1.Consensus on the intravitreal injection technique by the Vitreo-Retina Society of the Philippines
Jose Luis de Grano ; Juan Antonio Javellana ; Marie Joan Loy ; Paolo Antonio Silva
Philippine Journal of Ophthalmology 2014;39(1):3-5
Vascular endothelial growth factor (VEGF) has been shown to play a central role in the pathophysiologic
process underlying neovascular eye diseases. As such, anti-VEGF-based pharmacologic agents have emerged as a
highly effective treatment modality for various visually debilitating retinal and choroidal vascular pathologies. The
introduction of these pharmacologic agents directly into the vitreous cavity by means of an injection through the
pars plana has become a widely performed ophthalmic procedure both locally and overseas.
Intravitreal Injections
2.Comparison of The Effects of Healon(R) and BioLon(R) on Rabbit Eyeballs after Intracameral and Intravitreal Injections.
Seung Moo RYU ; Won Ki LEE ; Kee Yong CHOI
Journal of the Korean Ophthalmological Society 1995;36(9):1447-1453
We conducted a study to compare the effects of Healon(R) and BioLon(R), which are sodium hyaluronates made by different raw materials, on rabbit eyeballs after intracameral and intravitreal injections. In the intracameral-injection group, aqueous humor was replaced with 0.2 ml of Healon(R) or BioLon(R), and in the intravitreal-injection group. 0.4 ml of Healon(R) or BioLon(R) was injected after the removal of the same amount of vitreous. Slitlamp and indirect ophthalmoscopic examination, measurement of IOP, and measurement of corneal thickness were performed preoperatively and at 2hours, 24 hours, 3 days, and 7 days postoperatively. Histopathologic examinaion was done at 7 days postoperatively. No group had significant differences in all tests(p>0.05) and the findings were normalized within 7 days. These results indicated that there were no significant differences between the Healon(R) and BioLon(R) groups in the effects on rabbit eyeballs after intracameral and intravitreal injections.
Aqueous Humor
;
Intravitreal Injections*
;
Sodium
3.Retinal toxicity of moxifloxacin injected intravitreally into rabbit eyes: A histological study
Sy Jocelyn L ; Sua Alex S ; Domalanta Leandro J
Philippine Journal of Ophthalmology 2005;30(1):17-19
OBJECTIVE: To investigate the retinal toxicity of different doses of moxifloxacin after intravitreal injection into rabbit eyes.
METHODS: Eight male rabbits were divided into four groups; 2 rabbits each were injected intravitreally with moxifloxacin 48 ug, 240 ug, 480 ug, and normal saline solution. Ocular toxicity was assessed at day 3 and day 7 by slit-lamp biomicroscopy, ophthalmoscopy, and histology.
RESULTS: All eyes showed no abnormalities on histologic evaluation. No relevant complications were found during slit-lamp biomicroscopy and indirect ophthalmoscopy.
CONCLUSION: Intravitreal injection of 480 ug or less of moxifloxacin did not produce retinal toxicity histologically in rabbit eyes.
Animal
;
MOXIFLOXACIN
;
ENDOPHTHALMITIS
;
INTRAVITREAL INJECTIONS
4.The Effect of Intravitreal Melatonin on Rabbit Retina.
Do Gyun KIM ; Won Sup SOHN ; Hyung Woo KWAK
Journal of the Korean Ophthalmological Society 2002;43(9):1781-1788
PURPOSE: To investigate the effect of intravitreal melatonin on retina in rabbit. METHODS: In four pigmented rabbit, melatonin was intravitreally injected 100 mu g/0.1 ml, 300 mu g/0.1 ml concentration in left eye, DMSO was injected in right eye as control. we examined gross fundus finding and electroretinogram and then light and electronic microscopic findings at 24 hours and 1 week with both eye. RESULTS: intravitreally melatonin injected eye at 100 mu g/0.1 ml, 300 mu g/0.1 ml concentration and control eye at 1 day and 1 week, significant difference was not shown in gross fundus finding, electroretinogram, light and electronic microscopic finding. Additionally edema, toxic effect change was not found in retina. CONCLUSIONS: Intravitreally injected melatonin has not influenced on retina grossly, histologically, physiologically at 100 mu g/0.1 ml and 300 mu g/0.1 ml concentration. Further study is required about toxic effect of melatonin over 300 mu g/0.1 ml concentration and clinical usefulness of melatonin in retina.
Dimethyl Sulfoxide
;
Edema
;
Intravitreal Injections
;
Melatonin*
;
Retina*
5.Two Cases of Ischemic Retinopathy due to Intravitreal Gentamicin Toxicity after Vitrectomy.
