1.Multiple intestinal lymphomatous polyposis in a Jindo dog.
Da Hee JEONG ; Sun Hee DO ; Il Hwa HONG ; Hai Jie YANG ; Dong Wei YUAN ; Dong Hag CHOI ; Kyu Shik JEONG
Journal of Veterinary Science 2006;7(4):401-403
A male, 5-year-old Jindo dog underwent enterectomy and enteroanastomosis due to ileus of the intestine at a local veterinary hospital. Grossly, the excised intestine showed markedly thickened multinodular masses in the serosal layer of the upper part, and soft-to-firm, creamcolored neoplastic masses that displayed extensive nodular mucosal protuberances into the lumen. The neoplastic masses were filled with large round cells that were ovoid in shape and they had pale and/or hyperchromatic nuclei. The neoplastic cells had mainly infiltrated into the mucosal and submucosal layers, and they had diffusely invaded the muscular and serosal layers. Therefore, the diagnosis of canine multiple intestinal malignant lymphomatous polyposis was made based on the gross and histopathological findings. The origin of these tumor cells was determined to be B-cells since they were positive for anti-CD20.
Animals
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Antigens, CD20/metabolism
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Dog Diseases/*pathology/surgery
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Dogs
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Immunohistochemistry/veterinary
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Intestinal Neoplasms/pathology/surgery/*veterinary
;
Intestinal Polyps/*pathology/surgery
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Lymphoma, Mantle-Cell/pathology/surgery/*veterinary
;
Male
2.Meta-analysis of Predictive Clinicopathologic Factors for Lymph Node Metastasis in Patients with Early Colorectal Carcinoma.
Ju Young CHOI ; Sung Ae JUNG ; Ki Nam SHIM ; Won Young CHO ; Bora KEUM ; Jeong Sik BYEON ; Kyu Chan HUH ; Byung Ik JANG ; Dong Kyung CHANG ; Hwoon Yong JUNG ; Kyoung Ae KONG
Journal of Korean Medical Science 2015;30(4):398-406
The objective of this study was to conduct a meta-analysis to determine risk factors that may facilitate patient selection for radical resections or additional resections after a polypectomy. Eligible articles were identified by searches of PUBMED, Cochrane Library and Korean Medical Database using the terms (early colorectal carcinoma [ECC], lymph node metastasis [LNM], colectomy, endoscopic resection). Thirteen cohort studies of 7,066 ECC patients who only underwent radical surgery have been analysed. There was a significant risk of LNM when they had submucosal invasion (> or = SM2 or > or = 1,000 microm) (odds Ratio [OR], 3.00; 95% confidence interval [CI], 1.36-6.62, P = 0.007). Moreover, it has been found that vascular invasion (OR, 2.70; 95% CI, 1.95-3.74; P < 0.001), lymphatic invasion (OR, 6.91; 95% CI, 5.40-8.85; P < 0.001), poorly differentiated carcinomas (OR, 8.27; 95% CI, 4.67-14.66; P < 0.001) and tumor budding (OR, 4.59; 95% CI, 3.44-6.13; P < 0.001) were significantly associated with LNM. Furthermore, another analysis was carried out on eight cohort studies of 310 patients who underwent additional surgeries after an endoscopic resection. The major factors identified in these studies include lymphovascular invasion on polypectomy specimens (OR, 5.47; 95% CI, 2.46-12.17; P < 0.001) and poorly or moderately differentiated carcinomas (OR, 4.07; 95% CI, 1.08-15.33; P = 0.04). For ECC patients with > or = SM2 or > or = 1,000 microm submucosal invasion, vascular invasion, lymphatic invasion, poorly differentiated carcinomas or tumor budding, it is deemed that a more extensive resection accompanied by a lymph node dissection is necessary. Even if the lesion is completely removed by an endoscopic resection, an additional surgical resection should be considered in patients with poorly or moderately differentiated carcinomas or lymphovascular invasion.
