BACKGROUND As a Mongolian National University of Medical Sciences student rating point is calculated by transferring into 42 level quantitative point in accordance with procedure which assess student approved byDirector with 1st attachment of order no. A/144 on December 15, 2015. However, the calculation,estimated by mathematics allocation, of the student rating point, letter point and quantitative is notbased on research also allocation of transferring the rating point into quantitative point is different foranother universities. These reasons mentioned previously have seriously become basis backgroundof our research. The main objective of this research is to compare model of transferring rating pointinto quantitative point. METHODS Research was completed by quantitative method that based on moment descriptive study, case study, model of mathematic and geometry modeling.Under our research objective we did compare study using rate point that transfer into quantitativepoint of student at MNUHS, accuracy and methodology all among the Mongolian state and private universities. Now Mongolian National University of Life Sciences, Etugen University and New Mongolia Medical University are using 5 level table that approved Ministry of Education Science, Mongolian National University is using 9 level scale, Mongolian University of Science & Technology, Mongolian State University of Education, Mongolian State University of Art&Culture are using 12 level scale while MNUHS is using 42 scale table that calculate student average point. We compared model of GPA calculation that rate point transfer into quantitative point by using all tables belong each Universities mentioned above. We have developed mathematical and geometrical modeling on each assessment since we started study and made statistical process based on modeling. RESULTS Some articles of the regulation to adapt the credit hours, evaluate students’ knowledge and ability during the training where providing the higher educational degree were not fulfilled. Hereto: The article of the guidance that are taking: 70 rating point considering to the letter D, 80 rating point considering to the letter C, 90 rating point considering to the letter B are not providing the 12 level module. The modules with staging 9, 12, 42 of the article on regarding measurement of 2, 3, 4 in 70, 80, 90 rating grade are not meeting requirements. According to the survey among 470 students who’s GPA higher 2.5 in the 42 level scale shows mostly. Also, the percentage of the students with GPA higher than 3 are in high level. In other words, 158 students (33.6% of 470 students) are meeting requirements of the national scholarship programs and other scholarships. The calculation of the correlation relationship of the rating point and grades converted to the digit rate that are using in all universities were the positive correlation, linear dependence. For the module with staging Person Correlation 9, its influence rate is 98.7 per cent that shows the highest rate comparing with other modules. To calculate Determination Percentage (r2), the module with staging 9 is 97.4 per cent or these digit grades have the highest capacity to show the rating grade. CONCLUSION Level models are able to rate in points or statistical significant. The high correlation between rating point and digit grade’s and determination percentage in the 9 level module showing more relevant in statistics and reporting capacity. The modules with staging 9, 12, 42 are not meeting requirements of the guidance.

BACKGROUND Patient safety has become a matter of interest to healthcare professionals, governments and researchers worldwide. During the last decade, many studies have been conducted to assess the prevalence, severity and causes of a large variety of different types of adverse events in hospitals, as well as the effectiveness of various approaches to enhance safety. In Mongolia, it is also an arguable point, mistakes and errors associated with physicians, hospital staffs and healthcare organizations has been occurring frequently in recent years. Our main aim is to find difference between physicians and nurses’ attitude on patient safety culture. METHODS The study included 3 tertiary hospitals from Ulaanbaatar city, Mongolia with a total of 122 respondents; all hospital staff. The Hospital Survey on Patient Safety Culture (HSOPSC) Questionnaire from AHRQ (Agency for Healthcare Research and Quality) was used. AHRQ methods, Pearson’s Chi-squared test, pairwise proportion test (p≤ 0,05) were used for statistical analysis. RESULTS Patient safety in hospitals was evaluated as positive by 62.3% of healthcare workers. The highest scores were obtained in specific dimensions as teamwork within unit (77.3%), unit’s team learning from occurred adverse events (71%). Per our survey, health care workers considered non-punitive response to error (20.6%) and communication openness (27.7%) as being weak areas. In surveyed hospitals, physicians and nurses had a significantly different outlook at communication, adverse events reporting and management support. Physicians reported fewer errors than nurses. CONCLUSION Doctors rated safety culture less positively than nurses in some dimensions of patient safety culture- feedback and communication about error, transition and handoffs, management support for patient safety and teamwork across units. This result could indicate a need for more intensive interventions in certain areas of patient safety culture and is certainly an area for future research inquiry.

