Objective: To extract the syndrome elements of CHD angina pectoris with entropy-based complex system partition method and to analyze the distribution of the syndrome elements, in an effort to study the pathogenetic characteristics of CHD angina pectoris. Methods: The clinical data of 403 patients with CHD angina pectoris were collected by clinical epidemiological survey. Entropy-based Complex System Partition was used to extract the syndrome elements, contribution degree of symptoms to syndrome and diagnostic threshold. The combination rule of the syndrome elements was also analyzed. Results: CHD angina pectoris had the following basic syndromes: Qi Deficiency syndrome, Qi Stagnation syndrome, Blood Stasis syndrome, Phlegm Turbid syndrome, Phlegm-fire syndrome, Stagnation-fire syndrome, Yin Deficiency syndrome and Yang Deficiency syndrome. With the increase of syndrome elements, the frequencies of Qi Deficiency syndrome, Yin Deficiency syndrome, Qi Stagnation syndrome, Blood Stasis syndrome, and Phlegm turbid syndrome also increased. Qi Deficiency syndrome and Blood Stasis syndrome were the two syndrome elements seen most frequently. Conclusions: The syndrome elements extracted by entropy-based complex system partition method and their distribution rule can reflect the pathogenic characteristics of angina pectoris, which lays a base of quantify the diagnostic criteria of the angina pectoris syndrome.

Translational medicine, a kind of medical scientific practice oriented by patients'demands, emphasizes that basic theoretical study helps enhance clinical effect, transform into new drugs as well as meet major needs of social development and human health. It follows disciplinary development rules of TCM, persists in five-in-one (theory-clinic-new drug-experiment-evidence based) innovative new mode of TCM translational development, accelerates internal transformation of research findings, and promotes clinical effect and disciplinary development driven by the oretical innovation of collateral disease. In terms of the oretical research, establishment of new discipline of TCM collateral disease theory has become a practitioner and typical representative for promotion of TCM industry development. Important position and guiding role of theoretical innovation in disciplinary development has been valued. Systematically constructing ″collateral disease treatment based on syndrome differen?tiation″ and ″meridian-collateral theory″ lay a theoretical foundation for establishment of the discipline. With regard to clinical research, under the guidance of TCM theory-collateral disease theory, systematic researches on Chinese medical pathogenesis, intervention strategy and effective formula of major diseases are conducted; series of innovative Chinese medicines are developed. Through pharmacody?namics study, relevant action mechanisms are investigated and revealed in- depth. Evidence- based medical researches prove that representative activating-collateral drugs developed under guidance of collateral disease theory have great application values in prevention and treatment of major refractory diseases such as ischemic cardio-cerebrovascular disease, arrhythmia, chronic heart failure, influenza, tumors and diabetes, bringing about significant economic and social benefits. In this way, international cooperation is promoted and internationalization process of innovative Chinese medicine is accelerated. USA FDA phase-Ⅱ clinical research of Lianhua Qingwen Capsules has been successfully launched. Guided by inheritance and innovation of conventional theory of TCM, the new five- in- one mode of development is established. Such a mode conforms to disciplinary development rules of TCM, suffi?ciently exerts core driving effect of TCM theory, realizes combination of theoretical innovation with clinical practice, specialty construction with disciplinary development and clinical research with original new drug, as well as powerfully promotes progress of TCM collateral disease discipline.

Adolescent ; Cardiomyopathy, Dilated ; diagnosis ; etiology ; physiopathology ; Diagnosis, Differential ; Female ; Graves Disease ; complications ; diagnosis ; physiopathology ; Humans

"Vessels Collateral Theory", as the inherit and development of "blood vessels" in Huangdi Neijing, is a systematic system by integrating severe vascular diseases. In this article, by taking cardiovascular diseases (CVD) as a cut-in point, roles of "minute collateral-microvascular" lesions in the occurrence and development of CVD were further explored. The interventional effect of collateral-unblocking medicines under the guidance of Vessels Collateral Theory was also in-depth explored, hoping to leading Chinese medical prevention and treatment of CVD.
Cardiovascular Diseases ; drug therapy ; Humans ; Medicine, Chinese Traditional ; Research

