Objective: The aim of this study was to determine whether an association between study quality, other study characteristics, and Altmetric Attention Scores (AASs) existed in orthodontic studies. Methods: The Scopus database was searched to identify orthodontic studies published between January 1, 2017, and December 31, 2019. Articles that satisfied the eligibility criteria were included in this study. Study characteristics, including study quality were extracted and entered into a pre-pilot data collection sheet. Descriptive statistics were calculated. On an exploratory basis, random forest and gradient boosting machine learning algorithms were used to examine the influence of article characteristics on AAS. Results: In total, 586 studies with an AAS were analyzed.Overall, the mean AAS of the samples was 5. Twitter was the most popular social media platform for publicizing studies, accounting for 53.7%. In terms of study quality, only 19.1% of the studies were rated as having a high level of quality, with 41.8% of the studies deemed moderate quality. The type of social media platform, number of citations, impact factor, and study type were among the most influential characteristics of AAS in both models. In contrast, study quality was one of the least influential characteristics on the AAS. Conclusions Social media platforms contributed the most to the AAS for orthodontic studies, whereas study quality had little impact on the AAS.