BACKGROUND Bovine colostrums is the milk secreted by cows during the first few days after parturition. It contains many essential nutrients and bioactive components, including growth factors, immunoglobulins, lactoperoxidase, lactoferrin and cytokines ets. Lactoferrin has been reported for its multifunctional properties such as antifungal, antibacterial, antiviral antioxidant and anticancer activities. The aims of this study focused on the isolation and purification of lactoferrin from Mongolian bovine colostrums. Lactoferrin purified using HiTrap DEAE an ion exchange chromatography. Lactoferrin purification efficiency was about 60.5%. The single band of purified lactoferrin has been observed in SDS-PAGE electrophoresis. METHODS Bovine colostrum was collected at a cow farm in the Darkhan province of Mongolia. At first the cream was separated by centrifugation (10000 xg 20 min at 4oC). In order to separate the whey, the samples were precipitated with 1mol/l to pH 4.6 and centrifuged at 10000 g 20 min again. The samples of whey were stored at -18oC to the analysis. Lactoferrin was purified by HiTrap DEAE an ion exchange chromatography using 0.005 M phosphate buffer (pH 7.7) and linear gradient NaCl from 0.25M, 0.5M, 1M. During chromatography, protein in the eluents was monitored by ultraviolet absorbation at 280 nm with the instrument. Purity test done by using polyacrylamide gel electrophoresis under denaturated condition (SDS-PAGE) method by Laemmli (1970). For HPLC determination of the lactoferrin by Shimadzu Nexera X2 HPLC system with UV/ VIS detector were used. Detection was carried out at the wavelength 280 nm. Separation was performed on a chromatographic column Protein R C18 ,2.2 x 150 mm, 5 μm particle size. Linear gradient and flow rate 0.2 ml/min were used. Mobile phase a consisted of water / acetonitrile/ trifluoroacetic acid ( 95:5:0.1). The column temperature was set at 40oC and injection volume was 10 μl. Data were collected and evaluated by software Lab Solution. An external standard method for quantification analytes was used. RESULTS Purified lactoferrin in the present study had a good concentration and purification efficiency was about 60.5 %. Protein fraction from 1M NaCl gradient delivers sharp and clean peak to HPLC chromatogram that fits intensity and retention time of standard bovine lactoferrin. Ammount of lactoferrin in bovine colostrums was 0.6 mg/ml and it`s molecular weight 80 kDa as a standard sample. The retention time of lactoferrin fraction which is purified by SDS-PAGE gel electrophoresis. The peak of fraction same compared to the standard lactoferrin 5.8 minutes by HPLC analysis. CONCLUSION Ion exchange chromatography shows reliable and easy isolation of lactoferrin from Mongol bovine colostrum.

BACKGROUND The study was based on the facts that high patient satisfaction and good health indicators are common in countries where quality of nursing care and organization has reached high level and skill level of these professionals is the main factor for the improvement of health care service quality. OBJECTIVE Evaluate practical skill levels of nurses who are responsible for pre- and post-operative care in the National First Central Hospital (NFCH). METHOD Using cross-sectional design, we have conducted 120 questions questionnaire, which was developed by Canadian Nursing Association and Kwantlen Polytechnic University in 2008, to determine 4 levels of skill (never done – did independently) among 41 nurses who work in the Department of Surgery of NFCH. Data was analyzed using social studies statistics software SPSS 21. RESULT Average age and average work years of the 41 nurses who work in the Department of Surgery were 29.9±8.6 and 7.7±9.1, respectively. In terms of specialty, 4 were anesthesiology and intensive care nurse (9.8%) and 17 were surgical nurse (41.5%) while almost half of them (20, 48.8%) did not have specialty certification. During the evaluation of practical skill levels of participants in regards to pre- and post-operative care, for checking readiness of respiratory apparatus, there were 9 (22%) nurses who had never done it, 11 (27%) nurses who did it with assistance, 9 (22%) nurses who did it under guidance, and 12 (29%) nurses who did it independently, for checking neurologic function, there were 4 (11%) nurses who had never done it, 3 (7%) nurses who did it with assistance, 7 (17%) nurses who did it under guidance, and 27 (65%) nurses who did it independently, for operation wound care, there were 5 (12%) nurses who had never done it, 2 (5%) nurses who did it with assistance, 11 (27%) nurses who did it under guidance, and 23 (56%) nurses who did it independently, for using nasal and tracheal intubation, there were 10 (24%) nurses who had never done it, 4 (10%) nurses who did it with assistance, 10 (24%) nurses who did it under guidance, and 17 (42%) nurses who did it independently. There was correlation between average work years and skill level (p<0.001). CONCLUSION Varying skill levels (never done it 17.25%, with assistance 12.25%, under guidance 22.5%, and independently 48%) of surgical nurses who are responsible for pre- and post-operative care show that there is a need for improving practical skills of nurses in the Department of Surgery of NFCH.