Colectomy
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Colorectal Neoplasms/*pathology/surgery
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Endoscopy
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Female
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Humans
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Intestinal Polyps/surgery
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Lymphatic Metastasis
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Male
;
Neoplasm Invasiveness
3.A Giant Colonic Hamartoma and Multiple Colonic Hamartomatous Polyps in a Middle-Aged Man.
In Ja PARK ; Hee Cheol KIM ; Chang Sik YU ; Hyun Lyung KOO ; Jung Sun KIM ; Jin Cheon KIM
Yonsei Medical Journal 2006;47(5):755-758
Colonic hamartomas are rare polypoid lesions. We report an unusual case of multiple colonic hamartomatous polyps, including a giant hamartoma, unrelated to hereditary or familial polyposis syndromes, in a 48-year-old man. The diameter of the largest polyp was 9.5 cm, and endoscopy revealed that the lesion caused colonic obstruction. The clinical, endoscopic and histological aspects of this case are discussed.
Middle Aged
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Male
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Intestinal Obstruction/*pathology/surgery
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Humans
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Hamartoma/*pathology/surgery
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Colonoscopy
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Colonic Polyps/*pathology/surgery
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Colonic Diseases/*pathology/surgery
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Colectomy
4.Clinical classification of Peutz-Jeghers syndrome.
Yi-chen DAI ; Yu-gang SONG ; Bing XIAO ; Ya-li ZHANG ; Fa-chao ZHI ; Bo JIANG ; Dian-yuan ZHOU
Journal of Southern Medical University 2006;26(1):79-81
OBJECTIVETo propose the clinical classification of Peutz-Jeghers syndrome (PJS).
METHODS AND RESULTSRetrospective analysis of 52 patients with PJS admitted in Nanfang Hospital from 1980 to 2003 was conducted. Twenty-four patients were found to have family history of PJS, who had a mean age of 19 years. In the PJS patients, the incidence of gastric polyps was 64.4%, colorectal polyps 76%, and small bowel polyps 95%. The number of polyps was above 50 in 19 of the 31 patients with gastric polyps, in 18 of the 38 patients with colorectal polyps, and in 8 of the 19 patients with small bowel polyps. The pathology of the majority of the polyps (63/108) was characterized by hamartomas, and the incidence of malignancy was 13.5% in the PJS patients.
CONCLUSIONSPJS can be classified according to family history and location, pathology, and number of the polyps. As most patients with over 50 polyps require surgical intervention, 50 polyps is recommended as the criteria for PJS classification. Endoscopic surgery may suffice for management of patients with fewer polyps (<50), while in patients with more polyps or small bowel polyps, open surgery combined with intraoperative endoscopic surgery is recommended.
Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Humans ; Intestinal Polyps ; pathology ; Male ; Peutz-Jeghers Syndrome ; classification ; pathology ; surgery ; Retrospective Studies
5.Clinical, enteroscopic, and pathological characteristics of 796 cases of colorectal polyps.
Fu-e LI ; Hong-jun YE ; Jian LI ; Jun-ping WANG ; Yong-ge LIU ; Guang-yin YU ; Wei-hua YIN
Journal of Central South University(Medical Sciences) 2005;30(4):463-466
OBJECTIVE:
To study the age, clinical, enteroscopic and pathological characteristics of colorectal polyps and factors affected polyp-carcinoma.
METHODS:
We analyzed the clinical, enteroscopic and pathological characteristics of 7276 cases of colorectal polyps.
RESULTS
The incidence of colorectal polyps was 10.94%, including 521 men and 275 women. The rate of colorectal polyp was 82.29% in 30-69 year olds. The adenomatous, inflammatory, hyperplastic and juvenile polyps were 43.84%, 42.09%, 11.06% and 1.51%, respectively. Polypoid lesions were located at cecum 3.29%, ascending 11.88%, transverse 4.89%, descending 11.58%, sigmoid 26.05%, and rectum 42.32%. Thirty-five cases (4.4%) were found to have polpous canceration. The canceration rates in villous, mixed and tubular adenomas were 29.73%, 11.11%, and 4.86%. The rate of canceration seemed to depend on its dimensions, being 1.3%, 7.4%, and 25.6% for the 0.6 - 1.0 cm, 1.1 - 1.9 cm, and > or = 2.0 cm in size, respectively. Conclusion The ages between 30-69 tend to suffer from colorectal polyps. The incidence in the male is higher than that in the female. Colorectal polyps are more likely to locate in left colon. The common pathological types were adenomatous and inflammatory polyps. There is a high canceration of polyps in the left colon, villous adenomas and > or = 2.0 cm polyps. The broader the pedicles and the larger the diameters of polyps are, the higher the canceration rate. All of the colon polyps should be excised and undergo the pathological examination. Enteroscopic polypectomy helps prevent colorectal polpous canceration.
