Keratoacanthoma is a rapidly growing tumor that has the tendency of spontaneous involution but it may persist for some times, continue to enlarge and may become invasive and destructive. Many modalities are available for the treatment of keratoacanthoma. Although excisional surgery is the treatment of choice, this can result in functional and cosmetic defects when large or strategically located lesions are treated. An effective nonsurgical treatment would be desirable in such cases. We report two cases with unusually large or facial keratoacanthoma treated with intralesional methotrexate. One case showed complete resolution over 6 injections and the other after 2 injections. We suggest that intralesional injection of methotrexate is a simple, effective, safe and inexpensive method for the treatment of large keratoacanthoma.
Injections, Intralesional ; Keratoacanthoma* ; Methotrexate*

No abstract available.
Injections, Intralesional* ; Tuberculosis*

No abstract available.
Hemangioma* ; Injections, Intralesional* ; Propranolol ; Triamcinolone*

These are the first reported cases of granuloma faciale in two Koreans. Unilateral, slightly elevated violaceous plaque with illdefined margin on cheeck since 20 years ago was observed in 36 year old house-wife, and 40 year old male has had bilateral plaques on both cheek areas since 10 years ago, These plaques were showed the typical histological appearance of granuloma faciale respectively on both of two patients. Literature was briefly reviewed for the discussion of clinical and microseopic findings of this disease. Both patients were treated by intralesional injections and ointment of steroid with relative clinical improvements.
Adult ; Cheek ; Granuloma* ; Humans ; Injections, Intralesional ; Male

Keratoacanthoma is a not uncommon skin tumor characterized by rapid growth of a smooth dome-shaped nodule with a central plug of keratin, usually followed by spontaneous involution. Because the tumor leaves a nunsightly scar, this is one of the reasons why these lesions should be treated. Excision is desirable if the diagnosis is in doubt. But surgical removal may be difficult, alternative treatment approaches should be considered. We report two cases of keratocathoma successfully treated by intralesional injection of 5-fluorouracil.
Cicatrix ; Diagnosis ; Fluorouracil* ; Injections, Intralesional* ; Keratoacanthoma* ; Skin

Digital mucous cysts are observed frequently on the lateral or dorsal aspect of the digital fingers. Digital mucous cysts are prone to recur after simple excision, electrocoagulation, intralesional injection of corticosteroid and a variety of other therapeutic maneuvers. In this report, we describe one patient with digital mucous cyst who was successfully treated with intralesional injection of 1 mg/ml of minocycline hydrochloride without any sequelae.
Electrocoagulation ; Fingers ; Humans ; Injections, Intralesional ; Minocycline ; Sclerotherapy

No abstract available.
Injections, Intralesional ; Isotretinoin ; Triamcinolone ; Triamcinolone Acetonide

A typical case of lichen amyloidosis is reported. This case is considered to be the first one in Korea. Intralesional injection of prednisolone proved to be effective in this case. The etiologic and therapeutic aspects of this disease are discussed.
Amyloidosis* ; Injections, Intralesional ; Korea ; Lichens* ; Prednisolone

BACKGROUND: The warts may promptly return despite being treated with a myriad of destructive methods. The most successful treatment has been the intralesional injection of bleomycin sulfate, but unplessant side effects caused by the difficulty of infiltrating only the wart tissue have limited its use. OBJECTIVE: Our purpose was to determine the effects of bleopunciure technique in the treatment of warts. METHODS: We performed a multiple puncture technique using a 25 gauge hypodermic needle to introduce bleomycin hydrochloricle into warts. RESULTS: This technique resulted in elimination of 91.4% of a random series on 105 warts after a single treatment. Recurrence and side effects were not observed during a 1 year follow-up period. CONCLUSION: We experienced a superior technique for introducing Heomycin into the wart, which has resulted in the cure of a signficant number of warts following a sing treatment.
Bleomycin ; Follow-Up Studies ; Injections, Intralesional ; Needles ; Punctures ; Recurrence ; Warts*

Infantile hemangiomas are the most common benign tumors of infancy and they can occur on any part of the body. However, their presentation as a perianal ulcer prior to the development of a clinical hemangioma is extremely rare. A 5-week-old girl presented with painful ulcerated lesions on the perianal area, which developed about 10 days after her birth. Histopathologic examination showed the proliferation of dilated vessels in the upper dermis. The patient was treated with combined approach using topical steroid, 5% imiquimod cream and triamcinolone intralesional injection. Clinical improvement was observed. We herein report on a case of infantile hemangioma that presented with perianal ulcers.
Aminoquinolines ; Dermis ; Hemangioma ; Humans ; Injections, Intralesional ; Parturition ; Triamcinolone ; Ulcer