1.Clinical Application of the Quick Sepsis-Related Organ Failure Assessment Score at Intensive Care Unit Admission in Patients with Bacteremia: A Single-Center Experience of Korea.
Hae Jung NA ; Eun Suk JEONG ; Insu KIM ; Won Young KIM ; Kwangha LEE
Korean Journal of Critical Care Medicine 2017;32(3):247-255
BACKGROUND: We evaluated the clinical usefulness of the quick Sepsis-Related Organ Failure Assessment (qSOFA) score (based on the 2016 definition of sepsis) at intensive care unit admission in Korean patients with bacteremia. METHODS: We retrospectively analyzed clinical data from 236 patients between March 2011 and February 2016. In addition to the qSOFA, the Modified Early Warning score (MEWS) and systemic inflammatory response syndrome (SIRS) criteria were calculated. RESULTS: The patients' median age was 69 years, and 61.0% were male. Of the patients, 127 (53.8%) had a qSOFA score ≥2 points. They had significantly higher rates of septic shock, thrombocytopenia, and hyperlactatemia, and increased requirements for ventilator care, neuromuscular blocking agents, vasopressors, and hemodialysis within 72 hours after intensive care unit admission. They also had a significantly higher 28-day mortality rate. When analyzed using common thresholds (MEWS ≥5 and ≥2 SIRS criteria), patients with a MEWS ≥5 had the same results as those with a qSOFA score ≥2 (P < 0.05). However, patients with ≥2 SIRS criteria showed no significant differences. CONCLUSIONS: Our results show that a qSOFA score ≥2 at admission is a useful screening tool for predicting disease severity and medical resource usage within 72 hours after admission, and for predicting 28-day mortality rates in patients with bacteremia. In addition, qSOFA scores may be more useful than SIRS criteria in terms of prognostic utility.
Bacteremia*
;
Critical Care*
;
Humans
;
Hyperlactatemia
;
Intensive Care Units*
;
Korea*
;
Male
;
Mass Screening
;
Mortality
;
Neuromuscular Blocking Agents
;
Prognosis
;
Renal Dialysis
;
Retrospective Studies
;
Sepsis
;
Shock, Septic
;
Systemic Inflammatory Response Syndrome
;
Thrombocytopenia
;
Ventilators, Mechanical
2.Multiple Digital Mucinous Cysts.
In Young OH ; Insu KIM ; Kui Young PARK ; Kapsok LI ; Beom Joon KIM ; Seong Jun SEO ; Myeung Nam KIM ; Chang Kwun HONG
Korean Journal of Dermatology 2012;50(5):485-486
3.Clinical Application of the Quick Sepsis-Related Organ Failure Assessment Score at Intensive Care Unit Admission in Patients with Bacteremia: A Single-Center Experience of Korea
Hae Jung NA ; Eun Suk JEONG ; Insu KIM ; Won Young KIM ; Kwangha LEE
The Korean Journal of Critical Care Medicine 2017;32(3):247-255
BACKGROUND: We evaluated the clinical usefulness of the quick Sepsis-Related Organ Failure Assessment (qSOFA) score (based on the 2016 definition of sepsis) at intensive care unit admission in Korean patients with bacteremia. METHODS: We retrospectively analyzed clinical data from 236 patients between March 2011 and February 2016. In addition to the qSOFA, the Modified Early Warning score (MEWS) and systemic inflammatory response syndrome (SIRS) criteria were calculated. RESULTS: The patients' median age was 69 years, and 61.0% were male. Of the patients, 127 (53.8%) had a qSOFA score ≥2 points. They had significantly higher rates of septic shock, thrombocytopenia, and hyperlactatemia, and increased requirements for ventilator care, neuromuscular blocking agents, vasopressors, and hemodialysis within 72 hours after intensive care unit admission. They also had a significantly higher 28-day mortality rate. When analyzed using common thresholds (MEWS ≥5 and ≥2 SIRS criteria), patients with a MEWS ≥5 had the same results as those with a qSOFA score ≥2 (P < 0.05). However, patients with ≥2 SIRS criteria showed no significant differences. CONCLUSIONS: Our results show that a qSOFA score ≥2 at admission is a useful screening tool for predicting disease severity and medical resource usage within 72 hours after admission, and for predicting 28-day mortality rates in patients with bacteremia. In addition, qSOFA scores may be more useful than SIRS criteria in terms of prognostic utility.
Bacteremia
;
Critical Care
;
Humans
;
Hyperlactatemia
;
Intensive Care Units
;
Korea
;
Male
;
Mass Screening
;
Mortality
;
Neuromuscular Blocking Agents
;
Prognosis
;
Renal Dialysis
;
Retrospective Studies
;
Sepsis
;
Shock, Septic
;
Systemic Inflammatory Response Syndrome
;
Thrombocytopenia
;
Ventilators, Mechanical
4.Treatment of Low Back Pain and Sciatica by Local Anesthetic Injection through Epidural Catheter in Pregnant Woman
Jiseob KIM ; Hyo-jin LEE ; Najeong HA ; Insu KIM ; Kibeom PARK
Keimyung Medical Journal 2021;40(2):125-128
Lower back pain and sciatica are common symptoms in pregnancy. Treatment options for these conditions include physical therapy, medication, interventional treatment, and surgery. This case report involved a 32 weeks pregnant woman, who visited the emergency room with a three day history of lower back and right leg pain and a visual analogue scale (VAS) score of 9 - 10. Spinal computed tomography revealed lumbar 4/5 and 5/S1 disc protrusions. An epidural catheter was placed around the L3/4 vertebrae, and 6 ml of 0.15% ropivacaine was administered for pain control. Subsequently, her VAS score reduced to 2 - 3 and she was discharged five days later.