This paper uses the Luobing theory to guide the diagnosis and treatment of coronavirus disease-2019 (COVID-19), and states that lung collateral includes Qi collateral and blood collateral, and is the basis for playing the function of lung of dominating Qi, controlling breathing and connecting all vessels. The concept of Qi channel is different from that of Qi collateral, but its function is closely related to lung collateral. COVID-19 belongs to "pestilence" in traditional Chinese medicine. The epidemic pathogenic factor enters from mouth and nose and then causes the disease. The early characteristics of this disease include the invasion of the lung by the epidemic pathogenic factor, the obstruction of Qi channels, the prevailing of the evil and the retreat of the good, and the deficiency and stagnation of Qi collateral. Generation of toxic heat from inside, obstruction of Qi channels and dysfunction of "breathing and blood transfer" are the key links to the development and aggravation of this disease. Qi disease involves blood, blood wound intrudes into collateral, and blood consumption and hemorrhage are the late outcome of this disease. Based on the experience of doctors of all dynasties in the treatment and medication of pestilence, the treatment principle of active intervention in the early and middle stage is proposed, including focusing on pathogenesis and expelling of toxin, drug use before syndrome onset and active intervention, and the whole regulation and multi-target treatment. Lianhua Qingwen developed under the guidance of Luobing theory can inhibit the activity of novel coronavirus in vitro, relieve clinical symptoms (such as fever, cough, weakness, shortness of breath and so on) and reduce the rate of disease progression to severity. Lianhua Qingke can diffuse the lung, clear the lung heat, relieve cough and reduce sputum. It can be used to relieve the symptoms of cough and sputum in patients with COVID-19, which proves the important scientific value of Luobing theory and collateral-dredging drugs in epidemic prevention and control.

Bacterial N-Acyl-L-homoserine lactones (AHLs)-mediated quorum sensing is involved in the regulation of diverse biological functions. As the bacterial pathogen population density increases, AHLs concentration secreted by pathogen reaches a threshold and then interacts with their intercellular receptor and triggers expression of virulence genes. It is a promising approach to biologically control bacterial disease in plants and animals by manipulating bacterial AHL-quorum sensing with AHLs-degrading enzyme and AHL analogue.

Ralstonia metallidurans CH34 was isolated from the deposit of a znic factory .The degradation of phenol by R .metallidurans CH34 was investigated. The results showed that R . metallidurans CH34 possesses high ability to degrade phenol with the biodegradation rate constant of 0.33 . The optimal pH , temperature and volume of medium for phenol degradation are pH 7.0 , 30℃ , and 20%(v/v), respectively . In addition , this strain retains its ability to degrade phenol in the presence of high concentration of heavy metal ion .The sodium citrate , sodium succinate can enhance the degradation of phenol.

OBJECTIVEThe present study is concerning qualitative and quantitative detection of Poria cocos quality based on FT-near infrared (FT-NIR) spectroscopy combined with chemometrics.

METHODThe Poria cocos polysaccharides contents were determined by UV. Transmission mode was used in the collection of NIR spectral samples. The pretreatment method was first derivation and vector normalization. Then principal component analysis (PCA) was used to build classification model and partial least square (PLS) to build the calibration model.

RESULTThe results showed that conventional criteria such as the R, root mean square error of calibration (RMSEC), and the root mean square error of prediction (RMSEP) are 0.944 0, 0.072 1 and 0.076 2, respectively. The misclassified sample is 0 using the qualitative model built by PCA.

CONCLUSIONThe prediction models based on NIR have a better performance with high precision, good stability and adaptability and can be used to predict the polysaccharose content of Poria cocos rapidly, which can provide a fast approach to discriminate the different parts of Poria cocos.

Adult ; Female ; Forearm ; surgery ; Free Tissue Flaps ; Humans ; Male ; Middle Aged ; Oral Surgical Procedures ; methods ; Reconstructive Surgical Procedures ; methods ; Skin Transplantation

Adrenalectomy ; Adult ; Angiomyolipoma ; pathology ; surgery ; Follow-Up Studies ; Humans ; Kidney ; pathology ; Kidney Neoplasms ; pathology ; surgery ; Lymph Node Excision ; Lymph Nodes ; pathology ; Lymphatic Metastasis ; Male ; Nephrectomy ; Ureter ; surgery