1.Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
Lucía Daniela GRIPPO ; Ivana Gabriela REIDEL ; María Inés GARCÍA ; Alexis STREU ; Diana María MÜLLER ; Carolina Melania VEAUTE
Clinical and Experimental Vaccine Research 2020;9(2):159-163
The design of subunit vaccines requires new adjuvant systems. We designed and synthesized new lipopeptides (cysteine-based) of low molecular weight with different hydrophobic chains that dimerize becoming Gemini lipopeptides. They were characterized and their adjuvant capacity was tested in mice by the inoculation of a protein antigen formulated with the lipopeptides, with and without the addition of CpG-oligodeoxynucleotides. Formulations were able to induce an immune response and produced no adverse effects. An adjuvant ability is described for the first time for this type of molecules.
2.Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
Lucía Daniela GRIPPO ; Ivana Gabriela REIDEL ; María Inés GARCÍA ; Alexis STREU ; Diana María MÜLLER ; Carolina Melania VEAUTE
Clinical and Experimental Vaccine Research 2020;9(2):159-163
The design of subunit vaccines requires new adjuvant systems. We designed and synthesized new lipopeptides (cysteine-based) of low molecular weight with different hydrophobic chains that dimerize becoming Gemini lipopeptides. They were characterized and their adjuvant capacity was tested in mice by the inoculation of a protein antigen formulated with the lipopeptides, with and without the addition of CpG-oligodeoxynucleotides. Formulations were able to induce an immune response and produced no adverse effects. An adjuvant ability is described for the first time for this type of molecules.