BACKGROUND Cigarette smoking is known to reduce appetite and body weight. Even though number of studies explored different levels of effects of smoking, there are few studies which address short-term effect of smoking on metabolism. METHODS Inbred strain, Balb/cmice (n=20) were used. Mice were divided into two groups control (n=7) and treatment (n=9) group. Smoking treatment conducted in 5 days consequently in treatment group, three times a day with cigarette smoke. During experiment both control and treatment groups were monitored for food intake, water intake, body weight. RESULTS In the end of the experiment blood glucose and anxiety levels were measured. In addition, liver, white adipose tissue and brown adipose issue were sampled comparison. Short-term (5 days) treatment of smoking of treatment group result in significant difference in food and water intake (p<0.05) as well as tendency to lowering blood glucose and reduction of mesenterial, perirenal, epidydimal, white adipose tissues and brown adipose revealed tendency to reduction of mesenterial white adipose with control group. (Mes. White adipose tissue weights 0.44g in control group, 0.23g in treatment group). CONCLUSION There was not significant difference in blood glucose test and anxiety test evaluated by time spent on alleys and transition between alleys in two groups.

BACKGROUND. Statewide STIs does not decrease adamantly in last years, especially syphilis rate is amalgamative. Public health precaution cogency-based, assess prevalence of HIV/STI is supposed to encourage and organize intentionally. PURPOSE: assess prevalence of STIs2 among total persons of SBD. METHOD: analysis data based on outpatient department examination intelligences of patients examined in SBD clinic STI department from 2013 to 2016, controlling form and infectious disease activity EMT-304 reports. RESULT: 12.84% of total infectious disease registered in SBD from 2013-2016 is STI. 63% of the total STIs is syphilis. The causes of 68.05 females, 31.95% males of STIs total patients are that the females included more in a preventative inspection and pregnant inspections. Secondary and latent syphilis increasing regularly in every year and decreasing primary syphilis show the high prevalence of syphilis among SBD persons. Gonorrhea and trichomoniasisincreased by 1 promil on 10000 persons in every year. CONCLUSION: SBD STIs does not decrease constantly in last 4 years. Detection of STIs among pregnant improved by implementing ‘on point service’. High rate STI of among young persons caused insufficient information and knowledge about STIs and unhabit preventative of STIs.

BACKGROUND. In the worldwide every 40 seconds one person takes their life, annually 1 million people die on Earth by the means of suicide. Regardless of gender it is one of the main 3 causes of death in the population aged between 15-29. There have a tendency to increase of suicide rates with each passing year in the Mongolia. Therefore, our study goal is to determine the utilized methods and to identify some of the factors influencing the escalation of this phenomenon. The data and materials were gathered by quantitative research method from the post-mortem examination reports provided from the central archive of National Institute of Forensic Science according to the descriptive research design. The fact that the bulk of the increasing suicide cases might be attributed to the unemployed and working-age men without any chronic illnesses suggests correlation with gender and socio-economic status.

BACKGROUND. HCV-infected and obesity related liver diseases are leading to increases in the prevalence of advanced liver disease. So, studying liver disease, especially liver fibrosis is crucial issue of today. In Mongolia digestive system disease is second causation of non-communicable disease. Therefrom in last years hepatocellular carcinoma is most common malignancy, first of all cancers in Mongolia. In response to acute or chronic liver injury, hepatic fibrosis is the accumulation of extracellular matrix and ultimately leads to cirrhosis. Cirrhosis is the end-stage of fibrosis, resulting in nodule formation that may lead to altered hepatic function and blood flow. Defining the phase of liver fibrosis is crucial for therapeutic choice prognosis, important role in monitoring treatment. At the present time, use of direct and undirect biomarkers methods could be recommended for liver fibrosis stage. The aim of this study is to determine liver fibrosis stage and to compare undirect biomarkers in chronic viral hepatitis, cirrhosis. METHODS: 630 cases by chronic viral hepatitis and cirrhosis at third central hospital in Mongolia from retrospectively reviewed and analysed. The clinical data including AST, ALT, platelet count and INR were recorded. APRI, FIB-4, AAR and FibroQ were calculated. RESULT: From all, males 42.06% and females 57.94%, with mean age of 55.35±24.0, in 130 cases with chronic viral hepatitis and 500 cases with cirrhosis. In cases of cirrhosis, mean value of platelet count, ALT, AST, INR was 120.54±73.53, 104.55±500.22, 111.68±279.97, 2.19±10.45, respectively. And in cases of chronic viral hepatitis platelet count mean value was 211.18±6.42. APRI was detected <0.5 cutoff value (F0-F1) 11.7% non-fibrosis, 0.5-1.5 score (F2-F3) 27.5% fibrosis, >1.5 cutoff value (F4) 60.8% cirrhosis. FIB-4 was determined <1.45 cutoff value (F0-F1) 14.8% non-fibrosis, 1.45-3.25 score (F2-F3) 15.7% fibrosis, >3.25 cutoff value (F4) 69.5%, AAR was showed <0.4 cutoff value (F0-F1) 2.3% non-fibrosis, 0.4-1 score (F2-F3) 30.2% fibrosis, >1 cutoff value (F4) 67.5%. And FibroQ was detected <0.6 cutoff value (F0- F1) 0.5% non-fibrosis, 0.6-2.6 score (F2-F3) 6% fibrosis, cutoff value 2.6< (F4) 93.5 cirrhosis. In study liver fibrosis staging by APRI, AAR, FIB-4 and FibroQ score system, AAR was determined fibrosis in 190 cases. CONCLUSION: Recorded data ALT, AST, INR in cases of cirrhosis were detected 104.55±500.22, 111.68±279.97, 2.19±10.45, respectively. And in cases of chronic hepatitis platelet count mean value was 211.18±6.42. APRI, AAR, FIB-4, FibroQ was determined fibrosis 27.5%,30.16%,15.71% and 6.03%, respectively.

