No abstract available.
Arthrography* ; Wrist*

No abstract available.
DNA* ; Lung Neoplasms* ; Lung* ; Ploidies*

No abstract available.
Heart Diseases* ; Heart*

Focal segmental glomerulosclerosis (FSGS) is characterized by focal and segmental obliteration of glomerular capillary tufts with increased matrix. FSGS is classified as collapsing, tip, cellular, perihilar and not otherwise specified variants according to the location and character of the sclerotic lesion. Primary or idiopathic FSGS is considered to be related to podocyte injury, and the pathogenesis of podocyte injury has been actively investigated. Several circulating factors affecting podocyte permeability barrier have been proposed, but not proven to cause FSGS. FSGS may also be caused by genetic alterations. These genes are mainly those regulating slit diaphragm structure, actin cytoskeleton of podocytes, and foot process structure. The mode of inheritance and age of onset are different according to the gene involved. Recently, the role of parietal epithelial cells (PECs) has been highlighted. Podocytes and PECs have common mesenchymal progenitors, therefore, PECs could be a source of podocyte repopulation after podocyte injury. Activated PECs migrate along adhesion to the glomerular tuft and may also contribute to the progression of sclerosis. Markers of activated PECs, including CD44, could be used to distinguish FSGS from minimal change disease. The pathogenesis of FSGS is very complex; however, understanding basic mechanisms of podocyte injury is important not only for basic research, but also for daily diagnostic pathology practice.
Actin Cytoskeleton ; Age of Onset ; Capillaries ; Diaphragm ; Epithelial Cells ; Foot ; Glomerulosclerosis, Focal Segmental* ; Nephrosis, Lipoid ; Pathology ; Permeability ; Podocytes ; Rabeprazole ; Sclerosis ; Wills

To attempt a rigorous definition of the structure of the accessory spleen (AS) in the Chinese hamster, we examined twenty-one animals, and found AS in 5 animals (23.8%), which were over 7-month-old. The AS had no connection with the main spleen and was seen as a dark red oval organ (0.7 mm x 1.5 mm), which was embedded in the adipose tissue near the tail of the pancreas. It was demarcated from the adipose tissue and some pancreatic tissue. The organ was encapsulated by thin collagenous connective tissue and smooth muscle fibers, and contained lymphatic nodules, reticular fibers, nodular central arterioles, macrophages and megakaryocytes. Notably the incidence of AS appeared to increase with age in the Chinese hamsters.
Adipose Tissue/anatomy & histology ; Age Factors ; Animals ; Connective Tissue/anatomy & histology ; Cricetinae ; Cricetulus/*anatomy & histology ; Erythrocytes/cytology ; Lymphocytes/cytology ; Muscle, Smooth/anatomy & histology ; Pancreas ; Spleen/*anatomy & histology/cytology

No abstract available.
Animals ; Cryopreservation* ; Embryonic Structures* ; Mice* ; Ovum*

We experienced a case of primary malignant mixed mullerian tumors (MMMT) of the fallopian tube of FIGO stage I. In addition to endometrioid adenocarcinomas, multiple apparent heterologous elements encompassing myxoid chondrosarcoma, osteosarcoma, myxoid liposarcoma and well differentiated angiosarcoma were recognized as separate nodules. These findings have not been described previously in MMMTs of the female genital tract.
Carcinoma, Endometrioid ; Chondrosarcoma ; Fallopian Tubes* ; Female ; Hemangiosarcoma ; Humans ; Liposarcoma, Myxoid ; Osteosarcoma

No abstract available.
Carcinoma, Merkel Cell* ; Lymph Nodes* ; Lymphoscintigraphy* ; Neoplasm Metastasis*

PURPOSE: To determine the changes of location of intraocular lens (IOL) and refractive errors in the cases of vitrectomized eyes and non-vitrectomized eyes, we evaluated the anterior chamber depth and refractive errors after phacoemulsification and posterior chamber IOL implantation. METHODS: In 21 vitrectomized eyes of 21 patients (group 1) and 22 non-vitrecomized eyes of 22 patients (group 2), the anterior chamber depth was measured with Orbscan II (Bausch and Lomb Surgical, Germany) for the evaluation of changes of anterior chamber depth preoperatively, at 1 month and 3 months postoperatively. We compared the desired refraction by preoperative data, and postoperative manifest refraction of postoperative 1 month and 3 months. RESULTS: In group 1, the anterior chamber was deeper than that of group 2 postoperative 1 month but the result was not statistically significant. After 3 months the chamber depth was significantly deeper in group 1 than group 2, (P=0.047), and refractive errors were significantly more hyperopic in group 1 than group 2. CONCLUSIONS: The vitreous influenced the location of IOL after phacoemulsification and posterior chamber IOL implantation, so in the cases of vitrectomized eyes IOL was more posteriorly located, and thus hyperopic shift was noted.
Anterior Chamber* ; Cataract* ; Humans ; Lenses, Intraocular ; Phacoemulsification ; Refractive Errors

Adalimumab (Humira(TM)) is the first fully humanized monoclonal TNF-alpha antibody that antagonizes the effects of TNF-alpha. Its use has been found in the treatment of various rheumatologic disorders, namely rheumatoid arthritis, Crohn's disease, and ankylosing spondylitis, as well as for various skin conditions such as psoriasis. As the use of this particular biologic agent is becoming more widespread, cutaneous adverse effects of the drug is now being reported at a steady rate. The authors herein report a case of 32 year-old female who presented with multiple psoriasiform eruptions on her trunk, back and lower extremities. She had a four-year history of ankylosing spondylitis, for which she was started on subcutaneous adalimumab injection monthly, three and a half years prior to her initial visit.
Antibodies, Monoclonal, Humanized ; Arthritis, Rheumatoid ; Crohn Disease ; Dermatitis ; Female ; Humans ; Lower Extremity ; Psoriasis ; Skin ; Spondylitis, Ankylosing ; Tumor Necrosis Factor-alpha ; Adalimumab