A case of Toxic Epidermal Necrolysis affecting 24 years old, male Korean, who has been suffering from Pulmonary Tuberculosis, is presented. The skin lesions of the case have been developed about two months after administration of Thioacetazone, 150 mg. per day. The cause of this case may be due to Thioacetazone, one of the antituberculous drugs. Diagnosis of Toxic Epidermal Necrolysis was estsblished by clinical characteristics, histopathological and laboratory studies, and review of literatures were made also.
Diagnosis ; Humans ; Male ; Skin ; Stevens-Johnson Syndrome* ; Thioacetazone ; Tuberculosis, Pulmonary ; Young Adult

The distribution of the patterns of pubic hair and axillary hair was observed in 1970 men and 1761 women from 17 to 59 years of age. Among the 4 types usually found, the horizontal type predominated in male pubic hair irrespective of age, and the acuminate type, sagittal type and the disperse type followed in order. In the fernale public hair patterns, two new types were observed: a "linear type" and a "few type". The horizontal type was the predominant form and the acuminate type, the linear type, the few type, the disperse type and the sagittal type came in order. Women with no pubic hair rna,de up 4.4% of the total. But the patterns of pubic hair changed with age toward the types of little hair count such as the few and the linear type. In the axillary hair patterns of men, the whole type predominated and the brachial type, the central type came in order and men with no axillary hair made up 8.0% of the total. This distr!bution also changed with age, the central type being the commonest type in advanced age. In the a,xillary hair patterns of women, the whole type also predominated but with age, the numters of persons with no axillary hair increased. As to the relation of the body weight and the hair pattern, no conspicuous relation was found except for the female pubic hair pattern. In this group, persons below ideal body weight had low hair count, with statistical significance.
Body Weight ; Female ; Hair* ; Humans ; Ideal Body Weight ; Male

Dyschromatosis Symmetrica Hereditaria (Toyama) is one of the pigment anormaly hereditary skin disease which is known to manifest the Japanese. Various authors such as Toyama, Matsumoto, Komaya-Dohi and Ichikawa-Hiraga have reported the disease under different diagnostic name. Clinical characteristics of the disease are shown to have multiple reticular dark brown spotty macular skin lesion mostly over the face, neck, back of hands, feet, fingers and toes, which are affecting symmetrically, without subjective symptom, and occasionally the pigmented and depigmented macular lesions are intermingled. Among these author's reports to the disease, one postulate those which Matsumoto and Komaya-Dohi's cases were essentially similar type in clinical manifestation and were described as showing spotty pigmented macules intermingling with the depigmented over the areas as those of Toyama's. In this article, a case of Dyschromatosis Symemtrica Hereditaria manifesting 21 years old Korean male, which is similar to Matsumoto's type, is presented. Search for the heredity back ground revealed that the grandfather and mother were affected by this disease, and authors assumed the types of heredity of the disease to be irregular non-sexlinked dominant inheritance. Authors presented also distinctions of the histopathological findings of the disease which are hyperkeratosis, increased melanin granules in stratum mucosum layer and imperfect or immatured granular cells, and discussions of differential diagnosis and review of literatures are made.
Asian Continental Ancestry Group ; Diagnosis, Differential ; Fingers ; Foot ; Hand ; Heredity ; Humans ; Male ; Melanins ; Mothers ; Neck ; Skin ; Skin Diseases ; Toes ; Wills ; Young Adult

No abstract available.
Skin*

As increasing numbers of antibiotics, adrenocorticosteroids, and antitumor agents have come into use, so increasing numbars of mycotic diseases have been identified. Qtomycosis, a mycotic infection of the extcrnal ear which is occasionally accompanied by dermatitis of the surrounding skin, is corsidered to be such a disease. While opinion vari.es as to whether otomycosis is caused by a saprophytic or a pathogenic organism, our clinical obs:rvations revealed pathological inflammation of the external auditory canal with profuse fungal elements. During August 1975, l3 specimens of ear wax were taken from patients whv visited the out-patient ENT clinic of this hospital. All patients had had their ears clea,ned at a barber shop prior to visiting the ENT clinic. Because ar cleaning instrumenta (scoops and brushes) are re-used m Korean Sarber shops, 204 of theae in- strum.ent;s were randomly selected from different barber shops and examined. KGH mounts and Lactophenol cot@ten blue stains were used to examine the specimens. Qf the lR ear wax specimens, I2 samples (92. 3%) reveaIed Aspergillus sp. and 1 sample (7. 7%) revealed Penicillium sp. Of the 204 ear cleaning instrumenta tested, l94 colonies grew in culture. Of these cultures, 146 (75. 3 %) were Aspergillus sp., 9 (4. 6%) were Mycelia sterila, 5 (2. 6%) were Fenicillium sp., 4 (2. 1 %) wr Al- terna,ria, 2 (l. 0%) were Stemphylium sp., 1 (0. 5%) was Geotrichum sp., and 27 (13. 9%) were of an unknown species. Of the 146 Aspergillius sp. cultures, 99 (67. 8%) were Asp. terreus, 17 (11.6%) were Asp. glaucus, 5 (3.4%) were Asp. niger, 17 (11. 6%) were Asp. flavus-oryzRC, R (2. 1 %) Were Asp. versicolor, and 5 (3. 4 %) were athers. Beca.use of the close correlation between the fungi cultivated from ear wax apc imens and those cultured from ea,r cleaning instruments, the authors believe that the ear cleaning instruments used in the barber shops could well have been the primary source of infection. In this study the authors also discuss the probable causative factbrs of otomycosis arrd a review of the literature is presented.
Anti-Bacterial Agents ; Antineoplastic Agents ; Aspergillus ; Cerumen ; Coloring Agents ; Dermatitis ; Ear ; Ear Canal ; Epidemiologic Studies* ; Fungi ; Geotrichum ; Humans ; Inflammation ; Niger ; Otomycosis* ; Outpatients ; Penicillium ; Skin ; Viperidae