Adenoma
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pathology
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Cell Transformation, Neoplastic
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pathology
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Child
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Child, Preschool
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Colonic Polyps
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pathology
;
surgery
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Colonoscopy
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Colorectal Neoplasms
;
pathology
;
surgery
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Female
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Humans
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Intestinal Polyps
;
pathology
;
surgery
;
Male
6.A giant fibroepithelial polyp mimicking a subepithelial tumor.
Dong Hwahn KAHNG ; Gwang Ha KIM ; Do Youn PARK
The Korean Journal of Internal Medicine 2013;28(6):746-747
No abstract available.
Diagnosis, Differential
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Endosonography
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Female
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Humans
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Incidental Findings
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*Intestinal Mucosa/pathology/radiography/surgery
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Intestinal Polyps/*diagnosis/pathology/radiography/surgery
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Middle Aged
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Neoplasms, Fibroepithelial/*diagnosis/pathology/radiography/surgery
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Predictive Value of Tests
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Rectal Neoplasms/*diagnosis/pathology/radiography/surgery
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Tomography, X-Ray Computed
7.A Case of Crohn's Disease Accompanied by Peutz-Jeghers Syndrome.
Yoo Jin UM ; Sun Moon KIM ; Jin Sil PYO ; Joo Ah LEE ; Hoon Sup KOO ; Kyu Chan HUH
The Korean Journal of Gastroenterology 2013;62(4):243-247
Peutz-Jeghers syndrome is an autosomal dominant inherited disorder characterized by multiple gastrointestinal hamartomatous polyps and mucocutaneous pigmentation. Peutz-Jeghers syndrome has an incidence of approximately 1 in 25,000 to 300,000 births. Crohn's disease is a chronic inflammatory bowel disease that typically manifests as regional enteritis with its incidence ranging from 3.1 to 14.6 cases per 100,000 person-years in North America. Herein, we report a case of a 30-year-old male patient who had both Peutz-Jeghers syndrome and Crohn's disease. We believe that this is the first case in Korea and the second report in the English literatures on Peutz-Jeghers syndrome coincidentally accompanied by Crohn's disease.
Adult
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Crohn Disease/complications/*diagnosis/pathology
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Endoscopy, Gastrointestinal
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Humans
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Intestinal Obstruction/etiology
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Intestinal Perforation/etiology
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Intestinal Polyps/pathology/surgery
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Male
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Peutz-Jeghers Syndrome/complications/*diagnosis/genetics
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Protein-Serine-Threonine Kinases/genetics
8.Multiple lymphomatous polyposis of intestine: report of a case.
Cai-qin WANG ; Zhong-xin SHI ; Jing JIANG ; Ji-hong ZHANG ; Ying ZHANG ; Qian WANG
Chinese Journal of Pathology 2011;40(5):341-342
Antigens, CD20
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metabolism
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CD5 Antigens
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metabolism
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Colonic Neoplasms
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complications
;
metabolism
;
pathology
;
surgery
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Cyclin D1
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metabolism
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Diagnosis, Differential
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Female
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Humans
;
Ileal Diseases
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complications
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pathology
;
surgery
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Ileocecal Valve
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Intestinal Neoplasms
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complications
;
metabolism
;
pathology
;
surgery
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Intestinal Polyps
;
complications
;
metabolism
;
pathology
;
surgery
;
Intussusception
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complications
;
pathology
;
surgery
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Leukemia, Lymphocytic, Chronic, B-Cell
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metabolism
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pathology
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Lymphoma, Mantle-Cell
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complications
;
metabolism
;
pathology
;
surgery
;
Middle Aged
9.Advanced Neoplasm Detection and Its Associated Factors in Colonoscopic Surveillance of Endoscopically Resected Early Colorectal Cancer.
