1.In vitro cytotoxicity of self-etching primers.
Chang Hoon RHEE ; In Ryeon KIM ; Gyoo Cheon KIM ; Seong Sik KIM ; Woo Sung SON
Korean Journal of Orthodontics 2006;36(6):422-433
OBJECTIVE: Several ions and components are released from self-etching primers in the oral cavity. This may cause injury to the periodontal tissues throughout orthodontic treatment. The purpose of this study was to assess the cytotoxicity of self-etching primers to HGF-1, HaCaT, and RHEK cells. METHOD: Transbond XT Primer (3M Unitek, Monrovia, CA, USA), and self-etching primers, Clearfil SE Bond (Kuraray, Osaka, Japan), Transbond Plus SEP (3M Unitek, Monrovia, CA, USA), and Adper Prompt L-Pop (3M Unitek, Monrovia, CA, USA), were evaluated by MTT assay, and cellular changes were also observed. RESULTS: In all cells after 72 hours with all primers, severe morphological changes such as atrophy and necrosis were observed. In the MTT assay using HGF-1, Clearfil SE Bond, Transbond XT Primer, Transbond Plus SEP, and Adper Prompt L-Pop were lined up in order of ascending cytotoxicity.When using HaCaT, Clearfil SE Bond, Adper Prompt L-Pop, Transbond Plus SEP, and Transbond XT Primer were lined up in order of ascending cytotoxicity. When using RHEK, Clearfil SE Bond, Transbond XT Primer, Adper Prompt L-Pop, and Transbond Plus SEP were lined up in order of ascending cytotoxicity. CONCLUSION: The result of this study shows that care is needed because self-etching primers show cytotoxic properties similar to conventional primers.
Atrophy
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Ions
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Mouth
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Necrosis
2.Predicting graded young modulus values of Ti alloys modified by ion implantation.
The Medical journal of Malaysia 2004;59 Suppl F():164-5
There has been, and is still, concern about the high elastic modulus of Ti alloys compared to bone. Any reduction in the Young's modulus value of the implant is expected to enhance stress redistribution to the adjacent bone tissues, minimize stress shielding and eventually prolong device lifetime. Dynamic Monte Carlo simulation is used to predict the gradual reduction in Young's modulus values between the bulk of Ti alloys and the modified surface layers due to Ca ion implantation. The simulation can be used as a screening step when applying new alloys and/or coatings.
seconds
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Alloys
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Ions
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simulation
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Young
3.MinION(TM): New, Long Read, Portable Nucleic Acid Sequencing Device.
Journal of Bacteriology and Virology 2015;45(4):285-303
The MinION(TM) is a miniature nanopore-based analysis device in which the characteristics of an analyte, as it passes through the nanopore, cause changes in the flow of ions through the pore, which are measured, as current flow, by a low noise amplifier and analogue-to-digital converter. Potentially any molecular analyte capable of passing through the nanopore may modify the flow of ions and generate a signal which might be diagnostic. In practice the current device is focussed on DNA sequencing, directly sequencing RNA is a likely development. With the MinION Access Program making the MinION(TM) widely available a flood of applications exploiting its real time, long read capabilities have been published. We review the background to the technology and compare it to current next generation sequencing.
Ions
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Nanopores
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Noise
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RNA
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Sequence Analysis, DNA
4.Kimura's Disease: CT Features of Abdominal Involement in a Case.
In Jae LEE ; Soo Youn PARK ; Hyun Kwon HA ; Pyo Nyun KIM ; Moon Gyu LEE ; Yong Ho AUH
Journal of the Korean Radiological Society 1999;41(1):125-127
Kimura's disease is a benign chronic inflammatory condition with good prognosis, commonly involving the headand neck area. With regard to abdominal manifestat ions, howeve r, the information contained in the literature islimited. Diagnosis on the basis of imaging is difficult, especially in abdominal cases manifesting aslymphadenopathy. The purpose of this report is to illustrate and discuss an abdominal case of the diseasemanifesting as lymphadenopathy.
Diagnosis
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Ions
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Lymphatic Diseases
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Neck
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Prognosis
5.Metal-on-metal Articulation of Total Hip Replacement.
