Forehead ; surgery ; Humans ; Nose ; surgery ; Reconstructive Surgical Procedures ; methods ; Surgical Flaps

Cardiac involvement related to iron overload caused by long-term blood transfusion is a major cause of death for patients with thalassemia major. Patients' survival will be improved greatly if cardiomyopathy resulted from transfusional iron overload could be detected timely and effective iron chelation be initiated promptly. In the present article, various evaluation Methods currently used in clinical practice are reviewed, with particular focus on cardiac MRI for the monitoring of myocardial involvement related to iron overload.

Objective To develop a physical in vitro model of the human carotid artery(CA) and analyze the factors that influence the embolus-capturing efficiency of the retrievable artery filters. Methods The flow model closely simulated the physiological parameters of the human carotid artery. The influence of the following experimental parameters on the capturing rate was analyzed with a multiple logistic regression model: embolus diameter and length, CA diameter, flow quantity, type of filter, and type of testing. Results At the 5% level,except for flow quantity,a significant influence on the capturing rate could be demonstrated for the 6 factors mentioned above, the embolus diameter was the strongest influencing factor. In CA with diameters of 4,5,6,7 mm, the 8-wire filter captured (90?7)%, (91?8)%, (81?8)%,and (68?9)% of 0.5 mm emboli and (93?4)%, (95?6)%, (95?6)%,and (82?11)% of 1 mm emboli. In all, the smaller, the interlacing opening of the filter, the higher the capturing rate, and the presence of an embolus in a filter would decrease the capturing rate for the second embolus. Conclusion Retrievable artery filter is a promising cerebral protection device. The physical in vitro model is an effective alternative in studying the influence factors of the capturing rate of the filters.

Objective: To study the loss of heterozygosity (LOH) at 6 markers of microsatellite polymorphism on the chromosome 6 in T-cell lymphoma (TCL) to determine whether there existed tumor suppressor genes in the area related with the initiation and development of TCL. Methods: Six microsatellite polymorphism markers (D6S251, D6S275, D6S287, D6S267, D6S262, and D6S264) on the chromosome 6 were selected. We performed the amplification of microsatellite DNA with PCR, polyacrylamide gel electrophoresis and silver staining to detect LOH in 42 cases of T-cell lymphoma and the corresponding normal tissues. Results: LOH were detected at more than one locus in 13 out of 42 TCL patients (30.95%). Among the 6 loci, LOH occurred more frequently at D6S262 (10.3%), D6S287 (10.0%), and D6S267 (7.3%). No significant difference was found in LOH incidence between different clinicopathologic classifications (P > 0.05). Conclusion: The LOHs occur more frequently at markers D6S262, D6S287, and D6S267 on the chromosome 6q21 to 6q23. Cyclin C gene localized to chromosome 6q21 may be the candidate of tumor suppressor gene related with initiation and progression of TCL. Chromosome 6q21-6q23 may harbor a tumor suppressor locus which was related with TCL.

Child ; Humans ; Liver Failure ; therapy ; Liver Transplantation ; Male ; Plasma Exchange

Acupuncture Therapy ; instrumentation ; Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Hot Temperature ; Humans ; Male ; Mumps ; therapy ; Sulfur ; chemistry ; Young Adult

Fusion Proteins, bcr-abl ; genetics ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; complications ; genetics ; Male ; Middle Aged ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; etiology

Adult ; Cadmium ; Female ; Glomerulonephritis, IGA ; etiology ; Humans ; Occupational Exposure

Objective To explore the changes of serum IL‐6 ,IL‐10 ,PLA2 on intracranial infection and its prognosis .Methods Totallly 100 patients with intracranial infection during February 2011 to December 2013 were selected as the research object .In 100 cases of intracranial infection patients ,30 cases were cured (group A) and 52 cases improved (group B) ,18 cases of illness or death as poor prognosis group (group C) .Serum IL‐6 ,IL‐10 ,PLA2 content of the subjects in different time point were detected .Results One day After infection ,serum IL‐6 ,IL‐10 ,PLA2 levels in intracranial infection group were obviously higher than that of healthy control group (P< 0 .01) ;7 d after infection ,IL‐6 ,IL‐10 average level among 3 groups had obvious changed(P< 0 .05) ,7 d after in‐fection ,IL‐6 ,IL‐10 level of group B and group C was significantly higher than group A (P< 0 .05) ;and in group C ,IL‐6 ,IL‐10 was higher than group B (P< 0 .05) .7 d after infection ,the IL‐6 IL‐ 10 level of group A declined ,the IL‐6 ,IL‐ 10 levels of group B be‐gan decreasing 14 d after infection ,and the IL‐6 ,IL‐10 levels of group C had been in a rising trend .3 d after infection ,the PLA2 leves among 3 groups had obvious changed(P< 0 .05) ,7 d after infection ,the change rate increased ,7 d after infection ,PLA2 level of group B and group C was significantly higher than group A (P< 0 .05) ,and in group C ,PLA2 was higher than group B (P< 0 . 05) .7 d after infection ,the PLA2 level of group A declined ,in group B and group C ,PLA2 level began to decline significantly 14 d after infection .Conclusion IL‐6 ,IL‐10 ,PLA2 are closely related to the occurrence and prognosis of intracranial infection .

A 66-year-old male patient presented with rhinocnesmus and mild epistaxis. More than 100 maggots were found in the right nasal cavity by nasal endoscopy. The affected nasal mucosa was erythematous, edematous, ulcerated, and mild bleeding on probing was present. No nasal septal perforation or destruction of nose was noted. Middle and inferior meatus, nasopharyngeal mucosa, orbit, facial skin, oral cavity, gingiva and external auditory canal were normal. The maggot was identified as larvae of Chrysomyia megacephala.
Aged ; Humans ; Male ; Myiasis ; Nasal Cavity ; parasitology