Soon Ha KWON ; Jin Woo CHOO ; Hyun Gun KIM ; Seong Ran JEON ; Byung Hoo LEE ; Tae Hee LEE ; Wan Jung KIM ; Bong Min KO ; Jin Oh KIM ; Joo Young CHO ; Joon Seong LEE ; Moon Sung LEE
The Korean Journal of Gastroenterology 2013;62(4):219-226
BACKGROUND/AIMS: Early colon cancer can be effectively diagnosed and treated by colonoscopy, and surveillance colonoscopy is necessary to detect precursor lesions or new early colon cancer. We analyzed the surveillance results of patients with endoscopically resected early colon cancer to evaluate the detection rate of advanced neoplasia and its associated factors. METHODS: We conducted a retrospective study at Soonchunhyang University Seoul Hospital, from May 2003 to December 2011. Patients who underwent endoscopic resection for early colon cancer, showed mucosal and submucosal invasion on histopathologic examination, and received surveillance colonoscopy at least once were enrolled in the current study. Patients who underwent operation and those who were lost during surveillance period were excluded. RESULTS: Among a total of 305 patients diagnosed with early colon cancer, 211 patients met our inclusion criteria. Of these patients, 15 (7.1%) advanced neoplasias were detected at first colonoscopy. One hundred ninety-eight patients (93.8%) underwent surveillance colonoscopy within one year and 14 (7.0%) advanced neoplasias were detected in this group of patients. When patients with and without advanced neoplasia at first surveillance colonoscopy performed within one year were compared, inadequate bowel preparation (OR, 18.237; 95% CI, 3.741-88.895; p<0.001) and three or more colon polyps (OR, 9.479; 95% CI, 1.103-81.452; p=0.040) were significant risk factors for detecting advanced neoplasia. CONCLUSIONS: Considering the high detection rate of advanced neoplasia at first surveillance colonoscopy in patients with endoscopically resected early colon cancer, surveillance interval should be within one year, especially when the bowel preparation has been inadequate and three or more colon polyps have been detected.
Aged
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Colonic Polyps/pathology/surgery
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Colonoscopy
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Colorectal Neoplasms/*diagnosis/surgery
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Female
;
Follow-Up Studies
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Humans
;
Intestinal Mucosa/pathology
;
Male
;
Middle Aged
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Neoplasm Staging
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Odds Ratio
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Recurrence
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Retrospective Studies
;
Risk Factors
10.A Case of Cap Polyposis Complicated with Idiopathic Retroperitoneal Fibrosis.
Limhwa SONG ; Byung Woo JHUN ; Jihyeon PARK ; Damin KIM ; Dong Kyung CHANG ; Young Ho KIM ; Jae Jun KIM ; Jin Yong KIM
The Korean Journal of Gastroenterology 2011;58(5):275-279
An optimal treatment for cap polyposis has not been established. Several treatment approaches, including anti-inflammatory agents, antibiotics, immunomodulators, and endoscopic therapy have been described. Surgical resection of the affected colon and rectum may be indicated for patients with persistent disease. Repeat surgery is indicated in cases of recurrence after surgery. However, symptomatic polyposis may still recur, and spontaneous resolution of cap polyposis is possible. We report a case of recurrent cap polyposis complicated with retroperitoneal fibrosis after inadequate low anterior resection with a positive resection margin. Surgical approaches for the treatment of cap polyposis should be carefully considered before treatment.
Anti-Inflammatory Agents/therapeutic use
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Colonic Polyps/surgery
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Colonoscopy
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Female
;
Humans
;
Intestinal Polyposis/complications/*diagnosis/pathology
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Middle Aged
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Prednisolone/therapeutic use
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Recurrence
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Retroperitoneal Fibrosis/complications/*diagnosis/drug therapy
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Tomography, X-Ray Computed