BACKGROUND. Heart failure is the leading cause of the death among non-communicable diseases. Heart failure is a fatal disease that once its clinical symptoms appeared, five years of survival rate is 50-75%. Chronic heart failures are the main risk factors arterial hypertension, diabetes, obesity and dyslipidemia Thus, early diagnosis before its symptoms are presented and treatment with close monitoring is the most rational and effective approach for decreasing heart failure diseases and deaths caused by it. OBJECTIVE. To determine the level of NT-pro BNP in people with high risk of chronic heart failure and assess its results. METHODS. We conducted hospital-based descriptive study at State Second Central Hospital and Bayanzurkh District Medical Center. Total of 100 participants aged from 35 to 64 who had no symptom of chronic heart failure however with high risk were recruited in this study. Based on the document entitled “Heart failure prevention 2008” of the American Heart Association, old age, arterial hypertension, diabetes mellitus, heart attack and obesity were considered as higher risks of heart failure. Risk factors of heart failure were estimated by questionnaire and physical examination. The level of NT-pro BNP in plasma was determined using FIA8000 analyzer. According to the guideline produced by the European Society of Cardiology in 2016, result of the testing is considered “positive” when NT-pro BNP is higher than 125 pg/ml. Risk factors of chronic heart failure were studied in comparison with two groups which were NT-pro BNP positive and negative results and their statistically significant difference were determined. RESULTS. Of 87 participants, 51 (51%) were female and 49(49%) were male. Half of the participants (51%) were aged between 55-64. Arterial hypertension was determined in 88% of the participant, 38% were overdose drink of alcohol, therefore 55% were 1,2,3 levels obesity and 36% were diabetic. When determining the NT-pro BNP level, in 34 cases (34%) were positive. Hence, 31% of the people with arterial hypertension, 9% of the people overdose drink with alcohol, 20% of the people with obesity, 12% of the people with diabetes showed positive results of NT-pro BNP. When studying the risk factors of chronic heart failure of the compared two groups of NT-pro BNP positive and negative results, statistically significant difference (p<0.05) was increased of the with arterial hypertension and obesity. CONCLUSION. NT-pro BNP is the arterial hypertension and obesity which is increasing for people compared to the other risking factors

In valve surgery cases among Mongolia, post-arrhythmia is observed that as same as pre-arrhythmia by its kind and prevalence. Which is why post-operation complication, mortality, financial problems are high, also exceeding hospital care. Therefore we aimed to compare pre and post operation arrhythmia in patients who had aortic and mitral valve surgery. In order to compare, we measured pre and post surgery electrocardiogram from total 30 patients with satisfaction. Statistical analyses are completed by SPSS 23 software and the p-value is evaluated as significant when less than 0.05. The average age of patients were 43./±3/. The frequency of pre-surgery arrhythmia were 88.7% hence atrial fibrillation were 62.9%, moreover post-surgery arrhythmia were 80%. There was no statistically significant difference between pre and post surgery arrhythmia (p= 0.9). According to the result, we have concluded that arrhythmia frequency hasn’t been getting lower after valve surgery, consequently needed to improve arrhythmia control, treatment and admit novel methods such as Cox maze IV, and Catheter ablation.