5.Allergic Contact Dermatitis on the Periorbital Area: Report of Three Cases.
Hee Bong LEE ; Bo Young CHUNG ; Insu AHN ; Hyeone KIM ; Chun Wook PARK ; Cheol Heon LEE
Korean Journal of Dermatology 2010;48(5):429-434
The use of ophthalmic drugs and contact lens solutions has increased and allergic contact dermatitis due to these agents has also recently increased. The first case was a 67-year-old female patient who developed allergic contact dermatitis after application of Latano(R): The patch test with the ingredients in Latano(R) showed positive reaction to latanoprost and benzalkonium chloride. The second case was a 63-year-old female patient who developed allergic contact dermatitis after application of Ecolicin(R), Tolon(R), Forus(R) and Uniten-F(R): The patch test showed a positive reaction to Tolon(R). She didn't want further evaluation. The third case was a 51-year-old female patient who developed allergic contact dermatitis after application of Terramycin(R) eye ointment: the patch test with the ingredients of Terramycin(R) eye ointment showed a positive reaction to polymyxin B. When contact dermatitis occurs in periorbital areas, topical ophthalmic ointment or lens cleanser needs to be considered as a causative agent.
Aged
;
Benzalkonium Compounds
;
Contact Lens Solutions
;
Dermatitis, Allergic Contact
;
Dermatitis, Contact
;
Eye
;
Female
;
Humans
;
Middle Aged
;
Patch Tests
;
Polymyxin B
;
Prostaglandins F, Synthetic
6.Ecological Momentary Assessment Using Smartphone-Based Mobile Application for Affect and Stress Assessment.
Yong Sook YANG ; Gi Wook RYU ; Insu HAN ; Seojin OH ; Mona CHOI
Healthcare Informatics Research 2018;24(4):381-386
OBJECTIVES: This study aimed to describe the process of utilizing a mobile application for ecological momentary assessment (EMA) to collect data on stress and mood in daily life setting. METHODS: A mobile application for the Android operating system was developed and installed with a set of questions regarding momentary mood and stress into a smartphone of a participant. The application sets alarms at semi-random intervals in 60-minute blocks, four times a day for 7 days. After obtaining all momentary affect and stress, the questions to assess the usability of the mobile EMA application were also administered. RESULTS: The data were collected from 97 police officers working in Gyeonggi Province of South Korea. The mean completion rate was 60.0% ranging from 3.5% to 100%. The means of positive and negative affect were 18.34 of 28 and 19.09 of 63. The mean stress was 17.92 of 40. Participants responded that the mobile application correctly measured their affect (4.34 ± 0.83) and stress (4.48 ± 0.62) of 5-point Likert scale. CONCLUSIONS: Our study investigated the process of utilizing a mobile application to assess momentary affect and stress at repeated times. We found challenges regarding adherence to the research protocol, such as completion and delay of answering after alarm notification. Despite this inherent issue of adherence to the research protocol, the EMA still has advantages of reducing recall bias and assessing the actual moment of interest at multiple time points that improves ecological validity.
Bias (Epidemiology)
;
Gyeonggi-do
;
Humans
;
Korea
;
Methyltestosterone
;
Mobile Applications*
;
Police
;
Smartphone
;
Stress, Psychological
7.Chronic obstructive lung disease after ammonia inhalation burns: a report of two cases
Insu KIM ; Heock LEE ; Bo Hyoung KANG ; Dong Hyun LEE ; Young Hee NAM ; Mee Sook ROH ; Soo-Jung UM
Kosin Medical Journal 2022;37(4):354-360
Anhydrous ammonia is a commonly used chemical in industry. Ammonia gas inhalation causes thermal injuries and alkali burns in the airway and lung parenchyma. Previous case reports have stated that respiratory sequelae after acute ammonia inhalation burns were associated with structural lung disease, such as bronchiectasis or interstitial lung disease. We herein report two cases of long-term sequelae with persistent airflow limitation after ammonia inhalation burns.
8.Risk factors of postoperative remote intracerebral hemorrhage after craniotomy for ruptured cerebral aneurysms
Insu LEE ; Cheol Wan PARK ; Chan Jong YOU ; Dae Han CHOI ; Kwangwoo PARK ; Young Bo KIM ; Woo Kyung KIM ; Gi-Taek YEE ; Myeong-Jin KIM ; Eun Young KIM
Journal of Cerebrovascular and Endovascular Neurosurgery 2020;22(2):53-64
Objective:
We aimed to identify the relation between perioperative cerebrospinal fluid (CSF) drain through lumbar drainage (LD) and development of postoperative (POP) remote intracerebral hemorrhage (rICH) in craniotomy to treat ruptured intracranial aneurysms.