We present two cases of lymphangioma circumscriptum according to the clinical pattern and histopathological findings, one with lesions on the tongue and the other with lesions of the oral mucous membrane. The first case was a 5 year-old boy with a plaque of grouped transluscent vesicles resembling frog's spawn on ventral surface of the tongue of three years duration. The second case, also a 5 year-old boy, had a lymphangioma circumscriptum lesion in the right buccal mucous membrane which developed several months after birth and eventually produeed swelling of the right cheek. The histopathological findings of both cases showed variable-sized dilated lymphatic channels lined by one layer of normal endothelial cells, extending to the deep dermis, subcutaneous tissue and muscle layer and resembling the spongy type variant of classical lymphangoima circumscriptum using the classification of lymphangioma of Peacheyet al.
Cheek ; Child, Preschool ; Classification ; Dermis ; Endothelial Cells ; Humans ; Lymphangioma ; Male ; Mouth* ; Mucous Membrane ; Parturition ; Subcutaneous Tissue ; Tongue

Vascular tissue presumed to be the most sensitive target tissue of the immune and toxic reactions. Most of the vasculitides can be directly or indirectly associated with immunopathogenic rnechanisms. In this regards, the purpose of the study is to understand imrnunopathogenic mechanism of various cutaneous vasculitides by comparing their immunopathologic patterns. Imrnunopathologic studies were carried out on the blood vessel of various skin diseases by means of the direct immunofluorescent technique using FITC conjugated rabbit antihurnan IgG, IgA, IgM, C3 C1q, C4 and fibrinogen)(F). The results obtained were as follows : 16 patients with leukocytoclastic vasculitis out of 19 showed deposition of irnmune complex in the small upper dermal vessels and had positive reaction for F, 8 for IgA, 5 for C3 and 2 for IgM. Of the 6 patients with chronic pigmented purpura studied, 2 had IgM, 3 had Ca and all of these had F in small upper or middle dermal vessels. Immunopathologic patterns of livedo vasculitis were similar to those of chronic pigmented purpurs, except mainly affected in upper dermis. Nodular vasculitis and Behqets syndrome had deposits of F, C and IgM in medium or large vessels of the middle or lower dermis. Simultaneously, Cs in 2 patients with nodular vnsculitis and IgM in one patient with Behqets syndrorne were also noted along the basement mernbrane zone. In a patient with pityriasis lichenoides et varioliformis acuta, IgM and F were noted on the samll upper dermal vessels. With these results, the immune complex mechanism could be closly related the pathogenesis of most of cutaneous vasculitis. And various clinical manifestations or expression of vasculitis appear to be dependent upon 1) type of imrnune reaction, 2) size of blood vessels, 3) location and depth of blood vessels, 4) extend of affected areas and 5) involvement of other organs.
Antigen-Antibody Complex ; Blood Vessels ; Dermis ; Fluorescein-5-isothiocyanate ; Humans ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Pityriasis Lichenoides ; Purpura ; Skin Diseases ; Vasculitis*

