A case of Toxic Epidermal Necrolysis affecting 24 years old, male Korean, who has been suffering from Pulmonary Tuberculosis, is presented. The skin lesions of the case have been developed about two months after administration of Thioacetazone, 150 mg. per day. The cause of this case may be due to Thioacetazone, one of the antituberculous drugs. Diagnosis of Toxic Epidermal Necrolysis was estsblished by clinical characteristics, histopathological and laboratory studies, and review of literatures were made also.
Diagnosis ; Humans ; Male ; Skin ; Stevens-Johnson Syndrome* ; Thioacetazone ; Tuberculosis, Pulmonary ; Young Adult

Dyschromatosis Symmetrica Hereditaria (Toyama) is one of the pigment anormaly hereditary skin disease which is known to manifest the Japanese. Various authors such as Toyama, Matsumoto, Komaya-Dohi and Ichikawa-Hiraga have reported the disease under different diagnostic name. Clinical characteristics of the disease are shown to have multiple reticular dark brown spotty macular skin lesion mostly over the face, neck, back of hands, feet, fingers and toes, which are affecting symmetrically, without subjective symptom, and occasionally the pigmented and depigmented macular lesions are intermingled. Among these author's reports to the disease, one postulate those which Matsumoto and Komaya-Dohi's cases were essentially similar type in clinical manifestation and were described as showing spotty pigmented macules intermingling with the depigmented over the areas as those of Toyama's. In this article, a case of Dyschromatosis Symemtrica Hereditaria manifesting 21 years old Korean male, which is similar to Matsumoto's type, is presented. Search for the heredity back ground revealed that the grandfather and mother were affected by this disease, and authors assumed the types of heredity of the disease to be irregular non-sexlinked dominant inheritance. Authors presented also distinctions of the histopathological findings of the disease which are hyperkeratosis, increased melanin granules in stratum mucosum layer and imperfect or immatured granular cells, and discussions of differential diagnosis and review of literatures are made.
Asian Continental Ancestry Group ; Diagnosis, Differential ; Fingers ; Foot ; Hand ; Heredity ; Humans ; Male ; Melanins ; Mothers ; Neck ; Skin ; Skin Diseases ; Toes ; Wills ; Young Adult

The distribution of the patterns of pubic hair and axillary hair was observed in 1970 men and 1761 women from 17 to 59 years of age. Among the 4 types usually found, the horizontal type predominated in male pubic hair irrespective of age, and the acuminate type, sagittal type and the disperse type followed in order. In the fernale public hair patterns, two new types were observed: a "linear type" and a "few type". The horizontal type was the predominant form and the acuminate type, the linear type, the few type, the disperse type and the sagittal type came in order. Women with no pubic hair rna,de up 4.4% of the total. But the patterns of pubic hair changed with age toward the types of little hair count such as the few and the linear type. In the axillary hair patterns of men, the whole type predominated and the brachial type, the central type came in order and men with no axillary hair made up 8.0% of the total. This distr!bution also changed with age, the central type being the commonest type in advanced age. In the a,xillary hair patterns of women, the whole type also predominated but with age, the numters of persons with no axillary hair increased. As to the relation of the body weight and the hair pattern, no conspicuous relation was found except for the female pubic hair pattern. In this group, persons below ideal body weight had low hair count, with statistical significance.
Body Weight ; Female ; Hair* ; Humans ; Ideal Body Weight ; Male

