1.Prurigo Pigmentosa: Clinicopathologic Study and Expression of ICAM-1.
Annals of Dermatology 2004;16(4):153-162
No abstract available.
Intercellular Adhesion Molecule-1*
;
Prurigo*
2.Effects of IL-6 on the proliferation and ICAM-1 expression of keratinocytes.
Young YANG ; In Pyo CHOI ; Sang Hyun CHO ; Hyung Sik KANG ; Si Myung BYUN ; Kwang Ho PYUN
Korean Journal of Immunology 1993;15(2):183-189
No abstract available.
Intercellular Adhesion Molecule-1*
;
Interleukin-6*
;
Keratinocytes*
3.The Immunohistochemical Study of ICAM-1, Neutrophil, Macrophage and iNOS in the Partial Bladder Outlet Obstructed Rats.
Korean Journal of Urology 2000;41(6):767-774
No abstract available.
Animals
;
Intercellular Adhesion Molecule-1*
;
Macrophages*
;
Neutrophils*
;
Rats*
;
Urinary Bladder*
4.The Immunohistochemical Study of ICAM-1, Neutrophil, Macrophage and iNOS in the Partial Bladder Outlet Obstructed Rats.
Korean Journal of Urology 2000;41(6):767-774
No abstract available.
Animals
;
Intercellular Adhesion Molecule-1*
;
Macrophages*
;
Neutrophils*
;
Rats*
;
Urinary Bladder*
5.Hydromorphone attenuates intercellular adhesion molecule-1 expressions induced by lipopolysaccharide on HCT-116 human colon cancer cells.
Jae Jin LEE ; Woon Young KIM ; Ji Hye UM ; Too Jae MIN
Korean Journal of Anesthesiology 2014;67(Suppl):S124-S126
No abstract available.
Colonic Neoplasms*
;
Humans
;
Hydromorphone*
;
Intercellular Adhesion Molecule-1*
6.Expression of intercellular adhesion molecule-1 in human primary lung cancers.
Young Chun CHOI ; Dong Ho SHIN ; Sung Soo PARK ; Dong Hoo LEE ; Jung Hee LEE ; Jung Dal LEE
Korean Journal of Medicine 1993;45(4):467-472
No abstract available.
Humans*
;
Intercellular Adhesion Molecule-1*
;
Lung Neoplasms*
;
Lung*
7.Effects of different point association needling methods on IL-1, sICAM-1 and sVCAM-1 in the patient of cerebral infarction.
Wei ZHANG ; Zhi LIU ; Bi-dan LOU
Chinese Acupuncture & Moxibustion 2005;25(3):214-216
OBJECTIVETo observe effects of acupuncture on serum interleukin-1 (IL-1) and soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) in the patient of cerebral infarction.
METHODSEighty-two cases of cerebral infarction were randomly divided into a treatment group treated by balanced muscular tension needling method, and a control group by traditional needling method. The levels of serum IL-1, sICAM-1 and sVCAM-1 were determined with enzyme-linked immunosorbent assay (ELISA).
RESULTSThe levels of serum IL-1, sICAM-1 and sVCAM-1 in the patient of cerebral infarction were significantly higher than those in the healthy persons (P < 0.01); there were positive correlation between sICAM-1 or sVCAM-1 level and IL-1 level (r = 0.743, P < 0.001; r = 0.862, P < 0.001). The three indexes improved to a certain extent in the two groups, with the treatment group superior to the control group (P < 0.01).
CONCLUSIONThe improvement of nervous function by the balanced muscular tension needling method in the patient of cerebral infarction is possibly related with decrease of IL-1, sICAM-1 and sVCAM-1 levels.
Cerebral Infarction ; Enzyme-Linked Immunosorbent Assay ; Humans ; Intercellular Adhesion Molecule-1 ; Interleukin-1 ; Vascular Cell Adhesion Molecule-1
8.Effects of Angiotensin II and Shear Stress Interaction on Vascular Inflammation.
Sung Hyun CHOI ; Eun Hye PARK ; Yujin OH ; Sang Hong BAEK
Journal of the Korean Society of Hypertension 2011;17(1):17-27
BACKGROUND: Angiotensin II (AngII) and abnormal oscillatory shear stress are highly associated with vascular inflammation including atherosclerosis. However, it is poorly understood how interactions between AngII and shear stress in human aortic endothelial cells (HAEC) are involved in mechanisms by which cellular adhesion molecules are expressed. The purpose of this study was to improve that understanding. METHODS: AngII (10(-7)M for 6 hr) and two-types of shear stress treatments were used: laminar shear stress (LS: unidirectional, 12 dynes/cm2) and oscillatory shear stress (OS: bi-directional, 5 dynes/cm2, 1 Hz) in HAEC. Immunoblotting was used to detect expression of cellular adhesion molecules markers such as vascular cell adhesion molecule 1 (VCAM1) and intercellular adhesion molecule 1 (ICAM1). RESULTS: AngII significantly increased VCAM1 and ICAM1 expression in HAEC that had been reduced due to pretreatment with telmisartan. AngII-LS co-stimulation and AngII-OS co-stimulation significantly increased VCAM1 and ICAM1 expression in HAEC. The expression levels of VCAM1 and ICAM1 were also, significantly reduced when pretreated with telmisartan. However, VCAM1 and ICAM1 expression were significantly reduced under LS and OS stimulation. CONCLUSIONS: Telmisartan may modulate the expressions of VCAM1 and ICAM1 via different types of shear stress in HAEC that are activated by AngII.
