1.Serum alkaline phosphatase activity after intravenous administration of albumin preparation.
June HUH ; Kang Mo AHN ; Ja Wook KOO ; Il Soo HA ; Hae Il CHEONG ; Yong CHOI
Journal of the Korean Pediatric Society 1993;36(6):830-836
Serum alkaline phosphatase (AP) activity is elevated in hepatobiliary disease, bone disease, pregnancy and certain neoplasms. Recently we experienced marked elevation of serum AP activity after administration of albumin preparation in nephrotic patients who suffered from hypovolemic symptoms. So serum AP activity and the isoenzymes in the albumin preparations & patient's serum after the administration of albumin preparation were studied. Serum AP activity was significantly higher after administration of albumin preparation (318+/-101 IU/L) then before (123+/-43 IU/L). The predominant isoenzyme after administration of albumin was placental type, while liver and bone type was predominant before administration. AP activity in albumin preparation was high (2,133+/-1,410 IU/L) and the isoenzyme was mostly placental type. So we concluded that marked elevation of serum AP activity after administration of albumin was traced to the placental type AP isoenzyme in some albumin preparations which was manufactured from the plasma of placental origin. Elevated serum AP activity like these may lead to erroneous interpretation. Manufactures should notify alkaline phosphatase activity in albumin preparations of placental origin.
Administration, Intravenous*
;
Alkaline Phosphatase*
;
Bone Diseases
;
Humans
;
Hypovolemia
;
Isoenzymes
;
Liver
;
Plasma
;
Pregnancy
2.Peritonitis during CAPD in children.
Ja Wook KOO ; Tae Sun HA ; In Seok LIM ; Il Soo HA ; Hae Il CHEONG ; Yong CHOI ; Kwang Wook KO
Korean Journal of Nephrology 1991;10(3):379-386
No abstract available.
Child*
;
Humans
;
Peritoneal Dialysis, Continuous Ambulatory*
;
Peritonitis*
3.Thromboebolic complications in children wigh nephrotic syndrome.
Ja Wook KOO ; Hye Won PARK ; Tae Sun HA ; Il Soo HA ; Hae Il CHEONG ; Yong CHOI
Korean Journal of Nephrology 1993;12(4):579-587
No abstract available.
Child*
;
Humans
;
Nephrotic Syndrome*
4.A clinical study of continuous ambulatory peritoneal dialysis in childhood.
Tae Sun HA ; Hye Won PARK ; Ja Wook KOO ; In Seok LIM ; Hae Il CHEONG ; Yong CHOI ; Kwang Wook KO
Journal of the Korean Pediatric Society 1991;34(3):363-370
No abstract available.
Child
;
Humans
;
Kidney Failure, Chronic
;
Peritoneal Dialysis, Continuous Ambulatory*
5.A clinical study of continuous ambulatory peritoneal dialysis in childhood.
Tae Sun HA ; Hye Won PARK ; Ja Wook KOO ; In Seok LIM ; Hae Il CHEONG ; Yong CHOI ; Kwang Wook KO
Journal of the Korean Pediatric Society 1991;34(3):363-370
No abstract available.
Child
;
Humans
;
Kidney Failure, Chronic
;
Peritoneal Dialysis, Continuous Ambulatory*
6.A Clinical Study on the Posterior Subcapsular Cataracts in Childhood Nephrotic Syndrome.
Dong Kyu JIN ; Ja Wook KOO ; Hae Il CHEONG ; Yong CHOI ; Kwang Wook KO ; Jong Hoon LEE ; Young Suk YU
Journal of the Korean Pediatric Society 1990;33(8):1097-1103
No abstract available.
Cataract*
;
Nephrotic Syndrome*
7.IgA Nephropathy in Childhood.
Yong CHOI ; Dong Woo SON ; Ja Wook KOO ; Dong Kyu JIN ; Hae Il CHEONG ; Kwang Wook KO ; Hyun Soon LEE ; Yong Il KIM
Journal of the Korean Pediatric Society 1990;33(9):1237-1243
No abstract available.
Glomerulonephritis, IGA*
;
Immunoglobulin A*
8.Adult T-cell leukemia/lymphoma in a Korean: a case report.