No abstract available.
Skin*

As increasing numbers of antibiotics, adrenocorticosteroids, and antitumor agents have come into use, so increasing numbars of mycotic diseases have been identified. Qtomycosis, a mycotic infection of the extcrnal ear which is occasionally accompanied by dermatitis of the surrounding skin, is corsidered to be such a disease. While opinion vari.es as to whether otomycosis is caused by a saprophytic or a pathogenic organism, our clinical obs:rvations revealed pathological inflammation of the external auditory canal with profuse fungal elements. During August 1975, l3 specimens of ear wax were taken from patients whv visited the out-patient ENT clinic of this hospital. All patients had had their ears clea,ned at a barber shop prior to visiting the ENT clinic. Because ar cleaning instrumenta (scoops and brushes) are re-used m Korean Sarber shops, 204 of theae in- strum.ent;s were randomly selected from different barber shops and examined. KGH mounts and Lactophenol cot@ten blue stains were used to examine the specimens. Qf the lR ear wax specimens, I2 samples (92. 3%) reveaIed Aspergillus sp. and 1 sample (7. 7%) revealed Penicillium sp. Of the 204 ear cleaning instrumenta tested, l94 colonies grew in culture. Of these cultures, 146 (75. 3 %) were Aspergillus sp., 9 (4. 6%) were Mycelia sterila, 5 (2. 6%) were Fenicillium sp., 4 (2. 1 %) wr Al- terna,ria, 2 (l. 0%) were Stemphylium sp., 1 (0. 5%) was Geotrichum sp., and 27 (13. 9%) were of an unknown species. Of the 146 Aspergillius sp. cultures, 99 (67. 8%) were Asp. terreus, 17 (11.6%) were Asp. glaucus, 5 (3.4%) were Asp. niger, 17 (11. 6%) were Asp. flavus-oryzRC, R (2. 1 %) Were Asp. versicolor, and 5 (3. 4 %) were athers. Beca.use of the close correlation between the fungi cultivated from ear wax apc imens and those cultured from ea,r cleaning instruments, the authors believe that the ear cleaning instruments used in the barber shops could well have been the primary source of infection. In this study the authors also discuss the probable causative factbrs of otomycosis arrd a review of the literature is presented.
Anti-Bacterial Agents ; Antineoplastic Agents ; Aspergillus ; Cerumen ; Coloring Agents ; Dermatitis ; Ear ; Ear Canal ; Epidemiologic Studies* ; Fungi ; Geotrichum ; Humans ; Inflammation ; Niger ; Otomycosis* ; Outpatients ; Penicillium ; Skin ; Viperidae

Mycetoma is a clinical syndrome of localized, indolent, deforming, swollen lesions and sinuses, involving cutaneous and subcutaneous tissues, fascia, and bone. Its lesions. are composed of suppurat.ing abscesses, granulomata, and dra ning sinuses and the etiologic agents are wide variety of bacteria (actinomycotic mycetoma) and fungi(eumcotic mycetoma) from plant and soil. The patient was a 65-year-old female and a farnier. She was referred by the skin lesion loalized on the dorsum of her lefther left hand and wrist for three months. It showed multiple subcutaneclis nodules, abscesses, and discharging fitula based on the erythematous plaque. The skin biopsy frorn the lesion revealed the PAS positive hyphae in the granulocytic infiltration. Fungus cult,ure with a piece of tissue on sabouraud media shows hin, floccose, white colonies. Slide culture and biochemical idcrtification of pathogen led to the final diagnosis as Mycetoma caused by Pseudallescheria boydii(Monosporium apiospermum). The lesions disappeared gradualy following systemic oral administratior of Itraconazole 200mg daily for six weeks.
Abscess ; Aged ; Bacteria ; Biopsy ; Diagnosis ; Fascia ; Female ; Fungi ; Hand ; Humans ; Hyphae ; Itraconazole ; Mycetoma* ; Plants ; Pseudallescheria* ; Skin ; Soil ; Subcutaneous Tissue ; Wrist

BACKGROUND: Keloids may occur at any age, but tend tend velop between the ages of 10 and 30. The incidence and median age of onset are equal for both sexes. Keloids are common among the darker pigmented rices, but there have been a few clinia studies of keloids in Korea. OBJECTIVE: The purpcse of this study was to evaluate the variable clinical characteristics of keloids in Korea. METHODS: This clinical investigation was made with 223 of patients of keloid who had visited the Department of Derrnatology, Chonnam University Hosptal from January 1984 to December 1993. RESULTS: 1.The annual incidenie averaged over 10 years was 0.831 (361 cases of total 43,752 outpatients). 2.The ratio of male to female was 1: 0.94(Male. 115, Feila 108). 3.The mean age of the onset and at the first visit to our hospital were 24.5years and 29.2 years respectively. 4.In our series tte presternal area was the most commor saes, the shouder region next. Most keloids on the shoulder were related to BCG vaccination in ifoncy or chilhood. 5.The precipitating fa ctors associated with keloid were riaeeding dermatologic diseases(33.2 %), unknown(17.9%) rejection & vaccination(15.2%), operation(13.9%), burn(13.9%) and laceration(5.8%) in descending order. 6.Among preceeding as, iociated dermatologic diseases, acne w s the most common. 7. A positive family history is more likely in cases of mitile keloidal (p<0,001), and severe keloidal formation. 8.Most patients did not. complain of any symptorns(45.3%) nd a symptom of pain or tenderness(40.8%) was piesert rather than pruritus(13.9%). 9.The most prevaent tr eatment modality was intralesional injection with triamcinolone acetonide (84.3%). CONCLUSION: According, to this study, usually keloids occore in patients between 10 and 29 years of age, and most keloids were located on the antetio partion of the chest, shoulders, and face and scalp. A positive family history is more likely in as of multiple, severe keloidal for mation.
Acne Vulgaris ; Age of Onset ; Female ; Humans ; Incidence ; Injections, Intralesional ; Jeollanam-do ; Keloid* ; Korea ; Male ; Mycobacterium bovis ; Scalp ; Shoulder ; Thorax ; Triamcinolone Acetonide ; Vaccination