Angiotensin II
;
Angiotensins
;
Atherosclerosis
;
Benzimidazoles
;
Benzoates
;
Endothelial Cells
;
Humans
;
Immunoblotting
;
Inflammation
;
Intercellular Adhesion Molecule-1
;
Vascular Cell Adhesion Molecule-1
9.The Expression of the Adhesion Molecules on Interfacial Membrane fromthe Aseptically Loosened Failed Femoral Stems in Revisional Hip Arthroplasty.
Soo Ho LEE ; Ji Hyo HWANG ; Dong Wook KIM ; Byung Kwan KIM ; Ho Wook JEONG
The Journal of the Korean Orthopaedic Association 2007;42(4):490-497
PURPOSE: To clarify the relationship between aseptic loosening of hip arthroplasty and adhesion molecules on interfacial membrane from revisional hip arthroplasty. MATERIALS AND METHODS: We studied 26 revisional total hip arthroplasties between May 2004 and July 2006, and 15 synovial tissues from hip fractures were selected as the control group. We analyzed the degree of femoral osteolysis by Paprosky's classification. We examined the expression of soluble endothelial leukocyte adhesion molecule-1 (E-selectin), vascular adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) by immunohistochemical staining technique. We compared and analyzed radiologic evaluation and expression of adhesion molecules. RESULTS: Expression of E-selectin was observed in 100%, VCAM-1 in 42.3% and ICAM-1 in 34.6%. Expression of adhesion molecules were increased compared to the control group (p<0.05). The higher the expression of E-selectin, the higher the degree of osteolysis (p=0.023). CONCLUSION: These results showed that adhesion molecules are involved in aseptic loosening of hip arthroplasties, and we proposed that E-selectin may strongly engage in the cascade of aseptic loosening in hip arthroplasty.
Arthroplasty*
;
Classification
;
E-Selectin
;
Hip Fractures
;
Hip*
;
Intercellular Adhesion Molecule-1
;
Membranes*
;
Osteolysis
;
Vascular Cell Adhesion Molecule-1
10.Enhanced Expression of Cell Adhesion Molecules in the Aorta of Diabetic Mice is Mediated by gp91phox-derived Superoxide.
Mi Ran YUN ; Jong Jae KIM ; Sun Mi LEE ; Hye Jin HEO ; Sun Sik BAE ; Chi Dae KIM
The Korean Journal of Physiology and Pharmacology 2005;9(2):109-115
Endothelial activation and subsequent recruitment of inflammatory cells are important steps in atherogenesis. The increased levels of cell adhesion molecules (CAM) have been identified in diabetic vasculatures, but the underlying mechanisms remain unclear. To determine the relationship among vascular production of superoxide, expression of CAM and diabetes, superoxide generation and expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E- and P-selectin in the aorta from control (C57BL/6J) and diabetic mice (ob/ob) were measured. In situ staining for superoxide using dihydroethidium showed an increased superoxide production in diabetic aorta, accompanied with an enhanced NAD (P) H oxidase activity. Immunohistochemical analysis revealed that the endothelial expression of ICAM-1 (3.5+/-0.4) and VCAM-1 (3.8+/-0.3) in diabetic aorta was significantly higher than those in control aorta (0.9+/-0.5 and 1.6+/-0.3, respectively), accompanied with the enhanced expression of gp91phox, a membrane subunit of NAD (P) H oixdase. Furthermore, there was a strong positive correlation (r=0.89, P< 0.01 in ICAM-1 and r=0.88, P< 0.01 in VCAM-1) between ICAM-1/VCAM-1 expression and vascular production of superoxide. The present data indicate that the increased production of superoxide via NAD (P) H oxidase may explain the enhanced expression of CAM in diabetic vasculatures.
Animals
;
Aorta*
;
Atherosclerosis
;
Cell Adhesion Molecules*
;
Cell Adhesion*
;
E-Selectin
;
Intercellular Adhesion Molecule-1
;
Membranes
;
Mice*
;
NAD
;
Oxidoreductases
;
P-Selectin
;
Superoxides*
;
Vascular Cell Adhesion Molecule-1