1.“Antipodal asymmetry” – The undiagnosed twin in the opposite uteri: A case report of dicavitary twin pregnancy in uterine didelphys
Ivy Grace C. Lim ; Michelle E. Gamboa ; Lylah D. Reyes
Philippine Journal of Obstetrics and Gynecology 2021;45(2):76-81
Muüllerian duct anomalies (MDAs) are congenital defects arising from probable teratogenic assault at 6–22 weeks of gestation.Uterine didelphys arises from complete lack of fusion of Muüllerian ducts, resulting in two entirely separate hemiuteri, cervices and vaginas.The incidence of MDA is <5% and the frequency of uterine didelphys is 1 in 1000–30,000 women and twin pregnancy in uterus didelphys is only 1 in a million. This is a case of a gravida 1 para 0, with uterine didelphys and unilateral renal agenesis diagnosed of single live intrauterine pregnancy in the left half of uterine didelphys who had a spontaneous passage of meaty material from the right hemiuterus which were histopathologically consistent with degenerating products of conception, hence confirming a dicavitary twin pregnancy. Management should be wholistic encompassing preconception, prenatal, intrapartum, and postpartum period as any complications may arise at any point.
Uterine Anomalies
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Urogenital Abnormalities
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Abortion, Spontaneous
2.A comparison of retinoblastoma cases in the Philippines
Roland Joseph D. Tan ; Gary John V. Mercado ; Patricia E. Cabrera ; Paulita Pamela P. Astudillo ; Rolando Enrique D. Domingo ; Josept Mari S. Poblete ; Charmaine Grace M. Cabebe ; Adriel Vincent R. Te ; Melissa Anne S. Gonzales ; Jocelyn G. Sy ; Beltran Alexis A. Aclan ; Jayson T. So ; Fatima G. Regala ; Kimberley Amanda K. Comia ; Josemaria M. Castro ; Mara Augustine S. Galang ; Aldous Dominic C. Cabanlas ; Benedicto Juan E. Aguilar ; Gabrielle S. Evangelista ; John Michael Maniwan ; Andrei P. Martin ; Calvin Y. Martinez ; John Alfred A. Lim ; Rena Ivy Bascuna ; Rachel M. Ng ; Kevin B. Agsaoay ; Kris Zana A. Arao ; Ellaine Rose V. Apostol ; Beatriz M. Prieto
Philippine Journal of Ophthalmology 2024;49(2):106-114
OBJECTIVE
This study compared the demographics, clinical profile, treatment, and outcomes of retinoblastoma patients seen at medical institutions in the Philippines between two time periods: 2010 to 2015 and 2016 to 2020.
METHODSThis was a multicenter, analytical, cohort study using review of medical charts and databases of retinoblastoma patients seen in 11 medical institutions from 2010 to 2020.
RESULTSThere were 636 patients (821 eyes) included in this study: 330 patients were seen in 2010 to 2015 while 306 in 2016 to 2020. More cases per annum were seen in the latter timeline. The number of patients with unilateral disease was not significantly different between the two time periods (p=0.51). Age at onset of symptom, age at initial consultation, and delay in consult were also not significantly different between the two time periods (p > 0.05). Patients had significantly different distributions of intraocular grades (p < 0.0001) and systemic staging (p < 0.0001) between the two time periods. Enucleation was the most common surgical treatment performed in both timelines. There was significant difference in the status of patients based on the need for systemic chemotherapy (p < 0.01). There was significant difference in outcome between the two time periods, including the proportions of living and deceased patients.
CONCLUSIONThis study compared the most comprehensive data on retinoblastoma patients in the country. There was no improvement in early health seeking behavior based on similar age at initial consult and delay in consult. Enucleation remained the most common treatment mode as opposed to chemotherapy due to similar percentage of patients with unilateral disease, an indication for enucleation rather than chemotherapy.
Human ; Retinoblastoma ; Philippines ; Epidemiology ; Treatment ; Therapeutics
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