The V-to-T plasty was developed by Field(1985), of which purposes are to place scars in natural wrinkle lines, be hidden by natural anatomic landmarks, and, if possible, attain symmetry. The authors reported a case of basal cell carcinoma arising at the upper lip of 66 years old male, We treated him with V-T plasty using the natural landmarka and wrinkle lines around the upper lip and the nose, Two weeks after operation, we attained excellent funtional and cosmetic results. So we recommended its method to operate tumors arising at forehead, upper & lower evelid, upper and lower lip, both preauricular area, etc.
Aged ; Anatomic Landmarks ; Carcinoma, Basal Cell* ; Cicatrix ; Forehead ; Humans ; Lip ; Male ; Nose

No abstract available.

Leprosy is an infectious dis as in which the immune machanism, in addition to the bacillus, plays an important role in Pathogenesis. As leprosy has two polar types, one of which is characterized by well preserved cellular immunity with a good prognosis and the other which shows no cellular immunity and a poor prognosis, it has been considercd the best human model for immunologic research. By studying the differences between these two typs, insights into immune deficiecies might well lead to the improved treatment of leproatous leproy(i.e.no cellular immunity) patients. Therefore, some immuno-theraputic trials for leprosy patients have already been reported by somc authors. In an attempt to survey spcific as well as nonspecific cellular immunity in leprosy, the authors prformed the lepromin and tuberculin skin tests with DNCB active cutanous sensitization on 203 leprosy patients in residence at the national leprosarium of Korea. All groups of Ieprosy patients showed decreased skin reactivity to the three tests, compared with normal, healthy control groups(p<0.01). This phenomenon is probably due to disorganization of lymphnode architecture and antigenic competition. Although a, statiscally significant difference could not be found in the tubercuIin and DNCB sensitization test results among all groups, the tuberculoid leprosy group and the arrested leprosy group showed stronger reactivity than the non-tuberculoid leprosy group. Patients positive for DNCB sensitization showed more positivity to the tuberculin test (66%)than to the lepromin test (30%) (p<0.01), thus suggesting that nonsp cific CMI and specific CMI exerted diffenent effects. Patients positive for DNCB sensitization also showed a greater probability (77%) to be responsive to either of the other two delayed cutanous hyperssensitivity tests than not. Leprosy patients in the third or fourth decade of life showed 63-66% positivity to DNCB active sensitization, while those in the six or seventh decad showed a positivity of 18-28%. These points toward significant correlation batween age and immun status. (p<0.01). The spontansous flare up during DNCB sensitization most frequently occurred on the 10th to 12th day of senitization: positive reaction after chalenge was most frequent in 72 hrs. after the test but some ractions were seen as late as five days after th. test. Two patiants of whole blood and its equivalent of leukocyte-rich plasme were irfused into 10 patients who had shown negative reaction to al! three tests. Conversion of delayed cutaneous hyprs:nsitivity among then was as follows; Four in tuberculin test (3 cases of which were strengthenings of preexisting ractivity). 2 in lepromin test, and 4 m DNCB sensitization. Of th 6 patients who showed a conversion in any one of the delayed cutaneous hypcrsensitivity evaluation tests, 4 showed conversion in more than two tests Of the 10 patients, who receivcd the transfusions (whole blood or lecocyte-rich plasma), 5 cases showed a high fever for 2 days afterrvards. The authors regard histocytotoxicity, incompatible histocompatibility, or perhaps simply a transfusion reaction as the underlying cause of this febrile reaction. One patient developed probably a phobia type psychosis following the blood transfusion and was subseuetly dropped from this study. Two months of observation following the transfusion revealed no definite clinical improvement.
Bacillus ; Blood Group Incompatibility ; Blood Transfusion ; Dinitrochlorobenzene ; Fever ; Histocompatibility ; Humans ; Immunity, Cellular* ; Korea ; Lepromin ; Leprosy* ; Leprosy, Tuberculoid ; Phobic Disorders ; Prognosis ; Psychotic Disorders ; Skin ; Skin Tests ; Tuberculin ; Tuberculin Test