Hip & Pelvis 2013;25(4):245-253
Metal-on-metal (MoM) total hip replacement (THR) and hip resurfacing have an advantage of low wear rate and greater stability by larger head size and different characteristics of wear mechanism, tribology, lubrication or generating wear debris compared to conventional metal-on-polyethylene THR. Although the mid- or long term clinical reports of second generation MoM THR were excellent, concerns about local and systemic effect by metal particles or metal ions were remained. Recently, reports have emerged of abnormal soft-tissue reactions to metal particles or metal ions and some hip resurfacing implants were expelled from the market due to high revision rate. This article includes the history of MoM THR, tribology, the biologic effect of metal particles and ions, the clinical results of MoM THR and the issues regarding the problems associated with hip resurfacing.
Arthroplasty, Replacement, Hip*
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Head
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Hip
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Ions
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Lubrication
6.Size-dependent toxicity of silver nanoparticles to Glyptotendipes tokunagai.
Seona CHOI ; Soyoun KIM ; Yeon Jae BAE ; June Woo PARK ; Jinho JUNG
Environmental Health and Toxicology 2015;30(1):e2015003-
OBJECTIVES: This study aims to evaluate the size-dependent toxicity of spherical silver nanoparticles (Ag NPs) to an endemic benthic organism, Glyptotendipes tokunagai. METHODS: Ag nanoparticles of three nominal sizes (50, 100, and 150 nm) capped with polyvinyl pyrrolidone (PVP-Ag NPs) were used. Their physicochemical properties, acute toxicity (48 hours), and bioaccumulation were measured using third instar larvae of G. tokunagai. RESULTS: The aggregation and dissolution of PVP-Ag NPs increased with exposure time and concentration, respectively, particularly for 50 nm PVP-Ag NPs. However, the dissolved concentration of Ag ions was not significant compared with the median lethal concentration value for AgNO3 (3.51 mg/L). The acute toxicity of PVP-Ag NPs was highest for the smallest particles (50 nm), whereas bioaccumulation was greatest for the largest particles (150 nm). However, larger PVP-Ag NPs were absorbed and excreted rapidly, resulting in shorter stays in G. tokunagai than the smaller ones. CONCLUSIONS: The size of PVP-Ag NPs significantly affects their acute toxicity to G. tokunagai. In particular, smaller PVP-Ag NPs have a higher solubility and stay longer in the body of G. tokunagai, resulting in higher toxicity than larger PVP-Ag NPs.
Chironomidae
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Ions
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Larva
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Nanoparticles*
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Polyvinyls
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Silver*
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Solubility
7.Size-dependent toxicity of silver nanoparticles to Glyptotendipes tokunagai.
Seona CHOI ; Soyoun KIM ; Yeon Jae BAE ; June Woo PARK ; Jinho JUNG
Environmental Health and Toxicology 2015;30(1):e2015003-
OBJECTIVES: This study aims to evaluate the size-dependent toxicity of spherical silver nanoparticles (Ag NPs) to an endemic benthic organism, Glyptotendipes tokunagai. METHODS: Ag nanoparticles of three nominal sizes (50, 100, and 150 nm) capped with polyvinyl pyrrolidone (PVP-Ag NPs) were used. Their physicochemical properties, acute toxicity (48 hours), and bioaccumulation were measured using third instar larvae of G. tokunagai. RESULTS: The aggregation and dissolution of PVP-Ag NPs increased with exposure time and concentration, respectively, particularly for 50 nm PVP-Ag NPs. However, the dissolved concentration of Ag ions was not significant compared with the median lethal concentration value for AgNO3 (3.51 mg/L). The acute toxicity of PVP-Ag NPs was highest for the smallest particles (50 nm), whereas bioaccumulation was greatest for the largest particles (150 nm). However, larger PVP-Ag NPs were absorbed and excreted rapidly, resulting in shorter stays in G. tokunagai than the smaller ones. CONCLUSIONS: The size of PVP-Ag NPs significantly affects their acute toxicity to G. tokunagai. In particular, smaller PVP-Ag NPs have a higher solubility and stay longer in the body of G. tokunagai, resulting in higher toxicity than larger PVP-Ag NPs.
Chironomidae
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Ions
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Larva
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Nanoparticles*
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Polyvinyls
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Silver*
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Solubility
8.Analysis the cupric ion release characteristics of different copper raw materials in intrauterine device in vitro using ICP method.