Seung Sook LEE ; Seok Il HONG ; Dong Soon LEE ; Yoon Koo KANG ; Chul Woo KIM ; Ja June JANG
Journal of Korean Medical Science 1994;9(6):458-465
The clinicopathologic features of a Korean patient with adult T-cell leukemia/lymphoma(ATLL) are presented. A 51-year-old man, who has lived in Korea since birth, had multiple cutaneous nodules and multiple lymphadenopathy for the previous two months. A histopathologic study of the lymph node and skin lesion revealed T-cell non-Hodgkin's lymphoma of pleomorphic type, medium and large cell type. Peripheral blood examination showed leukemic features with 30% of abnormal lymphoid cells. HTLV-I proviral DNA pX region was detected in the DNA from peripheral blood mononuclear cells(PBMC) and the specific gag, pol, and env HTLV-I sequences were detected in the lymph node using polymerase chain reaction technique. Human T-cell leukemia/lymphoma type I(HTLV-I) antibodies were present in the serum. An immunophenotypic study of the lymph node revealed CD4 positive and CD8 negative helper/inducer T cell type surface markers. This case is the acute type, i.e. prototypic ATLL. He was treated with an intensive chemotherapy including cyclophosphamide, etoposide, doxorubicin, vincristine, and prednisone. Despite initial transient improvement, the tumor progressed after three cycles of the regimen and became refractory to further chemotherapy. These clinicopathologic findings, including the immunophenotypic analysis, established with certainty the diagnosis of HTLV-I-induced adult T-cell leukemia/lymphoma.
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
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Case Report
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Cyclophosphamide/administration & dosage
;
DNA, Viral/blood
;
Doxorubicin/administration & dosage
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Etoposide/administration & dosage
;
Human
;
Human T-lymphotropic virus 1/isolation & purification
;
Immunophenotyping
;
Korea/epidemiology
;
Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/drug therapy/epidemiology/pathology/virology
;
Lymph Nodes/pathology
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Male
;
Middle Age
;
Prednisone/administration & dosage
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Proviruses/isolation & purification
;
Tumor Stem Cells/chemistry/pathology
;
Vincristine/administration & dosage
9.How Many Sentinel Lymph Nodes Are Enough for Accurate Axillary Staging in T1-2 Breast Cancer?.
Eun Jeong BAN ; Jun Sang LEE ; Ja Seung KOO ; Seho PARK ; Seung Il KIM ; Byeong Woo PARK
Journal of Breast Cancer 2011;14(4):296-300
PURPOSE: During a sentinel lymph node biopsy (SLNB) for breast cancer, the appropriate number of sentinel lymph nodes (SLNs) to be removed for accurate axillary staging is still controversial. We hypothesized that there might be an optimal threshold number of SLNs. We investigated how many SLNs should be removed to achieve an acceptable accuracy and ensure minimal morbidity. METHODS: We reviewed data of 328 patients with invasive breast cancer who underwent SLNB followed by complete level I and II axillary dissection between January 2004 and December 2005. The false negative rate (FNR) and accuracy of SLNB according to the number of removed SLNs were evaluated. RESULTS: The mean number of SLNs removed was 3.0 (range, 1-14), and that of total retrieved axillary lymph nodes was 17.5 (range, 10-40). In total, 111 (33.8%) patients had positive nodes on the permanent pathological report. Among them, 12 patients had negative SLNs; thus, the overall FNR of SLNB was 10.8% (12/111) and the accuracy was 96.3% (316/328). The FNR was 26.6% for a single SLN, 8.0% for two, and 11.1% for three. In cases where four or more SLNs were removed, the FNR decreased to 0% and accuracy reached 100%. CONCLUSION: Our data suggest that a SLNB should not only remove one or two of the hottest node(s) when other hot nodes exist. We also suggest that four might be an optimal threshold number of SLNs to be removed and that removal of more than four SLNs does not improve axillary staging accuracy.
Breast
;
Breast Neoplasms
;
Dietary Sucrose
;
Humans
;
Lymph Nodes
;
Nitriles
;
Pyrethrins
;
Sentinel Lymph Node Biopsy
10.Effect of 0.05% Cyclosporine A on the Ocular Surface after Photorefractive Keratectomy.
Yong Il KIM ; Sung Hyun KOO ; Sang Won HA ; Gwang Ja LEE ; Kyoo Won LEE ; Young Jeung PARK
Journal of the Korean Ophthalmological Society 2016;57(5):710-717
PURPOSE: To evaluate the effect of 0.05% cyclosporine A on the ocular surface after photorefractive keratectomy (PRK). METHODS: This retrospective study included 50 patients who underwent PRK. Patients were divided into two groups: 25 patients in group I were treated with topical 0.05% cyclosporine A with conventional medication, and 25 patients in group II were treated with conventional medication. Visual acuity (VA), tear break-up time (BUT), fluorescein staining score (F-stain), Schirmer I test, and ocular surface disease index (OSDI) were evaluated before surgery and 2 weeks, 1 month, 2 months, and 3 months after surgery. RESULTS: F-stain was significantly lower in group I than in group II at 2 weeks and 1 month (p < 0.05). There was no significant difference in uncorrected VA, BUT, Schirmer I test, or OSDI between the groups. However, group I showed a more effective pattern in dry eye. CONCLUSIONS: Combination treatment with 0.05% cyclosporine A was helpful for early ocular surface stability in patients with dry eye after PRK.
Cyclosporine*
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Fluorescein
;
Humans
;
Photorefractive Keratectomy*
;
Refractive Surgical Procedures
;
Retrospective Studies
;
Tears
;
Visual Acuity