No abstract available.
Hypersensitivity* ; Intradermal Tests*

Dermographism is an exaggerated triple response of Lewis and appears as a lineat wheal with a flare at a site in which skin is briskIy stroked with a firm object. The etiology and pathogenesis of dermographism are uncertain but passive transfer tests are sometimes poeitive. The active serum factor has been characteiized as Ig E in some patients. In this experimental study, we tried passive transfer of dermographism with the sera of the patients with dermographism. Twelve dermographic patients' sera were tested to fourteen normal healthy persons and two asymptomatic dermographic persons, total number of thirty nine cases. Only two recipients were passively transferred but they showed positive responses to all sera tested, two and three respectively. This result suggests that not only serum factor but also recipient's factor(s) may be concerned in passive transfer of dermographism.
Humans ; Intradermal Tests ; Skin ; Stroke

We herein described a 27 year-old male who has been suffering from pruritic erythematous wheal and flare on sun-exposed areas, especially the midback for the past, ten months. The action spectrum of this patient was between 320 and 400 nm, .Passive and reverse passive transfer tests were negative. According to the classification by Harber et al, the current case seemed to belong to type II.
Adult ; Classification ; Humans ; Intradermal Tests ; Male ; Urticaria*

OBJECTIVE: To evaluate whether skin tests are suitable to predict the allergy reactions induced by Chinese herbal injections (CHIs). METHODS: The skin tests including skin prick tests (SPT), intradermal tests (IDT) and provocation tests including subcutaneous tests and intravenous tests were administered to 249 healthy subjects and 180 allergic patients for 3 CHIs, including ginkgolide injection, diterpene ginkgolide meglumine injection and Salvianolate lyophilized injection. The results of the provocation tests were used as the "gold standard" to determine the sensitivity and specificity of the skin tests. RESULTS: The results did not show any significant differences between the healthy and allergy groups in both skin tests and provocation tests (P>0.05). The specificities of SPT and IDT were 0.976 and 0.797, respectively, and the sensitivities of both SPT and IDT were 0. CONCLUSION Skin tests are insufficient to predict the likelihood of allergic reactions resulting from CHIs. (ChiCTR-CPC-15006921).
China ; Humans ; Hypersensitivity ; Intradermal Tests ; Sensitivity and Specificity ; Skin Tests

We report a case of solar urticaria being activated by both UVA and visible radiation and positive in passive transfer test by visible light, which was treated with sunlight and UVA radiation. A short course of treatment with sunlight produced no benificial effect. UVA phototherpy produced a rnarked increase in the minirnal urtication dose by UVA but there was no increased tolerance to sun exposure.
Intradermal Tests ; Light ; Phototherapy ; Solar System ; Sunlight* ; Urticaria*

Solar urticaria is an uncommon disorder characterized by rapid development of urticarial reaction in areas of skin exposed to nonizing electromagnetic radiation. Herber and Baer classified solar urticaria into eight types on the basis of action spectrum and passive or reverse passive transfer ability. We report two cases of type ]g solar urticaria which were activated by visible light and negative in both passive and reverse passive transfer test.
Electromagnetic Radiation ; Intradermal Tests ; Light ; Skin ; Transfer (Psychology) ; Urticaria*

Iodinated contrast media (CM) can cause immediate and late reactions. We treated a patient with a recurrent generalized maculopapular rash and a fever that occurred within two days of exposure to iodinated CM, iopromide (Ultravist(R)), for chest computed tomography. We performed skin testing including prick tests, intradermal tests, and patch tests. Our findings indicated a late skin reaction to Ultravist(R) in addition to cross-reactions to other iodinated CM such as ioversol (Optiray(R)), iohexol (Iobrix(R)), and iobitridol (Xenetix(R)). In this study, we report the case of a patient diagnosed with a late adverse reaction to Ultravist(R) in addition to cross-reactions to other iodinated CM.
Contrast Media ; Exanthema ; Fever ; Humans ; Intradermal Tests ; Iohexol ; Patch Tests ; Skin ; Skin Tests ; Thorax ; Triiodobenzoic Acids

BACKGROUND: Althogh drug euption refers to a common dermatological condition, there are numerous holdbacks on the diagnosis. OBJECTIVE: This study atternpts to define the clinical features and causavite drug of the patients with drug eruptions, and to evalarate the diagnostic value of various skin tests. METHOD: 130 patients with drug eruptions were reviewed clinically. In 54 patients, intradermal test, patch test, and scratch patch test were performed using suspected drugs. Result : The exanthematous eruption(53.0%), fixed drug eruptior.(29.2%), and urticaria(6.2%) were the common types of the drug eruption. The common causative agenst of drug eruptions were antibiotics/antimicrobials, antipyretics/NSAIDs, and CNS depressants. 28 paitients out of the 54 patients on skin tests with suspected drugs had positive results in at least one slinest. CONCLUSION: In our study, we were able to obtain somewhat meaningfi 1 results based on data from the combination of various skin tests.
Central Nervous System Depressants ; Diagnosis ; Drug Eruptions* ; Humans ; Intradermal Tests ; Patch Tests ; Skin Tests* ; Skin*

The use of topical anesthesia to perform intradermal tests (IDTs) for drug allergy diagnosis was never investigated. We aimed to determine the effects of a topical anesthetic patch containing prilocaine-lidocaine on wheal size of IDT with drugs. Patients who had positive IDT as part of their investigation process of suspected drug hypersensitivity were selected. IDT were performed according to guidelines. Anesthetic patch (AP) was placed and the same prior positive IDT, as well as positive histamine skin prick test (SPT) and negative (saline IDT) controls, were performed in the anesthetized area. Patients with negative IDT were also included to check for false positives with AP. Increase in wheals after 20 minutes both with and without AP was recorded and compared. 45 IDT were performed (36 patients), of which 37 have been previously positive (14 antibiotics, 10 general anesthetics, 6 non-steroidal anti-inflammatory drugs, 3 iodinated contrasts, 3 anti-Hi-histamines and 1 ranitidine). Mean histamine SPT size without the AP was 4.7 mm [95%CI (4.4-5.1]), and 4.6 mm [95%CI(4.2-5.0)] with anesthesia. Mean wheal increase in IDT for drugs without the anesthesia was 4.5 mm [95%CI(3.3-5.7)] and with anesthesia was 4.3 mm [95%CI(2.8-5.8)]. No statistical significant differences were observed between skin tests with or without AP for histamine SPT (P=0.089), IDT with saline (P=0.750), and IDT with drugs (P=0.995). None of the patients with negative IDT showed positivity with the AP, or vice-versa. The use of an AP containing prilocaine-lidocaine does not interfere with IDT to diagnose drug allergy, and no false positive tests were found.
Anesthesia ; Anesthetics, General ; Anti-Bacterial Agents ; Diagnosis* ; Drug Hypersensitivity* ; Histamine ; Humans ; Intradermal Tests* ; Skin ; Skin Tests

Macrolides antibiotics synthesized by Streptomyces strains are prescribed widely and seldom produce hypersensitivity reactions, even when administered topically. Consequently, they are considered very safe drugs. We report the case of a 32.year.old woman who developed anaphylactic shock after ingesting erythromycin, which she had taken twice before. The previous exposure to erythromycin, clinical findings, and a positive skin intradermal test with erythromycin (10 mg/mL) support the postulate that anaphylaxis was induced by erythromycin.
Anaphylaxis ; Anti-Bacterial Agents ; Erythromycin ; Female ; Humans ; Hypersensitivity ; Intradermal Tests ; Macrolides ; Skin ; Skin Tests ; Streptomyces