Leprosy is an infectious dis as in which the immune machanism, in addition to the bacillus, plays an important role in Pathogenesis. As leprosy has two polar types, one of which is characterized by well preserved cellular immunity with a good prognosis and the other which shows no cellular immunity and a poor prognosis, it has been considercd the best human model for immunologic research. By studying the differences between these two typs, insights into immune deficiecies might well lead to the improved treatment of leproatous leproy(i.e.no cellular immunity) patients. Therefore, some immuno-theraputic trials for leprosy patients have already been reported by somc authors. In an attempt to survey spcific as well as nonspecific cellular immunity in leprosy, the authors prformed the lepromin and tuberculin skin tests with DNCB active cutanous sensitization on 203 leprosy patients in residence at the national leprosarium of Korea. All groups of Ieprosy patients showed decreased skin reactivity to the three tests, compared with normal, healthy control groups(p<0.01). This phenomenon is probably due to disorganization of lymphnode architecture and antigenic competition. Although a, statiscally significant difference could not be found in the tubercuIin and DNCB sensitization test results among all groups, the tuberculoid leprosy group and the arrested leprosy group showed stronger reactivity than the non-tuberculoid leprosy group. Patients positive for DNCB sensitization showed more positivity to the tuberculin test (66%)than to the lepromin test (30%) (p<0.01), thus suggesting that nonsp cific CMI and specific CMI exerted diffenent effects. Patients positive for DNCB sensitization also showed a greater probability (77%) to be responsive to either of the other two delayed cutanous hyperssensitivity tests than not. Leprosy patients in the third or fourth decade of life showed 63-66% positivity to DNCB active sensitization, while those in the six or seventh decad showed a positivity of 18-28%. These points toward significant correlation batween age and immun status. (p<0.01). The spontansous flare up during DNCB sensitization most frequently occurred on the 10th to 12th day of senitization: positive reaction after chalenge was most frequent in 72 hrs. after the test but some ractions were seen as late as five days after th. test. Two patiants of whole blood and its equivalent of leukocyte-rich plasme were irfused into 10 patients who had shown negative reaction to al! three tests. Conversion of delayed cutaneous hyprs:nsitivity among then was as follows; Four in tuberculin test (3 cases of which were strengthenings of preexisting ractivity). 2 in lepromin test, and 4 m DNCB sensitization. Of th 6 patients who showed a conversion in any one of the delayed cutaneous hypcrsensitivity evaluation tests, 4 showed conversion in more than two tests Of the 10 patients, who receivcd the transfusions (whole blood or lecocyte-rich plasma), 5 cases showed a high fever for 2 days afterrvards. The authors regard histocytotoxicity, incompatible histocompatibility, or perhaps simply a transfusion reaction as the underlying cause of this febrile reaction. One patient developed probably a phobia type psychosis following the blood transfusion and was subseuetly dropped from this study. Two months of observation following the transfusion revealed no definite clinical improvement.
Bacillus ; Blood Group Incompatibility ; Blood Transfusion ; Dinitrochlorobenzene ; Fever ; Histocompatibility ; Humans ; Immunity, Cellular* ; Korea ; Lepromin ; Leprosy* ; Leprosy, Tuberculoid ; Phobic Disorders ; Prognosis ; Psychotic Disorders ; Skin ; Skin Tests ; Tuberculin ; Tuberculin Test

Omphalith generally consists of keratinous materials and sebum. It gradually forms a stone-like hard, dark brown to a black mass in elderly persons with deep umbilical depression and not clean umbilicus. A 75 years old male noticed a brownish black nodule on the umbilical depression 2 weeks ago. He did not try to remove it. This nodule gradually became to project from umbilical depression accompanied with intermittent pain. Removed specimen was brownish black stonelike on projecting polypoid lesion, but in umbilical depression, yellowish brown and not so hard. Histopathological examination showed a small quantity of melanin granules, but no nuclear components of cells.
Aged ; Depression ; Humans ; Male ; Melanins ; Sebum ; Umbilicus

Cutis naarmorata telangiectatica congenita(CMTC) was first lesribed by Van Lohuizen in 1992. Cases of CMTC were reported later under various names, includir gan Lohuizens syndrome, congenital generalized phlebectasia. congential phlebectasia and reticulatever scular nevus. It is charaterized by persistent livedo reticularis, telangiectasia and phlectnsia from birch hand atrophy and superficial ulceration of the overlying skin are uncornmonly encountered. They have a steady improvement with time, however various congenital abnormalties, such as varicosities, hen ariomas, hypoplasia or hypertrophy of soft tissue and bones, rarely generalized congenital fibrornatos ectal and genital anomaliies may be associated in approxirnately 50 percent of patients. In case 1, the patient was 45-day-old female infant with reticulated mottling and atrophy of the skin on the right leg. In case 2, the patient was 30-day-old male infant who depressed, bluish, and reticulated patches on the both upprarms, right side trunk, buttock and loen leg. Decreased circumferences of the affected extremities vas observed in case 2. No other assotated anomalies were found in physical and X-ray examinatiorwlin both cases. The skin biiopsy of bothed similar findings, which revealed mild dilatation and proliferation of capillaries, mild inflammatoryel infiltration and extravasated red blood cells in the dermis. The clinical follow-up, alneast all of th lisions disappeared spont.anously in 1 year at case 1, and some of lesions also disappeared in 3 month, 11 case 2. In addition, we reviewed and summerized the reported cases in Korea.
Atrophy ; Betula ; Buttocks ; Capillaries ; Dermis ; Dilatation ; Erythrocytes ; Extremities ; Female ; Follow-Up Studies ; Hand ; Humans ; Hypertrophy ; Infant ; Korea ; Leg ; Livedo Reticularis ; Male ; Nevus ; Skin ; Telangiectasis ; Ulcer