Methods:
We retrospectively reviewed consecutive patients who underwent craniotomy for ruptured cerebral aneurysms at the authors’ institution between 1998 and 2004. We subsequently compared the incidence and characteristics of POP rICH between the patients who had a perioperative LD and those who did not. All statistical analyses were conducted using the software package SPSS 19.0 (SPSS Inc., Chicago, IL, USA). A p value of <0.05 was considered statistically significant.
Results:
We enrolled 688 patients, of which 80 patients (11.6%) received perioperative LD, and 608 did not. LD and non-LD groups were comparable because although clinical characteristics of the two groups were significantly different considering history of hypertension, timing of surgery, and closed system negative pressure suction drain (SD) placement, none of these three variables was an independent risk factor associated with POP rICH in multivariate analysis. POP rICH incidence was significantly higher in the LD goup (12.5%) than non-LD group (0.8%) (p=0.000) in univariate analysis. LD placement was the only independent risk factor associated with the development of rICH in multivariate logistic regression analysis.
Conclusions
POP rICH incidence was significantly higher in patients who were managed with perioperative LD than in those who did not. LD insertion in craniotomy for ruptured intracranial aneurysm, should be closely monitored to address the occurrence of POP rICH.
9.Development of the Korean Association for Lung Cancer Clinical Practice Guidelines: Recommendations on Radial Probe Endobronchial Ultrasound for Diagnosing Lung Cancer - An Updated Meta-Analysis
Soo Han KIM ; Hyun Sung CHUNG ; Jinmi KIM ; Mi-Hyun KIM ; Min Ki LEE ; Insu KIM ; Jung Seop EOM
Cancer Research and Treatment 2024;56(2):464-483
Purpose:
Radial probe endobronchial ultrasound (RP-EBUS) accurately locates peripheral lung lesions (PLLs) during transbronchial biopsy (TBB). We performed an updated meta-analysis of the diagnostic yield of TBB for PLLs using RP-EBUS to generate recommendations for the development of the Korean Association of Lung Cancer guidelines.
Materials and Methods:
We systematically searched MEDLINE and EMBASE (from January 2013 to December 2022), and performed a meta-analysis using R software. The diagnostic yield was evaluated by dividing the number of successful diagnoses by the total lesion number. Subgroup analysis was performed to identify related factors.
Results:
Forty-one studies with a total of 13,133 PLLs were included. The pooled diagnostic yield of RP-EBUS was 0.72 (95% confidence interval [CI], 0.70 to 0.75). Significant heterogeneity was observed among studies (χ2=292.38, p < 0.01, I2=86.4%). In a subgroup analysis, there was a significant difference in diagnostic yield based on RP-EBUS findings (within, adjacent to, invisible), with a risk ratio of 1.45 (95% CI, 1.23 to 1.72) between within and adjacent to, 4.20 (95% CI, 1.89 to 9.32) between within and invisible, and 2.59 (95% CI, 1.32 to 5.01) between adjacent to and invisible. There was a significant difference in diagnostic yield based on lesion size, histologic diagnosis, computed tomography (CT) bronchus sign, lesion character, and location from the hilum. The overall complication rate of TBB with RP-EBUS was 6.8% (bleeding, 4.5%; pneumothorax, 1.4%).
Conclusion
Our study showed that TBB with RP-EBUS is an accurate diagnostic tool for PLLs with good safety profiles, especially for PLLs with within orientation on RP-EBUS or positive CT bronchus sign.
10.Introduction of the Korea BioData Station (K-BDS) for sharing biological data
Byungwook LEE ; Seungwoo HWANG ; Pan-Gyu KIM ; Gunwhan KO ; Kiwon JANG ; Sangok KIM ; Jong-Hwan KIM ; Jongbum JEON ; Hyerin KIM ; Jaeeun JUNG ; Byoung-Ha YOON ; Iksu BYEON ; Insu JANG ; Wangho SONG ; Jinhyuk CHOI ; Seon-Young KIM
Genomics & Informatics 2023;21(1):e12-
A wave of new technologies has created opportunities for the cost-effective generation of high-throughput profiles of biological systems, foreshadowing a "data-driven science" era. The large variety of data available from biological research is also a rich resource that can be used for innovative endeavors. However, we are facing considerable challenges in big data deposition, integration, and translation due to the complexity of biological data and its production at unprecedented exponential rates. To address these problems, in 2020, the Korean government officially announced a national strategy to collect and manage the biological data produced through national R&D fund allocations and provide the collected data to researchers. To this end, the Korea Bioinformation Center (KOBIC) developed a new biological data repository, the Korea BioData Station (K-BDS), for sharing data from individual researchers and research programs to create a data-driven biological study environment. The K-BDS is dedicated to providing free open access to a suite of featured data resources in support of worldwide activities in both academia and industry.