1.A case of bromadiolone poisoning leading to digestive tract, abdominal hemorrhage and secondary paralytic ileus.
Hong Fan CHEN ; Zhi Jian ZHANG ; Cheng Jin YOU ; Li CHEN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2022;40(9):707-709
Bromadiolone, commonly known as super warfarin, is a long-acting coumarin dicoumarin rodenticide. The mechanism of bromadiolone is mainly to inhibit vitamin K1 epoxide reductase and affect the synthesis of coagulation factors Ⅱ, Ⅶ, Ⅸ and Ⅹ, which causes blood coagulation dysfunction and systemic multiple organ hemorrhage. Here, we report of a case of bromadiolone poisoning patient who had digestive tract, abdominal hemorrhage, as well as secondary paralytic ileus. After blood product transfusion and vitamin K1 supplementation, the patient was discharged after the physical condition was improved. It's suggestied that clinicians should pay attention to rare complications to prevent missed diagnosis when treating other bromadiolone poisoning.
4-Hydroxycoumarins
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Blood Coagulation Factors
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Dicumarol
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Hemorrhage
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Humans
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Intestinal Pseudo-Obstruction/chemically induced*
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Oxidoreductases
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Rodenticides
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Vitamin K 1
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Warfarin