Dal Jun CHUNG ; Soo Hwan CHOI ; Shin Dong KIM
Journal of the Korean Ophthalmological Society 1993;34(11):1183-1187
Retinal toxicity secondary to intravitreal injection of gentamicin for the purpose of prophylaxis or treatment of endophthalmitis was reported infrequently and it was thought to be caused by an error in the intravitreal injection technique or by faulty dilution of gentamicin. After vitrecotomy, we experienced two cases of ischemic retinopathy secondary to intravitreal injection of gentamicin for prevention of endopthalmitist.
Endophthalmitis
;
Gentamicins*
;
Intravitreal Injections
;
Retinaldehyde
;
Vitrectomy*
6.The Effect of Intravitreal and Subconjunctival Ciprfloxacin in the Treatment of S.Aureus Endophthalmitis.
Hyeon Il LEE ; Hyeong Jun PARK ; Ka Young YI
Journal of the Korean Ophthalmological Society 2000;41(9):1807-1814
To investigate the therapeutic effect of ciprofloxacin for the treatment of endophthalmitis, we used 18 rabbits with Staphylococcus aureus induce dendophthalmitis. The rabbits were assigned into three groups according to the treatment regimen; those who were not given any drug into group I, those who were given 100 microgram/ml ciprofloxacin intrvitreally into group II, and those who were given 2 mg/ml ciprofloxacin subconjunctivaly for 5 days into group III. We assessed clinical score, culture result of vitreous aspirate and pathologic finding of various ocular tissue. We found clinically significant decrease in clinical score in group II, but there were no significant differences in the vitreous culture and in the histologic findings among the study groups. In conclusion, we assume that intravitreal injection of ciprofloxacin may be the better treatment modality to treat endophthalmitis by S.aureus. In addition we still think there ought to be more studies as to the determination the dosage of ciprofloxacin and the use of steroid in combination.
Ciprofloxacin
;
Endophthalmitis*
;
Intravitreal Injections
;
Rabbits
;
Staphylococcus aureus
7.The Histologic Change of Retina Induced by Intravitreal Silicone Oil.
Won Ryang WEE ; Woong San CHOI ; Jae Heung LEE
Journal of the Korean Ophthalmological Society 1992;33(4):375-380
We evaluated the histologic change of retina after gas compression of the vitreous followed by intravitreal injection of silicone oil in albino rabbits. The retinal architecture was well preserved and no abnormal findings could be demonstrated by light microscopic and electron microscopic examinaions 8 weeks after surgery.
Intravitreal Injections
;
Rabbits
;
Retina*
;
Retinaldehyde
;
Silicone Oils*
8.Precipitation of Vancomycin and Ceftazidime on Intravitreal Injection in Endophthalmitis Patients
Gwang Myeong NOH ; Ki Yup NAM ; Seung Uk LEE ; Sang Joon LEE
Korean Journal of Ophthalmology 2019;33(3):296-297
No abstract available.
Ceftazidime
;
Endophthalmitis
;
Humans
;
Intravitreal Injections
;
Vancomycin
9.Macular Hole Formation after Intravitreal Injection of Bevacizumab for Diabetic Macular Edema
Korean Journal of Ophthalmology 2019;33(2):198-199
No abstract available.
Bevacizumab
;
Intravitreal Injections
;
Macular Edema
;
Retinal Perforations
10.Study of Fluorescein Pharmacokinetics.
Byung Kee HYUN ; Hyung Woo KWAK
Journal of the Korean Ophthalmological Society 1989;30(5):693-700
Authority estimated the concentration of fluorescein sodium in the blood, anterior chamber and vitreous after injection of 10% fluorescein sodium, 25mg/kg, according to the lapse of time. Also intravitreal fluorescein sodium concentration was measured after intravitreal injection of 0.1 % fluorescein sodium 10 micro liter according to the lapse of time. The results were as follows. 1. In the normal rabbits, the concentration of fluorescein sodium in the anterior chamber and vitreous were 159.3 +/- 101.7 X 10(-9) gm/ml and 3.6 +/- 4.7 X 10(-9) gm/ml, respectively after 1 hour of fluorescein sodium intravenous injection. The Cv/Ca was 0.02 +/- 0.028(Cv: concentration of fluorescein in the vitreous) (Ca: concentration of fluorescein in the ant. chamber). 2. After injection of sodium fluorescein in the normal rabbit, the concentration of fluorescein in the blood showed rapid decrease in logarithmic manner in the vitreous, the concentration peaked 1 hour and 2 hours after injection which persisted several hours. 3. The concentration of fluorescein sodium in the vitreous after intravitreal injection of fluorescein decreased at logarithmic rate which disappeared 24 hours after injection.
Anterior Chamber
;
Ants
;
Fluorescein*
;
Injections, Intravenous
;
Intravitreal Injections
;
Pharmacokinetics*
;
Rabbits