Hua LU ; Tingting DING ; Tianping YAO ; Jiao SUN
Chinese Journal of Medical Instrumentation 2014;38(3):216-218
OBJECTIVETo study the Cupric ion release characteristics of different copper raw materials in intrauterine device in vitro by ICP. Reveal the relationship between purity and shape of Cu-IUD copper and copper ion release.
METHODSAccording to a certain proportion, the copper raw materials were 100 times diluted into the simulated uterine solution at 37 +/- 0.5 degrees C. Replaced medium at certain time points and collected soaking liquid. Using ICP analyzed the concentration of copper ion released.
RESULTSThe largest daily release of copper ions was in the first 7 days. There was no statistically significant difference between the copper ion release amount of 99.99% and 99.95% purity copper wire (P > 0.05). The release of copper ion of the copper wire was far greater than that of the copper pipe in early stage (P < 0.01). The release amount decreased and stabilized at 56 day.
CONCLUSIONRelease characteristics of copper ion could effectively analysis by ICP. And in the same area, the release amount of copper ions of copper wire was greater than that of copper pipe.
Copper ; chemistry ; Intrauterine Devices ; Ions ; chemistry
9.Effect of different types of counterion on the electronic structure of an antitumor polyoxomolybdate Mo7O246-.
Mingli XIANG ; Shenxiu XIAO ; Zirun YUAN ; Yanhui LONG
Journal of Biomedical Engineering 2002;19(2):291-296
The electronic structure of a Lindqvist type [Mo7O24]6- anion with 5 different types of counterion (K+, Na+, NH4+, [NH3Pr]+ and [NH3Pri]+) was calculated by using the Discrete Variational Method coupled with Density Functional Theory (DFT-DVM). It could be concluded through variance analysis to the calculated results that the type of counterion does not influence remarkably the electronic structure of [Mo7O24]6- anions. Perhaps it can be used to explain the experiment fact that the polyoxomolybdate structure of the Mo7O24 framework is apparently of critical significance to antitumor action. On these grounds we forecast that two other lindqvist type heptamolybadates(their counterions are Na+ and [NH3Pr]+ respectively) may also exhibit antitumor activities.
Antineoplastic Agents
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chemistry
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Ions
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chemistry
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Molybdenum
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chemistry
10.Effect of Keishibukuryogan on Silent Brain Infarction over 3 Years
Hirozo GOTO ; Yutaka SHIMADA ; Hiroaki HIKIAMI ; Shotai KOBAYASHI ; Shuhei YAMAGUCHI ; Ryukichi MATSUI ; Kohichi SHIMODE ; Tadamichi MITSUMA ; Takahiro SHINTANI ; Hiroyuki NINOMIYA ; Atsushi NIIZAWA ; Kazuhiko NAGASAKA ; Naotoshi SHIBAHARA ; Katsutoshi T
Kampo Medicine 2008;59(3):471-476
The purpose of this study was to evaluate the effect of keishibukuryogan (KB) against the cognitive symptoms associated with silent brain infarction in a prospective cohort study. The subjects were 93 patients with silent brain infarcts who visited the Department of Japanese Oriental Medicine, University of Toyama, and its allied hospitals. They consisted of 24 males and 69 females, mean age (± S.E.) 70.0±0.8.Group SK (n=51) consisted of patients who used KB extract for more than6months per year. Group SC (n=42) consisted of patients who did not use Kampo formulas. The NS group (n=44) consisted of elderly subjects who had no silent brain infarction, 21 males and 23 females, with a mean age (± S.E.) of 70.7±0.7 years. Among the three groups, the revised version of Hasegawa's dementia scale, apathy scale and self-rating depression scale were compared between the study start and after three years. In the SK and SC groups, these scores, and the subjective symptom levels (head heaviness, headache, dizziness or vertigo, stiff shoulder) were also studied. The results showed that the self-rating depression scales at study start for the SK and SC groups were significantly higher compared to the NS group. In spite of the scores for the NS group increasing after three years, the SK group scores were significantly decreased compared to the SC and NS groups. KB was effective against head heaviness, which often complicates silent brain infarction. In the above mentioned, KB was effective in treating cognitive disorders and subjective symptoms related to silent brain infarction.
Infarction
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Brain
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seconds
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Ions
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symptoms <1>