struma ovarii is diverse and does not give substantial information with regard to the nature of the ovarian tumor. Ten cases collected over a period of eight years from two institutes are presented which showed a wide diversity of clinical features, and in which the diagnosis was only made later by strict pathological criteria. The treatment for struma ovarii, and in even rarer cases, malignant struma ovarii, remains highly controvers-ial, but it is suggested that conservative treatment by tumor excision only may be sufficie-nt. Surgical treatment also greatly ameliorates any accompanying hydrothorax and ascites.
Academies and Institutes
;
Ascites
;
Diagnosis
;
Female
;
Hydrothorax
;
Ovary
;
Struma Ovarii*
;
Teratoma
;
Thyroid Gland