Keratoacanthoma is a rapidly growing tumor that has the tendency of spontaneous involution but it may persist for some times, continue to enlarge and may become invasive and destructive. Many modalities are available for the treatment of keratoacanthoma. Although excisional surgery is the treatment of choice, this can result in functional and cosmetic defects when large or strategically located lesions are treated. An effective nonsurgical treatment would be desirable in such cases. We report two cases with unusually large or facial keratoacanthoma treated with intralesional methotrexate. One case showed complete resolution over 6 injections and the other after 2 injections. We suggest that intralesional injection of methotrexate is a simple, effective, safe and inexpensive method for the treatment of large keratoacanthoma.
Injections, Intralesional ; Keratoacanthoma* ; Methotrexate*

No abstract available.
Injections, Intralesional* ; Tuberculosis*

32.
Injections, Intralesional ; Lymphangioma* ; Picibanil* ; Sclerotherapy*

No abstract available.
Hemangioma* ; Injections, Intralesional* ; Propranolol ; Triamcinolone*

Digital mucous cysts are observed frequently on the lateral or dorsal aspect of the digital fingers. Digital mucous cysts are prone to recur after simple excision, electrocoagulation, intralesional injection of corticosteroid and a variety of other therapeutic maneuvers. In this report, we describe one patient with digital mucous cyst who was successfully treated with intralesional injection of 1 mg/ml of minocycline hydrochloride without any sequelae.
Electrocoagulation ; Fingers ; Humans ; Injections, Intralesional ; Minocycline ; Sclerotherapy

These are the first reported cases of granuloma faciale in two Koreans. Unilateral, slightly elevated violaceous plaque with illdefined margin on cheeck since 20 years ago was observed in 36 year old house-wife, and 40 year old male has had bilateral plaques on both cheek areas since 10 years ago, These plaques were showed the typical histological appearance of granuloma faciale respectively on both of two patients. Literature was briefly reviewed for the discussion of clinical and microseopic findings of this disease. Both patients were treated by intralesional injections and ointment of steroid with relative clinical improvements.
Adult ; Cheek ; Granuloma* ; Humans ; Injections, Intralesional ; Male

Keratoacanthoma is a not uncommon skin tumor characterized by rapid growth of a smooth dome-shaped nodule with a central plug of keratin, usually followed by spontaneous involution. Because the tumor leaves a nunsightly scar, this is one of the reasons why these lesions should be treated. Excision is desirable if the diagnosis is in doubt. But surgical removal may be difficult, alternative treatment approaches should be considered. We report two cases of keratocathoma successfully treated by intralesional injection of 5-fluorouracil.
Cicatrix ; Diagnosis ; Fluorouracil* ; Injections, Intralesional* ; Keratoacanthoma* ; Skin

No abstract available.
Injections, Intralesional ; Isotretinoin ; Triamcinolone ; Triamcinolone Acetonide

A typical case of lichen amyloidosis is reported. This case is considered to be the first one in Korea. Intralesional injection of prednisolone proved to be effective in this case. The etiologic and therapeutic aspects of this disease are discussed.
Amyloidosis* ; Injections, Intralesional ; Korea ; Lichens* ; Prednisolone

This study was performed to investigate the clinical efficacy of intralesional recombinant interferon-γ (IFN-γ) in the treatments of warts, using a placebo comparison. Warts of each groups were injected with INF-γ containing 5×10⁶ IU/ml (high dose), 1×10⁶ IU/ml (low dose), or distilled water for injection as placebo, respectively, twice weekly for three weeks. The final therapeutic efficacy was determined on the fourth week after the beginning of therapy. Among the 74 patients with periungual warts, plantar warts, or warts of other sites, complete clearing of the treated warts at week four occurred in 56% of the 36 patients receiving the high dose IFN-γ compared to 30% of the 53 receiving the low dose IFN-γ and 17% of the 36 receiving the placebo. Marked improvement showing 75% or greater regression of wart lesions was noted as 89% of patients receiving the high dose INE compared with 55% receiving the low dose IFN and 50% receiving the placebo. The group of patients with warts of other sites showed the best response. The group receiving the high dose IFN experienced some adverse effects more frequently or more severely than the group receiving low dose IFN. However, the effects were relatively tolerable to the patients. Therefore, intralesional injection of the high dose IFN-γ may be more useful in treating warts than a low dose IFN-γ.
Humans ; Injections, Intralesional ; Interferon-gamma* ; Treatment Outcome ; Warts* ; Water